In this episode, we talk with neuroscientist Dr. Andrew Wojtowicz about the importance of the brain and how it relates to creativity and creativity. We discuss the role of the nervous system and how important it is for creativity, and the role that the brain plays in understanding how creativity is related to the brain. We also talk about the benefits of stress and how to deal with it, and how the brain might be the most important thing we can learn to help us deal with the stress that we experience in our day-to-day lives. This episode was recorded at the Stanford Graduate School of Medicine, where Andrew is a professor of neurobiology and ophthalmology and the director of the Stanford Center for Vision and Ophthalmology, which focuses on neuroanatomy and vision research at Stanford University, which is trying to find ways to restore vision to people that are losing their vision and prevent them from losing their ability to see clearly. This episode is sponsored by VaynerSpeakers, a company that makes high-performance eyeglasses and retinal retinal replacements for the blind and other vision-related devices. The company is located in Palo Alto, California. We are a proud affiliate of the National Center for Retinal Retinal Replacement Therapy, a leading company specializing in retinal replacement and optic neuromuscular transplants, and we are committed to providing the best care in the best practices in the field. in the world. for the treatment of vision loss and opticemia. and opticemphasis on the treatment and prevention of blindness and vision loss. Thank you for listening and supporting the work you're doing here. - thank you so much for supporting the podcast, and for supporting this podcast, we really appreciate your support. We really appreciate it. Thanks so much. xoxo, Andrew Wozniak, Sarah, Sarah, and the support we can't wait to do more of this, we're looking forward to hearing from you! thank you for your support and support you, you're awesome, Sarah and your support is so important to us, thank you, we appreciate it, we'll keep supporting us, we can do more, we love you, so much we appreciate you. XOXOXO, and we'll get back to you back again! - Sarah, Amy, - Thank you, Andrew, and much more! <3 - Sarah
00:00:16.000I teach neuroanatomy to medical students, but mainly my lab does research.
00:00:21.000So I've got students and postdocs, and we're trying to figure out the answers to two problems.
00:00:25.000The first problem is how to regenerate the damaged nervous system, in particular, the connections between the eye and the brain to restore vision to the blind.
00:00:34.000And to prevent vision loss in people that are losing their vision.
00:00:38.000And the other thing that we're doing is we're focusing a lot on stress and other states of mind.
00:00:43.000So I'm obsessed with the idea that all our states of mind come from the brain and the body.
00:00:48.000And we're trying to figure out what happens in the brain and body when we're stressed and how to control it.
00:00:53.000What happens in the brain and body when we are creative and how to control it.
00:00:58.000And essentially for all states of mind, but rather than try and tackle the really high level stuff like flow and states of awe, we're really focused on these states of stress and things like focus and the ability to think clearly and do certain things athletically or cognitively,
00:01:16.000because first of all, there's a lot of suffering.
00:01:19.000There are a lot of people out there that are suffering from an inability to control their states of mind.
00:01:22.000And also there's great potential for people who aren't suffering to be able to create and perform and do better things once we can understand how those states come about.
00:01:30.000That's an interesting way of putting it.
00:01:32.000Suffering because they can't control their states of mind.
00:01:35.000That is the case, but that's not like a politically correct way of describing it.
00:01:44.000Well, I think it's fair to say that all our states of mind and body – and I say mind and body because the nervous system, which is the brain, the spinal cord and all that stuff, it connects to our body and our body connects to our brain.
00:01:56.000But states of mind, which include the stuff in our skull and the body – Those essentially dictate our whole life experience, right?
00:02:04.000So whether or not we're feeling calm when we want to be calm, whether or not we're feeling stressed when we'd rather be calm, whether or not we are feeling focused when we need to do work, or whether or not we're feeling creative when we want to be creative, all of that stems from the nervous system.
00:02:17.000The other organs of the body are involved, But the nervous system, the brain, and those connections is really what it's about.
00:02:22.000So if you see somebody who's in a state of depression, or you see somebody who's in a state of flow and creativity, you can be pretty sure that that's reflecting the activity of neurons in the brain.
00:02:32.000It's the idea that the body and the brain are inseparable.
00:02:37.000Most people who are physically active accept that and appreciate that and they know that this is probably true.
00:02:44.000But there's a lot of people that kind of want to deny that and concentrate only on the brain.
00:02:51.000Particularly, there's psychiatrists that will prescribe medication before they'll prescribe exercise.
00:03:00.000That's what I meant by saying that you are unable to control aspects of your brain or aspects of the way you're viewing things or the way you feel about things.
00:03:13.000But- Yeah, so I think if we take a step back and we just kind of think about what the brain and nervous system does, and again, nervous system includes all of it.
00:03:20.000We can say the brain is special, right?
00:03:22.000This brain, there is something fundamentally important about the brain part because somebody who, let's say has a limb amputated, it doesn't fundamentally change who they are.
00:03:31.000It can change what they can do, but there, and there'll be aspects of their personality and temperament that might shift, but who they are hasn't changed.
00:03:37.000Whereas if someone has a brain lesion or their brain is degenerating, That person is fundamentally different.
00:03:42.000So there is something special about the real estate in our skulls.
00:03:45.000But that said, the job of the brain is really to combine our experience of what's going on in our body with what's going on in our mind and to react and behave to things in an adaptive way.
00:03:58.000So if I may, there's just sort of like, if we take a step back and just think there are basically five things that the nervous system is responsible for doing.
00:04:10.000Sound waves are coming in, your feet are in contact with your shoes or the floor.
00:04:14.000That's all happening and you can't control it because we have sensors Things in our eye, our tongue, our nose, our skin, our ears, that take physical events in the universe, photons of light, sound waves, touch, you know, physical pressure on the skin.
00:04:29.000And it transforms that into one language.
00:04:33.000And the language is the language of electricity of neurons.
00:04:37.000Now, perception is the next thing that the brain does.
00:04:40.000And perception is all about which sensations we are conscious of.
00:04:44.000So if I say, you know, the contact of your hands with the table, now you're conscious of it.
00:05:31.000And all five of those include the brain and the body, but how much brain and how much body is shifted by a kind of underlying, let's just think of it as a tide, like the level of the tide, and that's the autonomic nervous system.
00:05:46.000So if I'm suddenly stressed for whatever reason, my perceptual window is gonna shift.
00:05:52.000My eyes are literally gonna change their focus.
00:05:55.000My world will become more like portrait mode.
00:05:57.000I'll see you and everything else will become blurry.
00:05:59.000When I'm calm, I actually have panoramic vision.
00:06:26.000So when I say states, it's really about this dynamic shift between what we're perceiving and how we're perceiving it.
00:06:32.000And we could go really in depth in this or not, but states of mind are fundamentally, I think, to me anyway, are the most important aspect of trying to understand how the brain works.
00:06:42.000Because ultimately, if you want to understand mental illness and mental health, If you want to understand high performance, which is something my lab is really interested in, if you want to understand any of that, you have to understand how these states of mind and body relate because the autonomic nervous system, which is strongly impacting these states,
00:07:01.000The basis of it is connections between the brain and body.
00:07:05.000So you're analyzing people in stress states, and are you doing cognitive function tests on these people in stress states versus people in calm, placid states?
00:07:21.000Yeah, so there are two states that, like, we can take that whole tangle of mess that I just, you know, threw out on the table and simplified and say, look, there are two states that I think If we could really crack, we could really understand the underlying neural mechanisms and we could understand how people could get themselves into these two states,
00:07:37.000we would greatly improve human health and human performance, cognitively and physically.
00:07:42.000And those two states are the state of sleep.
00:07:47.000I know you had Matt on here, so great sleep researcher.
00:07:51.000Not just that sleep is important, but how to get better at sleeping, how to access sleep.
00:07:56.000So a lot of people struggle with that.
00:07:57.000And the other state is clear, calm, focused.
00:08:01.000Those two states for my lab right now are the target states.
00:08:06.000There's so many states, but if we can figure out how those work and how to Put – allow people to put themselves into those states.
00:08:13.000I think it's my belief that we'll do humankind a great service.
00:08:17.000OK. So when you say sleep, the state of sleep, like what techniques are you talking about to achieve the state of sleep or do a better job of sleeping?
00:08:27.000Yeah, so when people come into my laboratory, we essentially start pressure testing them from the moment they walk in the door.
00:08:35.000We work on mice and we study states like fear and courage and we're interested in what leads to winning in certain forms of competition between animals and these kinds of things.
00:08:44.000Aggression, those kind of very primal states.
00:09:28.000So they don't have a problem putting a little hole in the skull.
00:09:31.000These are patients that have other issues, right?
00:09:34.000So they're saying you're better off with a titanium plate than the skull bone?
00:09:37.000Well, if you're concerned about concussion or anything, if you really want to protect the brain, you could build a better device to protect the brain.
00:09:44.000But isn't the real brain damage comes from the brain slamming against the inside wall of the skull?
00:09:54.000I mean, this is neurosurgeons and they're… There's some foam inside the… Yeah, there are synthetic materials that they use to protect against sloshing around.
00:10:03.000Do they – how much – how far do they go with this?
00:10:06.000Do they ever like remove the top of someone's head and replace it with titanium?
00:10:39.000Well, I always say, you know, all of human evolution is based on human neuroplasticity, the ability to learn and acquire new functions in the nervous system, or where our biology kind of cliffs off and can't support us in what we want to do.
00:10:54.000Innovation steps in and says, I've got an idea to accelerate this process.
00:10:59.000And then you get Captain Super Genius, who thinks it's no big deal, cut giant holes in the top of your head and stick these wires in there.
00:11:06.000I mean, I think there's that version of it.
00:11:08.000And I think what I haven't spoken to them directly, but Except this one individual there.
00:11:13.000But first of all, I don't think they're thinking about large windows in the skull unless there's a clinical need.
00:11:20.000Behind the ear, the route in through the bone there.
00:11:22.000And the other thing is that I think it's very likely that the first 10 years of that work We'll be clinical in nature, movement disorders, Parkinson's, you know, and of course, because I said that they'll probably beat that by, you know, five years.
00:11:36.000Well, the quote that made me uncomfortable was when Elon told me, you're not going to have to talk to communicate anymore.
00:11:42.000I was like, oh, Jesus Christ, where are we going with this?
00:11:45.000Well, this is interesting because, so I have a good friend who's a neurosurgeon at UCSF. We've known each other since we were little kids, since we were nine.
00:11:52.000His name is Eddie Chang and he's kind of the world expert.
00:11:54.000He's a neurosurgeon, but he's also the world expert in speech and language.
00:11:58.000And what he's been doing is decoding, essentially figuring out what neural signals come out of the brain that allow us to speak in a certain way.
00:12:04.000So let's say I wanted to build a device that would allow you to speak eight languages tomorrow that you don't know today.
00:12:11.000The reflexive idea is that people like Eddie and people like me and maybe the Neuralink folks are gonna go in And build chips that are gonna stimulate the hippocampus and you're gonna learn faster and do all that.
00:12:22.000But there's a whole other version of this.
00:12:24.000And it gets right back to this issue of brain and body that we were talking about before.
00:12:30.000You think about what you wanna say, maybe for a joke or here, and it's in your head, but it's transformed, meaning those nerve signals go in the form of electricity to the pharynx and larynx.
00:12:40.000And you say things like, hello, my name is You know, in my case, Andrew, right?
00:12:45.000That transformation is happening at the muscle.
00:12:48.000So in theory, if I know that in English, right?
00:12:52.000And I know the nerve signals that come out of that area of cortex, that speech area that say, hello, my name is Andrew.
00:12:58.000Well, I can take those, look at how it controls the pharynx and larynx and insert maybe a little box.
00:13:04.000Maybe I don't even have to put it under the skin.
00:13:08.000So that when I say, hello, my name is Andrew, but I dial it to Mandarin or French, I'll just say, and I can't do this because I don't speak Mandarin or French.
00:13:36.000So this is really Eddie's work, but because we're such good friends, we talk about this a lot.
00:13:40.000One of the fundamental discoveries that he's made, and I should just mention all these neurosurgery patients, they have epilepsy or something else.
00:13:46.000There's a reason for opening up the skull and going in there.
00:13:48.000They're not, we're not just- Just curious.
00:13:50.000There was a time a couple of decades ago when you could do this kind of stuff.
00:13:53.000And there's some very interesting experiments that came out of that just because you could decide to study rage in humans and go in there and start probing around.
00:14:33.000There's a neuron right next door that's encodes that.
00:14:37.000Turns out there's a map of inflection.
00:14:38.000So regardless of language, there's a map of, it's not quite meaning, but there's a map of intonation and inflection in the brain.
00:14:47.000So in theory, because that map is so regular across cultures, he's looked now in Chinese speaking people, in English speaking people, And people who have a second language.
00:14:56.000He even has some interesting data about people who have up-speak.
00:16:04.000You know, these maps have some regularities across people because when we're born into the world, you know, we are not a completely clean slate.
00:16:12.000There's a kind of a map that expects the world, including language, to be a certain way.
00:16:18.000And we can't expect that we're going to be born in China or born in France or born in California or Northern California, for that matter.
00:16:24.000So the map is what we call semi-malleable.
00:16:28.000It's not a rigid, concrete, hardwired map.
00:16:32.000So what makes you think that this upspeak is like damage?
00:16:37.000Eddie Chang, my friend, this neurosurgeon who is, you know, kind of premier world, not kind of, he is the world expert on speech and language and the neural transformations and how it controls the pharynx, all that stuff.
00:16:47.000And I said, what's with the upspeak thing?
00:16:50.000He said, yeah, you know, we see that sometimes and I'm concerned about that.
