Making Sense - Sam Harris - March 23, 2021


#242 — Psychedelics and the Self


Episode Stats

Length

1 hour and 3 minutes

Words per Minute

141.94783

Word Count

9,054

Sentence Count

267

Misogynist Sentences

2

Hate Speech Sentences

9


Summary

James Fadiman is a psychologist who has degrees from Harvard and Stanford, and has taught at four different universities. He is one of the early researchers on psychedelics, and is probably more responsible than anyone for the phenomenon of microdosing. In this conversation, we cover the terrain in his books: how to think about taking them, who should take them, and who shouldn t take them. And then we move on to a discussion about the nature of the self, and the fiction of there being a unified self. And how this might relate to compassion and an understanding of what we are as people. This was one of those conversations during COVID where the local recording failed, so all we had in the end was the backup recording of the actual conversation. So I think your ear will get used to it. And I think you'll agree that the audio is less than ideal, but that's what makes it worth listening to. -Sam Harris If you can t afford a subscription, there's an option at Samharris.org to request a free account. And we grant 100% of those requests without any questions asked. No questions asked, no questions asked! -The Making Sense Podcast Team Sam Harris (Samharris) and the way to submit questions by sending an email to asksam at samharris@thedreams.org And we'll only be selecting AMA on those topics from actual listeners, and we'll be responding to those questions in the podcast by responding to them on the podcast! Thank you for the questions asked by you, by becoming one of you, the making sense podcast? by Sam Harris, the podcast is made possible entirely by the podcast, by The Making Sense Pod? - & the podcast's made possible by Sam Harris , by the Making Sense Poddy, is in a podcast by ? . , ) "No questions asked asked, by the Podcast, by , and the podcast ... # @ + This is a great pleasure. "A great pleasure, " AND : etc. - Thank you, Mr. ) -A very good friend, ? & ; ! ~ & ?? # 'A very bad novel? )


