In this episode of The Joe Rogan Experience, we talk about CBD, sleep, and how to get a good night's rest. We also talk about melatonin and why it's not a good sleep aid at all. Joe and Matt talk about the science of sleep and the benefits of CBD and other sleep aids, and why they don't work as well as you think they do and why you should try to get some sleep if you want to improve your overall quality of life. We also discuss the benefits and drawbacks of melatonin, and whether or not you should be taking it at all, and what you should do if you don't need to take it to help you fall asleep. If you like what you hear here, please HIT SUBSCRIBE and leave us a rating and review on Apple Podcasts and other podcasting platforms! We're listening to your favorite podcaster on Podcoin! Please rate, review, and subscribe to our other podcams, and tell us what you thought of this episode and what your favorite part of the pod is the most important thing you've listened to this week's episode so far! Cheers, and Happy Listening! XOXO, Joe and Mikey! xoxo, Caitlyn and Matt Thanks for listening and supporting the pod, Caitie & Mikey, and for supporting the podcast, and we'll see you next week with a new episode of the Joe Rogans Experience Podcast! Caitie and Jonny's podcast, on Tuesday Morning Podcast, by day, by night, by Monday, by Tuesday, by Wednesday, by Saturday, by day by night by day. xo, by week, by evening, by weekend, and by night by night. , by night all day, all day all day by day Thank you, are we rolling, are rolling. bye, bye, love, love you, love ya, bye. - - Joe and Jon, bye bye, Mikey and Jon xoe -- , bye, good night, bye Bye Bye, bye Love, - Mikey & Jon - P. -- - Mikey - Rachael . - Emily :) Jon & Rory ( ) Caitlyn & Joe John )
00:00:17.000Yeah, anyway, I'm just a giant fan of CBD. I use it constantly.
00:00:21.000I use it for, like, I use the roll-ons for muscle aches, and I use gummies, and CBDMD is one of my sponsors, but this Kill Cliff Company, this is actually a drink that I designed.
00:01:00.000You know, the problem, like, I used to get CBD with THC from a local company in LA, and they were so inconsistent in that, like, I'd take, like, I had a thing.
00:01:30.000The last thing we need is regulation on it, but it's like melatonin.
00:01:32.000I was talking to Matt Walker about this, my friend Matt, amazing sleep scientist.
00:01:37.000And it turns out that the amount of melatonin, if it's listed like three milligrams or six milligrams, it can vary anywhere from being 15% of what's actually listed on the bottle to 85% more.
00:01:51.000And if you look at how much melatonin is actually made by the pineal gland, It's a tiny fraction of the three milligrams it's supposed to be.
00:01:58.000So melatonin, it's all over the place.
00:02:01.000Does that mess you up if you take melatonin?
00:02:04.000Does your body say, well, I don't need any melatonin.
00:02:22.000So does it suppress your endocrine system?
00:02:25.000So in humans, it's probably not as dramatic as it is in animals that are seasonal breeders.
00:02:29.000But long ago, when I was a graduate student at Berkeley, we would do these experiments on these little, what are called Siberian hamsters, these little hamsters.
00:02:37.000And these hamsters only breed in long days because light, Basically suppresses melatonin, okay?
00:02:44.000So in short days, long nights, seasonal breeding animals shut down breeding, right?
00:02:49.000Humans can breed all year long, of course.
00:02:52.000But if you give melatonin to a male Siberian hamster, its testes go from the size of standard marbles to the size of a grain of rice within a week.
00:03:02.000And the females, their ovaries involute.
00:03:05.000They basically turn into like little shriveled, not even raisins, but little specks.
00:03:08.000So when I hear about people taking a lot of melatonin and you've got this whole issue with falling testosterone, dysregulated estrogen in men and women, I just think it's not the best sleep aid.
00:03:18.000The other thing, and Matt and I have talked about this a lot recently, just we've been hanging out and Chatting about science, or as he would say, splashing around in the science of sleep.
00:04:00.000Those two things work really well to, they essentially shut down the forebrain thinking, anticipating part of your brain, allow you to drift off into sleep really well.
00:04:08.000Oh, I need that all day then if you shut that down.
00:04:11.000Well, and then theanine is also the third thing in the cocktail.
00:04:15.000And theanine, that is also a nootropic.
00:04:18.000So theanine also turns on what's called the GABA system.
00:04:21.000It's like an inhibitory neurotransmitter and it helps suppress anxiety and kind of turn off thinking.
00:04:26.000It helps you make the transition into sleep.
00:04:39.000So it's magnesium threonate, T-H-R-E-O-N-A-T-E. And that's important because there are a lot of T-H-R-E-O-N-A-T-E. E-O-N-A. Three and eight.
00:05:08.000Magnesium three and eight can cross the blood brain barrier.
00:05:10.000Cause when you take magnesium, it goes into your gut.
00:05:12.000It doesn't necessarily get into your brain.
00:05:14.000You've got a barrier around your brain That prevents certain things from getting in because this tissue doesn't regenerate.
00:05:19.000So the threonate form gets brought across the blood brain barrier by a transporter.
00:05:28.000Other forms like magnesium malate, magnesium citrate, those are good for other things.
00:05:32.000Magnesium malate is great for muscle soreness.
00:05:34.000Magnesium citrate is a great laxative, but magnesium threonate is going to be the one that's going to allow you to drift into sleep You know, it's interesting that you're saying this because one of the things that I've found that relaxes me more than anything is Epsom salts.
00:05:47.000You know, I'm a big proponent of the isolation tank and the sensory deprivation tank is all filled with magnesium.
00:05:59.000So that's a really unusual situation where if you, you know, you get, and there are some magnesium creams and things like that.
00:06:04.000But you're not going to get it in the kind of volume that you get it when you lie in it like that.
00:06:08.000And when you're doing that, what magnesium is that?
00:06:11.000So that's usually magnesium biglycinate, which is another one of these forms of magnesium that can get transported into the brain really easily.
00:06:20.000And most people actually are magnesium deficient.
00:06:23.000I think most people would do well by increasing their magnesium intake.
00:06:27.000I supplement, but I think I supplement with citrate.
00:06:33.000Malate, again, it's good for muscle soreness, but three and eight, what you want to take is about 300 to 400 milligrams.
00:06:39.000But what you'll notice is on the bottle, it'll say elemental magnesium and then magnesium will be 300 to 400. And then it'll say equals 1000 milligrams.
00:06:47.000Basically just go for 300 to 400 milligrams and you're good.
00:06:51.000And then the other thing is apigenin, A-P-I-G-E-N-I-N. And this stuff is terrific.
00:06:59.000It basically, that's the only source I'm aware of.
00:07:47.000So apigenin turns on a chloride channel.
00:07:50.000The way neurons work is you got stuff going in and out of them, and the chloride channel tends to turn off neurons a little bit in a good way and creates a...
00:09:10.000I recommend taking these 30 to 60 minutes before sleep.
00:09:13.000And what do you recommend for a dose for theanine?
00:09:16.000For theanine, it's going to be 100 to 400 milligrams.
00:09:19.000However, if you're a sleepwalker or you have what are called night terrors where you have really disturbing dreams, leave the theanine out because the dreams on theanine are intense.
00:09:44.000The one thing about magnesium threenate I should mention is that there are some data, not a ton, that it's also neuroprotective.
00:09:51.000So there's at least one study, peer-reviewed, independent, you know, not a company paying for the study, but done by a laboratory with no bias, that shows that magnesium threenate can offset some forms of atrial cognitive decline.
00:10:06.000So the cocktail of the three of them, the reason for putting the three of them together?
00:10:12.000There seems to be some sort of synergistic effect because some people, of course, will take something for a long period of time and then it'll stop working.
00:10:20.000You can take these, they're not habit-forming.
00:10:22.000I mean, I've taken them consistently and then taken breaks and then go back on them.
00:10:26.000And they really, in most cases, I mean, I guess if someone had a heart condition, a serious heart condition, anytime you mess with magnesium, because you have neurons in your heart, magnesium is involved in neuron function, obviously the usual things, check with your doctor, you know, and obviously I'm not a doctor,
00:10:41.000I'm a professor, so I profess things, I'm not prescribing anything.
00:11:14.000It was important because people were ignoring sleep.
00:11:16.000We heard go hard driving, hard driving, hard driving.
00:11:18.000And it's very important that people understand that the fundamental layer of health, mental health and physical health is regular quality sleep.
00:11:26.000So he scared people appropriately, I think.
00:11:28.000And now he's shifting to how can you get better at sleeping?
00:11:32.000And we're joining forces in that mission.
00:11:37.000I don't want to give away what he's got planned, but basically he, so Matt, David Sinclair, me, you know, Lex, all the nerds were kind of like, we're trying to get out there with the scientific information and help people.
00:11:48.000And so Matt's got some really terrific sleep science and actionable sleep tool plans for the world.
00:11:59.000So, yeah, so he and I had a discussion recently.
00:12:03.000He is talking about doing a brief weekly podcast on sleep health, launching sometime in August or September, which I just think is going to help so many people.
00:12:14.000Sure, and brief would make it nice because it's easy to digest.
00:12:17.000Yeah, I still haven't learned the brief thing.
00:12:37.000Now, using theanine to help sleep seems so strange to me that it would also be a nootropic, that it would also be something that enhances brain function.
00:12:50.000AlphaBrain just released it today, AlphaBrain Black Label, the strongest version of AlphaBrain, which I've been testing over the last six months.
00:13:29.000So the theanine is going to take down some of the stimulant effect of the caffeine and kind of, you know, the best way to work, the best nootropic is something that's going to put you in alert but calm.
00:14:03.000Most people are riding high on cortisol and not a good way.
00:14:05.000You want cortisol each day, and we can talk about how to time it, but you want to time that peak in the right way.
00:14:11.000Acetylcholine is going to increase acetylcholine, which is involved in the brain's ability to focus, to create that tunnel of attention, which is critical, right?
00:14:20.000I mean, you can't be all over the place.
00:15:27.000I don't know your home environment or your lifestyle terribly much, at all really.
00:15:31.000But we know that long distance viewing and getting outside into sunlight can offset macular degeneration and myopia, nearsightedness.