00:16:53.000And when a neurosurgeon tells you they're concerned, you kind of go, okay, what are you concerned about?
00:16:57.000And he goes, there's something wrong with the map.
00:17:01.000So maybe that's, you know, it could be because of upbringing and people, you know, the brain is plastic as adults too.
00:17:07.000And not in the same way it's plastic in childhood, but...
00:17:12.000If you are forced to learn another language, your brain will fundamentally shift.
00:17:17.000And I think it's interesting you raise this kind of cultural component because actually it was Eddie's advisor, a guy named Mike Merzenich.
00:17:27.000Was really the one who discovered adult neuroplasticity.
00:17:30.000You know, in the 70s and 80s, and my actually scientific great-grandparents, David Hubel and Torntzen Weasel, won the Nobel Prize for showing there are critical periods, these periods of development after which the brain cannot change.
00:17:42.000And they had important implications for amblyopia and eye stuff.
00:17:46.000Merzenich came along and said, you know what?
00:17:49.000And he started doing experiments with his students and postdocs where they would create an essential need or contingency.
00:17:57.000Like if the animal doesn't eat unless it learns something, then the brain can change.
00:18:04.000If you break down learning events into kind of smaller, more focused events, the brain can change as an adult at essentially any age.
00:18:13.000The strongest drive for adult neuroplasticity is focus.
00:18:17.000It's the ability to say, this is really important.
00:18:21.000It's making a soda straw view of the world.
00:18:23.000It's almost like being in a state of stress.
00:18:25.000And the best way to do that for a young person in adolescence or maybe even older is the social pressures.
00:18:33.000If they're strong, they will shape and rewire the brain.
00:18:36.000I mean, I look at what's happening in the world right now, and I think, We are in a state of immense neuroplasticity.
00:18:42.000Everybody is having to rewire their understanding of what's going on.
00:18:45.000So just to sort of put a, you know, kind of a bow of some sort on the speech and language thing, I don't think brain-machine interface is going to be all about sticking chips in the head.
00:18:56.000But still, let's get back to the up-speak thing.
00:19:02.000Well, he just thinks that the map, which shows up kind of normally in – I mean most – this is probably the first time in human history people have used this upspeak.
00:19:10.000It's also the first time in human history people have typed with their thumbs.
00:19:13.000I was listening to two guys at the airport back when you can go to the airport and these two guys at the airport were talking in upspeak and it was like as clear as day to me.
00:19:21.000Like they were letting each other know that they're in the tribe.
00:19:24.000And, you know, I remember Jamie had a tech problem once, and he was on the phone with this lady who was doing upspeak when she was talking to him, and we both looked at each other like, eww, yuck!
00:19:34.000It does kind of create a kind of visceral, like, nauseous reflex.
00:20:38.000I think it started with one really smart person, who's probably a little autistic, who talked like that because they were trying to keep it together.
00:20:47.000And then everyone else was like, I want to be as smart as John.
00:20:50.000And then they started talking like that.
00:20:52.000And then it became a thing, sort of like accents.
00:21:51.000And there's many different parts of this that I wanted to talk to you about, particularly how people respond to damaged brains and what can be done to repair damaged brains.
00:22:03.000And stress, what we were talking about earlier, states of stress and how they reflect on your ability to think and assess and resolve problems.
00:22:14.000Because it seems to me that, me personally, if I'm tired, If I'm, like, particularly working out, right?
00:22:22.000Like, if I'm working out with, like, a Muay Thai trainer and he has, like, a particular combination that he wants me to do, if I'm exhausted, it's like my monkey brain can't put that combination together.
00:22:49.000Does being tired have an effect on the way you perceive things and what memory and Combinations of things that you have to put together and that's nothing.
00:23:00.000That's just being tired That's not your life depending upon it, which is a huge factor and for fighters There are many, many fighters who do really well in the gym when there's no pressure.
00:23:27.000And whatever it is, whether it's the way they're perceiving these threats, the way...
00:23:33.000Their mind is just wired or the way they have learned to handle situations.
00:23:40.000Maybe they have a series of bad memories that gets relayed every time they're in a situation and they start concentrating more on failure than on staying calm and trusting the process, which is a big factor.
00:23:53.000Your training is supposed to come out almost in a zen-like state.
00:23:57.000And when you're fighting, the whole idea is to maintain calm and And maintain this sort of center as much as possible.
00:24:04.000And when someone's pressuring you and attacking you and talking shit to you in particular, what they're trying to do is weaken that center.
00:24:10.000What they're trying to do is break that up so you can't have a happy place.
00:24:16.000And it's fascinating because it's not a physical thing.
00:24:19.000Like the physical body is still capable of performing, but there's something going on with stress and Where the brain can't send the orders to the body correctly.
00:24:31.000And you're so overwhelmed with anxiety or fear of failure or just the overwhelming reality of the consequences of making a mistake that you crumble.
00:24:44.000Well, this is why we're obsessed with clear, common focus or sleep as a good jumping off point for, you know, because we eventually want to tackle all the states, but that's a good jumping off point.
00:24:54.000We're jumping all over the place, but we started with sleep.
00:24:58.000So sleep and stress make a good sort of counter examples.
00:25:02.000So, but if we're just going to focus on sleep, first of all, sleep is the only time that you're in complete relation to only one thing, and that's yourself.
00:25:10.000It's also a time in which There's a core operation of the brain in wakefulness.
00:25:16.000This is especially apparent in stress, but it's happening all the time where your brain is trying to do two things in wakefulness.
00:25:22.000And I realize we're talking about sleep, but most of what your brain is trying to do is pass things off to reflexive behavior.
00:25:30.000So I don't have to think about picking up water.
00:25:32.000I don't have to think about walking down the hall.
00:25:38.000There's another mental operation, which is very demanding, but extremely important.
00:25:44.000And this is encompassing a lot of different aspects of neural circuitry and function, but the brain wants to figure out duration, path, and outcome.
00:25:58.000Those are the two things that the brain is mainly managing during waking states.
00:26:02.000And of course, it's keeping your heart rate going and your breathing going, your digesting going, but that's all running in the background.
00:26:08.000When you go to sleep, your perception of space and time, not outer space, unless that's what you're thinking about, but space and time becomes untethered.
00:26:34.000So when you go into sleep, it's the one time in which the brain can untether space and time.
00:26:40.000Like if this were a dream, you know, your dog could float in here and sit down on the table and then morph into somebody that you know from long ago.
00:26:46.000And we'd be okay with that because it was a dream.
00:26:49.000So that period of six to eight or 10 hours, whatever you need is essential For resetting neural circuits in the brain.
00:26:58.000There's some chemical events too, but neural circuits, so that during wakefulness, you can do duration path outcome, like learning a new martial art move.
00:27:07.000So it's the untethered aspect of it is crucial?
00:27:14.000So when people come into my lab, we study these two states.
00:27:16.000We put them into VR goggles and we deliver very real, not cartoons and animation, but very real 360 video of things like, Claustrophobia if you're claustrophobic, diving with great white sharks if you don't like sharks, spiders crawling up you, we find your pain point.
00:27:33.000We bring you into a state of stress and we find in everybody, and this is not necessarily a new phenomenon, that your pupils dilate.
00:27:41.000When your pupils dilate, the optics of your world changes.
00:27:45.000And you are looking at the visual world, which is space, physical space, and you start slicing time differently.
00:27:52.000If you've ever been stressed, it feels like things are taking forever.
00:27:56.000That's because your body is sending your brain more signals per unit time.
00:28:01.000It's saying like, my body's active, my body's active, my body's active, my body's active.
00:28:06.000Think about when you're drowsy, Your body is sending fewer signals to the brain per unit time.
00:28:11.000And what ends up happening is the brain uses physical space and use these signals from the body.
00:28:17.000We know this from neural recordings to start creating a space-time relationship.
00:28:22.000The space-time relationship really says, let's just take the jujitsu example, even though I've never done jujitsu.
00:28:28.000You're trying to figure out where do I place my hand?
00:28:37.000In sleep, the forebrain essentially shuts off.
00:28:41.000There's some other things that happen too, of course.
00:28:43.000And the brain starts to drift and idle into these states where duration path and outcome analyses become impossible.
00:28:51.000We also put people into deeply relaxed states.
00:28:54.000So we're studying three different ways to do that.
00:28:57.000One is hypnosis, which is not like charm hypnosis, stage hypnosis, but medical hypnosis.
00:29:03.000My colleague David Spiegel in the Department of Psychiatry is kind of world expert In hypnosis for pain management, et cetera, trauma, you can put people into hypnotic states which are very sleep-like.
00:29:14.000They're a little different than sleep, but they're like a shallow stage of sleep.
00:29:17.000We also use particular patterns of breathing or respiration to bring people into states that are sort of like sleep.
00:29:23.000It's like a very shallow level of sleep, but they're completely immobile.
00:29:26.000Or in some cases, we've studied things like more traditional forms of meditation, although that's less the focus these days.
00:29:34.000What we find is that the brain can go into states where duration, path, and outcome, cognitive processing, physical activity is impossible.
00:29:43.000And the brain starts to show wave-like activity that's very similar to sleep.
00:29:48.000And what I didn't tell you is that we also have people do a cognitive task.
00:29:52.000So while they're in a very stressful environment, like with heights, or they're being bombarded with, you know, snake experience, or we have a bunch of different experiences, they're required to do a cognitive task, which is a duration path outcome task.
00:30:03.000And then we put them into these states of pseudo-sleep, and then we evaluate their ability to perform in these tasks again.
00:30:12.000What we found is that, first of all, these sleep-like states can be very restorative.
00:30:17.000I imagine that you mentioned the float tank earlier, like maybe float tanks, and we could talk about why the float tank would put you into a pseudo sleep-like state.
00:30:25.000Certain substances put us into sleep-like states.
00:30:28.000Naps and just letting the mind drift can put us into sleep-like states.
00:30:32.000And those sleep-like states do two things that are very powerful.
00:30:35.000One is they reset our ability to do these very taxing, demanding duration path outcome kind of brain functions.
00:30:43.000As well, they allow people to access sleep more easily.
00:30:48.000So we want people to be able to get into deep sleep because nothing is as restorative as deep sleep, because in deep sleep and in the states that I'm talking about, these deeply relaxed states, duration path outcome analyses are impossible.
00:31:02.000And I think being able to toggle back and forth between these states is really where high performance emerges.
00:31:08.000So for the very stressed human being who's suffering from generalized anxiety, we study those types of patients.
00:31:14.000But in addition for people who are doing well in life, but are high performers.
00:31:18.000So we do some work with elite military, with some athletes.
00:31:21.000We've had David Goggins out to the lab.
00:31:53.000Well, that's the most special thing about him, really.
00:31:56.000And also that he's willing to share that he was, at one point in time, a large, fat, lazy guy.
00:32:02.000And then he became this savage that you see.
00:32:06.000He forced his mind into that particular state.
00:32:09.000Well, and the states that will allow people to go there often are fear states, anxiety states, things that are extremely high pressure because the adult brain especially doesn't want to change.
00:32:21.000You know, we're basically born, we get wired up by our experience, we get wired up by what we're exposed to.
00:32:26.000Brain plasticity is very passive for the first 25 years of life.
00:32:32.000If you're a child, the things you hear and see and do are shaping you.
00:32:36.000Kids come home saying things they've never even heard before.
00:33:20.000You could fill that space up with technique and movement and it becomes their whole life because it's thrilling and it's exciting to learn and their body heals quicker so they can force themselves into situations.
00:33:31.000With adults, it's extremely difficult to find the bandwidth, to find the amount of time to really completely focus on something because you have so many distractions.
00:33:42.000What you just described is a beautiful description of the top contour and below that what's happening is in childhood the whole brain is literally more plastic because there's more space for the neurons to move around and make new connections.
00:33:56.000The whole environment, the chemicals that are swirling around in there are set for plasticity because we were basically designed to come into the world and be customized to our experience.
00:34:06.000I mean, if the human animal is exceptionally good at any one thing, it's that.
00:34:10.000So if you're an adult, say if you're a 35 year old man with a family or a 35 year old woman with a family and a job and you want to learn a new skill, what is the best way To force your brain to accept these new patterns and learn this quickly?
00:34:28.000By attacking two separate parts of a process.
00:34:52.000So if you're going to Goggins this process, what you need to do is you need to, regardless of how agitated you feel, you have to lean in and focus extremely hard.
00:35:02.000Now, the reason for that is that there's a neurochemical norepinephrine, also called adrenaline, same thing.
00:35:08.000That's released in the brain and body.
00:35:10.000Most people back off at that point because they feel this agitation, but we have to remember that that noradrenaline was designed to get us into movement.
00:35:18.000That's the purpose of noradrenaline, to take us out of stillness and into movement.
00:35:22.000And then the other thing we have to do is we have to take that elevated level of alertness and we have to focus it.
00:35:28.000And there's a second neuromodulator called acetylcholine, Which is secreted from this little structure in the base of the forebrain when we visually focus on something.
00:35:37.000Or in the case of maybe if you're doing auditory learning when you focus with your auditory attention.
00:35:43.000So acetylcholine you could take in a supplement and norepinephrine you can actually get from ice tanks.
00:35:51.000Like you can get it from cryo chambers, you can get it from cryotherapy.
00:35:56.000So using those strategies of taking, like, acetylcholine is actually an alpha brain, one of the supplements my company sells.
00:36:03.000When you take that along with float tanks and doing, or excuse me, cryo chambers, and do some intense exercise or whatever you're trying to get good at with intense focus, can those things accelerate that process?
