Full Comment - May 03, 2021


Episode 2: Dr. Jennifer Grant


Episode Stats

Length

41 minutes

Words per Minute

171.30357

Word Count

7,126

Sentence Count

354

Hate Speech Sentences

3


Summary

In this episode, Dr. Jennifer Grant, a medical microbiologist and infectious diseases physician at the University of British Columbia, shares her perspective on the SARS coronavirus outbreak in China, and why we should all be worried about it.


Transcript

00:00:00.000 Welcome to Full Comment with Anthony Furey. Thanks for joining us. Canadians are currently
00:00:09.720 dealing with the most significant upheaval we have collectively faced throughout our lifetimes.
00:00:14.140 For over a year now, we've been grappling with a new emerging virus and with the various
00:00:18.300 restrictions and lockdowns that officials enacted in response. Are we making the right choices?
00:00:23.940 What if some of them are the wrong choices? What if we're doing things wrong? What do we do now?
00:00:28.260 Is it too late to change paths? What are some of the issues that we should be discussing
00:00:32.620 that we should be focusing on right now? I know we can really get lost in the details discussing
00:00:37.020 COVID-19. You know, should we have stores open at 10% capacity or 25% capacity? What age group should
00:00:43.240 be allowed to access this or that vaccine on this or that week? But I wanted to step back a bit from
00:00:47.400 that and take a bird's eye view look at what we've been doing in Canada throughout the course of the
00:00:51.340 pandemic. And I think our guest today is the perfect person to help us with just that. Dr. Jennifer
00:00:56.440 Grant is a medical microbiologist and infectious diseases physician in Vancouver. She's a clinical
00:01:01.480 associate professor at the University of British Columbia. Dr. Grant, hello, welcome.
00:01:06.280 Hello, thanks very much for having me.
00:01:08.060 Yeah, thanks so much for joining us on the program, Jen. You're just a great person to have take a look
00:01:12.740 at this issue here. Of course, this, you know, huge thing that's been changing our lives for the past
00:01:17.280 year from your perspective as an infectious diseases physician. And I want to start really at the
00:01:22.800 beginning and before the beginning in terms of what your community, persons who are experts in
00:01:30.380 infectious diseases, were kind of expecting in terms of pandemics, what you thought would happen,
00:01:35.480 when you thought it would happen. You know, prior to February 2020 or January 2020, whenever things
00:01:41.300 really hit the fan in Wuhan, what was your professional perspective on pandemics and what we
00:01:47.240 were to expect? So pandemics are much like death and taxes. It's not a question of if, it's a question
00:01:53.580 of when. And we've seen that multiple times, even in our lifetimes. Certainly in my career, the HIV
00:02:02.320 pandemic was sort of our first taste of that. We know that influenza pandemics are an inevitability,
00:02:10.060 and that we see them every 20 to 40 years of varying severities. And we had had a hint of the
00:02:19.720 potential for coronavirus with both SARS coronavirus and MERS coronavirus, which for whatever biological
00:02:28.280 reason decided to stay relatively geographically restricted. But anyone who knows anything about
00:02:35.620 infectious disease knows that the next pandemic is inevitable. What components of what we're seeing
00:02:42.800 right now surprised you in terms of this? Or is it such that anything was always possible and nothing
00:02:50.100 is a surprise in terms of the way this is rolled out in its sort of medical sense? I think the big
00:02:56.520 surprise about SARS-CoV-2 was its almost perfection, if you want to use that word, in terms of its
00:03:07.980 adaption to doing exactly what it's doing. So if you're a virus, we'll put ourselves into the heads of
00:03:15.720 a virus, you want to be, in fact, if you really want to be completely non-pathogenic. But the viruses that
00:03:24.200 we're going to care about want to be sufficiently non-pathogenic that they can be carried about
00:03:30.940 the community by unknowing hosts and spread to other people. And that requires that you don't kill
00:03:38.180 your host immediately. So if you look at the other coronaviruses like the MERS-CoV or the SARS-CoV-1,
00:03:46.860 they are very pathogenic, and they kill their hosts if they're going to kill them quite quickly,
00:03:52.220 and they give severe symptoms for those people who get sick. So the surprise with this virus,
00:03:58.520 I think, was just how exactly in the sweet spot it was to get out unnoticed until it was able to
00:04:09.100 cause quite a bit of disease, very widespread before being identified.
00:04:14.180 There was a lot of confusion earlier on about just, you know, how bad is this virus,
00:04:18.620 who's getting hard hit by it, and so forth. Although I know some people have countered with,
00:04:22.000 no, we actually did really know all along. It was just sort of media coverage, the way information
00:04:26.020 was, you know, making its way down through the line. I mean, what did we first think we were
00:04:31.020 dealing with? There was a lot of, definitely when it comes to media and social media, those famous
00:04:35.240 videos from Wuhan of people literally dropping dead in the streets or falling over in hospital
00:04:41.260 hallways and so forth, you know, clinging on to themselves. It's still unknown whether those were,
00:04:45.080 in fact, videos related to coronavirus or just repurposed things from TV shows or whatnot.