00:15:40.000There's a huge, meaning thousands of subjects.
00:15:43.000Study that was done in the US, also overseas, so the multiple site clinical trial, showing that if children get outside for two hours a day, even if they're on their phones, I hate to say it, but even if they're on their phones and they're reading and doing their thing, they don't develop nearsightedness.
00:15:59.000And just being outside in natural light seems to help Offset vision loss.
00:16:05.000And the reason is that when you look at things up close, the eyeball actually lengthens.
00:16:10.000And because there's a lens there, the light gets focused in front of the retina, not on the retina, which is what you need in order to pass that information to the brain.
00:16:18.000So that when you put on eyeglasses, you're basically giving it another lens to focus at the right place.
00:16:22.000When you look at things at a distance, you use the musculature of the eye in a process called accommodation.
00:16:39.000And so looking at things in the distance, getting natural light, actually blue light is good for us in the sense during the daytime, improves eye health.
00:16:47.000It reduces myopia nearsightedness and can offset the progression of age-related macular degeneration.
00:16:53.000Now, people shouldn't be blasting themselves with bright light because that can cause other issues.
00:16:57.000But as long as the light isn't painful to look at, you're in safe territory.
00:17:02.000So if someone is experiencing the beginning of macular degeneration, do you recommend going somewhere where you can see long distances and just concentrate on just how often should you do something like that?
00:17:13.000For every 30 minutes of looking at a screen or a phone, you should look off into the distance for about five minutes.
00:17:18.000Now that doesn't mean you have to do the thousand mile stair.
00:20:14.000The ability to jump, they're very well correlated with health and well-being and the ability to, I think, as Sinclair says, hip fractures are a big cause of early death.
00:20:23.000It sounds weird, you think it's a hip fracture, Then you're sedentary.
00:20:29.000But knees over toes, guys, I love his stuff because he's really pointing to the fact that this muscle on the shin, right, is so vital for knee health.
00:20:39.000And for me, it's really helped with the lower back thing.
00:20:42.000And it's an odd thing to sit there and kind of point your toes like ballerina exercises, but you feel stable when you run.
00:23:20.000This knee, I got a cadaver ACL. It's actually not an ACL. They take the Achilles tendon, which is thicker and stronger, so it's 150% stronger than the original ACL, and then they replace it.
00:23:30.000And then the other one, I have a patella tendon graft ACL. Wow.
00:23:34.000Yeah, I mean, I agree completely with your statement.
00:23:39.000These days, I'm still a neuroscientist, obviously, thinking about the brain a lot, but the connections between the brain and body and all the stuff going on in the body, we now know impacts the brain.
00:24:44.000He had the knee resurfacing multiple months ago.
00:24:48.000I think it was like five or six months ago.
00:24:51.000And he's already deadlifting, doing all kinds of crazy stuff.
00:24:55.000And apparently the way they do it now, if you go to a really good doctor, you know, there's obviously, you want to be real careful with something like this because this is something that It's not necessarily really permanent.
00:25:07.000You know, if you beat it up, because they're using different surfaces, different people using different plastics and ceramics and different things to resurface the knee.
00:25:16.000But, you know, he's able to do all kinds of wild shit that he couldn't do anymore.
00:25:23.000So for him, it was one of those choices that it's an unfortunate choice, but he had to make it.
00:25:29.000Michael Bisping, former UFC middleweight champion, He actually just got both of his knees resurfaced.
00:25:56.000I wasn't real close with him, but Danny Wei, the guy that jumped the Great Wall of China and all that, he's had his knees replaced so many times.
00:26:46.000So what's interesting, recently there's a lot of discussion about broken ankles.
00:26:51.000So when Danny Wei jumped the Great Wall of China, I think it was 16 years ago recently, it was in July, when he did that, That's one of those...
00:27:00.000When he jumped the Great Wall of China, he broke his ankle, legitimate break of the ankle, the day before, and then jumped it three times.
00:28:23.000Look at him walking like that with a broken ankle, like it ain't shit.
00:28:26.000When we were kids, we'd go to these what are called lock-ins, they'd lock up the skate park at night, you could skate all night, but if you left, you couldn't come back in.
00:28:32.000And Danny and his buddy Colin McKay, they were this little gang, they called themselves the Red Dragons, and they would just, for every time, it's like one run when you drop in and take a run, Danny would get 20 runs to everyone's run.
00:28:44.000He'd just start, I mean, he's always had that.
00:28:47.000Listen to Slayer, like, just, that's him.
00:28:51.000And, well, that's, you know, that's that.
00:28:54.000So John Cavanaugh, who's Conor McGregor's coach, That's Laura.
00:29:00.000Laura Sanko is one of the UFC commentators, and she did an excellent interview with Kavanaugh, and they went over all the things that happened, and one of the things that happened in training camp was they think it probably cracked in training camp,
00:29:16.000and he got it scanned, and they said there might have been something there, but it's hard to tell.
00:29:22.000It's probably some sort of a hairline fracture.
00:29:24.000And they did their best to just stay healthy until they get into the fight.
00:29:28.000But if you go to Laura's interview, it's really excellent.
00:31:24.000There's been so many fights in the UFC, and to have all these breaks in a row, there's been Jacques-Roy Sousa got his arm broken, Chris Weidman got his leg broken.
00:31:38.000There's been a ton of breaks over and over and over again.
00:32:51.000The ones in Nevada are getting really good, and that's the gold standard.
00:32:54.000But the problem is, in other states, we'll go to these different states, and the MMA commissions are very new, so they're using boxing judges.
00:33:04.000And the boxing judges don't understand some boxing judges, don't understand these submission techniques.
00:34:14.000You know, there's two arms and two legs and a neck, right?
00:34:17.000These are basically the things that you're trying to submit.
00:34:20.000But the combinations and the variables, when you add them all together, there's just so many possibilities of things that you can do to someone and things that you can do to counter someone when they're trying to do something to you.
00:36:43.000But there's guys that are really good.
00:36:45.000You know, Eddie Bravo is really fucking good.
00:36:46.000I mean, he might be as good as John as a coach.
00:36:49.000But to get a better coach is not humanly possible.
00:36:52.000And to get a more dedicated coach, they don't exist.
00:36:55.000You're not going to find someone that can teach the way that guy does seven days a week and also afterwards study tape all day.
00:37:04.000So something will happen in class where someone will catch someone with some sort of a technique and then they'll say, okay, what is the counter to this?
00:37:15.000Let's start in that position and let's analyze it.
00:37:17.000So they'll do that and he'll go home and he'll find incidences of this technique being used in MMA, this technique being used in wrestling, and he'll analyze it and he'll break it down in slow motion and then he'll take notes and then he'll come back to class the next day with some new strategies.
00:37:37.000Yeah, the way you describe it is the way a scientist gets obsessed with a problem and goes into the literature and then starts tinkering around in the lab, and it's a process.
00:38:03.000And Stanford has a whole growing interest in human performance.
00:38:06.000And I've had an interest in this for a long time.
00:38:08.000I mean, you know, there are all the things that we talk about for normal health and well-being for the general public, all the stuff that before 2020 no one thought about.
00:38:15.000And now people are saying, oh, maybe I should take some responsibility for my mental and physical health sleep.
00:38:21.000Hydration, physical exercise, all the things that you talk about and that I certainly believe in wholeheartedly people should do.
00:38:27.000In the world of high performance, Those same things, it's gonna be light, temperature, hormone.
00:38:35.000The hormone augmentation thing is always a little bit of a complicated discussion, but there's so much that's happening there right now that's really interesting.
00:38:42.000Well, for instance, sort of back to the topic of supplements, I always say, look, their behaviors are the fundamental layer.
00:38:49.000You have to do the right things for anything, for sleep, for learning, for sports performance, but then there's nutrition, supplementation, Prescription drugs and then off-label stuff, right?
00:39:00.000And so we always think about when you hear hormones in sports, you always think just the raw conversation about anabolics, all the band stuff.
00:39:07.000We can talk about that stuff and how it works.
00:39:08.000Years ago, I used to work on androgens, testosterone and its derivatives and how it impacts brain development and body function, fear and also mental states.
00:39:17.000But there's a category of supplements that are very interesting That for most people who aren't exploring testosterone augmentation for sport, work very well to increase testosterone by about 100 to 200 points.
00:39:30.000Not, you know, 300, you know, not a tripling or anything like that.
00:39:45.000So it can be in its free form, unbound form, free testosterone.
00:39:48.000And everyone says, oh, I want more free testosterone.
00:39:50.000You want more, but these what are called sex hormone binding globulins.
00:39:54.000So there's something called sex hormone binding globulin and albumin, They carry the testosterone molecule to the different tissues of the body.
00:40:02.000So you don't want all your testosterone free.
00:40:04.000You want some of it bound up so that it can be delivered to the different tissues, including your brain.
00:40:08.000But if you have too much sex hormone binding globulin, the testosterone can't really do its things, okay?
00:40:15.000So Tonga Ali, about 400 milligrams per day, has the effect of raising free testosterone and overall testosterone by about 100 to 200 points.
00:40:25.000And so we're not talking about full TRT or blasting or now that I'm always amused on YouTube.
00:40:30.000They now call it sports TRT. That's when you get above 200 milligrams per week.
00:41:26.000I mean, I actually think that a lot of people who think they need TRT, when I hear about guys in their 20s and 30s, Look, I'm in my mid 40s and I can tell you that you can get and maintain very healthy testosterone levels without TRT if you do the right things, the behaviors, the nutrition,
00:41:55.000But when you look at TRT, I mean, the way that the clinics and the doctors typically do it is to give 200 milligrams and then send people out for two weeks and then they come back because they can charge them to come back repeatedly.
00:42:08.000It's clear that without any TRT, the testes normally make anywhere from seven to 15 milligrams of testosterone per day.
00:42:15.000So taking this massive dose and then waiting two weeks is absolutely foolish.
00:42:20.000It's amazing to me that the medical profession does this because it doesn't match anything about the normal patterns of endocrinology.
00:42:48.000The normal pattern of release and avoids these estrogenic crashes.