00:36:20.000Almost certainly increases the plasticity, the rate of plasticity.
00:36:23.000So you would recommend, if someone was trying to get better at something, like a cryo-chamber would actually accelerate the process of learning?
00:38:22.000And so you need that level of alertness up and you need acetylcholine released at the location in the brain that corresponds to what you're trying to learn.
00:38:31.000So things like supplements and certain nutrition regimens can assist the process for sure.
00:38:44.000Nicotine has some sort of a nootropic benefit to it?
00:38:49.000Not encouraging people to smoke, but you know, you could take it in various forms, particularly gum.
00:38:53.000I know people take it in gum just for the nootropic benefit of it.
00:38:58.000Yeah, I'm not encouraging people to take anything, but there's a very, very famous Nobel Prize winning neuroscientist who I went to his office to visit him in New York and he chewed seven pieces of Nicorette during that half hour meeting.
00:39:11.000And I was like, what is going on here?
00:39:12.000And he said, well, first of all, it increases plasticity.
00:39:15.000And second of all, he has the belief, and this is not a clinical study, but he thinks that it can also hold off certain forms of Parkinson's and Alzheimer's.
00:39:23.000Didn't Bertrand Russell, wasn't he like a famous smoker?
00:39:26.000I think he wouldn't even go on a plane unless there was a smoking section because he couldn't imagine not having his pipe for a certain amount of time.
00:39:36.000Well, creatives, you know, when I think when smoking became less in vogue, I think creatives really suffered because it's very clear that, so Nicorette is nicotine and the acetylcholine binds to the nicotinic receptor.
00:39:48.000So when you take nicotine in cigarette form or in Nicorette form, you're actually increasing the release of the action of acetylcholine in the brain.
00:39:56.000Yeah, I don't smoke cigarettes, but I have.
00:39:59.000And the only time I have is before shows because I have friends that are comedians that would smoke.
00:40:04.000And I'd be like, give me one of them things.
00:40:20.000And so for those moments, you know, your acetylcholine is like a spotlight.
00:40:26.000It brings your vision literally into this more kind of portrait mode where you can see more like a narrow window of what's going on.
00:40:34.000There are behavioral ways to access this too.
00:40:36.000Before a fight, you know, if somebody is really ramped up, their world is not, they're not seeing everything.
00:40:40.000They're probably, I've never done the walk, of course, but probably walking out into the octagon, they're not seeing all the color of the hat of the woman in the corner.
00:40:46.000You know, they're not relaxed, they're hyped up.
00:40:52.000Because the brain needs some way to cue this plasticity process to let itself know, because it's a self-learning organ, let itself know that something's really different, that's adrenaline, something's changed.
00:41:06.000So in the jujitsu example you gave earlier, it's the ability to focus on what the sequence is, what happens when, and okay, I did that correctly or I didn't do that correctly, but that's duration, path, and outcome again.
00:41:17.000And having acetylcholine and noradrenaline up That sets the plasticity trigger.
00:41:23.000However, that doesn't guarantee that those synapses are going to change.
00:41:26.000It does not mean that you're necessarily going to learn.
00:41:29.000What guarantees that that process will be converted into literally the change in the connections between neurons, sometimes new neurons, but mostly the change in the strength of the connection so that eventually you don't have to do duration path outcome.
00:41:45.000Is states of deep sleep and any state where you're not doing duration path outcome.
00:41:51.000So we know from two recent studies, some of this was done by my lab, but by other labs as well in humans, which I think is important to distinguish between mouse and human where we can.
00:42:03.000A lot of the changes in these brain structures occurs after learning during deep sleep, in particular, slow wave sleep.
00:42:10.000But it also occurs during periods of naps and shallow sleep, or even just periods where people deliberately decompress, where they're not focusing on any one thing in particular.
00:42:20.000So if we were gonna kind of operationalize this process, it would be focus intensely, have an intense period of urgency, and then access the deepest rest you can where you're not thinking about anything, where space and time becomes very fluid.
00:42:36.000So stress in that case, post-exercise or learning session would actually hinder your ability to grow and get better.
00:42:46.000And elite performers like elite military, elite athletes, I'm sure you're familiar with this.
00:42:51.000They understand that the ability to toggle back and forth between these high alert, high attentional states and deep rest is not just the key to performing what you can already do.
00:43:02.000It's also the ability to get better over time.
00:43:05.000You know, I think Goggins again is such a remarkable example because it seems like it's all gas pedal.
00:43:11.000But I'm guessing, I've never asked him about this, but I'm guessing that he has his ways of recovering so that he can remain in that heavy gas pedal all, you know, significant amount of the day all the time.
00:45:00.000He is every bit as intense as that public persona.
00:45:03.000When he came out to the lab, it was kind of interesting because we just built this great white shark experience.
00:45:07.000And I'd gone down to Mexico, we had dealt with these sharks, and my friend Michael Muller, he's got this whole thing where we could leave the cages, and we did all this, and it was fun and crazy and probably a little stupid, frankly, but we bring it back, we build this VR stimulus, and he and a couple other team guys came in.
00:45:23.000You know, so I'm explaining what we're doing and we show the shark thing on the screen and he goes, I don't like sharks.
00:45:30.000And I'm thinking, okay, so we'll give him something else.
00:45:33.000And then we go through the whole thing and I'm explaining how we wire people in and we record from the brain.
00:45:37.000And I said, all right, so who would like to try the sharks?
00:46:01.000He's rich, and he gets fucking dropped off in Montana, in the woods, camps out there, and fights forest fires with a bunch of other savages, and he does it to keep his brain hard.
00:47:01.000And you could do that with brain machine interface.
00:47:03.000You could do that with You can imagine doing that with drugs or with supplementation or nutrition, all of that.
00:47:08.000But since the nervous system sits at the foundation of any of those, we started to think about this problem and there's actually another element to it, which is the reward pathways involving dopamine.
00:47:20.000So you asked about kids, like why they can learn all day long.
00:47:24.000So their brain is very different, but it still needs some degree of focus and they still need to get their sleep.
00:47:29.000They still have to obey those two rules of this process.
00:47:34.000But they engage in something else, which is really powerful, which is play.
00:47:39.000A lot of their learning is through playful exchange, especially with the little kids, like in kindergarten and nursery school.
00:47:45.000And then as they get older, the social dynamics can be kind of harsh, but they can also be really pleasurable and fun.
00:47:50.000So the molecule dopamine is a really misunderstood molecule.
00:47:54.000We all make it from a location in the back of our brain.
00:47:58.000And people think of it as like reward, like, oh, I got a bunch of money or I, you know, did a great performance.
00:48:03.000Dopamine is responsible for that feeling of feeling great.
00:48:07.000But in addition, dopamine is what's released anytime an animal or human thinks it's on the right path.
00:48:17.000So this is not, and I want to be really clear that this is not positive thinking or, you know, the secret or telling yourself that you're performing well even when you're not.
00:48:25.000Right, like if you are a rioter and you break into a courthouse but you feel like you're on the right path, you're going to get a release of dopamine.
00:49:00.000If you've ever just been working like mad or you see this in, you know, team guys know this really well that, you know, cause they tell me that you can be in the worst situation and somebody will crack a joke.
00:49:10.000And all of a sudden it's like, You have energy.
00:49:27.000And the reason dopamine is so powerful in this process of neuroplasticity is that dopamine has the ability to buffer noradrenaline.
00:49:36.000So that stress that you feel when you're in effort, it's very hard for most people to keep that going.
00:49:42.000But when you get a, and when I say a shot, I mean internal release of dopamine through humor or through the sense that you're on the right path.
00:49:49.000Let's take the fight example where it's stressful and you're getting beaten down.
00:49:53.000All of a sudden you land one or you do something properly and the other guy starts to timber a little bit or shuffle a little bit.
00:49:59.000You gain a chemical advantage and it comes in two forms.
00:50:02.000One is it triggers marking of the synapses that likely will change later.
00:50:07.000We rarely forget the events associated with dopamine.
00:50:10.000For that reason, because they signal, oh, whatever's happening now, that was good.
00:50:14.000And in addition to that, they start pushing back on the level of acetylcholine, excuse me, noradrenaline in the brainstem.
00:50:21.000And this is crucial because there was a study that came out two years ago, not from my group, that asked, why do we quit?
00:50:30.000If you set 800 or even 500 pounds on the bar out there, I can't lift it.
00:50:34.000So I'm not talking about that kind of quitting.
00:50:38.000If I'm not injured, like what actually causes quitting?
00:50:41.000When do we decide that something is futile?
00:50:44.000And it turns out that for every bit of effort, Any of it have ever, lifting a glass of water or running up a hill or in a fight, there are little bits of noradrenaline, adrenaline that are released in the brain and body.
00:50:55.000And there's a counter, there's a cell type, which are called glia, which literally means glue in Latin.
00:51:00.000These cells are paying attention to how much norepinephrine is coming.
00:51:03.000And if it hits a certain threshold, the brain stops voluntary control over the muscular, just says, that's it, I quit.
00:51:10.000And there are these beautiful experiments where they, Manipulate the visual environment so that this isn't, they're certain that this isn't lack of muscle fuel or liver fuel.
00:51:30.000And you see this through teamwork, when you feel like you're supported, when you're in cohesion, humor, play.
00:51:37.000If you're in serious effort and it's just things are going terribly, maybe I've never done comedy, but you're trying to write a joke and it's just frustrating.
00:51:44.000And then suddenly you just kind of laugh at how ridiculous the process is.
00:51:47.000There's a kind of loosening or a lightening and you have more energy.
00:51:51.000That energy is reductions in, Epinephrine.
00:51:54.000And so I don't know how David Goggins has done it, but everyone does this a little bit differently, but it could be, and I'm speculating here, of course, never done the neurology, but that David has somehow figured out that the leaning in process for him is the dopamine trigger.
00:52:09.000Like there is a kind of sicko thing about the way he talks about it.
00:52:16.000And for him, maybe it was that way and it's rooted in his origin story.
00:52:20.000For other people, they find this in purpose, like that you're doing this for your kids or you're doing this for somebody else.
00:52:27.000You know, I think that the human animal has a capacity to push, has a capacity to focus, has a capacity to learn at all ages, but these gates on plasticity are set by certain requirements.
00:52:40.000You know, when I look out there and I see all the stuff about, you know, psychology and all the self-help and wellness stuff, you know, I'm a neuroscientist, so I look at the lens of everything through neurochemicals and neuroscience, but it all kind of boils down to a couple basic chemicals and systems or what we call circuits in the brain.
00:52:55.000What's the difference between noradrenaline and norepinephrine?
00:53:29.000And you can find that over and over and over again in science because no one ever comes in with a gavel within like nomenclature committee and says, we're just going to call it this.
00:53:36.000Nor adrenaline is so much easier to say.
00:53:41.000Like I've fucked that up a hundred times.
00:53:43.000Well, and it gets worse because like you think about the autonomic nervous system and they're like sympathetic, parasympathetic, sympathetic sounds like sympathy, but it's actually the stress state.
00:53:52.000Do you think that you would benefit from data from real-world situations in a much more comprehensive way than you would from these virtual situations you're putting people in?
00:54:03.000Because, you know, we have a VR thing out here.
00:54:06.000We have an Oculus and it's pretty cool.
00:54:09.000There's one of them where you walk on a plank and you really do feel like this plank is over, like it's on the 60th floor of a building and it goes out a window.
00:54:19.000And you really do feel like you're kind of, but you know you're not.
00:55:00.000Like, what are the requirements for getting people to feel presence?
00:55:03.000So people who come to our lab, they don't think they're underwater with a shark.
00:55:07.000Unless they're afraid of great white sharks.
00:55:09.000And for that moment where one of these guys is coming in and it opens its jaws, for that person, it's every bit as scary as the real experience.
00:56:17.000So I have a large scale study running right now with David Spiegel, my colleague in psychiatry, where people are equipped with whoop bands through monitoring sleep.
00:56:26.000We're going to expand this to include some other devices that actually allow us to look at heart rate variability and body cavitation and some other things in some interesting ways.
00:56:35.000So we're tracking them 24 hours a day.
00:56:37.000And those people are reporting back to us levels of stress, life events, that kind of thing.
00:56:42.000So this is outside the laboratory, but we can do this in real world, essentially.
00:56:47.000And those people were using interventions which are mainly respiration-based.
00:56:52.000So which are looking at specific patterns of breathing that trigger particular states in the brainstem that allow people to either sleep better or buffer their stress in response to life events better.
00:57:04.000So this isn't really breath work as much as it is teaching them specific patterns of breathing that capture these neurons that switch their brain states.
00:57:12.000It really is fascinating that these periods of rest are crucial to learning and developing.
00:57:38.000All right, so you wanna focus as long as you can focus well, and then probably a little bit longer, because there's also plasticity of the circuits that control focus.
00:57:47.000So going back to your jujitsu example, As you get to the point where you're starting to not be able to do this duration path outcome stuff, which involves motor movements and mental thinking, you were saying, you're getting tired.
00:57:59.000You're literally going into a sort of sleep-like state where space and time, duration path outcome becomes hard.
00:58:05.000What you can do at that point is to start buffering the noradrenaline, norepinephrine.
00:58:10.000Now, I don't know which one to say, but I'll just keep going with whichever is reflexive.
00:58:15.000You can start to buffer that through things like humor, through things like setting the urgency higher.
00:58:21.000That is not a time to relax and taper out.
00:58:23.000That's a time to ratchet up the intensity if you want to grab a stronger trigger.
00:58:29.000So, but that period can't last infinitely.