00:04:50.300 But that was kind of the stuff that did the rounds there. And a lot of people thought that is what
00:04:56.700 we would be dealing with in a very acute sense here in Canada. Of course, what materialized was very
00:05:01.440 different. What was going on in those early kind of months where there was a lot of confusion?
00:05:05.440 So a lot of that confusion is natural at the very beginning of a pandemic. What we usually see as
00:05:16.200 pandemics start are the extreme cases. That's what twigs our attention. So if you think about the 2009 H1N1
00:05:26.560 pandemic, it came across initially for the first few cases that were identified in Mexico as being
00:05:34.380 extremely severe. What we learned afterwards as we did more testing, as we saw the broader view of the
00:05:42.800 virus, is the mortality rate went down. We saw that with this virus as well. When we first started getting
00:05:51.180 notification, it seemed to be matching SARS-CoV-1. The mortality rate was around six or seven percent
00:05:58.200 of the identified cases. And that was actually quite worrisome. And it looked like it was going
00:06:03.620 to be the very same thing again. But the natural history of these things is that once you've identified
00:06:09.120 those very severe clusters of people who twig your attention, when you do the broader look, you realize
00:06:19.740 that, in fact, there's a much broader spectrum of disease, much of which has gone unnoticed. And that
00:06:27.340 over the next several months, you get to a more realistic assessment of what the viral pathology is
00:06:35.720 likely to really be. In the case of this virus, I don't know that we are there yet, as we are sort
00:06:44.540 of understanding how many people through serial surveys and whatnot have been unknowingly infected.
00:06:51.440 Yeah, I was going to ask about that, because right now we are, of course, hyper attentive to the idea
00:06:56.000 of, you know, just, you know, wear your mask, keep away from anyone in the grocery store, and then we're
00:07:00.160 going to have apps to alert us if we were close to anyone who, you know, tested positive regardless of
00:07:04.380 symptoms and so forth. But to your point, back, you know, over a year ago, it was just what are the most
00:07:08.300 extreme cases? To what degree was the virus actually circulating around society? And I know there continue
00:07:13.420 to be studies and, and sort of lab work and so forth done to determine just how, how great a volume of
00:07:19.880 people actually have these antibodies? Did it actually come to the West Coast much earlier than we thought?
00:07:24.100 What's your current perspective on all of that? When coronavirus actually hit Canada, hit North
00:07:29.480 America, you know, do a whole lot more people have it than, than we say right now? I mean,
00:07:33.580 obviously it stands to reason, obviously it's, it's more than the official numbers, but just how much
00:07:37.660 more? So the, the quick answer to that is nobody knows. And so I'm going to break that question down
00:07:45.500 because there's quite a few questions in there. In terms of timing, they've actually gone and looked
00:07:50.500 at wastewater samples historically. And it seems like the, the SARS-CoV-2 was probably much wider
00:07:58.940 spread than originally thought, even in December of 20, 2019. And, and it may be that in fact,
00:08:07.180 the Wuhan area was the first major detected super spreader event rather than necessarily being the
00:08:14.600 origin. We'll probably never truly know that. We'll never know if somebody who happened to
00:08:20.640 transit through Wuhan ended up somewhere else in the world. Well, to a certain extent, it kind of
00:08:28.440 doesn't matter. We are where we are right now. And it was undoubtedly much wider spread at the time
00:08:36.640 that it was identified in Wuhan than was initially thought. Again, just masquerading as your common
00:08:43.900 garden variety, a cold or a flu virus. Jen, we had this period in the spring of 2020 where the virus
00:08:51.760 was most acutely spreading and also having the worst outcomes in long-term care homes. And that
00:08:57.740 was a period where obviously there was no vaccine at all, but there also really wasn't much treatment
00:09:02.200 at that point. I'll embarrass myself if I try and list the names of the actual drugs that people in
00:09:07.700 your profession have figured out are the ones to, to actually do a really good job helping people deal
00:09:12.320 with coronavirus when they're hospitalized with it. But, but there was a couple of months there where
00:09:15.600 I feel like it was probably pretty, I don't know if scary is the right term, but kind of uncertain
00:09:19.640 terrain in terms of just, you know, what's really going to happen here. I'm thinking, you know,
00:09:23.340 I guess, April, May, 2020, what was going on during that period?
00:09:28.180 I think that was probably the scariest time for everybody because we were dealing with a number of
00:09:34.520 unknown variables. We didn't know what the mortality rate was or wasn't. We didn't have a 100% clear
00:09:43.700 handle on nature of spread. We had all sorts of unexplained cases that we now probably can explain
00:09:53.300 with the knowledge that it was much more widespread than originally thought. But at the time we didn't
00:09:58.980 know. So it seemed like the cases were cropping out of nowhere. That was a time when we started