00:42:52.000And a lot of problems that are layered onto estrogen are actually problems with prolactin, which is a molecule that's involved in milk letdown and lactating women, but it actually shuts down the sexual desire and aggression.
00:43:08.000So this happens in brooding birds and it happens in humans.
00:43:12.000They've done this, a study published in the journal Nature, which is our kind of apex journal.
00:43:16.000Showed that when the husbands of pregnant women, because of something, maybe a pheromone, maybe some odor of the pregnant woman, actually increases the man's prolactin when they're pregnant, puts body weight on the guy, starts laying down body fat, presumably to prepare The father for the long sleepless nights ahead because humans have always co-parented.
00:43:49.000And testosterone and prolactin are kind of working in opposite fashion.
00:43:52.000So it's a very interesting thing, but the way you describe it is correct.
00:43:56.000Now, for people that aren't getting prescribed TRT but want the increase in testosterone, there are these plant compounds like Tonga Ali and another one which is very interesting.
00:44:04.000It's a Nigerian shrub called Fadojia agrestis, And it mimics luteinizing hormone, which is the hormone that comes out of the hypothalamus that stimulates the testes if you got those and the ovaries if you've got those to make more testosterone or estrogen.
00:44:19.000And so those two herbal supplements together can give a significant boost in free and active testosterone.
00:44:26.000So you said Tonga Ali can give you 100 to 200?
00:44:31.000Fadoja is usually taken at about 600 milligrams.
00:44:35.000And that can mean the most dramatic effect I've ever seen was somebody who had his testosterone down in the low twos, or I think it was like low twos.
00:44:43.000And he got it up to the 700 range, which but that's it.
00:44:58.000Well, the reason I know about this stuff, people are probably thinking like, you know, Huberman's running gear out of the back of his cars.
00:45:04.000And that's not what this is about, is that I do a certain amount of work with military and I do a certain amount of work with professional athletes who cannot take androgen compounds out of a syringe because they'll lose their job.
00:45:17.000Or they've been doing that and they want to come off.
00:45:19.000Although, and I'm not going to out the organization, but there is one major professional sports organization where, let's just say if somebody gets injured, they have permission to take up to 200 milligrams a week of testosterone.
00:46:30.000And so the way this works in animals and in humans as well is that for most species, the males of that species never get a chance to mate.
00:46:42.000I'll probably pick an example where you'll know the exception because I know you know a lot about natural animals and animals that are hunted.
00:46:47.000But if you think about animals with antlers, like rams, there's been a lot of research, believe it or not, on rams.
00:47:02.000And the decision to walk away is a choice usually.
00:47:04.000They usually don't kill each other, although I know some of the injuries can lead to death.
00:47:08.000So testosterone, these surges in testosterone that happens seasonally in certain species like rams or even these little hamsters, the males will rip each other's testicles off in order to fight for the right to mate.
00:47:20.000So males of a given species have to actually overcome the fear of pain and punishment.
00:47:25.000And the surge in testosterone is what causes the shift to the willingness to engage in battle.
00:47:32.000And so when humans are taking low doses or reasonable doses of testosterone or they're increasing their testosterone or they're going through puberty, Effort and leaning into pain and challenge actually has the effect of making the body feel soothed and good.
00:47:47.000It's a drive, just like sex is a drive or drinking water when you're thirsty is a drive.
00:47:51.000This stuff is all anchored deep within the hypothalamus.
00:47:56.000That makes sense why young men in particular are really driven to hard exercise and sports that are very difficult that require extreme effort.
00:49:36.000But what's interesting is another male lion comes along in this particular segment.
00:49:40.000Normally these two male lions would fight, but this other male lion comes in and essentially saves the other one, runs off the hyenas.
00:49:46.000And if you think about that behavior, it's incredible because this is an animal whose natural innate drive is to kill the other competition within his species, kill the other lion, and instead puts his own life on the line To try and rescue the other member of his species.
00:50:02.000And lions don't sit around and think like, oh, I'm going to post this later on Instagram, or this is the right thing to do for my species.
00:51:02.000When, you know, female-female competition, when there's a male, desirable male in the equation, can be brutal.
00:51:09.000I mean, you know, remember, I think there was this astronaut lady who, like, drove in diapers down to kill somebody Yeah, she was having an affair with this guy, and she...
00:51:20.000It was either the guy's girlfriend or the guy's wife, but she drove for a full day to go to meet the lady, maest her, tried to get her to open up the door.
00:51:30.000The girl wouldn't open up the door, she maest her, and she had worn a diaper so that she didn't have to stop to go to the bathroom, so she just...
00:51:41.000And you know, there are all sorts of interesting facts around how hormones regulate brain development.
00:51:45.000One of the ones that always makes usually men kind of go wide-eyed is that during development, the testes give off testosterone, no surprise there.
00:51:56.000But the actual masculinization of traits within the brain, and there are certain traits that anatomically you can see, The masculinization of the brain is not by testosterone.
00:52:07.000It's by testosterone that's aromatized, converted into estrogen.
00:52:12.000So estrogen is actually what masculinizes the male brain.
00:52:21.000And so going back to the sort of the TRT discussion and the testosterone discussion, these days there's a lot of discussion around, oh, you know, if your testosterone's too high, then, you know, it converts to estrogen and that creates these effects like, you know, gynecomastia, growth of the male breast tissue, reduction in libido,
00:53:08.000You don't want a ton of it, but for longevity of the brain and health of the brain and for repair of the brain, you need ample levels of estrogen.
00:53:16.000So prolactin is what's causing that growth of breast tissue.
00:53:20.000Because I went down a rabbit hole the other day and I watched a bunch of YouTube videos of guys having their, what they call bitch tits, have them removed.
00:53:45.000I have a colleague, he's a physician, he always says, you know, the male breast tissue, it's one of those things that it's there, it's just not very interesting.
00:53:52.000It just happens to be there and it's very small.
00:53:55.000But if there's a big increase in prolactin, then you will see that.
00:53:59.000People who take opioids, Like with the opioid crisis or heroin users, the reason why they get breast development is because dopamine inhibits prolactin.
00:54:09.000So dopamine and testosterone are close cousins.
00:54:12.000And this will immediately be familiar to you or anyone else that has had that experience of really being in the zone and hard driving and you're getting wins.
00:54:20.000And we know that testosterone goes up as you're succeeding.
00:54:25.000I mean, I didn't do the blood serum analysis, but you can bet that in the Poirier-McGregor fight, if you did blood draws before, I don't know whose testosterone would be higher, doesn't really matter.
00:54:34.000But afterward, you're going to see a significant decrease in the loser.
00:54:39.000And you're going to see a significant increase in the winner.
00:54:41.000You see this in day traders, you see this in school teachers.
00:54:44.000Because testosterone feeds back on the brain and releases more dopamine because the brain is trying to learn what was the behavior that led to the win.
00:54:52.000Is this a similar thing that happens with women when women succeed?
00:54:57.000Yeah, so women have some testosterone.
00:54:59.000They mostly make it from their adrenal glands, these little glands that ride atop the kidneys and the lower back.
00:55:03.000And at the core of the adrenals, they can release these androgens.
00:55:08.000Occasionally, and just as a kind of a side note, occasionally a female child is born with a very enlarged clitoris.
00:55:16.000Oftentimes you'll find a tumor on the adrenals in the pregnant mother.
00:55:22.000There could be other reasons for that, but it's from elevated levels of androgens, testosterone.
00:55:26.000And when females have a given species, You know, humans included.
00:55:31.000When they have a win, they succeed, you know, get a degree or something good happens to them, whatever that is, they will release more dopamine and testosterone will go up a little bit.
00:55:39.000And testosterone is responsible, a little increase in testosterone each month during the menstrual cycle is responsible for an increase in libido about 10 to 14 days before ovulation that kicks in right around ovulation for the purpose of trying to fertilize the egg.
00:56:21.000It's what causes you to grow bald and it's what causes beard growth.
00:56:24.000It has an inverse effect on the hair follicles of the face and on the hair follicles on the head.
00:56:28.000And how many DHT receptors you have is very strongly genetically determined.
00:56:34.000You go to some areas of the world, like Chile, and the men are all bald with like serious beards, legit beards, not like mine, like which is an attempt at a beard, right?
00:56:42.000They have real beards or in Afghanistan, serious beards, that's genetic, okay?
00:56:47.000So DHT has 600 times the affinity for the testosterone receptor than actual testosterone.
00:56:56.000And nandrolone, deca, that the bodybuilders take to give that really hard look and the females in particular, female bodybuilders like, that gives that really hard kind of crisp grainy look.
00:57:08.000Deca has, it's basically It's anabolic, but it's not androgenic.
00:57:13.000It causes a lot of the muscle growth, the muscle repair without creating the deepening of the voice.
00:57:17.000Actually, an Olympic runner was eliminated, sadly, because she was a phenomenal runner for, you know, urinalysis that was positive for DECA recently.
00:57:28.000She blamed it on a pork burrito that she ate from a taco truck or something a couple nights before.
00:57:32.000And my mind on this is, I hope she did Decca, only because if she lost her career from a pork burrito, that's tragic.
00:57:41.000But if she took Decca and lost her career, well then, you know...
00:57:48.000It would be very unusual for a meat to maintain that, especially if the meat was cooked.
00:57:55.000So no one asked me, but a few people reached out, and I have some relationship to some Olympic committees, not the ones that drug test, but Olympic teams, I should say, to be specific.
00:58:05.000If that pork was cooked, the deck is destroyed.
00:58:09.000And you can't really eat pork that's not cooked.
00:58:36.000So you've got receptors on your heart and on your blood vessels that dilate or constrict them.
00:58:41.000And there's a drug, Climbuterol, that creates a lot of increase in core body temperature, helps you burn fat, but it also has this effect of maintaining muscle.
00:58:52.000So it's not really a steroid, it's not working on hormones, it's working on the so-called autonomic nervous system, heating and cooling of the body.
00:58:58.000And this is, I believe, because he cuts a lot of weight.
00:59:03.000Yeah, because when guys cut weight, one of the things that happens during these, I mean, it's not just starvation, but it's also massive dehydration, and you have a lot of decreased bodily function that's directly related to that.