Transcript

00:00:00.000 Welcome to the Making Sense Podcast.
00:00:08.860 This is Sam Harris.
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00:00:52.280 Okay, a lot going on out there in the world.
00:01:05.380 Lots of shootings and other chaos,
00:01:08.400 and just absolutely abysmal coverage of seemingly everything in the media.
00:01:17.480 If ever we needed a sign that journalism was broken,
00:01:23.280 my God, some of the stories we're telling ourselves now.
00:01:27.700 But rather than get pulled into that morass,
00:01:32.500 I will press on here.
00:01:34.260 But I'll be doing some more AMAs.
00:01:36.700 That might be the context in which to process a lot of this topical stuff.
00:01:41.400 We're bringing AMAs back on the podcast.
00:01:45.380 And the way to submit questions, if you're a subscriber,
00:01:49.100 you can submit questions by sending an email to asksam at samharris.org.
00:01:58.220 Or you can do this on Twitter with the hashtag AskSam.
00:02:02.600 And we will gather questions,
00:02:05.680 and I will release AMAs on those topics.
00:02:11.400 And again, we'll only be selecting questions from actual subscribers.
00:02:15.720 Whether you're paying for that or it's free, doesn't matter.
00:02:18.840 But you need to be a subscriber.
00:02:22.640 Okay.
00:02:25.020 Today I'm speaking with James Fadiman.
00:02:28.760 Jim is a psychologist who has degrees from Harvard and Stanford.
00:02:34.320 He's also taught at four different universities.
00:02:37.180 And has had a very long-standing influence on the topic of psychedelics.
00:02:43.780 He is one of the early researchers here.
00:02:46.640 And is probably more responsible than anyone for the phenomenon of microdosing.
00:02:52.220 He's written several books.
00:02:54.680 Most relevantly here, The Psychedelic Explorer's Guide.
00:02:58.100 He also has a new book on the structure of the self that he co-authored with Jordan Gruber,
00:03:06.420 titled Your Symphony of Selves.
00:03:09.300 And in today's conversation, we cover the terrain in both those books, to some degree.
00:03:15.100 The first half is entirely on psychedelics.
00:03:17.560 How to think about taking them.
00:03:20.440 Who should take them.
00:03:21.280 Who shouldn't take them.
00:03:22.980 Considerations of set and setting.
00:03:25.240 The role of a guide.
00:03:27.120 The effects of microdosing.
00:03:28.780 The difference between MDMA and other proper psychedelics.
00:03:32.580 So-called good and bad trips.
00:03:35.280 The power of thought.
00:03:37.480 And then we move on to a discussion about the nature of the self.
00:03:41.360 And the fiction of there being a unified self.
00:03:44.660 And so we talk about the self in its multiple forms.
00:03:49.120 As states of self and even multiple selves, per se.
00:03:54.560 And how all this might relate to compassion and an understanding of and acceptance of what
00:04:03.100 we are as people.
00:04:05.540 Anyway, if this is your cup of tea, Jim is a very wise companion for this terrain.
00:04:11.480 Apologies for the audio quality.
00:04:14.660 This was one of those conversations during COVID where the local recording failed.
00:04:21.200 So all we had in the end was the backup recording of the actual Zoom conversation.
00:04:26.380 So there are some dropouts on Jim's side.
00:04:30.020 Everything of importance is intelligible.
00:04:32.360 But the audio is certainly less than ideal.
00:04:35.100 So I think your ear will get used to it.
00:04:37.520 And now I bring you James Fadiman.
00:04:39.840 I am here with James Fadiman.
00:04:48.600 Jim, thanks for joining me.
00:04:50.660 It's a great pleasure.
00:04:52.220 We could spend a lot of time trying to figure out our, where our mutual history intersected.
00:04:57.320 I'm about 95% sure that you and I once met face-to-face, at least once.
00:05:04.060 And I'm sure we know many people in common.
00:05:05.880 But perhaps we'll get there organically.
00:05:10.180 But perhaps you can summarize your background here.
00:05:14.420 How do you describe what you've focused on, lo, these many decades that you've been covering the topics we're about to touch?
00:05:23.100 Well, I got involved in psychedelics before I entered graduate school, because Richard Alpert turned me on.
00:05:31.520 And I was living in Paris, writing a very bad novel.
00:05:35.720 And my draft board said, would you like to go to graduate school or Vietnam?
00:05:39.520 And I took the obvious choice and then worked with a clinical group in Menlo Park.
00:05:49.160 And just as I had completed my dissertation on psychedelic therapy, and by the way, I said it was good.
00:05:56.120 The government said, we don't want to know anything more.
00:05:58.920 Thank you very much.
00:05:59.860 And closed us down in the midst of a research project where people were using psychedelics to solve absolutely linear, rational, physical, scientific problems.
00:06:15.100 And then I had another few careers outside of psychedelics, since the government didn't want us to know much.
00:06:22.280 And a number of years ago, got back involved in psychedelic research, particularly in microdosing.
00:06:27.960 And in between, I've worked with and taught a number of psychology systems or life-changing systems like affirmations, psychosynthesis.
00:06:41.780 And I recently just completed a book on internal healthy multiplicity, which was apparently from the outside, like, where did that come from, given what I just told you?
00:06:56.060 And I've been working on that quietly for 25 years and finally got it out.
00:07:01.520 So I'm at a place of feeling a lot of life ambitions, perhaps, or inclinations or directions are in a completed state.
00:07:13.660 So I have a couple of turns left and a lot of things I'm intending to do.
00:07:19.100 And it's a pleasure to be with you.
00:07:22.160 And several of my relatives are very excited because they are long-term fans of yours.