00:10:05.680 looking at mathematical models that were based on the, again, information that it was natural at the
00:10:13.140 time to have had, but with a, with a much higher mortality than is probably correct. And without sort
00:10:19.860 of stratifying the different risks per age, which would have given a much more
00:10:26.260 sophisticated understanding of what was likely to happen. At that point, we went into planning mode,
00:10:36.960 which is completely appropriate and prepared for the worst case scenario. And it turns out that that
00:10:42.400 did not, at least in my jurisdiction, develop as expected. And so then we had to sort of take a step
00:10:50.740 back and rethink the approach. Now, that's a really interesting period where we went into first
00:10:58.220 lockdown, shut everything down. We don't know what this is. We don't know how it spreads. We don't
00:11:02.200 know who dies from it and so forth. And then, and I appreciate that a lot of people were really nervous
00:11:06.960 at that point in time. And then we learned a bit more, you and your colleagues in the profession
00:11:12.240 learned about treatments, learning who's getting it and so forth. And we had a bit of a summer in
00:11:16.580 Canada. And I think some people were able to enjoy some times there. And then we hit into the second
00:11:21.660 wave and a second lockdown. And here where I am in Ontario, we're now in a third lockdown. And I feel
00:11:26.460 like things started to change a bit in terms of how we talk about the virus, how the information gets
00:11:32.660 out there. And I think a lot of, a lot of public frustration and anxiety and confusion really set in.
00:11:39.500 What do you think really happened after we sort of grabbed our bearings and to your point,
00:11:44.560 things in your jurisdiction, and I believe pretty much in most jurisdictions didn't turn out as bad
00:11:48.920 as was what first feared, but it kind of feels like we're doing the same response right now than we
00:11:55.220 did then. So to understand the full nature of that, you need probably a social psychologist rather
00:12:04.160 than infectious diseases specialist. I think there's a number of themes going on. I do put a fair amount
00:12:15.020 of blame on the nature of social media. It, there has been, from my observation, the sort of rational
00:12:25.740 medical response, which admittedly does not make great headlines, talking about how we know actually
00:12:36.640 a fair amount, how we know what we can do to mitigate risk. Unfortunately, that does not get as much
00:12:45.080 attention, clicks, playtime, as do the more sensational points of view. Because of the nature of our
00:12:55.400 psychology as people. And so I feel like this is the pandemic that Twitter is driving, and it gets
00:13:02.840 to a point where public officials can't, I don't want to say can't, that's not, it's unfair to say
00:13:10.740 they can't manage, but they're in a, they're put in a position where what they're saying is not perceived
00:13:15.620 as being credible. And so they have to change their message, despite the science, to placate the,
00:13:23.920 um, the Twitterverse. Yeah, I found it interesting that, you know, initially, a lot of public health
00:13:30.240 communications are about making sure people take this seriously. So even if they're not sure if this or
00:13:35.420 that intervention is going to work, well, let's do all we can to take it seriously, take our precautions
00:13:40.060 and so forth. But I think one of the consequences of that was it led people to believe that things were
00:13:45.960 risk factors that weren't risk factors. Like I feel like there are many millions of people in Canada
00:13:51.360 who would believe that anybody can get coronavirus at any time in any setting and anybody can have a
00:13:57.120 serious outcome and be hospitalized and die of it. And obviously, I know there's a, you know, one in
00:14:00.620 however many millions odds where I guess, you know, every scenario is conceivably possible. But
00:14:05.180 generally speaking, correct me if I'm mistaken, that is not the case that we have a lot of information
00:14:10.380 about things that are safe, unsafe, people who are high risk, people who are not high risk,
00:14:14.300 and so forth. But I feel like that that doesn't get communicated, perhaps for just what you're
00:14:18.560 saying, because it doesn't fit in a tweet. Absolutely. And certainly, speaking to my
00:14:25.560 relatives who are elderly, they are absolutely convinced that if they get the coronavirus,
00:14:31.800 they will die. Now, their risk is much higher than I'm sure they would like it to be. So for a
00:14:37.320 community dwelling elder, the risk is somewhere between 2.5 and 5% of death once you
00:14:42.860 contract the disease, unvaccinated. But again, that's much higher risk than you'd like. But you
00:14:51.940 have a 95 to 97.5% chance of doing well. So I think that we've gone from a subtle, nuanced discussion
00:15:02.880 about risk to an absolute black and white, you either die or you don't, which is which is probably
00:15:11.240 incorrect. Looking at our population structure, and this is true, actually, also of SARS and SARS-1
00:15:19.380 and MERS-CoV, young people are generally speaking at incredibly low risk, certainly at lower risk than
00:15:27.420 many of the other risks we take in day to day living, such as driving a car, which is probably
00:15:33.500 the highest risk for any of us under the age of about 50. Dr. Jennifer Grant is our guest, a medical
00:15:39.900 microbiologist and infectious diseases physician in Vancouver, and a clinical associate professor at