00:59:18.000Yeah, the kidneys don't like dehydration.
00:59:23.000I mean, gosh, I always say this, people who think they have low blood sugar, please try putting a little bit of salt in a glass of water and drinking it first.
00:59:31.000My sister used to think she had labile blood sugar, would like pass out, all this stuff.
00:59:35.000She's a bit of a hypochondriac anyway.
00:59:37.000But anyway, there's a genetic thing there.
00:59:41.000I said, look, just consume a small teaspoon of salt in your water.
01:00:25.000If you think about the cattle industry and what they want to do, they want to make bigger, heavier cows, but they don't want to make big, heavy, super lean cows.
01:00:33.000They want marbling in there and all that stuff.
01:00:36.000Again, I didn't look at the blood analysis.
01:00:39.000If he got popped for clembuterol and he didn't take it, that's tragic.
01:00:42.000If he got popped for clembuterol and he did take it, it doesn't seem to be harming his career anyway.
01:00:49.000I don't know what he's doing, but I do know that he is...
01:00:55.000He's one of those guys that's maintained his power as he's gone up in weight, which is really rare.
01:01:01.000It's rare that you can knock a guy out at 175 pounds who used to be a world champion when you were a 154 pound champion.
01:01:19.000But there's also always been talk of him being elevated.
01:01:25.000Well, they have great knowledge of these plant compounds and how they affect the hormone system overseas.
01:01:31.000You know, over here we are, you know, I'm a serious patriot, so it hurts me to say this, but we are miles behind what other countries are doing in terms of hormone augmentation and sports performance.
01:01:43.000In the realm of hormones, but also temperature modulation, there are incredible plant compounds out there.
01:01:49.000Like there's this thing that's now kind of going wild on the internet.
01:01:53.000I've never tried it, but it's called Turkesterone.
01:01:57.000And this is basically, and I actually reviewed, I did one episode of my podcast all about hormones, and I went deep into this literature, and Turkesterone, side by side with Deca or another testosterone derivative, it essentially acts the same way.
01:02:11.000It increases testosterone and performance and recovery.
01:02:56.000I thought it came from Turkey and that's why.
01:02:57.000So these ectosterones, where it says ectosterone, ectosterones are actually known to, they are insect hormones.
01:03:06.000That doesn't mean people are ingesting insects, but in insects, they have hormone systems that are similar to ours, but different, and they get their hormones often from plants.
01:03:17.000There's a very interesting relationship between the marijuana plant and estrogen and testosterone.
01:03:22.000And I want to say this is a very controversial area.
01:03:25.000And when I say this, a lot of pot smokers get upset.
01:03:28.000For some people, not all, marijuana and certain components of the plant, including the seeds, do you remember that rumor way back when, when I was in college, they'd say, you know, the seeds will make you sterile?
01:03:38.000Turns out that certain elements of the marijuana plant increase aromatase, the enzyme that converts testosterone into estrogen.
01:03:46.000And in talking to some of my colleagues who are plant biologists, they said, yeah, I'm not surprised at all.
01:03:50.000There's an active component of plant to animal warfare where in order to control the populations of animals that eat a plant, a plant will make certain hormones that will sterilize the males of that species.
01:04:04.000So I'm not saying smoking pot will make you sterile.
01:04:07.000There's one study that shows that it increases testosterone and several studies that show that it decreases it.
01:04:44.000Just like some people do real well on the carnivore diet, other people do well on a vegan diet, and some people like me are omnivores and we're happy that way.
01:04:51.000There are going to be people that just don't do well hormonally on marijuana, and there are going to be other people that do.
01:05:02.000It is highly individual and it's so interesting when it comes to whether it's diet or when it comes to consuming something controversial like marijuana that everybody wants this one size fits all approach and it's not realistic.
01:05:23.000Like for me, I know that fasting in the early part of the day, I'm more focused and I'm a little bit high strong early in the day.
01:05:30.000And so I train then and then I dig into work and then I eat low carb throughout the day.
01:05:34.000So I'm effectively low carbohydrate because when you're low carbohydrate, because carbohydrates trigger the release of serotonin, they have a calming effect.
01:07:39.000And I'm almost, like, every day there's some kind of heavy exercise going on, pretty much, except for Sundays.
01:07:46.000And sometimes Saturdays I take off too, but unless there's something crazy going on where I can't work out during the day on a weekday, most weekdays there's a pretty brutal workout session in there.
01:07:58.000And so by the time the end of the day comes with podcasts, then I'm doing stand-up at night a lot of these nights, I'm tired.
01:08:41.000I don't, but, so there's a really interesting thing around temperature.
01:08:45.000We hear so much about light, hormones, nutrition.
01:08:47.000To me, temperature is the untapped power tool.
01:08:52.000It's just amazing what you can do with temperature.
01:08:55.000So when you wake up in the morning, your temperature is increasing.
01:08:59.000If you exercise early in the day, your temperature will undergo a further increase.
01:09:03.000And then what you effectively do by exercising early in the day, especially viewing light and exercising early in the day, is you time the onset of that melatonin pulse to come on 16 hours later, which is going to put you to sleep.
01:09:16.000But in order to get into sleep and stay asleep, your temperature's got to drop.
01:09:21.000And that starts for most people around 4 or 5 o'clock in the afternoon, although it depends on when you're waking up.
01:09:26.000As that temperature drops, it's going to be much easier to get into sleep.
01:09:29.000So there are a couple ways to accelerate that transition.
01:09:31.000One is to get into a sauna, which sounds counterproductive, or take a hot bath or a hot shower.
01:09:36.000But when you do that, the body actively cools.
01:09:39.000And when you get out, your body is dumping heat like crazy.
01:09:42.000And then you have that kind of almost coma-like feel where you get into sleep.
01:09:46.000That's interesting because that's something I also do.
01:09:52.000Well, there you also get something really powerful.
01:09:54.000I know Rhonda Patrick has talked a lot about this and knows more about this than I do, but in researching some of the literature, if you do 20 minutes of sauna or so in the evening and you crank it up, you're getting up to the 200, 210 zone or 190 to 210. And that has this huge effect on growth hormone release,
01:10:11.00016-fold increase in growth hormone release.
01:10:14.000If you do it regularly, you kind of adapt to it.
01:10:16.000And you might say, well, how does that work?
01:10:19.000One of the ways to coordinate the systems of the body is by changing core body temperature.
01:10:24.000And it sounds so obvious when you hear it, but we don't often think about that.
01:10:28.000So when you wake up early in the day and you view sunlight, you're creating an increase in body temperature by the signals that go through the eye to the hypothalamus and to the systems of the body.
01:10:36.000And then that exercise in the day also sets you up for a lot of energy during the day and then a kind of a crash into sleep later that night.
01:10:43.000The other thing is they say to keep the room cool at night while you're sleeping, or if you need it, one of these eight sleep things, or chili pad, I think is the other one.
01:10:51.000I don't have any relationship to either one.
01:10:53.000I asked my colleague, Craig Heller at Stanford, who's a world expert in thermal regulation, temperature regulation.
01:11:11.000It's the hairless skin, which is on the upper part of the face, the palms of the hands and the bottoms of your feet.
01:11:18.000Now you can dump heat through those, they're like portals where you dump heat and you actually can pass cool and heat into the body too, but this is a separate conversation.
01:11:26.000So you're asleep in the middle of the night and if you start heating up, what you'll notice is you start putting a foot out or a handout and what you're doing is you're dumping heat in order to stay asleep.
01:11:37.000Whereas if the room is too hot, What are you going to do?
01:11:40.000You're going to put your hand in an ice bucket?
01:11:41.000You'd need to have some cooling device in the room.
01:11:44.000So this is why it's good to drop the temperature in the room at night.
01:11:47.000And these surfaces are super interesting.
01:11:50.000They have what are called AVAs, arteriovenous astimoses.
01:11:55.000It's a fascinating aspect of how we're built and how animals are built.
01:11:59.000Normally blood goes from the heart through arteries, then goes through the little capillaries, which are like the little fine ones and then to veins and then back to the heart.
01:12:06.000There's some exceptions that that's basically how it works.
01:12:09.000In the palms of our hands, in the bottoms of our feet, and in our upper face, it goes direct from arteries to veins, these AVAs.
01:12:17.000And animals and humans where there's, it's because there's no hair follicles there.
01:12:21.000Even if you're not really hairy, you have hair, little tiny hair follicles everywhere except these three locations.
01:12:27.000And we dump heat very readily from the body through them.
01:12:31.000And so this is why I was going to say, you know, in the hot months, it's actually really hot here in Texas.
01:12:35.000If you're overheating, people will put like a cold ice bucket or a blanket or something around their neck.
01:12:50.000The best way, and they do this now with firefighters, have done some work and we're starting to do some work, Craig and I, with military and with the UFC guys, with Duncan French, we've got something planned here.
01:13:00.000You want to get the palms or the bottoms of the feet into cool water.
01:13:04.000And that has the effect of cooling off the core of the body much, much faster.
01:13:09.000And this has profound effects on athletic performance and job performance.
01:13:13.000We always think about the athlete stuff, but there are a lot of guys working construction sites, they're out in the desert, you know, sitting around like shooting bad guys and doing all sorts of stuff.
01:13:23.000So you can cool the body by effectively taking something like this.
01:13:28.000There's a device that Craig has, there's this company called Cool Mitt.
01:13:32.000It's only available now to athletes and to military, but it should be available to consumers soon, where you can cool the core of the body simply by holding Something of the appropriate cold temperature.
01:13:44.000Now, if it's too cold, it'll constrict the vessels and it just shuts down the system.
01:13:50.000They've done some experiments in Craig's lab with the guys from the 49ers who could come in, they give them 10 sets of dips.
01:13:56.000This is wild, but it's published peer-reviewed data, 10 sets of dips.
01:13:59.000One of their athletes, I forget, because he's a pro athlete, did 40 dips on the first set, and then it kind of drops 10, 10, with three minutes rest in between.
01:14:06.000Comes back in a few days, and now they have him in between sets for three minutes.