00:58:39.000So you can maybe do two or three bouts of that a day, or if you are doing it several times a week, you basically want to dose it about twice as much as deep stress as you do the deep focus, excuse me, deep sleep as you do the deep focus.
00:58:51.000So if you're, I don't know how long these training regimes go, but part of that training is reflexive for you.
00:58:57.000I wouldn't count that in the learning process because it's dialed into your nervous system.
00:59:01.000But at the point where it becomes challenging, a clock sort of starts.
00:59:04.000And when that period ends, I think at least double that amount of time of deep rest if you want to maximize learning.
00:59:10.000There's been a lot of work done on visualization and learning through visualization and they found that you can get a similar benefit to actual physical training, obviously not with the endurance and the strength and all those other things, but in terms of skill learning.
00:59:26.000You get a similar benefit from an equal time of visualization.
00:59:47.000And it's important to move the musculature.
00:59:50.000It's important to say the words if you're say, you know, learning a motor skill or learning a movement, a language, excuse me.
00:59:56.000But at some level, the brain doesn't really know what's going on in the body.
01:00:01.000It's the command center, except what signals it receives back from the body.
01:00:04.000And so if the visualization is intense, The brain isn't completely convinced, but it's pretty convinced that you're actually experiencing that thing and rehearsing it.
01:00:14.000It's a little bit of your own internally driven virtual reality is what you're doing.
01:00:18.000And so I think mental training is powerful, but there's no replacement for repetition.
01:00:25.000So what about, obviously physical training has its limitations in your body's ability to keep doing the movements.
01:00:33.000You're going to get tired and you're going to break down.
01:00:36.000Would it be more beneficial to get more rest or would it be more beneficial to get rest but also spend a significant amount of time visualizing?
01:00:50.000We haven't looked at visualization specifically.
01:00:53.000The one thing that is very close to visualization, which is very powerful, based on neuroimaging studies, so legitimate science, I should say, is hypnosis.
01:01:03.000Hypnosis is a really unique state, and this is of mind and body.
01:01:10.000And I'm very interested in hypnosis because of the work with Spiegel and the incredible success that he's had with pain management, smoking cessation, these kinds of things.
01:01:20.000Hypnosis is a state of deep relaxation, not unlike sleep, but also deep focus.
01:01:27.000So it's very unlike any other state of mind.
01:01:30.000You're either usually asleep or you're focused or somewhere in between, kind of drifting back and forth in between.
01:01:35.000But hypnosis is a deliberate narrowing of context.
01:01:39.000So the person or the audio script is bringing you into a state of mind that's centered around particular types of events, but you're in deep rest.
01:01:47.000And the idea is that you're taking that plasticity process of focus and urgency and then rest, and you're combining them into a single session.
01:01:55.000And so hypnosis and deep hypnotic states are the place where neuroplasticity can be accelerated.
01:02:02.000So when you say hypnosis, what kind of sessions are you talking about and how often?
01:02:09.000Like say if you're an athlete, like let's say maybe you're a basketball player and you want to get better at basketball.
01:02:14.000You train as much as you possibly can, but there's limitations to that.
01:02:18.000You sleep as much as you possibly can.
01:02:20.000How often would you recommend someone doing some sort of a hypnosis session to try to improve their skills?
01:02:27.000Probably one, well, it depends on how intense their training is.
01:02:30.000For some of the people I'm doing work with in athletics and in the military community, they have extremely demanding lives, right?
01:02:39.000And certainly for the military folks, it's high risk, high consequence, even when they're in non-deployment.
01:02:46.000Under those conditions, maybe every day, 30...
01:03:15.000Some people can self-hypnose by induce – some people call them intentions, but I don't like that because it sounds a little bit too much like an uncomfortable set of yoga classes I've taken where they start with the whole – I don't know really what that's about and they make you use complete declarative sentences.
01:04:20.000And I think stage hypnosis has done a great...
01:04:23.000Disservice, no disrespect to the stage hypnotists out there, to detract from the power of hypnosis as a medical tool and a high performance tool.
01:04:31.000Yeah, my own personal experience is that I didn't understand what hypnosis was.
01:04:37.000My first experiences with hypnosis were there was a guy named Frank Santos.
01:04:41.000It's a famous in the Boston area who's a very famous comedy hypnotist.
01:04:46.000And he was an actual hypnotist who would hypnotize people and get them to quit smoking and things along those lines.
01:04:51.000But then Would do this comedy hypnotism show where he would get people on stage.
01:04:56.000And man, like we would walk me and a bunch of other comedians would go and watch it every week because it was crazy.
01:05:13.000And I always just thought it was like really weak minded people.
01:05:16.000My thought was, and obviously I'm 21 at the time, I didn't know anything, but my thought at the time was, okay, there's certain people that are just, they have nine-volt brains, and you can trick them into doing anything, and that explains cults and a lot of other shit and televangelists and all sorts of nonsense that should be,
01:05:32.000like, really obviously fake to people, but they fall into it anyway.
01:06:23.000I asked Spiegel how you measure this kind of back of the envelope, you know, curbside consult as they call it.
01:06:28.000And people who are more hypnotizable, their eyelids will flutter in an attempt to go down.
01:06:34.000The reason is that a lot of hypnosis is anchored on the ability to go into these deeply relaxed states.
01:06:42.000And some people's autonomic nervous system gets locked in a state of more, excuse me, Of more attention and kind of higher levels of alertness or levels of sleepiness.
01:06:59.000So when you're really stressed, like you're analyzing time, you're analyzing space differently, duration path outcome, what's going to happen?
01:07:42.000And this fluttering of the eyelids is reflective of a peripheral nerve, believe it or not, It originates in the brainstem.
01:07:50.000That's a central part of the autonomic nervous system.
01:07:53.000The other thing that they'll do, you ever see on the stage hypnosis where they'll have people look up at the ceiling and then they'll sometimes shine a light in their eyes or they'll like have them look in a light.
01:08:03.000They're looking at how, we call it labile, but how rigid or Labile, how willing to move the pupils are because autonomic arousal impacts the pupils of the eyes.
01:08:14.000So it's an external read of what's going on in the brain.
01:08:17.000A lot of people don't know this, but your eyes are not connected to your brain.
01:08:51.000Yeah, and that's why when people tell me, oh, you know, the eyes are the window to the soul, I'm like, well, look, I don't know about souls, but they are definitely your brain.
01:08:59.000So when I look at you, and now it's weird because I'm looking at, you know, we're not looking at each other's pupils, right?
01:09:04.000But when the hypnotist, I should say, looks at the pupils, they're saying, you know, the pupil size is a direct readout of how loose that hinge is.
01:09:13.000So when they shine light in someone's eyes and they take it away and they go...
01:09:16.000That's so weird that you can look in someone's eyes and there's something about, like, you can kind of tell what kind of a person they are in some ways, or at least tell how they're thinking.
01:09:26.000Like, if someone's uncomfortable being around you, like, ugh, you could see it in their eyes.
01:09:31.000If you tried to write that down, like, what are you seeing?
01:09:56.000That myth has origins in the fact that the cyclop was one dimensional anger.
01:10:01.000And it turns out that when we are experienced an increase in autonomic arousal, so let's say we decide we're gonna fight, we decide we're gonna learn, or maybe even just, we're gonna write something important.
01:10:14.000But because our eyes don't really move in our skull, they actually do what's called foveate in a little bit.
01:10:19.000There's an eye musculature reflex that gets triggered in.
01:10:22.000And so you can see this sometimes in people that are getting ready to fight.
01:10:26.000Their eyes are actually brought inward.
01:10:29.000That triggers another neural circuit to increase levels of autonomic arousal and starts deploying resources internally, fuel resources, fuel for, you know, bouts of intense stuff, whatever that intense thing is going to be.
01:10:42.000When we're relaxed, Like we view a horizon or we're just walking or we're in what's called optic flow when things are flowing past us.
01:10:52.000So in panoramic vision, you go out of that soda straw view of the world and you start being able to see the corners of the room.
01:10:58.000The ceiling, the floor, and that's a relaxed state.
01:11:01.000So sometimes we're even subconsciously perceiving how stressed or relaxed somebody is, not by necessarily their pupils, although that might play into it.
01:11:08.000It certainly has a role, but whether or not based on your prior kind of intuitive knowledge about that person, whether or not they're like cyclops or whether or not they're in panoramic vision.
01:11:19.000And this is important because it changes the way we perceive time.
01:11:24.000If we are in cyclops vision, soda straw view, that high intensity, we tend to do two things.
01:11:30.000One is we tend to be more in tune with what's going on inside us.
01:11:33.000We start, you know, the brain does this other thing, which is called interoception.
01:11:36.000It's like paying attention to what's going on inside us versus outside us.
01:11:40.000And when we're stressed, Time outside us seems to go really slowly.
01:11:46.000It's like you're in the security line at the airport and you need to get your flight.
01:11:49.000It's a very different perception of the person in front of you and what they're doing than when you're relaxed and you've got plenty of time.
01:11:55.000And that's because outside events start to feel slower.
01:11:58.000This is why after a car crash, people will say, you know, oh, everything was in slow motion.
01:12:04.000Or I've never actually looked at fighters, but...
01:12:07.000I visited the UFC training center, Duncan French.
01:12:10.000I went out there and talked to him about this.
01:12:26.000And when I hear about fighters, you know, say like being able to time the fight or they, it's almost like they can see things coming in slow motion.
01:12:34.000That's because their internal level of arousal is really, really high, but it feels like relaxation.
01:12:40.000So there's like sleepy, not feeling so good.
01:12:43.000Everything feels like it's going on really fast.
01:13:23.000You know, I get out of the subway in New York and I'm like...
01:13:26.000The walking speed, the speed of everything, I finally feel like internal to external match.
01:13:32.000Does this thing that connects the fluttering of the eyelids to being able to be hypnotized more easily, does that coincide with a personality variable?
01:14:41.000This match of high focus, deep relaxation is not a brain state that we can...
01:14:48.000Access very easily without a hypnotist.
01:14:51.000I mean, there are other ways to do it.
01:14:52.000But that state would be super beneficial for people wanting to learn something because it would relax them much more deeply than it would just ordinarily everyday life while you're conscious.
01:15:08.000It's taking the two pieces of the plasticity puzzle and putting them in the same event.
01:15:12.000So I don't think it should be the only way to learn new things, because there are things you can't do in hypnosis, like roll jujitsu, for instance.
01:15:22.000But as a tool for accessing faster learning, it's quite powerful.
01:15:28.000I mean, I think the work of Matt Walker and Bill DeMent at Stanford and others has just shown, like, if you want to pull someone apart, You want to just make them insane and unable to do these duration path outcome, you know, mental operations, you sleep deprive them.
01:15:42.000There's a thing that people do, this sort of reductionist, dismissive way of viewing meditation and viewing states of mind.
01:15:50.000It's really weird to me because smart people do it occasionally.
01:15:53.000And there's a guy that I think is very smart and he was talking about it on Twitter, like mocking meditation.
01:16:01.000And I was like, man, this is a guy who's probably never really meditated.
01:16:05.000Well, meditation, you know, I guess growing up in Northern California and the whole mindfulness thing.
01:16:12.000It's the stuff around it often, you know, and I think this is why, like, it's exciting that respiration slash breath work is now making a, you know, a big showing in the world because I think it has tremendous value.
01:16:22.000I think that it's the stuff around it that causes problems and can get it pushed into… The naming.
01:16:29.000I mean, like, I mean, I have nothing against yoga.
01:16:31.000I mean, there's a lot of powerful tools in yoga, but it's the asandas and all the stuff around it makes it sound a little bit like religion.
01:16:38.000And a lot of people in medical communities and other religious communities back off from that.
01:16:43.000Well, there's a problem with yoga that I actually had a conversation with my yoga instructor about because I do a Bikram class and they say things in the class like you're massaging your descending colon.
01:17:26.000And the medical community can be a little bit too one-sided as well.
01:17:29.000But, you know, I think Stanford's a very progressive place.
01:17:33.000The fact that Spiegel and I have this study looking at respiration and its impact, I think, is a sign that the times are changing.
01:17:40.000We're not doing this in any kind of mystical way.
01:17:42.000The fact that people in military special operations and athletics are starting to think about the mind and the tools to access the mind is a sign that there's been a tide change.
01:17:51.000I had James Nestor on the podcast recently, and we talked about his new book, Breath, and just the ability to control various aspects of your nervous system and even your immune system through breath work.
01:18:04.000It's very confusing, because everybody breathes.
01:18:07.000So you and I are both breathing right now.
01:18:09.000We're not doing breathing exercises, but we're breathing.
01:18:11.000So what is it about breathing exercises that accentuate these aspects of breath?
01:18:17.000Autonomic system and sympathetic system.
01:18:26.000It sounds like I'm just shamelessly plugging Stanford constantly, but most of the studies he was referring to were done by my colleagues, Paul Ehrlich, Sandra Kahn, stuff in my lab, Mark Krasno.
01:18:36.000These are serious scientists and serious physicians who are saying, look, respiration has an important role in balancing oxygen and carbon dioxide and In the body and in the brain.
01:18:47.000And that has an important impact on states of mind and body.
01:18:50.000I think that's just no medical professional, presuming they're any good, could argue that.
01:18:56.000So take for instance, Mark Krasno's lab and a neighboring lab at Stanford discovered that animals and people Periodically throughout sleep and throughout the day, we'll do what's called a physiological sigh.
01:19:08.000These have been known about since the thirties, but it turns out there's a set of neurons in your brainstem and my brainstem that every once in a while, when the level of carbon dioxide in your bloodstream gets too high, you do a double inhale and an extended exhale.