00:07:28.780 And I'm a short-term fan of yours.
00:07:32.340 Nice.
00:07:32.900 Well, the admiration is mutual.
00:07:34.920 I found your books very useful and illuminating.
00:07:40.320 And I want to cover them somewhat systematically here.
00:07:43.620 I think that the focus will be on this first book that—not your first book, but this first book I want to touch, the Psychedelic Explorer's Guide.
00:07:53.960 And I want to have a fairly structured conversation that can be useful to people who are thinking about taking psychedelics, that they are taking them, and how that can be done safely, you know, who should do it, who shouldn't do it, you know, all the related questions here.
00:08:12.740 And then we can—
00:08:14.180 Happy to do those.
00:08:14.940 Yeah, and then we can touch your latest book, which is titled Your Symphony of Selves, which you wrote with co-author Jordan Gruber, and talking about, you know, just how you think about the self or selves, plural, and that could be interesting.
00:08:31.860 But just to get a little more of your backstory, so when were you—you were—you did your graduate work at Stanford, correct?
00:08:39.140 Yeah, that's correct.
00:08:39.920 So you weren't at Harvard getting dosed by Richard Alpert and Tim Leary.
00:08:45.520 How did you—how did you come to—
00:08:46.680 No, I—I—I was just before that, and they—Richard—Richard—Richard—Dick Alpert and I had become friends.
00:08:53.200 I was an undergraduate, and I worked for a summer for him in a research project in California, so—and we actually shared a house.
00:09:00.660 So we were really genuine friends, and I was living in Paris, truly writing a novel, and he showed up on his way to Copenhagen, where he was to present with Aldous Huxley and Tim Leary the first major presentation about psychedelics to the World Council of Psychologists.
00:09:22.580 We met, and I took him to a little cafe on the—Richard Alpert and I are sitting there, and he's—he's really looking and feeling a lot—a lot less neurotic than I knew him to be.
00:09:37.900 He was brilliant, neurotic, ambitious, charming, a lot of wonderful things.
00:09:41.540 And he said, the greatest thing in the world has happened to me, and I want to share it with you.
00:09:46.220 And I thought, well, how bad can that be?
00:09:49.520 And then he took out of his breast pocket a little bottle of pills, and I—I didn't freak out, but I certainly withdrew emotionally.
00:09:57.740 I was so straight, I was not drinking coffee.
00:10:01.180 But he said, here, try this.
00:10:04.220 So I took a pill, which I now would say would be a moderate dose of psilocybin.
00:10:09.180 Mm-hmm.
00:10:10.300 Oh, you said this was synthetic psilocybin.
00:10:12.240 This is not the LSD.
00:10:14.080 Right.
00:10:14.440 Yeah.
00:10:14.760 So this was—they had not—they had not discovered LSD at this time.
00:10:18.000 They started with psilocybin.
00:10:20.300 And after a while, the colors got brighter, and everything began to, you know, jiggle a little with energy.
00:10:29.040 And that was all new to me.
00:10:30.420 And then I was also aware of the conversations behind me as people were walking by, as one does.
00:10:36.840 And then I suddenly realized that my French isn't that good, wasn't that good.
00:10:41.600 And I could never hear those conversations prior to this.
00:10:45.840 And I looked at Dick, and I said, this is really too much for me.
00:10:49.760 And he said, well, why don't we go back to your hotel room?
00:10:52.560 And that was great.
00:10:53.960 And he said, it's too much for me, too.
00:10:55.660 And I said, what do you mean?
00:10:56.640 You haven't taken anything.
00:10:57.780 He said, this is my first night in Paris.
00:10:59.720 So we both withdrew to my sixth-floor walk-up, and some of my cherished beliefs were disassembled about what was valuable and not valuable in my life.
00:11:12.500 Nothing therapeutic breakthrough, but just an awareness that there was a more to the way the world was.
00:11:20.360 But I was still me, and it was still my personality and my issues.
00:11:26.000 And a week later, I had followed Dick to Copenhagen, and where I had another session with him, which was really about human closeness and connection and kindness and support of one another at a level that the words don't handle too well.
00:11:44.640 If we had one more notch up in value of each of those words, that's what it was.
00:11:51.180 Life went on, and a few weeks later, I was at Stanford, and I discovered in one little tiny corner of Stanford a professor who was working with psychedelics.
00:12:03.640 And experience that has forever shifted my awareness, my belief system, and also shifted my career.
00:12:15.300 So that's a little more backstory.
00:12:18.000 When would this have been?
00:12:18.820 Around the early 60s?
00:12:21.220 1961.
00:12:22.600 Yeah.
00:12:22.800 Yeah.
00:12:23.100 Yeah, well, it's, yeah, so I'm sure that you and I met with Richard Alpert, who was then later known as Ram Dass, at some point in the late 80s, somewhere near Stanford.
00:12:40.300 So anyway, it's great to meet again.
00:12:41.840 Before we dive into this, I just want to offer the obligatory disclaimer to our listeners that, you know, we're not giving medical advice.
00:12:49.600 We're not recommending that you personally take psychedelics, and we, obviously, we don't know your personal situation, dear listener.
00:12:59.420 So you just have to read the lines and between the lines in this conversation to extract anything that might be useful to you in your specific situation.
00:13:09.780 I mean, obviously, we're not going to soft-pedal the underlying truth here, which is that psychedelics have been incredibly useful to each of us personally, and the resurgence of research on them holds great promise for everyone, really.
00:13:28.000 And it's one of the happier developments in recent years in psychological science.