01:14:11.000I think it was three, maybe two minutes.
01:14:12.000Hold on to the appropriate temperature cooling device.
01:14:16.000Now he punches out six-fold more dips.
01:14:21.000He can just go set after set after set.
01:14:23.000He's increasing volume and repetitions.
01:14:25.000So he's not getting stronger, he can do more.
01:14:28.000I know it's crazy, but the way it works is very well understood.
01:14:32.000Do you have, when your muscle works, like let's say you're doing curls on, yeah.
01:14:55.000It's only one hand because you're passing, you can't really pass cool into the body, but you're cooling off the heat of the body.
01:15:01.000And we don't often think about the relationship between heat and performance, but it's very straightforward.
01:15:08.000So when you, let's say you're doing a set of curls, curls always seem to be the example, but you're doing a set of curls, the bicep is heating up and eventually you hit failure.
01:15:17.000The reason you hit failure is not because you don't have the strength to do it.
01:15:50.000And this literature actually goes back about 10 years, but no one had ever devised this.
01:15:54.000So they could do this to fighters in between rounds?
01:15:56.000So what we're planning with UFC is we're going to get, so there is to have people cool between rounds properly, not by putting ice on the back of the neck, which just feels good or by dampening the, but by actually cooling the core of the body.
01:16:09.000And we think this is going to have important effects, not the hypothesis is it will have important effects, not just for performance, but also a lot of the brain injury that occurs, you know, part of it is the head hit, but part of it is the hyperthermia, the dehydration.
01:16:24.000You know, if you look at the history of fights where guys died in boxing, when they went from 15 rounds to 12, fewer people were dying.
01:16:31.000And it could be more head hits, but the idea that we're going to test Duncan and the folks out at the UFC and the folks at Stanford is that we know it improves performance, but that it will also help with recovery and hopefully that it'll help with some of the brain injury issues.
01:16:45.000I think one of the things that happens with boxers in particular, with deaths, is most of them, like the vast majority in the lighter weight classes, which indicates that these guys are, again, they're dehydrating themselves, they're cutting weight, which is...
01:17:01.000One thing that I've been really vocal about that I've tried to get people to listen to, but right now it falls on deaf ears, except for fans and athletes who agree, is to cut weight cutting out.
01:17:10.000And I think there's got to be a way to do it.
01:17:12.000My position is that it's legalized cheating.
01:17:14.000I think when you look at what weight cutting is, weight cutting is essentially you're pretending you're lighter than you are.
01:17:21.000And then they usually eat afterwards, right?
01:18:12.000So now I say, you know, Jamie Vernon, official weight, 190 pounds, and Jamie flexes, and then he gets off the scale.
01:18:20.000So the thing is, that person is probably, when they get on that scale for the official weigh-in, anywhere in the range of 10 pounds heavier.
01:18:31.000And then as the day goes on, they'll continue to slowly rehydrate.
01:19:08.000It is literally the dumbest thing we do in the sport.
01:19:10.000And I would love it if they instituted some sort of a radical change where they...
01:19:17.000There's a company called One FC. I don't know how they do it.
01:19:21.000They're out of Singapore and they have some sort of a hydration test that they use on athletes.
01:19:26.000I know they also have this in wrestling.
01:19:28.000They have hydration tests that they use, particularly, I believe, in high school and college wrestling.
01:19:32.000They want to make sure that these guys aren't, because in those days, they're making weight the day of the event.
01:19:39.000At least the UFC athletes have ample time to rehydrate, but it's still, it's a ridiculous stressor on the body to make someone dehydrate to the tone of, so for some guys, it's 30 pounds.
01:19:51.000Well, what I don't understand is it seems like You know, one of the reasons athletes take steroids is because they want to break records and crowds love it when athletes break records.
01:19:58.000No one wants to see everyone run progressively slower in the Olympics every year.
01:20:03.000So, you know, now you don't let them take anabolics just ad libitum because otherwise that would just be a mess.
01:20:09.000Although they do it anyway, let's be honest.
01:20:11.000There are so many ways around these tests.
01:20:14.000In terms of dehydration and weight cutting, you would think in the UFC that the fans would love it because they would see better performances.
01:20:20.000I think you would see better performances.
01:20:22.000I think you'd see longer careers because there's some guys that...
01:20:51.000And if you're a guy who's walking around at 195 or whatever and you decide to fight at 85 pounds, you're cutting 10 pounds, you might have a guy who's 215 pounds and decides to get down to 85 pounds.
01:21:05.000And when he gets down to 185, what he's going to do is try to grab ahold of you.
01:21:10.000A lot of these guys, or they'll have more punching power, or they take a shot better because they're just larger human beings.
01:21:17.000And again, there's bad weight cuts where it doesn't work out well, and the guys have poor performances, and they blame it on a bad weight cut, and it's true.
01:21:24.000I would like all that to be factored out, and I think it's 100% possible.
01:21:30.000And I've spoken to the UFC about it multiple times, but I'm like, alright, no one's listening to me.
01:21:35.000It's like, it should be too big of a change.
01:21:38.000But I think it would be very important for the health of the athletes, the longevity of the athletes, and then also the integrity of the sport.
01:21:48.000You're pretending, like, I'll give you an example.
01:22:50.000And you could see he missed weight a couple of times, and then he goes up to 155, and then he becomes the champion.
01:22:56.000But even then, he's really not 155, he's probably 170. You know, he's probably walking around at 170 and then he dehydrates himself down to 55 and then weighs in and then rehydrates himself up again.
01:23:38.000Totally understandable, but it should be illegal.
01:23:41.000And the only way to really make it so that it makes any sense is you've got to give these guys more options in terms of weight classes to compete at.
01:23:49.000I think at the bare minimum, there should be a weight class every 10 pounds.
01:23:52.000And in boxing, it's a lot more than that.
01:23:55.000In boxing, you have 147, which is welterweight, but then you have junior middleweight, which is 154. That's nothing.
01:24:40.000There's too many belts That's why when you get a rare the very very rare undisputed champion of the world You know where the guy owns all the weight classes.
01:24:49.000It's so rare and box the last person to have that good question Somebody probably has it today.
01:26:33.000You know, in the U.S., like they got a sign for everything.
01:26:35.000And he goes, oh, yeah, well, everybody knows that.
01:26:37.000And I thought, oh, my goodness, like basically the bad weather saved my life because I would have just gone during one of the breaks or probably during one of the sessions.
01:27:20.000You know, in the laboratory we have all these toxins.
01:27:22.000Fugu toxin from the Puffervish TTX. We've got alpha-latra toxin, which is from Black widow spiders.
01:27:29.000You have alpha bungro toxin from the pit vipers.
01:27:31.000These are research tools that are used to block transmitters, what, you know, the chemicals that neurons use to communicate with one another.
01:27:37.000And they were all derived and discovered from these animals.
01:27:41.000And the animal actually that can kill you the fastest is one of these cone fish, Or it's a cone snail, excuse me, it's like a snail that sits on the bottom of the ocean and it shoots this little tentacle up into the body of the fish.
01:27:54.000And it puts in these neurotoxins that their potency, they work at what we call, you know, sort of picomolar concentration, which for the non-scientists out there just means very, very tiny concentrations.
01:28:03.000And so in the lab, you know, you have a tiny vialis that could kill, you know, 40, 50 people.
01:28:07.000They're all regulated, of course, because these are bio-warfare.
01:28:11.000They're actually botulinum neurotoxin, you know, from cans.
01:28:15.000Remember, cans could have botulinum that would cause freeze-up of the muscles.
01:28:35.000It looks it's progressively worse and worse.
01:28:37.000There's this runaway effect of the Botox.
01:28:39.000Yeah, well they get shiny and for some reason it's it doesn't move and why is it shiny like I'm shiny, but I swear to God I don't have Botox.
01:28:46.000I'm guessing it's because the so the sweat gland As interesting, we were talking about temperature.
01:28:52.000The sweat gland is actually controlled by the same receptor, the acetylcholine receptor, as is the muscles that contract.
01:28:59.000When you move a muscle of any kind, it's because you have acetylcholine receptors.
01:29:16.000There are all these things that can kill you that you have in the laboratory that uses a research tool.
01:29:20.000You're obviously very careful with them, but it was reported, I don't know if they ever verified it, that before he was killed, Saddam Hussein had botulinum spores.
01:29:33.000In laboratories over there because all you would have to do is release a small amount of these spores into the air and you could kill an entire city with botulinum easily.
01:29:46.000So bioterrorism is something that we don't hear about as much these days because now we hear more about information terrorism and control over information grids and The internet, the viruses and the whole thing, but these toxins work at extremely low concentrations and they all come from the natural kingdom,
01:30:05.000you know, pit vipers and the black widow's spider one is a, I can imagine be a particularly bad death.
01:30:12.000Alpha-lateral toxin causes the nerve that releases acetylcholine to vomit all the acetylcholine at once.
01:30:19.000So if you had A lot of alpha-latra toxin injected in your body.
01:30:22.000Every muscle would be completely flaccid.
01:30:25.000Every nerve cell would dump all the acetylcholine and you would just, it's gotta be the most horrible death ever.
01:30:30.000Is that extremely toxic to the point of death of black widow spiders?
01:30:35.000Yeah, so it's very low concentration in one black widow spider, but in a vial of alpha-latra toxin, which we use all the time.
01:30:42.000I've heard of people getting stung by black widows.
01:30:44.000I used to see them all the time in California.
01:32:02.000So this little toddler is walking around by the water, and this fucking alligator came out, snatched the toddler, and dragged it into the water and ate it.
01:32:49.000He's a famous kind of celebrity photographer in Hollywood, does all the Marvel stuff, but he also takes pictures of sharks.
01:32:55.000Oh, that's where he took some of Whitney's early photos because he does a lot of photos.
01:32:59.000Anyway, I've gone out there with him to Guadalupe and he dived with the Great Whites and he does this thing of cage exiting and the whole thing.
01:33:06.000He was down in Cuba when they opened up Cuba.
01:33:09.000And he was getting virtual reality footage.
01:33:12.000He's doing these incredible underwater movies for sake of conservation.
01:33:16.000He's got one now, I think it's called Into the Now.