00:15:44.780 the University of British Columbia. Facebook recently updated their policies for what classifies
00:15:50.040 as misinformation and things that you're not tolerated to discuss on Facebook and posts will be
00:15:54.880 removed and so forth. And one of them, they said, posts that downplay the severity of the virus,
00:16:02.620 for instance, saying it's just the flu, or that call into question the official death tally. And I read
00:16:08.480 that and I thought, well, we have a bit of a problem on our hands, because I appreciate that in older age
00:16:13.500 cohorts, yes, coronavirus is definitely more serious than the flu. But we've got pediatric experts and
00:16:20.460 an expert such as yourself, Jen, who are saying, well, actually, influenza is more serious in
00:16:25.340 children. So there's, you know, one of those Facebook red flags, and then saying, oh, the death
00:16:29.600 count is, you know, not what it is, and so forth. Well, we've got Statistics Canada saying that about
00:16:33.300 10% of coronavirus deaths were people who died of something else like cancer, but had coronavirus at
00:16:38.480 the time. So, okay, I know they're not doing, you know, full blown conspiracy theory talk at
00:16:42.540 Statistics Canada. But the facts they present in the nuance seem to, you know, cause trouble with what
00:16:47.660 Facebook is putting as their rules, you know, to your point about how a lot of this, this, this online
00:16:53.360 discussion is almost getting in the way of a more nuanced conversation.
00:16:57.120 Well, absolutely. And I would say that it's, if you can't question facts, there's a problem if you can
00:17:08.700 back those facts up with data. Now, obviously, people say all sorts of things online, that are clearly
00:17:14.800 wrong. And so there has to be a balance in there. But it's very problematic. The degree of power that
00:17:24.080 Facebook has in that is problematic. And the inability to have a nuanced discussion is also
00:17:32.480 problematic. Although I would put to the universe that possibly Facebook is not the place to be having
00:17:38.880 nuanced discussions. Right. Fair enough. Going back to the kids conversation, and to your point,
00:17:43.680 some people very resistant, very adamant to say, no, no, kids are, you know, they're still getting it,
00:17:48.680 or kids are the secret super spreaders, and so forth. In Ontario, where I am, they've closed the
00:17:52.820 schools again, for the third wave. And the justification, they acknowledge that children
00:17:57.240 themselves are not actually spreading the virus in classroom, there's no in class transmission going
00:18:03.020 on. But they've said, well, you know, there's community spread. So we have to close the schools
00:18:07.600 because of that. And also mobility issues, something that they talk about, I'd say sort of below the
00:18:13.900 fold, they don't talk about as their top lines in the press conference, but they get into a 20 minutes
00:18:17.720 into it saying, well, we got these mobility charts, these anonymized cell phone data that show us people
00:18:22.840 are driving around like it's not pandemic time. So we got to get those numbers down. They've learned
00:18:26.920 that closing the schools is a good way to keep parents at home to bring that mobility data down.
00:18:31.540 Do you think that any of that broader community spread, mobility data, are those justifications
00:18:37.140 to close schools during this situation? So I would say no, I would say that there is no
00:18:44.760 justification for closing schools, until you can show that it's more harmful to the children
00:18:51.320 themselves to be in school. The problem is that cell phones, as far as I'm aware, don't spread
00:19:00.020 the coronavirus. People are mobile for all sorts of reasons. And until you can show the direct
00:19:09.480 line of children in school being the cause of spread, you're just using children as victims
00:19:16.880 and a strategy that might be better done in some other way. What we're doing to our children right
00:19:22.340 now is, in my opinion, appalling. We need to care for our children, which includes taking care of their
00:19:31.140 mental, physical, and spiritual health, their economic health, and frankly, their physical
00:19:36.360 health. Children are far more at risk from self-harm than they are from the coronavirus.
00:19:42.480 Well, if I can throw back at you a line that gets thrown back at me, one of those snarky Twitter
00:19:47.300 lines, people say, oh, well, that's all well and good. But try telling one of those children why
00:19:51.680 their grandparents have died, or why mom or dad died, or why their grandparents died, because they
00:19:56.540 brought the coronavirus back to them from school. What would you say to people who, based on my
00:20:01.640 Twitter feed, there's a lot of people who like to say that? What I'd like to say is not appropriate.
00:20:07.700 Fair enough.
00:20:08.180 So, I think we really need to have a conversation about who is to blame for a virus. A virus is a
00:20:20.660 virus. It's not a child's fault if they got a virus. It's not a child's fault that somebody else got a
00:20:28.640 virus. And we know that children are the least likely to spread disease. They are far more likely
00:20:38.020 to have got it in the community. And in fact, from personal conversations I've had with various
00:20:45.000 public health officials, the risk of a child spreading is substantially less than 1%. So, I