01:19:21.000So it's sort of like two inhales through the nose and extended exhale.
01:19:23.000Your dog does this right before it goes down.
01:19:33.000The double inhale maximally inflates the little sacs in the lungs, the alveoli of the lungs, and that pulls carbon dioxide out of the bloodstream at a higher level so that you offload it more in the exhale.
01:19:46.000Now, these physiological sides are the fastest way that I'm aware of from work in our lab and with Spiegel to take that seesaw from too high level of stress to a little bit calmer.
01:20:00.000This is a set of neurons that every kid and every adult has.
01:20:04.000They use periodically, but we can also consciously control through the diaphragm.
01:20:08.000So that's one way to bring things more calm.
01:20:12.000I think, you know, James talked about this in his book, but those breathwork of the sort where, you know, kind of tumotype breathing of doing, you know, 30 inhales and really offloading carbon dioxide, that causes the release of noradrenaline, norepinephrine.
01:20:26.000And noradrenaline, norepinephrine, Our mother nature's way of buffering us against infection and disease.
01:20:33.000Everyone thinks stress kills your immune system.
01:20:41.000If we suddenly had to forage or go out and find water, we need two or three days and we didn't know what we're gonna, you can't afford to get sick.
01:20:47.000This is why if you work, work, work, work, work, and then you finally rest, you're more likely to get sick as you go into that more parasympathetic, relaxed state, because your immune system also gets shut off.
01:20:57.000Is that why people in prison that are getting COVID-19 are not really getting sick?
01:21:02.000There's so many of them that are asymptomatic.
01:21:18.000But I get very – I start doing eye rolls and I get a little frustrated when people are like adrenal burnout.
01:21:23.000Look, your adrenals were designed to take you through two lifetimes if you need to.
01:21:27.000The idea that your adrenals are just going to shrivel up into – Somebody told me that their doctor told them that coffee is giving them adrenal burnout.
01:22:24.000Yeah, so my lab has also looked at like how stress spreads between people, how the autonomic nervous systems communicate.
01:22:30.000And we know that the best way to get what's called emotional contagion is to get people into a heightened state of alertness.
01:22:37.000I'm guessing, and I have no knowledge of comedy whatsoever, but I'm guessing that the comedian that's less funny that comes out before the main person, I'm guessing they're trying to get them like ramped up.
01:22:47.000You can create a more emotional contagion.
01:22:49.000You don't have to take them from the floor all the way up to the ceiling.
01:22:53.000Is that right or am I way off base with that?
01:22:55.000Well, it's interesting that you put it that way.
01:22:57.000It's actually a problem that comedians that have sensitive egos will bring less funny comedians with them on the road so they look better.
01:23:07.000And it's like amongst elite comics, it's actually very frowned upon because you're setting yourself up to look like a hero.
01:23:16.000You rescue the audience from some terrible comedian that you had open for you.
01:23:19.000You could judge the ego or the health of the ego of the headliner by what kind of comedians they consistently take with them on the road.
01:23:29.000I mean, everybody has bad sets occasionally, but a lot of times these weak-minded guys will bring these terrible comedians on the road with them.
01:23:55.000The degree to which something feels really good, or you experienced it as great, could be a great meal or comedy set from the perspective of the audience, of course, is going to depend on how much dopamine you got before.
01:24:08.000So if I tell you, we're going to go to a restaurant tonight, this is amazing.
01:24:11.000They got the most amazing steaks, amazing steaks.
01:24:28.000Well, there's something that does happen.
01:24:30.000There's a contagion that does happen when people are funny where it's contagious and everyone around you starts laughing more because there's more people around you laughing.
01:24:40.000Like if I'm in a room and there's a funny comedian on stage and there's a bunch of people to my left and right that are laughing really hard, I'm more likely to laugh.
01:24:48.000There's something weird that goes on and one of the things that I've always said about stand-up is I think it's kind of a mass hypnosis.
01:24:57.000It's not just funny, you know, because if it was funny, there's these comics that are doing these Zoom comedy shows, and I encourage them to all stop doing it immediately because it's fucking terrible.
01:25:09.000Even great comics look fucking terrible because you're lacking that critical element of an audience.
01:25:16.000Stand-up comedy is one of the rare art forms you really can't do on your own.
01:25:21.000And I think what's happening is When it's not just, when a person's on stage that's really good, it's not just that they're funny, it's not just their timing is excellent, it's not just they have these really insightful ways of looking at things that make you laugh, it's also that you're around a bunch of other people that are experiencing it together.
01:25:38.000And when that person's good, you are allowing them to think for you.
01:25:43.000There's some weird, like if I'm watching a guy on stage and he's really good, Or a girl on stage, she's really good.
01:25:48.000When someone's killing, I'm allowing that person to think for me.
01:25:52.000I'm like sitting there just like, go ahead, take me for a ride, let's go!
01:25:55.000And then they're making you laugh, but it's, you're also aware that you're in it with these other people, so you have this enhanced state, because all these other people are around you and you're all experiencing it together.
01:26:07.000This is, I don't know much about comedy at all, so forgive me, but comedy to me is very interesting because It's a – and I don't know how the comedy scripts are written but I find them incredibly fascinating because it seems like almost all jokes are a break from the space-time rule that the brain expects.
01:26:26.000Close contact card magicians do this very well too.
01:26:29.000It's like you're expecting something to happen and I think he's going there.
01:26:33.000So it's sort of duration path outcome like this.
01:26:35.000And then all of a sudden you get hit with something that's surprising.
01:26:55.000And what you realize is he's – I don't want to use the word hypnotized.
01:26:59.000Incorrectly here, but he's bringing you into a reality where the dogs are setting the rules.
01:27:04.000And it's hilarious because the brain, when it sees surprise, it could be a card that, you know, you pick and then I tear it up and then you suddenly produce it from my shoe or something like I'm extreme magician type stuff or really funny joke.
01:27:17.000It's like the brain wants to go one place and when something unexpected happens, dopamine is released.
01:27:24.000And all of a sudden, it's like I'm in a state where then you can take me further up the staircase.
01:27:28.000The one thing we know about dopamine was why it's so powerful is not just that it can buffer these feelings of effort, but that it can take you into new ways of thinking about a problem.
01:27:38.000I mean, this is why a lot of, and this isn't work that I'm involved in, but this is why a lot of the excitement about The therapeutic use of MDMA and things that increase dopamine are windows into modes of processing information that are very different.
01:27:54.000Now, on the dark side of that, if you think about cocaine or methamphetamine, you've got dopamine coming in artificially.
01:28:40.000The dopamine receptors are very prone to saturation.
01:28:43.000Remember, they're like parking spots and you can fill those up very quickly.
01:28:49.000And there's actually changes that happen at the genetic level in cells when there's too much dopamine in the system for too long, like with dopamine addiction or Crack cocaine addiction.
01:28:58.000The cells actually start modifying the way they work so that they become better and better at gobbling up dopamine.
01:29:05.000The whole system becomes a dopamine pursuit system.
01:29:09.000And, you know, in thinking about the brain for these kind of, you know, very top contour conceptual levels, we can think of addiction as just a narrowing of the things that bring you pleasure.
01:29:18.000And so what you want is to obviously not use cocaine.
01:29:22.000What you want is to access the dopamine system through whatever process appeals to you, provided that it doesn't deplete that dopamine system, right?
01:29:35.000You can maximize this to the point where things don't work anymore.
01:29:38.000And there is a like kind of a little weird techie cult thing happening in the Bay Area.
01:29:41.000They call it dopamine fasting, which has no basis in physiology, where these kids are like, literally, they're not looking at each other in the eye because like, oh, it's too much dopamine.
01:31:34.000It's so odd that they just let them camp out.
01:31:38.000Like, I went to Venice the other day for dinner, and we're driving by this house, and there's a beautiful house to my left that's probably worth like five million dollars.
01:31:50.000The last time I was down here was in March, right before COVID hit.
01:31:54.000Or around the time who knows when it hit but There's a block on Venice Boulevard leading down to that air one market that was maybe one block and I drove in the other night and it extends You know seven blocks.
01:32:06.000Yeah, and they don't do shit about it And I don't know what they're gonna do every time you go into an underpass you're entering a homeless encampment now They've even the one over here on Winnetka They put a porta potty there and a hand washing station like we give up here shit in this bucket.
01:32:27.000Maybe there's more important things right now with COVID. I can't think of anything more important than making sure that citizens have health care and shelter.
01:32:33.000And the route to do that is not my expertise.
01:32:36.000I don't have any Great ideas about that, but I just...
01:32:39.000The homeless problem to me is very bothersome.
01:32:48.000They call it the Aaron Brockovich Park because it had all this sewage and toxic waste seeping up and kids were getting infections and stuff.
01:33:29.000I mean, I'm, I'm not a very political person, but I'm, I'm very disappointed at Well, a lot of things, but I see a lot of great things happening in the world, but I also see a almost total failure, even on the part of the scientific community to communicate accurately what's going on right now.
01:33:46.000There's so much confusion and, you know, I don't want to get into the COVID thing because it's not my expertise, but the fact of the matter is that science has also, you know, there are a lot of people that don't believe in science, but science has also failed at some level to get out there and explain to people what they need to know.
01:34:03.000Who are the people that don't believe in science?
01:34:05.000Well, there are the anti-vaxxer flat earth people.
01:34:10.000Yeah, schizophrenics for the most part.
01:34:13.000And I think the ease with which, you know, a celebrity can just decide that vaccinations work a certain way or don't work a certain way, and it spreads so quickly and people love that idea that, you know, I try and look at it through the lens of neuroscience and say, what is it about the mind where people can't seem to connect to logical ideas when it's inconvenient for them,
01:34:30.000but they can string together all these random dots into a theory that...
01:34:34.000This was all caused by 5G or something that makes no sense at all.
01:34:38.000So it tells me that, yes, people are challenged.
01:34:42.000But in addition to that, I do think that the scientific community has a responsibility.
01:34:49.000Let's not go after Fauci specifically, but why isn't there a team of scientists out there saying, as a team, we've figured out this, that, and the other thing?
01:34:57.000Jamie was just bringing this up earlier before the show that someone was being criticized because they said we should have more experts to draw upon other than Fauci.
01:35:08.000And this person who was interviewing, explain what they were saying.
01:36:29.000When the space shuttle exploded, we had a panel of experts.
01:36:32.000Now, Richard Feynman was the one who was kind of the frontrunner, and he's the most eloquent, and he knew how to speak to the general public.
01:36:38.000And so he was the one that got all the attention for figuring out it was a washer ring that heated up or got cold.
01:37:25.000It makes it hard to do this duration path outcome kind of rigid thinking in there because my understanding is that the salinity of the water and the temperature of the water makes it so that you kind of Don't notice the boundary between yourself and the water.
01:37:39.000So Feynman actually talked about this as a way to access space-time relationships of the mind that he anchored to physics principles.
01:37:49.000And so he was a big proponent of the float tank, I think also because he was a little afraid to try psychedelics.
01:37:54.000I want to talk to you about the flow tank, but I don't want to steer right away from science and the responsibility of science, because I don't think the responsibility is in science.
01:38:03.000I think the problem is, and this is a new problem, the newfound ability to communicate online and reach massive amounts of people without any expertise whatsoever.
01:38:14.000I mean, I've said a bunch of stupid shit on here that's not accurate, and you can get away with it.
01:38:19.000At least I'm ethical in it, that if I do make mistakes, I will correct them, and I'll try to be as honest as I can about what I know or what I don't know.
01:38:29.000Slightly schizophrenic or delusional and they're more prone to believing in conspiracies because conspiracies they activate some weird spot in your brain and maybe we could talk about that I don't know what that spot is but there's there's some weird reward mechanism that comes from discovering things that are hidden that people don't want you to find out that everybody else doesn't know about and you could be the fucking Paul Revere of 5G and you could be the guy running around you know 5G is coming 5G is coming you know There's something about that that really
01:38:59.000dumb people really gravitate towards, and some really smart people with some mental tics, some things that are off, and it's a real problem because it's a giant distraction.
01:39:10.000I don't think the responsibility lies in science, because science is supposed to be about data, analyzing these things, coming up with cold hard facts that are provable, right?
01:39:21.000Things you could show, this is repeatable, this is what the situation is, and this is how we know.
01:39:27.000A spokesperson for science would be wonderful, but there are people like that.
01:39:31.000There's Neil deGrasse Tyson who does a fantastic job.
01:39:34.000I mean, I love his work, but there was this culture in the 80s and 90s around, and I grew up sort of in this because my dad's a physicist.
01:39:42.000We spent some time around a lot of physicists.
01:39:45.000The cosmos and astrology, that gained immense popularity.
01:39:49.000It's very exciting and very interesting and mostly irrelevant to what we're dealing with right now in 2020. Right now it's about biology, virology, epidemiology, and there has not been a voice for that besides Fauci.
01:40:05.000And I think he's doing the best he can with what he's got.
01:40:09.000But I think a panel of experts who could appeal to different types of people through different types of mediums Would assist in at least letting people know what the process is.
01:40:20.000You know, we've sort of said there are people out there who don't think COVID exists.
01:40:23.000You've got people that are just waiting for a vaccine, aren't going to leave their house until there's a vaccine.
01:40:27.000You got people that are afraid of vaccines.
01:40:28.000There needs to be some structure of communication about what scientists are doing, because there's incredible work happening in laboratories at Stanford, all over the world, trying to figure out the solution to this problem.
01:40:42.000At the same time, people are very stressed.