01:33:18.000It's amazing to see in VR these sharks coming right up close.
01:33:22.000But then they were swimming with these saltwater crocodiles.
01:33:25.000And I remember he came back and he said, check this out.
01:34:08.000Yeah, my friend Jim Shockey, he's a famous hunter.
01:34:13.000He lives in Canada, and they actually hired him to go to, I think it was Zimbabwe.
01:34:20.000There was some river in Africa where the local people were getting preyed upon by crocodiles at such an alarming rate that everyone in the village had scars.
01:34:30.000There was guys missing an arm, a lady would miss a leg, people with, like, bites taken out of their thighs.
01:35:00.000But, you know, you're putting a dent in a population of super predators that's probably established itself very deeply, like the roots of those things.
01:35:08.000There's probably so many of them, you're not really going to do enough to keep these people safe.
01:35:13.000But they would put these poles in the ground and set up almost like a crude fence around an area where they could gather water and then, you know, and wash their clothes and stuff.
01:35:25.000And the crocodiles would figure their way through it.
01:35:45.000I spent a lot of time, I work for a journal called the Journal of Comparative Neurology, where you compare the eyes and brains to a lot of different species.
01:35:52.000When you look at the brain of a given species, you get a really good picture about what that species cares about.
01:35:56.000If you look at the brain of a sent hound, These are scent hounds that went down in veterinary clinics.
01:38:04.000You know, there was a thing that just was published very recently that said there's a direct correlation between castration and life extension.
01:38:15.000I mean, along these lines, I just to your doctor is a good one because whoever that is, because there was an article recently, I think it was Wall Street Journal, maybe it was Washington Post that said that they've been pulling vets and vets are starting to say, yeah, if you really ask me, it's not the right thing to do for their health.
01:42:55.000It's more they're playing long game, kind of terrible stuff.
01:42:58.000In any event, when your cat shifts into seeing something it wants to eat, complete transformation.
01:43:05.000And then the stalking is a lot of top-down control, as we call it, the forebrain going, no go, no go, no go.
01:43:11.000And that teeth chatter is a little bit of behavior sneaking through It's like in that tonic, tonic, as we call it, tonic paralysis, and then bam, it just does the attack.
01:43:22.000Predation is a beautiful example of the brain regulating its own behavior because it gets one shot to bolt out after that mouse or bird or whatever it is.
01:43:30.000And so that teeth chatter is just a little bit of reflex that is creeping through that, and then it, whoosh, the valve hits.
01:44:03.000People who are really into veganism, they look up other vegans and they're all excited about vegan posts.
01:44:10.000And so for me having this hunk of deer meat and a joke, you know, that it was a deer that liked to kick babies and was about to join ISIS. When I did that all these fucking people came after me in like the most mean Vicious way like what are they do?
01:44:26.000They said so compassionate these vegans, but one of the things they did was this one lady came at me in this really Ruth when people get really mean one things I always like to do is like to try to see This is before I stopped reading people's comments by the way.
01:44:39.000This is quite a few years back Lex and I have been talking about that.
01:44:42.000I want to get very important so I get to the to this lady's page and she's a fucking complete lunatic and And one thing I see in one of her hashtags is hashtag vegan cat.
01:45:04.000So, literally in my bit, I go, fuck, should I click this?
01:45:08.000Because it was late at night, and I was like, goddammit, this is going to keep me up all night long, because I know I'm going to go down a rabbit hole.
01:45:15.000And I did, so I went down this rabbit hole.
01:45:16.000And what I said is, it's a series of photographs of cats that look like they're in a house with a gas leak.
01:45:24.000Every cat is just like, and it's like vegan cat.
01:45:44.000I mean, you have to be thoughtful about what you do and why, but it is important because you're not going to put experimental stuff into humans, you know.
01:45:53.000So when we take these animals and we domesticate them, sometimes It's kind, and we enter this reciprocal, symbiotic relationship with them.
01:46:02.000But sometimes you're depriving the animal of some basic instincts that's so innate that you're actually torturing the animal.
01:46:09.000You are torturing a cat if you make that cat eat soybeans.
01:46:42.000I guess it sounds like Donaher is his name.
01:46:43.000People have just really poured themselves into something, but he's a hunter as well.
01:46:47.000Hunters and ranchers really understand the relationship between animal and human, and they understand that before this thing is your pet, before it's got its name or it's your dog or it's your cat, it's an animal.
01:46:58.000And if you look at the brain of an animal, you can understand that this brain needs certain things.
01:47:04.000And if you deprive it of those things, it is a form of animal cruelty.
01:47:07.000People need to understand about hunting that it's highly regulated, too.
01:47:11.000The idea is that you're going to kill all these animals.
01:47:14.000Well, listen, you are not going to kill all these animals.
01:47:19.000They had a problem in the early 19th century.
01:47:23.000When there was essentially a mass extinction of wild game animals on this planet because of market hunting.
01:47:32.000Because it was unrestricted, unregulated market hunting.
01:47:35.000So people, this is before refrigeration, people would run around and they would shoot as many things as they can and they would sell them at markets.
01:47:42.000And it led to a massive decrease in deer, elk, bear, everything.
01:47:47.000Now, they're highly regulated, and there's more deer in America today than when Columbus came here.
01:47:55.000Don't they even have them in Hawaii or something?
01:47:57.000Yes, that's Axis deer, and that's a real problem.
01:47:59.000Because those were brought by the King of India, brought them to King Kamehameha, who was the king of Hawaii at the time, and they brought in this incredibly prolific animal with no predators.
01:48:12.000So, in the island of Lanai, you gotta say it right.
01:48:26.000When you're there at night and you drive, like we were there and this lady turned the headlights on for us and turned towards the field, and you see...
01:49:00.000When I went there, I went there with Cam Haynes, who's probably the best bow hunter on earth, and John Dudley, who's probably neck and neck with him.
01:49:08.000There's like us and a couple other hunters who are like top of the food chain, like Adam Greentree and Remy Warren.
01:49:15.000We were all successful in bow hunting these animals.
01:51:12.000So you're staying at the beach in paradise and then you hang out all day.
01:51:18.000Lift weights, fuck around, swim in the pool, and then in the late afternoon you go hunting.
01:51:23.000So you go hunting, you leave at like 3 o'clock in the afternoon, and that's when the wind starts to pick up, and that wind will disguise your sound and your movement, and we found that to be the most effective way.
01:51:49.000Spend time with the family and then go kill.
01:51:51.000It's also one of the best places to hunt.
01:51:54.000It's an odd place to hunt because it's kind of unnatural, right?
01:51:57.000You're in paradise and it's also an invasive species.
01:52:00.000But it's one of the best places to hunt ethically because they must kill these things because they're very overpopulated.
01:52:08.000They don't have a disease problem, but it's always a possibility that something could be introduced into the population, whether it's brucellosis or CWD or something that does...
01:52:17.000Yeah, well, this whole thing, whether or not it was from a lab or it was from an animal, this whole thing with the virus out of China, it was definitely out of China.
01:55:58.000And that's the idea, is that this animal has bred.
01:56:01.000They have passed on their genetics, and they have successfully, you know, bred for multiple years.
01:56:08.000Now, here they are in, you know, when you're around nine years old, an elk, if they're lucky, lives to be like 11 or 12. Oh, that's the full lifespan.
01:56:18.000I mean, maybe if you have them and you have no predators and you feed them, maybe they can live longer.
01:56:23.000But the odds are, I mean, if you find a 15-year-old elk in the wild, that's crazy.
01:56:30.000Like, usually their antlers are shrinking, their body's shrinking like an old man, and they're deteriorating.
01:56:36.000So when someone gets an animal with large antlers, it's A, good for conservation, because you're not taking an animal out before it spreads its genetics.
01:56:48.000In fact, it spreads its genetics from multiple seasons.
01:56:54.000Because you're getting an animal that's wise, that's seen it all, that's seen mountain lions, that's seen bears, and they've avoided all this.
01:57:42.000They'll spread these pellets, so they'll hear the noise of the machine go off, and they'll wade towards the pellets like it's dinner time, like a fucking dog.
01:57:51.000It's no different than large animals in a zoo.
02:01:34.000But with modern methods now, you can really...
02:01:37.000Turn on and off the different populations of neurons.
02:01:40.000So they did this study a few years ago, looking at an area of the hypothalamus called the ventromedial hypothalamus.
02:01:45.000And for years, people were confused about this area because you'd lesion it in an animal and the animals wouldn't fight, but they also wouldn't mate.
02:01:52.000And what they eventually discovered is they have two populations of neurons in the structure, some that are responsible for mating and some for fighting.
02:01:58.000So then using modern methods, what the Anderson lab showed is that if you trigger activation of one set of neurons in these In this ventromedial hypothalamus, the animals will just, the males will go and mount the female and mate as a mice.
02:02:11.000If you at that moment, turn off those neurons and turn on the neurons that are right near them that are responsible for aggression, the male mouse will try and kill the female mouse.
02:02:21.000But it's so extreme that if you just give a male mouse a glove filled with air or water and you turn on these neurons, The mouse will just go into a rage and try and kill the glove.
02:02:34.000And just to kind of explain just how strong these switches in the brain are, Last year, that same lab published a really interesting paper.
02:03:11.000Or the dog park phenomenon, where people always say, if your dog is mounting another dog, they always say, oh, yeah, they're dominating them.
02:03:18.000And female animals have this circuit too.
02:03:50.000But let's face it, all of that would not fetishes and mounting and subs and doms and all that stuff would not be as much interest as it was if that circuitry didn't exist.
02:03:58.000So in mammals, there are circuits for mounting for dominance that is independent of any desire to reproduce.
02:04:06.000Super interesting, at least to my mind, because what this tells us is that deep within our biology, these drives exist.
02:04:12.000So when you show the lions attacking a goat, There has to be a circuit in the hypothalamus that says, pursue, kill, and then eat.
02:04:19.000And if you just give animal meat, you're essentially depriving it of some basic function.
02:04:24.000Now in humans, it's different because you have to have societies that get along.
02:04:27.000You can't have people just running their hypothalamus That's why you got the part up front.