00:20:51.420 would ask that person, really, are you sure the grandparent got it from that child? Because
00:20:57.300 directionality is incredibly hard to prove. So, on the one hand, we shouldn't, how can you blame
00:21:05.040 children for happening to have a virus? That's just, that's nonsensical to me. We don't blame
00:21:12.220 the adults who gave it to the kids. So, why would we blame in the other direction? It's just, it's, it's
00:21:18.400 a false morality. It's scientifically incorrect. And it is just so unfair to put that on children.
00:21:29.020 There's been a little bit of an emphasis on health officials on attempting to quantify sort of direct
00:21:35.020 harms of lockdowns vis-a-vis a spike in overdoses. I know in BC, there's been a lot of looking into
00:21:41.680 that data, suicide rates and so forth, deferred surgeries that have resulted in cancers and so
00:21:46.960 forth, and cardiac issues. But I know there has not been anywhere in Canada a more formal cost-benefit
00:21:52.060 analysis that takes into effect various things related to children and what we call quality-adjusted
00:21:57.080 life years, sort of stunted growth, how education held back. Even people who've said, you know,
00:22:02.020 I'm in university, but I'm in crisis now because life is a mess in university, so I'm dropping out
00:22:06.280 and so forth. And what that means for society, what that means for that young person. How do we begin
00:22:12.120 to robustly talk about this stuff? Because I feel like a lot of people are really at the sort of
00:22:16.400 cover the eyes, plug the ears, see no evil, hear no evil kind of stuff.
00:22:20.860 Yeah, it's really challenging. The problem is we can't quantify it now because those are harms that will
00:22:26.120 be felt over the next 20 to 30 years in many cases. Obviously, suicides can be identified. And
00:22:32.100 I believe it's Las Vegas opened their school system because children were dying from suicide.
00:22:39.460 So there are some of those harms that can be quantified, but a lot of them can't be. And a lot
00:22:45.280 of them will be born out of the next 30 years. Now, there are some places trying to do that.
00:22:51.320 So the OECD has a publication out, as does Simon Fraser University, looking at the likely economic
00:23:00.660 consequences for the kids, for the, essentially quantify it by future earnings lost per day of
00:23:09.540 education lost or something along those lines. And it's enormous. And for those people who say,
00:23:16.660 well, yes, but it's, that's money. And we're talking about health. The truth is that wealth
00:23:21.540 and health are so tightly linked that we actually have the science of the social determinants of
00:23:28.480 health. So if you're, have more income, you can have better food, you can exercise, you have better
00:23:35.060 housing, you engage in medical care more, all of those things makes you healthier, having not having
00:23:41.560 those things makes you die earlier. People are also trying to quantify the number of children lost
00:23:47.920 to the education system. And it's enormous. I saw a newspaper article saying that they're laying teachers
00:23:55.280 off, they've lost so many kids. These are kids who are not completing their education. With a lower
00:24:00.020 level of education, not only do you have lower economic output, but you end up with poorer health
00:24:06.420 over the course of your lifetime. So people are trying to do it here and there. There is, in BC,
00:24:12.500 to the credit of my colleagues, they have the unintended consequences group, and they are trying
00:24:17.340 to pull those data together. But again, you can't pull future data together. That's, that's going to
00:24:22.960 come in, in 10 to 15 years. Dr. Grant, correct me if I'm mistaken, but in, in infectious disease
00:24:28.500 circles, epidemiological circles, public health community prior to Wuhan entering lockdown, this idea
00:24:35.520 of shut everything down for a prolonged period of time is, is not really a thing. I mean, I've read
00:24:42.280 the various pandemic preparedness plans that, that all levels of government have put together, and
00:24:46.480 there's not really any discussion of this. It's about, you know, protecting people, minimizing illness
00:24:51.460 to allow for the proper functioning of society. How, how are we, I don't even know how to ask the
00:24:59.260 question, because whenever I try to say it, it kind of boggles the mind that I even have to ask the
00:25:02.940 question, but how did we get to this point? I, I don't know. You're right. Every pandemic
00:25:09.700 plan we've looked at has, that we've written, and ours is written in 2018, and it's still up on our
00:25:15.200 website, and so I'm sure you've, you've seen it. It basically says, we don't close schools, because
00:25:19.860 closing schools, even if, and this, and this was written for influenza, which children are known to
00:25:24.720 spread. We don't close schools, because the harms to children are so high. No, we don't close
00:25:30.900 businesses, because people need that to work. I don't understand how the narrative moved to
00:25:36.680 shutting everything down is the best thing to do. Now, is the, is there some benefit to it? There
00:25:43.520 probably is, but there needs to be a discussion about balancing harms and benefits, and that's the
00:25:51.620 dialogue that seems to have gone missing at a societal level. You're, you're, you're bad if you
00:25:58.780 don't want more shutdown. Right. And, and, you know, some of that is probably fair. We, we, no one's