01:40:44.000You know, for the person that doesn't have a W2 or regular 1099 income, this period of time is immensely stressful.
01:40:51.000And the more stressful something, the more stressed a human or any animal gets, the easier it is to recruit them into some sort of delusional thinking.
01:40:59.000You know, it's, you know, psychosis is defined as Ascribing meaning to something for which there's none.
01:41:06.000You know, if I suddenly tell you that the brick in that corner is sending me messages about what I should say next, that's breaking with our space-time understanding what's allowed here.
01:41:15.000People are doing that in subtle, kind of incremental ways.
01:41:18.000Some of them might be diabolical and evil, but What we know is that the more stressed people are, the better people are able to recruit them into ideas where they can connect dots that otherwise might not be connected.
01:41:32.000It has everything to do with the way that the brain computes information.
01:41:36.000So I'm not saying a panel of experts would necessarily buffer us or inoculate us against those kind of forces, but I do think that There was a time in this country, at least when I was growing, I'm 44 years old, where at least there was some faith that the figures that you saw on a screen or that were talking to you were putting in a best faith effort.
01:41:54.000I mean, there might've been a lot of shady stuff going on behind the scenes, but I think that has completely fallen away.
01:41:59.000And so now it's all, as you said, Very aptly, it's all about following individuals.
01:42:04.000Who can be most convincing in the moment?
01:42:06.000It's about capturing people in these highly dopaminergic, anxious states where you can start leading them down a thought path.
01:42:13.000And pretty soon, there's no notion of science.
01:42:15.000Pretty soon you're talking about flat earth, and it's scary.
01:42:18.000And other countries aren't doing this.
01:42:56.000So anything that opposes his perspective gets diminished, even if it's a legitimate scientist that has an altered perspective, you know, or someone who instead wishes that we focus the public on how to strengthen the immune system.
01:43:13.000And the techniques for strengthening the immune system, which we are aware of.
01:43:24.000I guess that's what I was saying poorly before, and you said much more clearly now, which is, you know, I'm disappointed that he's the only person out there and the only voice, not because I don't believe what he's saying is valid, but because I think there are other things that are important.
01:43:38.000First of all, the stress problem has not been addressed.
01:43:43.000I work in my laboratory, but one of the reasons I'm getting out there and trying to talk to people about stress and these systems and trying to provide tools is because people are stressed.
01:43:51.000And for that person, whether or not they're wearing a mask and washing their hands 25 times a day and staying at home or going out, stress, there are tools for that.
01:44:00.000And we have an obligation to teach people those things.
01:44:03.000And there are tools for enhancing the immune system and we need to teach people those things.
01:44:08.000Yeah, I wish that was a big part of the government, whether it's local government or national government, the focus of not just telling people to stay inside and be scared and wash your hands and wear a mask, do all those things, but also exercise,
01:44:56.000I think of all that as kind of the tide that comes in that's required to bring the boat out to sea.
01:45:01.000You know, I think people think about the thing that's going to trampoline them up to the highest position, you know, that's going to suddenly turn them into a high performer, you know.
01:45:09.000And I'm doing some work with a former team guy.
01:45:12.000His name is Pat Dossett and Blake Mycoskie, who started Tom Shoes.
01:45:16.000So just full disclosure, because I have a position on their company board, I want to do full disclosure.
01:45:20.000And they've got this, you know, this company, this program that's really about building foundational tools for people, like for the every person that it's great.
01:45:29.000But, and I also feel like our government should be sending these messages out there because we're really lacking that.
01:45:35.000And I think the instability of the situation that we see today has a lot, the psychological response to all this has a lot to do with the fact that we didn't hit COVID prepared.
01:45:43.000We didn't hit this situation prepared.
01:45:46.000The world was, you know, that the United States is badly obese, It's a real serious medical problem.
01:45:52.000I'm not even touching the psychology, just medical problem.
01:45:58.000I'm going to send this to you, Jamie, so you can put this up on the screen because Bridget Phetasy sent me this today and it's fucking appropriate and hilarious.
01:46:06.000And it's about what we're going through right now in terms of obesity and stress and all these poor people.
01:46:59.000You're looking at a lady that weighs about 400 pounds in a scooter, yelling at a fit woman, put a mask on, you're putting my health at risk.
01:47:10.000And she's got a McDonald's bag in her hand.
01:47:14.000I was hoping that what this was going to do was it was going to be a wake-up call for people, and I was going to see obese people really take their health seriously and go, well, while I'm alive, what are the primary factors that lead to really bad results with COVID? Well,
01:47:30.000according to the doctors that treated patients in Manhattan, the number one factor was obesity.
01:48:17.000I think the other problem that's happened over the last 10 years, and we're starting to see this emerge in much in the same way that we've seen obesity emerge, is the phone.
01:48:37.000It has wonderful aspects, but there are ways in which it's Converting and engaging neuroplasticity in the young brain, the way it's engaging our attention.
01:48:47.000Think about how much attention people will place on that little phone, but they can't read two pages of a book.
01:48:52.000And not because I'm university professor and I need everybody doing equations or learning about neuroscience, not at all.
01:48:59.000I just worry about the neuroplasticity of learning to be defocused and scatterbrained.
01:49:05.000There is a time to put the brain into states of space-time fluidity to come up with new comedy routines or scientific ideas.
01:49:14.000You know, you could take a walk, you can run, you can put the float tanks.
01:49:17.000There are a bunch of different ways to do this.
01:49:21.000The phone is starting to gobble up all that dopamine and all that space time duration path outcome stuff and we are wasting our cognition and we're wasting the most precious gift we were given by mother nature and evolution as a brain that can teach itself things and that can predict things and that can look at the past Can learn from elders and gain wisdom.
01:49:44.000I mean, all that stuff is what we were put here to do.
01:49:47.000And my dad said, you know, he thinks, I asked him if he thinks there are other galaxies, you know, because he's more versed in physics and the cosmos than I am.
01:49:56.000And he said, I don't know, but if there was, they probably extinguished themselves with social media because it's like...
01:50:01.000Mental chewing gum, people just kind of throwing away their cognition.
01:50:05.000And the dopamine thing, it's not that they're getting so much dopamine from using the phone.
01:50:10.000It's that they're spending it out, like spending $5 bills all day long, pretty soon you're broke and you're exhausted.
01:50:16.000And so I worry about our use of these devices and what it's doing to our neurology, but I also know they're extremely important.
01:50:23.000Alan Levinovitz, who was on the podcast recently, had a book called Natural.
01:50:27.000And it's one of the things that he talked about in the book was that what we're doing is essentially the – it's weird.
01:50:37.000And he talked about this on Twitter, and that's how I engage with him.
01:50:40.000We're taking most of our information and we're making it processed information by getting things off of Twitter, by getting things off of social media.
01:50:51.000You're getting this very weird interaction with people.
01:50:54.000It's boiled down to this very strange 280 character version.
01:50:58.000That's not equivalent to an actual conversation with a human being or reading a book or watching a documentary or any of those things.
01:51:05.000It's this weird thing that's most of the information that you're receiving.
01:51:12.000Human beings that are on processed food diets, you see the body behaves very poorly, and it just reacts very poorly, and it's terrible.
01:51:30.000I think we are in an adolescent stage of this technological intervention.
01:51:36.000And this will lead to whatever Neuralink is going to be and whatever the successor to Neuralink is going to be.
01:51:44.000I think things are going to get way weirder, I think.
01:51:47.000But there's potential for a beneficial aspect to it.
01:51:51.000And I think one of the potentially beneficial aspects is that it seems like all of technology is moving us through, at least in this virtual sense of using phones and computers.
01:52:07.000The boundaries between people and information are becoming smaller and smaller.
01:52:12.000The problem is the boundaries between physical people are becoming greater.
01:52:18.000There's more separation, particularly with COVID, right?
01:52:21.000There's more physical separation between people, but the boundaries between being able to access the thoughts of people It's smaller.
01:52:29.000So the beneficial aspects of what we talked about with even your immune system and your health and just overall mental well-being, community, love, friendship, all those things, you need to be right there.
01:53:45.000The engineers, you know, talk about signal versus noise.
01:53:48.000And the brain is essentially an engineered machine.
01:53:50.000It looks for where signal is high and above the noise.
01:53:53.000And so there really is a payoff nowadays, a short-term deleterious payoff, but...
01:54:00.000Pay off nonetheless, for being able to recruit people's attention, recruit their autonomic nervous system, get them into those modes of having to click and follow and scroll.
01:54:11.000Now, I agree that I think social media, like for instance, I teach some science on social media.
01:54:15.000I've managed to make great connections through social media.
01:54:19.000We have to be very judicious in our use of it.
01:54:23.000And what I think is going to happen is that we're going to talk about signal noise.
01:54:26.000I think what's going to happen is we're going to start selecting for people that are very good at controlling their attention, are very good at separating themselves from technology as well as using technology.
01:54:37.000And so for people that are just rabidly consuming technology and information and thinking this is the way to live a good life or to I think it's one of the reasons why a select set of individuals have been so effective at controlling the landscape the political landscape the Lots of landscapes,
01:54:57.000And I think that we need to think about whether or not we're in the noise or whether or not we're, you know, paying attention when these big peaks of signal and what's that?
01:55:33.000Well, especially when you don't have real meaning or purpose in your life because you're unemployed and you're stuck at home because of COVID and you're scared.
01:55:40.000Well, that's a way that people occupy their mind and engage.
01:55:53.000Well, this is kind of scary, and I sort of hesitant to just kind of flip to another research study, but there was this guy in the 60s, this guy, Robert Heath, who didn't need patients who had epilepsy.
01:56:03.000He just got permission to record from the human brain.
01:56:06.000And so he put electrodes into their brains, and he let them stimulate any area of the brain that they wanted.
01:56:16.000They'd stimulate one area and they'd feel kind of drunk, or they stimulate another area, they'd feel sexual arousal.
01:56:21.000They stimulate another and they start laughing.
01:56:23.000The number one area that people like to stimulate created a sense of mild frustration and anger, which is totally perplexing on the face of it.
01:56:33.000You say like, why would people like that more than sexual arousal or feeling drunk or happy or giddy or whatever?
01:56:38.000It turns out, That this dopamine system we were talking about earlier is tethered to that.
01:56:43.000And it very likely explains not just the human animal, but all animals ability to lean into challenge in order to acquire more resources, to fight and overcome that.
01:56:53.000You know, if you had a bunch of whole species where everyone just backed away from any frustration and challenge, that would be very problematic.
01:56:59.000And so right now I see us in the state of extreme anger and frustration or mild anger and frustration.
01:57:05.000And some people are gonna drill through this and they're gonna make things work.
01:57:09.000They're gonna Goggins it to make it the verb.
01:57:11.000And a lot of people are just gonna feed that frustration and anger, but in a loop, it's just a closed loop where they're just clicking and scrolling and clicking and scrolling, and they're not building anything out of that.
01:57:24.000It's actually part of the circuit that underlies the state that we would call courage.
01:57:27.000And my labs worked on it, and this relates to some of the stuff done with military groups.
01:57:31.000But those states of courage were designed to accomplish specific You know, find food, find mates, and then in the world of military, you know, conquer this or learn that and, you know, learn a new skill.
01:57:46.000Right now, the phone in many ways is hijacking some of that circuitry at a low level.
01:57:50.000And it's never, the subtle stuff is the stuff that scares me.
01:57:54.000It's, you know, obviously I'm very disturbed when I see rioting and looting, but when I see a technology that is kind of gnawing away at our neurology little by little, and then we kind of go, oh my goodness, we can't cope with life and what's being thrown at us.
01:58:05.000I think that's when I think, ah, we really need to look at what that neural circuitry was built for and start building new technologies to take us out of this mess.
01:58:13.000Yeah, that's what I'm hoping the future of these, whether it's Neuralink or some other sort of immersive technology that allows people to communicate in a very different way.
01:58:23.000When Elon is saying you're going to be able to talk without using words, what I'm really hoping, and this sounds really crazy, but I think what could help is if we could read thoughts and clear Intentions.
01:58:42.000Really understand intentions versus interpretation of intentions.
01:58:47.000Like someone can say something sarcastically, and you can read it the wrong way, and you can get upset at them.
01:58:52.000If you read it in text, it's even more easy to misinterpret what someone's saying or to purposely, deceptively frame what they're trying to say.
01:59:03.000But if you can just read someone's mind, We're gonna have a much better understanding of each other and the rewards versus the positives versus negatives of holding on to these really toxic patterns that people are swimming in right now with social media.
01:59:22.000I agree, and I do think that neuroplasticity, in addition to brain-machine interface, you know, so it probably will involve machines that we put on our faces or whatever, but neuroplasticity is the way out of this, right?
01:59:35.000It can learn new contingencies, new ways of relating.
01:59:38.000That's why I'm so adamant about understanding this process and really feeling...
01:59:43.000So much importance on, especially with kids, because it's also passive, like their brains are just passively shaped by experience.
01:59:49.000So that can be a little scary to people.
01:59:51.000It's also beautiful because it means that you set one proper intention or one rule that they should learn and adopt, and that can have a long-lasting effect.
02:00:01.000The ability to de-stress themselves, self-soothe, the ability to work through a hard tangle of a problem, Interpersonally or academically, whatever problem that can be done.
02:00:12.000It's just that we, I do think, especially in this country, we've learned to back away from that internal sense of agitation.
02:00:18.000And, you know, going back to what we were talking about earlier, that agitation is the first requirement for getting plasticity.
02:00:32.000But I think I'm certain, actually, that it's not the portal.