02:04:45.000It is like a door opens up to the past and you get this rush of whatever the endorphin is that I'd never experienced before I did that.
02:04:56.000And it convinced me on the spot that I was going to be a hunter for the rest of my life.
02:05:01.000I was like, that day, I can remember that day, my friend Steve Rinell that I talked about earlier took me hunting, we shot a mule deer, and then we're eating its liver, we cooked it over the fire.
02:06:02.000Well, that's because the gallbladder actually contains a number of androgen-like compounds that literally make your mind and your body stronger.
02:08:01.000But I think what's what's great is as people start to understand more about how I would say the five pillars essentially of health are like light, temperature, movement, nutrients, and then there's the other stuff like breathing and all the other stuff you do.
02:08:16.000But in that nutrients category, it's like the quality of what you eat is without question as important as the amount and all that.
02:08:24.000And I think that a focus on food quality and sourcing is it's such an important conversation.
02:08:29.000I think that hunters And ranchers, they understand this relationship.
02:08:33.000Well, that's what I was going to say, because the quality of meat from Wild Game is far superior.
02:10:30.000He got into it to be the best bow hunter he could be because it's very difficult.
02:10:35.000Bow hunting success, general bow hunting success, and a lot of this, you have to factor in public land, which is, I generally hunt private land.
02:10:43.000A, because I have the financial resources, and B, because I don't want to be around that many people.
02:10:47.000It's just like public land is, it's kind of, you're hunting two things.
02:10:52.000You're doing two things that are difficult.
02:10:54.000You're hunting a wild animal and you're in competition with a bunch of other people that are hunting the wild animal.
02:10:58.000To me, I understand that there's an access issue that's tied to finances and I understand that for a lot of these people there's a badge of courage to be able to be successful hunting on public land.
02:11:11.000But these animals are heavily, heavily pressured.
02:11:16.000And many times what these real hardcore guys do is they'll hike into the backcountry 20 miles so they get away from people that aren't willing to do that.
02:11:27.000Well now, because of people like Cam Haynes, because of a lot of these like Aaron Snyder and a lot of these crazy backpacking people, other people are doing that now too.
02:11:36.000You'll go 20 miles in and you'll see a fucking wall tent filled with five guys and you're like, shit!
02:12:08.000The issue is an issue of access and whether or not these highfalutin fuckheads like me who can afford to go to these private places, whether it's just as much of an accomplishment.
02:12:21.000It's certainly you have more opportunity because there's more animals and they're more undisturbed.
02:12:32.000If you go to a place that's a public land place on opening day, like I was in Wisconsin for opening day of deer season, and it sounds like World War II. Oh, because most people aren't using bow hunting.
02:14:58.000Have you seen, there's this kid, Michael, he goes by Guanzhou Sound on Instagram, and he's been doing these song mashups of Lex and Donaher and you and, dare I say, me?
02:15:20.000The problem with these animals, the crazy antlers, is not just that it's gross and that they feed these animals and then they release them on these properties and these guys shoot them and make it look like they did a big thing when they really are basically shooting a tamed animal.
02:15:31.000The problem is they spread CWD. And one of the main ways that CWD gets spread is the captive-servit industry.
02:15:39.000So there's a whole thing about this where some people that have a vested interest in the captive-servit industry are in denial about CWD and how dangerous it is.
02:16:30.000It's called Cazenovia, Wisconsin, is where he's at.
02:16:34.000And they are finding, like, you know, a large percentage of their deer that have this CWD. And the problem with CWD is when an animal's infected, it starts oozing out of its mouth.
02:17:55.000Yeah, they start dripping CWD, that's blue tongue, I guess that's a different disease.
02:18:01.000They start dripping this CWD out of their mouth and nose, and it gets into the tree, see if I can find some other versions of it.
02:18:10.000It gets into the plants, and when it gets into the plants, it actually, I don't want to fuck this up, but I think it actually gets into the DNA of the plants.
02:18:22.000And somehow or another, it stays in those plants.
02:18:25.000Like, it has a really long fucking half-life.
02:18:28.000And these new animals come along, and they can eat the plant, and then get CWD from it.
02:18:34.000So, the odds are, and these things, they...
02:18:40.000They travel for miles, and so they're traveling, and they're spraying this oozy shit out of their mouth, and it's getting onto these other plants, and then other deer coming along and getting it and doing the same thing and spreading it, and it's now all through most of the country,
02:20:04.000Yeah, and there's a particularly nasty type of coyote that lives in B.C. that they took out a woman in, I want to say it was like 2007 or something like that, a young singer.
02:20:17.000She was a very promising singer, and she was apparently really talented, and she went for a walk, and a pack of coyotes ate her.
02:20:54.000Oh, you need to see this one because it'll freak you out.
02:20:57.000Because apparently the mama was walking with her cubs and this guy was on this trail and she crossed and he's like talking because he filmed it.
02:26:00.000People hunt giraffes and it's one of those weird things where people don't want to be photographed with giraffes because people come after you.
02:26:07.000Because if you're standing there with a rifle with a giraffe down, oh my god.
02:26:12.000Yeah, we think of them as very placid.
02:27:11.000First of all, if you don't shoot bears, you're going to have bears everywhere because bears don't have any natural predators other than other bears.
02:27:19.000And if you think you like bears, you're not going to like bears if they eat your family because that's what they'll do because bears have been eating people since the beginning of time.
02:27:27.000Well, and if there are sufficient numbers, I mean, actually, you might find this interesting.
02:27:30.000I was researching taste recently, the sense of taste, and there are these five senses, right?
02:27:35.000We have the umami, the savory receptor.
02:27:38.000That's what gives like that really nice taste of meat.
02:27:40.000It's actually cueing the brain and the gut of the presence of amino acids, which is one of the most important things to ingest, amino acids.
02:27:47.000Lions and bears and carnivores have 5,000 times the density of umami receptors in their mouth, but they have, except for the panda bear, Which has 5,000 times more sweet receptors.
02:28:01.000So your dog actually doesn't have sweet receptors in its mouth.
02:29:23.000So seasonally breeding animals, there's more light, more dopamine, more testosterone, they mate.
02:29:27.000Days get shorter, less dopamine, less testosterone and estrogen, and they don't mate.
02:29:31.000But the other thing that's really fascinating is that in animals that during the winter, their coat is white, and in the summer and spring months, their coat is dark.
02:29:57.000And so people who are albinos or animals that are albinos, it's because they have a mutation in this tyrosinase.
02:30:03.000So with the white, red eyes, typically, not always red eyes, but often red eyes, white fur, They can't actually take sunlight and convert it into melanin.
02:30:15.000Basically it goes sunlight and then there's a bunch of other biochemical steps and melanin.
02:30:18.000So there's this beautiful relationship between light, dopamine, testosterone, mating, hair color, right?
02:30:25.000And temperature, because in long days, generally it's warmer than in short days where it's cooler.
02:30:30.000So light and temperature are kind of pushing on a bunch of physiological mechanisms to make some animals want to breed at particular times of year.
02:30:38.000And the break on breeding is what we talked about earlier is melatonin.
02:30:42.000When there's very little light, you get a lot more melatonin and it shuts down dopamine.
02:30:49.000So melatonin, you want it a little bit, but you don't want too much of it.
02:30:53.000And when you're saying that light makes the brain produce dopamine, I wonder if there's long periods of rain and a lack of light if then once you hit sunlight you have more dopamine.
02:31:09.000This is, I mean, if you go to Scandinavia, I have a relative, my stepmom is Danish.
02:31:14.000You go to Scandinavia, you go to Denmark in the winter, and everyone is, some people are resilient too, but most people are a little bit, I'm not gonna say clinically depressed, but everything is depressed.
02:31:30.000And literally, people start going, or at least they did when I was in college, you know, like women and men start going topless in the sun, in the parks.
02:31:36.000People are definitely mating a lot more than they are in the winter months.
02:31:40.000Even though they're drinking more alcohol in the winter months, for sure, they're mating a lot more.
02:32:06.000It rained every single day, except for a few hours.
02:32:09.000We were able to start a campfire one day.
02:32:11.000When I came back, I came back to LA, and of course it was sunny, because it's always sunny in LA, and I called my friend up, I go, dude, I don't know what's going on, I've never been happier in my life.
02:32:21.000Yeah, it was a surge, like I was on a crazy drug.
02:32:24.000I'm like, if you could keep this high all the time, like what a wonderful world it would be.
02:32:29.000Well, there's another hormone that's super cool that people are now abusing, unfortunately, which is called a melanocyte-stimulating hormone.
02:32:37.000A melanocyte is a kind of cell, basically, that creates pigmentation in the body, makes you go tan.
02:32:43.000And melanocyte-stimulating hormone is in the pituitary, and when you get sunlight, you release this melanocyte-stimulating hormone.
02:33:31.000Bodybuilders take something called, you know, there's this whole world of peptides that we should, you know, maybe that the peptide world is blowing up.
02:33:39.000I would love to talk to you about peptides.
02:34:10.000So you're talking about this effect, or I talked about this effect in Scandinavia, of sunlight comes out, people have dopamine, they have also melanocyte stimulating hormone, they're not as hungry, they wanna have sex a lot, that's MSH, alpha MSH is the molecule.
02:36:40.000White German model claims she's well on her way to becoming a black girl now that she's undergone a series of tanning injections to darken her skin and somehow has convinced an African hairdresser to give her black textured hair.
02:37:59.000Things like dopamine are basically a kind of a trigger for a menu of a bunch of other things, of testosterone or estrogen, primarily in females, but also for motivation, for sexual behavior, for drive, for tan, you know, Pigmentation and these kinds of things.
02:39:07.000So it acts kind of, as we say, systemically.
02:39:10.000Peptides can act as hormones, so melanotan obviously changes the skin, changes libido, all sorts of things.
02:39:17.000There are peptides like GP157, gastric peptide 157. This is a peptide that is naturally made by the body, but people have synthesized and turned into a compound that they take and inject, that does seem to have the ability to repair damaged tissues of various kinds.
02:39:34.000It mimics some of the downstream effects of growth hormone.