00:26:06.100 saying, let her rip. What we're saying is, that's fine, but let's find the sweet spot where we maximize
00:26:11.880 everybody's health. There's a perspective out there, dare I say, maybe an ideology, I don't know what to
00:26:17.480 call it, called COVID zero, which is something that I guess they've been working on achieving in New
00:26:22.180 Zealand, and perhaps in Australia, and there are definitely adherents of it here in Canada. It has a
00:26:26.780 spiffy logo and, and, you know, a mission statement and so forth. And the basic idea is
00:26:30.840 aggressive suppression of the virus until you get to near zero new daily cases. There's one document
00:26:37.040 I read that said, I think Canada has to stay in some form of restriction until 40 cases per day,
00:26:43.220 which is about, you know, one per million and so forth. I'm kind of confused by that, whether or not
00:26:48.680 it's even something we should aspire to, whether it's even possible if, you know, my understanding is
00:26:53.820 that this is becoming an endemic illness, meaning it is going to be around for the rest of my natural
00:26:57.980 life to some degree or another. Yet I do feel that idea has taken hold in, you know, persons in the
00:27:04.080 medical community, public health community, and also just a lot of members of the public who hear it and
00:27:07.520 think that that is an attractive idea, getting, you know, a complete elimination of coronavirus.
00:27:13.240 Oh, it's a very attractive idea. Wouldn't that be nice? I mean, if we could do it
00:27:18.380 at an acceptable cost, I think would be a wonderful thing to do. The problem is that the, at this point,
00:27:29.560 the costs would be, and costs, I don't mean financial, I mean, in terms of health, societal
00:27:36.640 cohesion, all of the things that make life worth living, would be enormous. And I am of the opinion
00:27:44.340 that it's not possible. If you look at places that have been severely locking down, like the Peel
00:27:52.080 region in Toronto, Toronto generally, essentially you've been in lockdown as hard as you can reasonably
00:27:58.140 get before we start impacting on people's ability to feed themselves. And it's not actually stopped
00:28:06.620 transmission. And so, you know, I think it's a reasonable thing to try. And if you're a isolated
00:28:14.080 island in the Pacific, you have a shot of doing that. I suspect that in Australia, New Zealand got
00:28:18.940 a little bit of a heads up because of further away, they were able to more effectively control their
00:28:24.700 borders. There is a, for anybody coming in on by ship, there's a good period of time between leaving
00:28:31.960 your port of exit and come and arriving. So they have a number of advantages that we really don't
00:28:38.160 have. By the time we got to the point where it was across all of our provinces, the chances that
00:28:44.720 we're going to get to that without a vaccine are exceedingly low. Let's talk about vaccines for a
00:28:51.480 minute here. Right now, there's a lot of concerns, I guess, that people have over various vaccines.
00:28:57.220 We're hearing statistics that, you know, five or 10 among 100,000 or a million or 2 million or whatever
00:29:02.260 adverse reaction, blood clots, those sorts of issues. What should people think about when they
00:29:07.840 see those headlines? So I think we need to be aware, and this speaks to sort of the general
00:29:14.220 sense that we're not at risk for anything ever that society seems to have come to in the past 20
00:29:22.060 years. But remember, people get blood clots every year. About one in a thousand people gets a blood
00:29:28.600 clot per year. And so if you give 5 million doses of a vaccine, there will be blood clots. The study
00:29:36.780 looking at the AstraZeneca vaccine, in fact, there were, I believe, 12 blood clots in the several
00:29:43.260 hundred thousand doses they used to study, but there were more in the control group than there were in
00:29:47.700 the vaccine group. So there's things that happen just by chance that are unrelated to the vaccine
00:29:54.660 and shouldn't make us worry. But that's what our regulatory agencies are there to do. That's why
00:30:00.020 there was a pause in the AstraZeneca vaccine. In general, vaccines are very safe. Certainly,
00:30:06.320 the initial study showed good safety of all the vaccines that have been deployed. Now, what happens,
00:30:13.300 though, and what we have to think about is the safety of the vaccine has to exceed the risk of
00:30:19.180 the disease. And that's where it's really important for us to understand to what degree any one individual
00:30:26.160 or any group is at risk of disease. So if you take a vaccine that has, for example, a one in a million
00:30:33.360 adverse event rate, which would be sort of in line with what we see normally. If you have a 5% risk of
00:30:39.680 death from disease, that's an obvious benefit to you. However, if your risk of disease is one in
00:30:46.460 2 million, you might not want to take the vaccine. And so we need a really detailed epidemiologic
00:30:51.160 understanding of what your precise risk is, so that when we get to the younger age groups,
00:30:57.920 we decide whether the vaccine offers more or less benefit than not being vaccinated.
00:31:03.600 I was attending his media press conference that one public health official was on. And I was asking
00:31:08.460 about will children's sports be greenlit this summer, outdoor sports, soccer, baseball, and so
00:31:12.740 forth. And the official responded by musing about vaccines and when they will or will not be available
