Abiogenesis: What Is the Probability Life Arose from Inorganic Chemicals?
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Summary
In this episode of the podcast, we have a guest on the show who is a science fiction and fantasy nerd. He's a writer, a podcaster, a nerd, and a skeptic who happens to be a scientist. We talk about the mystery of life on Earth and how it came to be, and why it might have happened.
Transcript
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What you have communicated to me is that there have been far more viable pathways to life
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springing out of no life than was previously something I thought was a thing.
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You know, I thought, oh, something, something, lightning, something, something, hot air
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vents, something, something, whatever chemical processes.
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But you're indicating that there are a lot of different ways and that life coming to
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exist is not that surprising, at least in our environment, in the earth.
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In fact, I think the most compelling hypothesis for ambiogenesis is the clay hypothesis, which
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So it literally means the thing that later became life was originally clay.
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I remember listening to a podcast or something with Andrew Tate, where he was talking about
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him getting blood work done to prove that he wasn't doping.
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And he couldn't remember really anything about his actual blood work results.
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And he kept saying hydroglobin, which is not a part of it.
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I mean, at first he knew, I think at first he got it wrong by mistake and then probably
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saw how everyone was looking at him and then just kind of leaned into it.
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You know, the reason why I'm wearing a vest right now.
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And the reason why people don't know this, you don't bottom button, the bottom button
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on a vest is because the King, I want to say, I forget which, it might've been King Henry
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Didn't you say it was the regent of the Prince regent during the Regency era?
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So like, yeah, he couldn't wear the bottom button.
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So Andrew Tate makes a mistake in how he says hemoglobin.
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It's one I have sort of been putting off for a while because it requires a lot of technicalities
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to talk about, but it's in, to me, an incredibly important topic because I see it talked
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We've entered a world in which education has gotten really, really bad.
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Um, especially along things that could have like challenge woke stuff, but also stuff
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that can be overly challenging sometimes to religious stuff.
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So I'll ask you in school, did you ever study ambiogenesis?
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Did you ever study how the first life evolved on the planet?
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And then in college, in historical geology class, we did discuss like here are, and we
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What really got me is actually talking to Robin Hanson.
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Um, and he had said that he thought, he's talking about great filtration events, right?
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So if you're talking about the Fermi paradox, this actually becomes a very important thing
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to have information on and know about, because you need to judge in your calculations of like,
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Is it unlikely that life evolves on a planet with the preconditions for life?
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Like that was one of the biggest filters was that the first life came on our planet.
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And I think if it's a topic that you're particularly educated on, and he said, when he said it,
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he's like, and weirdly, a lot of people who are studying this area don't think it's that
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And he's like, and I don't understand why, like, and this to me just had me realize it
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must just be that he's never dug that deep into it as a concept because it is actually
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not a big filter life appearing on this planet.
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And this is another problem with, with a lot of attacks that religious people will use
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against atheism that just don't land very hard because they haven't studied these subjects
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in a lot of detail, or they just haven't put a lot of thought into these subjects.
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Life evolving on a planet like Earth was incredibly likely, almost guaranteed from what we understand
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So first you need to understand why it's almost guaranteed, because you need to understand
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what you need as a prerequisite for life and all its complexity that we know it as having
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What you need is any type of, it does not need to be RNA.
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In fact, I think the most compelling hypothesis for ambiogenesis is the clay hypothesis, which
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So it literally means the thing that later became life was originally clay.
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We just went over the Adam and Eve story and we didn't talk about clay.
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Well, I tell you, that story has all sorts of truths in it.
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It did a very good job of capturing the truth of reality in a very big way.
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And that's why I think that it had some sort of actual spiritualist or not spiritualist,
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but like some sort of supernatural inspiration to it.
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But let's go back to this and stop talking about the religious stuff, okay?
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And maybe the Bible is pointing to us that that actually is how life started.
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But this is something that people really get wrong.
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They think that the early life needs to kind of look like life today.
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All you need is a self-replicating pattern that has some degree of variability in its replication.
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Any simple self-replicating pattern will eventually, given enough time,
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become something similar to life as we understand it,
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so long as it has minor variabilities in that self-replication.
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Because the minor variabilities allow for evolution.
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So if you have something really, really, really...
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So this then comes to something that a lot of people don't get, right?
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So I should talk about Spiegelman's monster really quickly.
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And they think that it makes it look unlikely that ambiogenesis happened,
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when it's just a misunderstanding of ambiogenesis.
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Spiegelman's monster is an RNA chain of only 218 nucleotides
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that is able to reproduce by the RNA replication enzyme,
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RNA-dependent RNA polymerase, also called RNA replicase.
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So basically, Spiegelman introduced RNA from a simple bacteriophage
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into a solution which contained the bacteriophage replicase,
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In this environment, the RNA started to replicate.