02:39:38.000So this is actually, I actually trained with him once, although he with far more weight than I, this guy, Ryan Crowley, who tore his pack recently, this very dramatic Instagram video where you see him doing an incline press with like 515 and it rips off the bone.
02:39:52.000Now I'm not going to say whether or not Ryan's using GP157 or not, but I don't think there's anyone needs to do a Natty or Not video on him.
02:40:47.000BPC is a different, I think it's either a different string of amino acids, excuse me, or something related.
02:40:54.000You know, the gut has a bunch of stuff that it secretes that tells the rest of the body about health status.
02:41:00.000This is why the gut microbiome is so critical.
02:41:03.000As a not unrelated aside, I have a colleague upstairs from my lab at Stanford, Justin Sonnenberg, who's shown that the ingestion of two or three servings of fermented food per day It dramatically decreases the levels of interleukin-6, these inflammatory cytokines.
02:41:39.000The Sonnenberg lab published a paper in Cell, another one of these premier journals, super, super stringent journal, today showing that if you ingest two or three servings of these fermented foods, basically what you do is you create an acidity in the gut that's perfect for the anti-inflammatory environment.
02:42:03.000And GP157 and these other peptides are things that when the gut is happy, the body starts secreting these things that allow you to heal faster.
02:42:10.000This is why when people are like, when they're sick in a hospital or they can't move, they get sores that turn into massive infections, right?
02:42:17.000And it's not just because hospitals have a lot of infection.
02:42:20.000It's because when we're sedentary, the gut suffers.
02:42:23.000When we're eating the kind of garbage they feed you in most hospitals, the gut suffers.
02:42:47.000Yeah, I mean this is why this is why 2020 to me has changed everything because I look I work alongside many doctors I train and teach medical students and I have great reverence and respect for the field of medicine however It's clear that most places are not updating the training to stay modern.
02:43:06.000You have people, the scientists and the physicians talk.
02:43:08.000And so, and there are other places too, but I think that this kind of communication, when that happens, then the physicians learn about all the modern studies.
02:43:16.000I mean, that's why, God forbid, you have to go to a hospital, try and go to a hospital that's related to a research institution because they hear all the latest.
02:43:23.000Now with BPC 157 or GP 157, whichever one is most effective, is there one more effective than the other?
02:43:30.000GP 157 is the one that I hear more athletes and various other communities who need to repair injuries taking.
02:43:37.000Now, are they taking it locally, or are they taking it subcutaneously?
02:43:41.000So, you take it systemically, but people have this thing, just like with testosterone, people, it acts systemically, but people, like, if they want to repair a tissue, they'll inject locally, and there are local effects of these hormones and these peptides.
02:43:53.000So there's some benefit to injecting it locally?
02:43:57.000Enough so that it's not going to hurt you because it's also going to be systemic, right?
02:44:01.000Higher concentrations delivered to a particular area, if it has to be distributed systemically, you have receptors everywhere, putting it locally can definitely enhance the effect.
02:44:11.000So like similar to the way they treat stem cells, like stem cells, they shoot it locally or you can get an IV. Yeah.
02:44:17.000And I should say the stem cell therapies are very controversial because the academic community and the clinics that are doing these in various places, they haven't joined forces.
02:45:11.000And Mel Gibson sent his dad down there when his dad was 92. When he was 100, he was getting boners, which Mel wanted to tell us about for whatever reason.
02:45:23.000I had some stem cells in Santa Monica shot into my shoulder, or maybe, no, this was Vegas.
02:45:31.000And this was Dr. Roddy McGee did some stuff in Vegas, and then we did an MRI eight months later, I believe it was, and I had a full-length tear in my rotator cuff.
02:47:51.000Well, there have been, I agree with everything you're saying.
02:47:55.000In fairness, there was a case in Florida of an eye clinic treating macular degeneration with stem cells, injected these people to try and save their vision.
02:48:05.000They were early stage and they all went blind.
02:48:09.000So I do think when you talk about the brain and the eyes, which as we talked about last time I was on here, are two pieces of brain hanging out outside the crying, you know, vault.
02:48:18.000There you have to be very, very careful.
02:48:39.000And I think this is why I think people need to approach this with caution.
02:48:43.000It's one of the reasons why people are looking to peptides because like, for instance, you have what are called secretagogues, sounds like synagogue, but secretagogue, which is basically a hormone stimulating hormone.
02:48:54.000So growth hormone, as we know, various people use AIDS and growth hormone really causes metabolism and repair.
02:49:07.000But there's growth hormone-releasing hormone, and those go under the names like ipamoralin, tesamoralin, things of that sort.
02:49:17.000And now there are a lot of people who are taking those peptides in order to stimulate their more growth hormone, as opposed to taking growth hormone directly.
02:49:24.000So now there's this whole class of peptides that are not hormones per se, but that they stimulate more hormones.
02:49:57.000Because they can take certain peptides because every time something's on a banned substance list, all you have to do is get right outside the list and take something that is chemically similar enough They don't ban pathways.
02:50:53.000They're not prescribed by doctors, except Sermoralin is actually prescribed by MDs for growth hormone deficiency.
02:50:59.000And it's actually was a popular diet a few years ago where people were given Sermoralin and told to go on very low calorie diets and because of the way growth hormone can preserve muscle and kill appetite.
02:51:10.000And so in Hollywood, peptides are really big because unlike steroids, unlike hormones, peptides don't scare the category of people in Hollywood who don't want to put on muscle.
02:51:22.000Let's just say it's big with the ladies.
02:51:24.000They're big because it keeps your appetite down.
02:52:44.000Well, you're tickling cells in the pituitary to secrete more hormone.
02:52:48.000So you're going to get some balancing out of other hormones.
02:52:51.000If guys want to run out and just increase growth hormone, you'll increase testosterone and you'll also increase estrogen in parallel.
02:52:59.000So people have different sensitivities and so this is why it's an experimental science and this is why Most MDs are not going to prescribe any of this stuff because an individual has to really be able to think intelligently and know, they have to understand their system.
02:53:12.000It's clear you know your system, you know when you're feeling good and you know when you're not feeling good.
02:53:16.000But when you see all these crazy videos on the web of guys getting ridiculous gyno and like tanning to the point where they look like a different human being, it's because people just have this more is better mentality.
02:53:27.000Well, also, people, you know, they're doing it for Instagram likes.
02:54:14.000Big ups in government, in the national institutes of whatever, and et cetera, well-intentioned, very educated people.
02:54:21.000We're not coming out with public statements that were clear about how people should manage their stress, how they should manage their children's stress, how they should stay on a sleep schedule.
02:54:28.000And so that's why I essentially just stepped up.
02:54:30.000I think, well, I got a mouth and I know the literature.
02:54:33.000And where I don't know the literature, I can communicate with these amazing colleagues that I have.
02:54:38.000I can ask four of the best MDs on gut health.
02:54:41.000I can talk to Matt Walker, the Stanford Sleep Clinic and find out what are the three things everyone should do to optimize their sleep.
02:54:47.000And so from pulling from these various sources and communities, you can put it out there.
02:54:51.000So I feel like social media has this very dark and kind of strange side.
02:54:54.000And then it also is the opportunity to just put information out there for free.
02:54:57.000And I think, you know, all the stuff about peptides and hormones, et cetera, that's kind of the more niche, but for most people, they're just struggling to figure out, like get oriented, like what is happening in the world with viruses and should I take vitamin D3? It's so hard to get good information.
02:55:15.000And that's one of the more rewarding things about this podcast is that I can have people like you on and Matthew Walker and David Sinclair and all these people that are experts in health and wellness and they understand all these things and you can...
02:55:29.000I mean, it's just an amazing resource, and it's free, and people can get educated about this stuff and understand that you can take some control over your own destiny in a small way by actually a pretty large way.
02:55:46.000I mean, the peptides and all these various things, they have a cost, but the basic things of viewing light in the morning, controlling your breathing as a way to modulate yourself.
02:55:55.000It's great if you have a sauna, but you can also take a hot shower.
02:55:58.000Not everybody, of course, but most people.
02:56:01.000Fasting for some portion of the day, trying to make better food choices.
02:56:04.000These things don't just have a small effect on health and wellbeing.
02:56:07.000They have a huge outsized effect and no one is going to provide it in pill form.
02:56:12.000It's never going to be delivered by the government.
02:56:14.000It's never going to be delivered in schools, although I would hope it would be someday.
02:56:17.000But basically what we're trying to do, those of us that are interested in public science and health education, is provide a kind of a user manual for all this stuff, this technology that's been built into us.
02:56:28.000I mean, we always think about a device technology, but the eyes, there's dopamine, the gut.
02:56:33.000I mean, everyone's equipped with this stuff, but we never actually learn how to use it.
02:56:36.000And so that's what, like you said, David and Matt and Rhonda Patrick, who I don't know, but has done great, you know, I think is doing great work.
02:56:45.000Yeah, I think it's I think we're entering a new era now where people are feeling comfortable to do it.
02:56:49.000And I, you know, and I'm grateful to you because I think this podcast, it's actually I'm absolutely clear that this podcast has promoted more health information than any other Media venue, clear directives or opportunities to explore.
02:57:05.000You know, I know a few months back things got a little crazy around stuff and even Fauci was commenting back, but that just told me that this podcast is actually a primary source of public health information and for people to go ferret out The people, the resources, the papers enter the discussion.
02:57:21.000And I think that is fundamentally important.
02:57:24.000Without that, we are never going to make it.
02:57:27.000And because we have that, I think I speak for many people, I'm extremely grateful.
02:57:32.000Not just for this opportunity to come on here and speak, but for the opportunity for people to learn about choices, basically.
02:57:38.000Well, I'm extremely grateful for people like you that come on here and are willing to share all your information and help educate people about this stuff because it's super important.
02:57:49.000So tell me, we hit three hours, believe it or not, just flew by.
02:58:35.000So we did an episode about that, then we spent a month on hormones, growth hormone, peptides, and we spent a month on sleep and eye health and just basically everything.
02:58:43.000So it's kind of a class that you can go and watch or listen to.
02:58:46.000And then I also teach on Instagram, just Huberman Lab.