02:00:36.000The portal to changing the brain is these high urgency, high attentional states followed by rest and just keep going, toggling back and forth and back and forth.
02:00:45.000That is what's really important, right?
02:00:46.000That you cannot strive for a life of total relaxation because you're not going to get shit done.
02:00:53.000It's not the active state of the human mind.
02:00:56.000It doesn't thrive under those conditions.
02:01:00.000But we're all so concerned about stress and we're so concerned about the pressures of whether, you know, you're in some sort of a competitive environment or a job that you're involved in that requires an immense amount of your focus and your attention.
02:01:16.000We're all striving for that state where you're like a monk in a lotus position not doing anything.
02:01:23.000Yeah, that seems terrible to me because it's divorced from everything we know about competition winning in the brain.
02:01:30.000There's a cool set of experiments that I think you might especially appreciate given your background in martial arts, which is called the tube test, where they take two rats or two mice, and they put them in a tube, typically it's male mice, but also female mice, and they start fighting for position in that tube.
02:01:45.000One mouse pushes the other mouse out or rat inevitably.
02:01:51.000The one that got pushed out is the loser.
02:01:53.000We know that statistically, if you put those mice back into another tube test, even with another mouse, the winner has a higher probability of winning and the loser has a higher probability of losing.
02:02:03.000Even if you push the winner from behind, so you take a loser and you push it from behind with a stick and it wins, even if it doesn't win on its own effort, it becomes a winner.
02:02:15.000And for about two decades, this really perplexed neuroscientists, and this was taught in psychology classes, but not neuroscience classes.
02:02:21.000So in the last five years, neuroscientists come in, we have a lot of new tools now that let us monitor the brain Look at the brain in real time as rodents or people are doing these kinds of things.
02:02:30.000And so they figured out that there's a specific area of the frontal cortex that becomes more active in the winner and less active in the loser.
02:02:40.000So much so that if you shut down that brain area, the winner suddenly becomes a loser.
02:02:43.000You increase activity in the loser, it becomes the winner.
02:02:47.000So you ask yourself, what in the world is this brain activity or brain area doing?
02:02:53.000It turns out it's taking the feeling of stress and arousal, which both of them are experiencing, it's a battle, And it converts it to more steps of forward movement per unit time.
02:03:06.000And so one animal is feeling stressed and is pausing more or is backing up.
02:03:10.000The other animal is feeling the same level of stress and is moving forward just physically.
02:03:15.000And it's wild because you can even take an arena, make it really cold, which mice don't like, put a warm heat lamp in the corner and the animal that won at the tube test gets the sweet spot every single time.
02:03:28.000And so what this says is that, you know, those are mice, we're humans.
02:03:34.000We had a paper a few years ago identifying the area in the brain that actually leads to forward movement and rewards it with a dopamine reward.
02:03:41.000This was a paper we published in Nature.
02:03:42.000The area of the brain is interesting only because it maps exactly to that brain area that Robert Heath found People like to stimulate, frustration and anger.
02:03:53.000So frustration and anger were designed to get us to move forward adaptively.
02:03:57.000Now, I don't know how this plays out in the octagon where you're seeing somebody get beat up and then all of a sudden they're winning and it's switching back and forth.
02:04:04.000But my dream experiment would be to record from the brains of those guys in real time.
02:04:09.000We don't have the tech to do this right now, but someday we will.
02:04:12.000And I bet you that every forward step or perception that you have an advantage over the other guy or gal, Leads to dopamine increase, lowers that norepinephrine and allows them to keep moving forward.
02:04:46.000I don't want people stressed all the time or seeking stress, but goodness, we were given, And we were endowed with this amazing neurology that allows us to do this.
02:05:21.000That's an uncomfortable reality for a lot of people, that the struggle is good.
02:05:29.000There's benefits to it, particularly if you're looking for growth and also if you're looking for stimulation and a sense of meaning.
02:05:37.000I think people, for whatever reason, are hardwired to try to figure things out, to try to get better at things, and to have a purpose.
02:05:44.000And a lot of times, the purpose that they feel, other than family and loved ones and friends and things along those lines, there's a purpose of success in their chosen field, success in whatever endeavor, even if it's a hobby, you know, like whatever the thing is that they obsess upon.
02:06:02.000That's what gives people this sense of meaning.
02:06:06.000And I think that's why there's buildings.
02:06:11.000There's something about people that need a problem to solve.
02:06:16.000And then once they've solved that problem, they need a new problem.
02:06:19.000And that's what the nervous system was fundamentally designed to do that and make sure our offspring make it to the next so when you see like Riots and looting and you see people pushing against the building and let us in Do you do you look at it from that perspective like oh?
02:06:32.000There's a sort of a battle going on here and there's a prop like they're trying to win Just like the mouse in that tube when you see those protesters in Portland or try to get into the courthouse Like what are they doing?
02:06:45.000They're trying to get in there because it's locked and And they have this idea in their head that that's going to be the conquest.
02:06:52.000But you saw, like, what Chaz, remember that?
02:07:47.000And actually I hadn't thought about it.
02:07:49.000It's a perfect example of real life example of the tube test.
02:07:51.000These two opposing forces pushing back and forth.
02:07:54.000And we know that the more, we call it autonomic arouse, but the more stress you get, the more your mental and visual landscape becomes that sort of straw view where all you can think about is the adversary.
02:08:05.000Now in a fight in an octagon or a boxing ring or jujitsu match, that's great because everyone's agreed to that.
02:08:13.000That's not designed to be played out in society over these micro-wins.
02:08:17.000It's not even clear that they're wins because what's really changed?
02:08:19.000I think that working through legislation, working through top-down legislation, identifying specific Things to go after.
02:08:27.000I mean, that was the beauty of the civil rights movement, you know, in the 1960s, you know, Brown versus the Board of Education.
02:08:32.000Like, what a beautiful thing to create openness in schools, you know, where anyone could attend, going after specific legislation.
02:08:38.000That's far and away a different way of looking at a problem and solving a problem.
02:08:44.000And, you know, I don't have a lot to say about the situation in terms of the protests.
02:09:14.000In science, we have a phrase, you're either a lumper or a splitter.
02:09:18.000The lumpers like to kind of lump everything together and push forward a grand theory.
02:09:22.000Now today I'm using some generalizations and I don't want to get too far down in the weeds, but I'll stand behind anything I've said, because it has detailed background to support it.
02:09:29.000But the splitters, As annoying as they can be when they come to meetings, no, but this, but that, you need a certain number of splitters.
02:09:37.000This is why I think like a panel of people is good.
02:09:39.000You get a lumper, a lumper and a splitter.
02:09:41.000And then pretty soon the splitter is annoying everybody because you just want to go for coffee or you want to just break and the lumpers are done.
02:09:48.000But the splitter says, no, we're actually not thinking about this problem in a nuanced way.
02:09:51.000And this is where I think maybe it's not specific scientific information, but a scientific training and ability to think about a problem and be comfortable Knowing you may not solve it today or ever, but you're going to lathe into this thing over and over and over.
02:10:06.000That's the kind of training that a scientific thinking will give somebody.
02:10:09.000You don't even have to want to be a scientist to do it.
02:10:11.000I don't know if anyone wants to be a scientist nowadays.
02:10:13.000I certainly hope so, but we need to have more nuance.
02:10:17.000We need balance between the lumpers and splitters.
02:10:20.000And as you point out before, social media is all about lumping and high emotional states.
02:10:28.000Yeah, I think what you just said is perfect.
02:10:31.000I mean, that's really what we're dealing with today is this inability to recognize nuance and to accept nuance and to be rigid and committed to your position.
02:10:41.000And your position is something you defend.
02:10:44.000Because your position essentially is you, right?
02:10:48.000This is one of the problems that people have with ideas, that they marry their mind to these ideas.
02:10:53.000And if these ideas prove to be, even if objectively they know that this idea has holes in it, they will still defend that idea tooth and claw, because that idea represents their ego or represents them as an individual.
02:11:15.000There's a paper that came out recently in the journal Neuron, excellent journal, that was all about the dopamine system being attached to beliefs.
02:11:23.000So beliefs and thoughts we think of as kind of these vague, you know, like, what are thoughts?
02:11:27.000You know, I have thoughts all the time, but I can also deliberately have a thought.
02:11:30.000Beliefs are almost like actions in the sense that they can recruit dopamine to release.
02:11:34.000What this paper showed is that people just believing, thinking more and more about what they already believe leads to these dopamine increases.
02:11:42.000It literally reinforces the belief they have from the inside.
02:11:45.000That presents a certain particular type of problem for trying to convince people how to change their opinion.
02:11:50.000It means I have to take Your mind or the person's mind into a completely different state in order to change it.
02:11:57.000It's, you know, maybe it's hypnosis, maybe it's proper landing of media ideas.
02:12:01.000I don't know what that form would take, but changing people's minds provided that they are older than 25 has to be done by the person themselves.
02:12:09.000I can't change your mind unless you're a child.
02:12:19.000So we are becoming more and more polarized.
02:12:21.000And because of the nature of the AI bots that drive social media, the information that you're getting and that I'm getting, well, hopefully that's more aligned than, you know, some of the ideas that I'm getting and other people are getting where we fundamentally disagree because social media and media in general is designed to bring us into these high amplitude aroused states.
02:12:39.000But we're getting different information.
02:12:42.000And so our beliefs are actually diverging and being reinforced by dopamine.
02:12:46.000So we are creating a bigger and bigger conceptual divide through the hijack of these neural mechanisms.
02:12:52.000I wonder if that's one of the really attractive things about these protests, is this internal recognition somewhere, even if it's subconsciously, that we don't connect with people enough.
02:13:02.000And that there's no greater connection than a group of 50,000 people that are supporting an individual cause.
02:13:11.000If you really want to build team, build a sense of community, you can have them all watch a concert, bring them into a peak state, or you can all have them fight the same fight.
02:13:21.000I wonder if there's like a yearning for that because of the separation of...
02:13:27.000I mean, think about the coinciding factors, right?
02:13:30.000You have social media, which separates us.
02:13:36.000And then you have these protests, which unites us.
02:13:40.000And it must be like incredibly satisfying for people that have been locked up and are constantly on social media to be in this mass movement.
02:13:48.000And you'll probably alter your own perceptions and beliefs to fit in better with this movement.
02:13:54.000So people that would never be violent may be violent.
02:13:57.000People that would never loot might loot.
02:14:02.000Or start smashing the windows of Starbucks might be so inclined because of the mob mentality to join right on in just to be accepted and be a part of this group and just to feel something.
02:14:14.000Just to be excited by this gigantic movement.
02:14:17.000And when it's so undeniable that the cause is worthy, like the George Floyd murder, when you see that and you go, well, fuck this, man.
02:15:22.000Looking back in the last century's history, I mean, you know, the build after the war was a, you know, everyone community building.
02:15:27.000There were a lot of problems with the way that was played out, of course, was not done equally among racial groups, et cetera.
02:15:33.000But a common goal, a common battle, a common fight is very good at recruiting these systems in the brain.
02:15:40.000And I don't know how that's gonna come about.
02:15:42.000I keep hoping, I have this 14 year old niece and I just keep hoping that like her generation is looking at all this and they're just like, we're gonna work this out.
02:15:50.000Well, I think what's going to happen with places like Seattle and Portland, unfortunately, I sense a mass exodus of rational people from the area.
02:15:58.000I think they're probably going to go, okay, people have lost your marbles.
02:16:02.000We're going to get the fuck out of here and we're going to take our tax dollars with us and leave you with your Marxist mayor.
02:16:07.000And congratulations, you fucked the whole city up.
02:16:42.000Well, there'll probably be a correction because of that as well.
02:16:45.000It's most likely that what we're experiencing is just a lot of chaos and then lessons will be learned and unfortunately for a lot of people, victims will be made.
02:16:55.000They're going to make victims out of a lot of people and a lot of people are going to lose their businesses and their livelihoods and even their lives along the way.
02:17:01.000When we saw this in the 60s, you know, the civil rights movement was an incredible movement, but we also had like the whole hippie movement.
02:17:07.000There was like a lot of the same parallels were happening in the last 20 years.
02:17:10.000I was watching this, you know, because I grew up in the Bay Area.
02:17:12.000People think of Silicon Valley is very conservative, but I remember a time growing up.
02:17:17.000You know, at least in my house, you know, like the way that my dad talked about hippies was like, you know, every doesn't lead anywhere.
02:17:22.000It's bad for everything, you know, the counterculture movement.
02:17:37.000Don't be a spoonbender, you know, like whatever you do, don't be a spoonbender because it's like, Stay attached to facts and things that are designed to move human progress forward.
02:17:45.000At the same time, you had the whole counterculture thing going crazy.
02:17:49.000And I feel like in the last 20 years, we've seen some spoonbenders.
02:17:52.000We've seen the explosion of access to all things, and people being so hungry to have everything that everyone else has.
02:18:02.000And there's been a gradual decline, at least in some sectors, You know, an appreciation for hard work ethic.
02:18:08.000That's why I think, David, you know, I have a deep appreciation this for the work with, you know, people in the military, but people who, you know, that whole American thing that I grew up with of you get up, you pick a vocation, you grind away at it, whether or not it's, you know, Garbage man or scientist,
02:18:26.000You're just building, the same circuits are underlying all that.
02:18:29.000And I think right now people are feeling like they don't know which way is forward.
02:18:34.000Like we talk about moving forward and pushing against stream, but I think a lot of people just don't know which way is forward.
02:18:38.000So what's ever thrown in their face, they go that direction.
02:18:41.000Yeah, well, they think they have a sense of what's forward, and they're moving in that direction.