00:31:20.020 for children. And I found it a rather odd response because, well, let me just ask you, Dr. Grant,
00:31:27.000 do kids even really need to get this vaccine? Is it that much of an issue?
00:31:29.960 Well, right now they can't get it because there's no vaccine approved for children.
00:31:35.340 There may be a small group of children because of the nature of their medical illness
00:31:40.200 where a qualified physician might look at the risk benefit and have a discussion with
00:31:46.640 children's parents. But widespread vaccination of children, certainly based on the numbers I've seen,
00:31:53.480 does not seem like a high priority.
00:31:57.600 So when we use phrases like vaccine passports, which I understand is a bigger debate to elsewhere
00:32:03.720 in other countries here in Canada, there's not really discussion of formalizing that, but who
00:32:07.540 knows, you know, anything could come into play. Some jurisdictions mean it just in terms of this
00:32:13.220 is what you will need to get on and off a flight. Okay, fair enough. Others mean it more broadly,
00:32:16.920 this is what you'll need to go to the movie theater and so forth, or maybe even to show it when you
00:32:21.400 enter a restaurant. What do you think of that idea that people are going to need to show proof
00:32:25.560 of vaccination to sort of return to living their lives?
00:32:29.340 I guess I would say that if we were going to do that, we should have done it on vaccines that
00:32:37.820 prevent much more high mortality diseases. So measles, for example, is an exceedingly high
00:32:45.400 mortality disease. It has a 1% mortality rate with current medical care. If you look at places in the
00:32:52.160 developing world, it has about a 10% mortality rate, especially, especially in children. But
00:32:56.780 the reason adults don't get sick is because they've all had measles as children, or that have been
00:33:01.300 vaccinated. So I don't know why this particular virus would be the virus on which we place that
00:33:09.560 from a medical professional point of view. I think that that severely impinges on the question of
00:33:15.720 consent. We don't impose medical procedures on people who don't want them. That's sort of the
00:33:23.780 inviolable nature of our own bodies and our own decision making. But this would actually be
00:33:31.620 tantamount to coercion. So essentially, if you don't get this vaccine, you're not going to be allowed to
00:33:38.120 live your life normally. From a philosophic point of view, I have significant concern about that.
00:33:44.640 We've never done it before. And yet we have very high vaccination rates. So I don't see why it's
00:33:49.820 necessary. If everyone else is vaccinated, who wants to be, they are protected from severe disease.
00:33:57.340 So the need to force that on the 5% or 10% of people who choose not to get vaccinated for whatever
00:34:03.840 reason strikes me as problematic. And that's not even talking about the people who can't get
00:34:11.520 vaccinated for some medical reason. Speaking about total compliance rates, one thing that I've
00:34:16.980 always found a little odd, over the past year, there's been a number of different, you know,
00:34:20.640 videos and stories out there of a person who, for whatever reason, didn't want to wear a mask in the
00:34:24.820 grocery store. You know, they said they had a medical exemption, they forgot the mask, they want
00:34:29.100 to be conscientious objectors, maybe they're conspiracy theorists, I don't know, they said they
00:34:32.800 didn't want to wear it. And then you see them being hauled out by police, and then they get into a
00:34:36.000 scuffle, and these people are being beaten by the cops. And I think, for not wearing a mask,
00:34:39.320 and I kind of think, you know, what is our approach to some of these rules and the enforcement from
00:34:44.360 it? I think if we said, please wear a mask in store at this point, I think we'd probably have
00:34:47.540 what 90% of people actually doing it. And, you know, I wonder what is the utility of this? You know,
00:34:54.880 is it theater of all of this to bring out the police and to call the cops, and you see someone not
00:34:59.660 wearing the mask? I'm not so much focused on just the mask issue per se, but sort of all of these
00:35:04.160 rules out there where we have to have sort of 100% compliance. And if one person doesn't go along,
00:35:09.960 we have very disproportionate reactions. There's one barbecue joint in Toronto, it became, I think,
00:35:16.060 an international story of a fellow who decided, well, I really want to keep the barbecue place
00:35:19.080 open and so forth. And at the end, they brought in, I think, 100 police officers to shut it down.
00:35:23.260 It was quite a scene. Yeah, I have to say, it's never historically been public health policy
00:35:31.320 to enforce the same with coercive measures. The one exception would be tuberculosis. So we do have
00:35:40.040 the right for somebody who has tuberculosis to, we can't force treatment on them, but we can make
00:35:46.820 them stay away from other people. So there is a precedent for it. But we generally speaking,
00:35:51.900 get much further with harm reduction and being encouraging. If you think about something like
00:35:59.840 HIV, we, in fact, have legal precedent saying that, you know, we'd really like it if you wore
00:36:09.300 a condom, please take all your antiretrovirals. But when people have knowingly had unprotected