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Oh, shit. He created life. You're not supposed to do that.
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Not exactly. He took part of something that was already living
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Oh, okay. Okay. Okay. Here we be remixed. Okay.
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So shorter RNA chains were able to be replicated faster.
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So the RNA became shorter and shorter as selection favored speed.
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After 74 generations, the original strand was 4,500 nucleotide bases
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ended up as a dwarf genome with only 218 bases.
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This short RNA sequence replicated very quickly in these unnatural circumstances.
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So when people are arguing against ambiogenesis, they go,
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he took something alive, put it in another solution,
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That is the antithesis of evolution in their mind.
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But that's not. That is the thing that was more fit.
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The thing that was able to replicate faster was in that environment,
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out-competing the things that replicated more slowly.
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And eventually, after a certain period of time,
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one iteration of them will develop some mutation
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that prevents the ones around them from replicating as fast.
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Or maybe starts consuming some of the ones that were replicating around it
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There's all sorts of little things that it might evolve,
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that give it a leg up that allows it to out-compete the other ones.
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And then you begin to get evolution going in the other direction.
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But even when you are talking about evolution on Earth today,
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typically when you first put something in an environment
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that is just abundant in food and has no natural predators,
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you are going to have that thing become, quote-unquote, simpler,
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It's losing all of the complicated things about it at first.
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The classic dodo bird, although that's not really a good example,
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but it's the way that people think about it in their mind.
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Like it lost flight, it lost a lot of its defensive mechanisms
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because it didn't have those types of predators in its environment
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and it didn't need those defensive mechanisms anymore.
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And it was more efficient to just be a simpler bird.
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you're having this on crack basically happen, right?
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You're having the true simplest self-replicating pattern end up winning.
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And I should also note that there has been further work.
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So if you look at the work of M. Sumper and R. Luce
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replicated the experiment except without adding RNA,
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And they found that under the right conditions,
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the replicase could spontaneously generate RNA,
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which evolves into a similar form of Spiegelton Monster.
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So what you're seeing here is sort of a convergent evolution
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of this simple replicator within this environment, right?
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But I actually don't think that this is particularly important to me.
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there are many hypotheses for how life first evolved.
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they'll think that that was the first thing that evolved.
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Because as soon as you understand something well,
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you realize how it could form under natural circumstances
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think that the cell membrane was basically the first thing that evolved.
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was the very first thing that was self-replicating.
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Because we see the self-replicate in nature all the time.
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and a stable enough environment for it to replicate for a while
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that it begins to build up protective mechanisms and stuff like that.
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You know, they think that RNA was the very first thing that existed.
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Oh, and so you're just trying to show that this is,
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this demonstrates the abundance of plausible ways
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And so this is really important to understanding all of this.
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some of these pathways because I think that they are,
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So I'll talk about some of the more specific ones, right?
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which says the citric cycle was a key metabolic pathway.
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So basically it's concentrating organic molecules
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is because it creates such a stable environment.
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into so many different patterns and configurations
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that eventually you're going to get something that's-
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because it's useful in a lot of sort of protein interactions
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And it's very hard to keep stable chemical reactions.
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Actually, I want to talk about a side note here
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is one of the most famous experiments in this place
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where he basically puts a bunch of chemicals together
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and he saw that you got simple biological chemicals
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First, it's had some issues with replicability,
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might've existed in the natural environment with abundance
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when these very simplistic early things were evolving.
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So no, I don't think that the Uri Miller experiment
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really adds, like makes ambiogenesis any more likely.
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Can we jump back to the citric acid hypothesis?
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And I, one, I don't remember the reaction exactly.
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It's simple enough that you can see it on screen.
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You can be like, oh, that's the citric acid cycle.
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That's the only thing that needed to happen naturally
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So what it needed to happen was in an environment
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with stability, changing environmental pressures,
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because the citric acid cycle is working on energy
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And then the waves created sort of a changing thing.
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Phosphates could have helped organize protocells
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where heat and minerals could drive chemical reactions
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the heat that's coming out of these hydrothermal vents,
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but they also created a semi-protected environment
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from things like earthquake, lightning strikes,
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In the environment that everyone's familiar with,
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The panspermia hypothesis is that life on Earth
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was actually seeded by life somewhere else in the galaxy.
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That seems to me just like shunting the problem
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where it was much more likely to come to evolve.
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Well, we kind of get the gist of planetary mixes.
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that Earth had all of these very convenient things
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I mean, life is only going to evolve on a planet
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And then you're still going to have to explain to me
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that some species out there have panspermic patterns.
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And I think that we might become one of those species
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I even looked at seeding other planets with life,
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to make resistant to those planets' environments,
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like the radiation, the heat, everything like that,
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especially if you pre-engineered this ecosystem
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that had already collated the energy on the planet
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and then they wouldn't have any defenses to us.