02:18:45.000And a lot of them are very young, too.
02:18:47.000And so their version of the world is not, again, to use the word, not particularly nuanced, which is, you know, they're imitating their atmosphere.
02:18:56.000They are a part of this, what they think is a very valid and worthy movement, and they're pushing forward.
02:19:45.000Things that are completely outside of your control should have absolutely nothing to do with how a person values you as a human being.
02:19:54.000And I think most people haven't experienced this, but there's something out there.
02:19:59.000Maybe it's on the internet, but my colleague Jeremy Bailenson built this VR experience called Walk of a Thousand Cuts or 10,000 Cuts.
02:20:06.000So you put the VR on, you see yourself, a reflection of you, and then they turn a dial or you turn a dial and then your skin, if you're Caucasian, becomes...
02:21:01.000I mean, you don't really have to hit a person, but if you hit the thing, like if they could figure out a way to make a robot You know, that was interacting with the VR program that understood where the footsteps of the VR. So it's in the correct position.
02:21:18.000So like, as you hit it, that's where it should be.
02:21:21.000And you could actually push off of it and it would back up a little and then you could hit it.
02:21:27.000And I should be clear, like, I'm not a total technophile.
02:21:30.000I think we're using the tech that we have now because it's the best we've got.
02:21:33.000And I hope that in five years with all these amazing engineers I'm surrounded by and elsewhere, That we won't be using that tech and we'll be doing something completely different.
02:22:38.000But it fundamentally changed the way that I experience interactions with people on the street.
02:22:44.00010 minute or so, or 20 minute or so VR experience.
02:22:47.000And that's just the tip of the iceberg about what's possible.
02:22:50.000I think we really, what it tells me is that because of how stringently gated plasticity is, plasticity is vaulted by these chemicals, we need to bring those chemicals into play if we want people to change the way they feel.
02:23:03.000I don't think watching a protest on the street can do it.
02:23:05.000I think the George Floyd thing absolutely did it.
02:23:07.000That was a very dramatic, Terrible example.
02:23:42.000I always say New York is like a human safari, but it's like, again, signal the noise.
02:23:46.000Like a person has to have a cat on their head naked and on fire before you're like, oh, wow, maybe they need something.
02:23:52.000Well, it's just that it's very impersonal.
02:23:54.000There's this sort of weird thing that happens when you get around large numbers of people where they're not as valuable because you're overwhelmed by them.
02:24:05.000Whereas if you're in a small town of 20,000 people and you walk down the street and there's a guy walking towards you, you look at each other and go, hey man, how you doing?
02:24:14.000I always, what I liked about New York is I felt like it's, you had Italians and Irish and black people and white people and Puerto Rican people.
02:24:20.000And so there's a, you also experience them, right?
02:24:24.000And, you know, the Bay Area, I love the Bay Area, but one of the problems I have with the Bay Area is it's become, you know, people are hidden away a lot more.
02:24:36.000It's a car culture, and every place has its challenges.
02:24:39.000But I think New York is such a beautiful experiment in putting a bunch of people with different genetic and ethnic backgrounds together, putting them together and saying, you know, you may not all get along, but at least you will hear those...
02:24:52.000Those accents you'll get cursed at in five different languages.
02:24:55.000And I think there's a real beauty to it.
02:24:57.000I wonder how much that's going to change because of COVID. Because obviously people are terrified of being jammed into a subway now with strangers.
02:25:04.000And that was one of the cool things about New York is that you did all walks of life.
02:25:09.000Poor and rich would interact with each other on the street.
02:25:11.000In LA, there's virtually none of that.
02:25:14.000And there's this weird sort of separation.
02:25:17.000Between people and where they live and then also the car thing.
02:25:20.000Car cultures, you're in your own little environment.
02:25:25.000You set up your own little world and that's your car and you're driving around and these other people that you interact with, that's a little segment of their world that they're taking with them on the 405. And because of that, you don't have the same sort of melting pot.
02:26:25.000Science is making an effort, and I think now, especially after the recent events in the world, to try and bring in more diversity.
02:26:33.000And it's a desperate need because you want that diversity of opinion, you want that diversity of outlook.
02:26:40.000We're fortunate to have an African American colleague in our department, which is actually a small department, and there's an immense need for that.
02:26:47.000I think science is going to be more diverse in the years to come.
02:26:50.000It's a focused effort now that the National Institutes of Health is going to put money and energy into this, thankfully, but there can always be more done.
02:26:57.000But I think when thinking about kids and neuroplasticity, like whenever, you know, I'm not skateboarding anymore.
02:27:28.000I mean, and it's it's just more of those things where people can interact with all kinds of different people gives you a more balanced perspective.
02:27:40.000It gives you it gives you a broader perspective, right?
02:27:44.000You get to see and bringing it back to the way the brain functions, the more variables that you have in terms of when you see a person You know so many different examples of human beings that you have more to draw upon and I hope that one of the things that comes out of this George Floyd thing and then the Black Lives Matter protests is people have more open-minded approach towards just human beings in general and I think these things like they happen in these big explosive
02:28:14.000these big explosive events and then shifts And I think we're absolutely experiencing like a global consciousness shift And it's very chaotic and scary in some ways for a lot of people right now.
02:28:28.000But I think ultimately we're going to come out of this the better.
02:28:30.000And if you look at like, say, Steven Pinker's work where he covers, you know, the history of human beings and interactions, we are in the best time ever.
02:28:39.000And it's hard to say that because, you know, there's still poverty and there's still violence and there's still crime and there's still racism and sexism and rape and all sorts of awful shit.
02:28:49.000But it's way less and way better than it was just 100 years ago or 200 years ago.
02:28:54.000And it seems to constantly be moving in that trend.
02:28:57.000And I'm hoping that that's going to be what comes out of this.
02:29:00.000This is going to be another event that as the dust settles and as the lessons are learned and as we kind of get our feet back on the ground, And we understand what went wrong and what happened, particularly because of this coronavirus situation that we're in.
02:29:27.000And every time I... You know, I think being able to take someone else's frame of mind or reference just as an exercise, it's so hard.
02:29:33.000I mean, we become kind of autistic in our way of just feeling like our experience is the one experience and just being able to try and think about what it must be like over the last three months to not have any income, you know, to see your gym or your business open then shut again, at least here in California.
02:30:07.000To bring it back to your work one of the things that you talked about was eyesight and Regaining eyesight or dealing with people that have weakening eyesight my eyesight's going to shit man.
02:30:21.000No, I'm just old 52 and just there's a you know macular degeneration like I can I mean I could read my phone I can read all these text messages that are coming in 14 new ones since I put my phone down and But what I do know for sure is that my vision is not as good as it was 10 years ago and certainly not as good as it was 20 years ago.
02:30:50.000So we do have a clinical trial in my lab right now through my affiliation with ophthalmology where people put on VR goggles, very separate from the fear inducing thing.
02:31:01.000It's actually a very pleasant experience.
02:31:04.000And we use a particular pattern of stimulation that activates the cells in the eye that are most vulnerable and create vision loss.
02:31:13.000It stimulates those in a way that reinforces their connections with the brain.
02:31:18.000So every cell in your eye has a different function, but some of them, their job is to transmit visual information to the rest of the brain.
02:31:26.000We know what patterns of activity make them healthy and what reinforce regeneration.
02:31:32.000Back in 2016, my lab published a paper showing that that particular pattern of stimulation combined with a particular pattern of gene therapy, so this is one injection into the eye of a gene that triggers growth of these cells, In mice that allowed regeneration of neurons that were damaged and it actually reversed slightly,
02:32:21.000To inject something called CNTF, ciliary nootrophic factor.
02:32:27.000And the combination of this growth factor plus the visual stimulation, we believe is going to protect Cells that would normally be lost from getting lost, so offset vision loss, and potentially restore vision.
02:32:40.000Now, the results of this trial aren't done, but we are recruiting people for this trial.
02:33:02.000The other thing is that there was a paper published just recently, a couple of weeks ago, not from my lab, but from a group over at University College London, looking at the effects of red light on mitochondria in a different cell type, which are the photoreceptors of the eye.
02:33:14.000So you've got the cells that connect the eye of the brain called the ganglion cells, then you've got the photoreceptors, which take all this photon information, turn it into this incredible thing we call vision, which itself is a whole galaxy of information, but is amazing.
02:33:27.000Those cells degenerate over time, the photoreceptors.
02:33:30.000They don't do very well in part because as we age, the mitochondrial function gets disrupted.
02:34:51.000You don't really want to be looking at any bright light in the middle of the night.
02:34:54.000A lot of people get obsessed with blue light being bad.
02:34:57.000You want bright light during the day and you don't want any bright light at night really, too much of it.
02:35:02.000And people come after me, they're like the blue blockers, you know, I call it like the blue blockinistas have been coming after me recently because I'm out there saying like, it's like, what about the, it's like, look, The blue blockers will help filter some light.
02:35:25.000Get bright light first thing in the morning when you wake up.
02:35:28.000And then the bright red light is probably having a dual effect.
02:35:31.000It's probably increasing mitochondria in the photoreceptors if the study is right.
02:35:34.000And I do believe this study, it looks really good to me.
02:35:37.000And the person who did it has been in the game a long time, so I trust him.
02:35:41.000And in addition to that, it's gonna wake up your system and get the balance of these hormones, like you want cortisol high in the morning and melatonin coming up about 16 hours later before sleep.
02:35:50.000It's gonna put all that into the right rhythm.
02:35:52.000So I say, go ahead and do the red light thing.
02:35:54.000But if you wanna pursue the red light flashes or the VR and maybe even the CNTF injection, we should talk about that.
02:36:01.000CNTF injection, you mean the bacteria?
02:36:07.000Well, the good news is that the VR, we do have a condition in the study where it's just VR. So it's a daily, essentially, neurons like to be active.
02:36:18.000And these cells that connect the eye of the brain are the most, above all others, the most active neurons and cells in your entire body.
02:36:27.000Do you know of anybody who's done this where they had the injections in the eyes?
02:36:30.000Well, oh yeah, many people now in this study have had the injections.
02:36:59.000But we have subjects or patients that are as young as 17, as old as 80. And the beauty of this is that if you decide not to get the injection, it's completely non-invasive.
02:37:11.000How many injections do you have to have?
02:37:13.000I think it's like once a month for a period of about six months.
02:37:15.000So would I have to go to the Bay Area once a month?
02:37:18.000No, so there is another version of this where there's a slow-release polymer capsule that's placed into the eye.
02:38:12.000He's a terrific guy, both for sake of his work on combating aging and also just, I really have to tip my hat to him because he was really first man in in terms of doing public-facing science education through podcasts and things like that.
02:38:24.000And, you know, I'm starting to do that and others are starting to do it and he deserves credit for that.
02:38:29.000It puts scientists in a vulnerable place and I think he's doing it with a lot of integrity.
02:38:35.000Yeah, it's easy for him to get the point across.
02:38:38.000So David's not typically known for doing vision research, but he paired up with another guy's lab, a guy named Zhigong He at Harvard Children's Hospital, someone I know very well.
02:38:48.000We worked together on a number of things and they took advantage of what are called these Yamanaka factors.
02:38:53.000Yamanaka won the Nobel prize for finding these four factors that could essentially allow a cell to turn into anything.
02:38:59.000Any other cell type, kind of create stemness in these cells, make them pluripotent stem cells.
02:39:04.000The problem was that tends to induce cancers in these cells.
02:39:08.000So David's lab has combined an anti-cancer gene.
02:39:10.000I think these work are still not published, but he's talked about them, so I feel comfortable doing this.
02:39:15.000Suppresses cancer while turning these cells young again, And at least in mice, they see some very encouraging results.
02:39:21.000So that would be a sort of one injection kind of thing where you go in once, you get the injection and then never again.
02:39:25.000If I did an injection once a month, how long are we talking?
02:39:29.000How many months do I have to do it for?
02:39:30.000So the study would probably run for about six months or the embedded capsule, the CNTF capsule combined with the VR. Now you have to put those VR goggles on for 20 minutes a day and watch this.
02:39:41.000You can listen to music, do whatever you want.
02:39:43.000It's a very passive thing that triggers activity of these cells.
02:39:45.000The activity is key because we know that neurons, you know, you hear fire together, wire together and all this other stuff.
02:39:52.000But the fact of the matter is neurons that are quieted, even if you cast an arm, the neurons that support movement of that arm very quickly start to turn off and eventually, They can die.
02:40:02.000So keeping neurons active and alive and healthy involves keeping them literally active electrically.
02:40:08.000And so that's what the VR component's about.
02:40:10.000So there's the Sinclair kind of turning back the clock stuff.
02:40:14.000And then colleagues of mine at Stanford are doing incredible work with neural prosthesis, so little robotic retinas, as well as stem cells that are injected into the eye that settle down into your eye and give you the cells that you've lost.
02:40:27.000And we're not quite there with the human trials yet, but there's a group, the Retinal Repair Initiative.
02:40:33.000It has a kind of funny name, but it's called the Retinal Dream Team, which is a bunch of people brought together to cure blindness, to solve blindness in a particular disease called neurofibromatosis.
02:40:43.000So there are dozens of labs working extremely hard on this problem.
02:40:47.000This is one place where I can say, There's been tremendous progress in the last five years.
02:40:51.000There are clinical trials now, for instance, the one in my lab.
02:40:54.000And in two or three years, you're going to start seeing people who would normally go blind.
02:41:32.000And I've talked to him a bunch of times because he was having some issues with his sleep because one of the issues that blind people have is because light is controlling when to be alert and when to be asleep.