00:36:15.860 sex with other people, we've said, well, that's not something, that's not a role for the police.
00:36:19.620 Right. So this is, and I think we can both agree that that is much more personally damaging than a
00:36:27.900 person who isn't wearing a mask. So it's something that I find confusing. I don't think that it's
00:36:36.020 appropriate to use the police or punishing fines or other law enforcement mechanisms to enforce public
00:36:48.580 health policy. That's a personal opinion. But it certainly does become, it makes the whole
00:36:56.740 discussion just that much more high stakes. And as you say, I think it's disproportionate to get
00:37:03.380 beaten for not wearing a mask. Dr. Grant, where do we go next? There's certainly a great deal of
00:37:09.220 optimism that the pandemic will soon be behind us in terms of vaccines rolling out, maybe not as great
00:37:13.900 as we'd like them to be in Canada, but they're still happening. And long-term care vaccinations
00:37:17.880 are almost at like a hundred percent. And the death rate in LTCs has just dropped drastically
00:37:23.040 from coronavirus. While there are sort of third wave spikes, there does seem to be optimism towards
00:37:29.060 a light at the end of the tunnel. Then at the same time, I know we do have these fraught conversations,
00:37:33.760 vaccine passports, and we see some doctors on television saying wearing masks for, you know,
00:37:38.700 the foreseeable future and so forth. Where are we headed? What is the exit ramp?
00:37:43.860 Well, that's what we need as a society to sit down and discuss. We've not actually had a good
00:37:51.120 societal debate about what our goals are. So essentially, a lot of the contention has been
00:37:59.460 the zero COVID versus the peaceful coexistent sort of dichotomy. Now, what do we want? Are, you know,
00:38:08.180 are we as a society going to agree that we will continue everything we're doing until there are
00:38:14.380 no detectable cases? That's something we could decide to do. And if we do that, then we have to
00:38:19.100 have a long conversation about what that's going to cost us. Or do we say, well, once we have everyone
00:38:25.020 who wants a vaccine, have a vaccine and be largely protected from the adverse outcomes, do we then say,
00:38:31.900 well, then, you know, that's what we care about. And we'll keep our eyes out for, you know,
00:38:37.720 new variants that might be different or that might merit a different vaccine or a different strategy.
00:38:45.080 We have to have that conversation and we haven't. Unfortunately, the people dominating that
00:38:49.840 conversation are doing so in a way that really does gloss over the downsides of either strategy.
00:38:58.200 Which path should we be pursuing?
00:38:59.360 In my opinion, I think we need to move to peaceful coexistence.
00:39:05.240 I don't think we're going to eliminate the virus. I think once we get to a point where those people
00:39:09.860 at high risk are vaccinated, we stop spending our time worrying about case counts and more time looking
00:39:17.500 at how we make sure that our kids get the education caught back up and that our healthcare system
00:39:25.360 goes to a place where we don't end up overwhelmed every flu season in our hospitals and our ICUs.
00:39:34.080 You mentioned earlier the HIV AIDS pandemic. And I know there was a time in not too long ago history
00:39:39.740 where there was no such thing as say an AIDS hospice. Then those things were created. The healthcare
00:39:43.660 system, I guess, was expanding to deal with that challenge for a number of decades. Are we going to
00:39:51.180 have a time? Are we going to have to accept the fact that for the next 10, 20, 30 calendar years
00:39:55.520 or what have you, there will be, I don't know, two or three hospital beds in each region or I don't
00:40:01.160 know what the number is of people who are dealing with severe coronavirus outcomes and we just need
00:40:06.100 to address that fact. Is that something that's going to be happening in the endemic portion of this?
00:40:11.100 Oh, of course. But we do that every year with the flu.
00:40:13.800 I mean, we do everything we can to try and prevent the flu. We vaccinate our high-risk people.
00:40:19.380 But like coronavirus, flu adapts and changes every year. And we, every year, have numerous people in
00:40:27.660 our hospitals and in our intensive care units with the flu. And it's not just the flu. We have
00:40:33.340 numerous other viruses that do the same thing. We have human metanema virus. We have respiratory
00:40:37.220 syncytial virus in the right population. Those can be devastating. And that's why we have hospitals
00:40:44.480 to care for the sick. When they get ill with anything, we're there. Influenza and pneumonia
00:40:52.420 are one of our number one killers, especially in the elderly age group. So that's not going away.
00:40:58.700 Dr. Jennifer Grant, you are a medical microbiologist, infectious diseases physician
00:41:02.200 in Vancouver, a clinical associate professor at the University of British Columbia.
00:41:05.700 And we thank you so much for this great conversation. Thanks very much for your time.
00:41:09.660 Thanks for having me.
00:41:11.020 Full Comment with Anthony Fury is a post-media podcast. This episode was produced by Andre Pru
00:41:16.380 with theme music by Bryce Hall. Kevin Libin is the executive producer. Thanks to our guest,
00:41:21.940 Dr. Jennifer Grant. The host is Anthony Fury. You can subscribe to Full Comment on Apple Podcasts,
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