00:13:33.900 But obviously, where most people are living, these drugs are likely to be illegal, and therefore you encourage some risk just taking them, however benign your experience on them might be.
00:13:47.060 And, you know, some people can have bad experiences, which we'll get into.
00:13:51.820 So with that caveat out of the way, let's start with general considerations here, Jim.
00:13:59.420 Who should and shouldn't think about taking psychedelics?
00:14:05.080 Well, one of, obviously, the questions I get a lot over the years is, I'm thinking of taking LSD, but, and I say, don't do it.
00:14:15.300 And they say, but I haven't told you my reasons.
00:14:17.560 I said, no, if you feel there's a reason you shouldn't take a psychedelic, you have to listen to that.
00:14:23.080 So my caveat is much stronger than yours, Sam, in that way.
00:14:28.860 And the question of who and who shouldn't take it is only one that can be answered by an individual.
00:14:35.920 I can tell you that if you read the literature, there's a lot of discussion about not having a psychedelic.
00:14:43.960 These are all high-dose discussions we're having right now.
00:14:46.900 Yeah, we'll talk about microdosing later.
00:14:49.160 But for high doses, the science world says, not if you've had a psychotic episode, not if you've been a schizophrenic, not if you're bipolar, and not if you've had a serious mental, you know, something like that.
00:15:03.600 Now, I used to wonder about that, is where did we get that information?
00:15:08.160 So I started searching around, and I asked some of the senior researchers who were friends, and the answer was, actually, there isn't any information like that out there.
00:15:19.100 What there is is people doing research don't want those people in the research, because if they have a bad experience or six months later they have a bad experience that has nothing to do with psychedelics, they will blame it on psychedelics.
00:15:35.440 Now, I follow this a little bit more with bipolar, because that's one of the groups that can never get in any research projects.
00:15:45.620 And if you go online, of course, if you go to the web, of course, there's a group of people who are bipolar who talk to each other.
00:15:52.400 And so I asked them, would you comment, if any of you have had any psychedelic experience, do you have any advice for the other people on this group?
00:16:05.040 And the general advice was from people who had used psychedelics, and I don't know how and under what conditions, but they said, on the manic phase of being bipolar, don't take anything.
00:16:20.020 And on the depressive phase of bipolar, a number of them said that psychedelics had been very helpful.
00:16:27.240 So that's not published, and that's not science, but that's what I call citizen science, which is what's actually happening out there.
00:16:35.640 And it's important to keep, there are a lot of research studies, and most of them are very favorable and exciting.
00:16:40.760 But behind that, since psychedelics were made illegal in the late 60s, early 70s, in the United States, and just the United States, 30 million people have tried high-dose psychedelics, or just LSD, not all psychedelics.
00:16:59.360 And as of yet, we have no deaths, and we have a lot of people who had very unhappy and difficult experiences.
00:17:09.320 But in some senses, it's a very safe, these are safe substances physiologically, and if you don't know what you're doing, you can have a terrible experience, even on a moderate dose.
00:17:21.540 So the variable is having some understanding of what you're doing and what you're learning.
00:17:29.580 And so recommending or not recommending is not something I do except to not recommend unless you know what you're doing.
00:17:36.000 Yeah, this is a bit of a conundrum, however, because even very experienced psychonauts, as you know, can feel significant trepidation when thinking about taking a high dose of anything.
00:17:52.340 I mean, it's just that even knowing what you're in for, even having experiences under your belt that you consider to be not only benign, but incredibly transformative, you still approach this howling abyss with the appropriate awe and concern, you know, often.
00:18:12.120 And even someone as seasoned as Terrence McKenna would talk about the feeling of fear he would live with around this consideration of whether he should trip again.
00:18:25.380 And so if your prescription or non-prescription is, if you feel any hesitation about doing this, don't do it, it's a little hard to apply.
00:18:36.400 Well, that's probably why I put it out there, because it gives people a hesitation.
00:18:40.780 And the image that came to mind, as you were saying it, is skydiving.
00:18:45.120 No matter how many times you skydive and how carefully you check your gear, you know that sometimes people fall out of the sky and the chute doesn't open.
00:18:58.640 And it's not a matter of skill or experience.
00:19:02.340 It's a matter of the facts are that these substances will take you places you do not intend.
00:19:09.460 And I think that's part of the reason why I've backed off from high-dose work and high-dose research, because it can be, it can always be not only a scary experience, which is fine.
00:19:25.620 People, you know, pay a lot of money to be frightened if you've ever been to what's called an amusement park.
00:19:31.480 But the question of benefit is really where I'm looking at.
00:19:37.420 I'm not really that interested in people who kind of are tripping because their streaming service is down.
00:19:46.740 I'm very interested in people who are saying,
00:19:50.420 I really want to learn something important that will perhaps change my life, and therefore I'm preparing appropriately.
00:19:58.780 Hmm.
00:19:59.860 Yeah, I should say, I've said before, that I didn't take any psychedelics for at least 25 years based on the kinds of concerns we've just sketched here.
00:20:11.060 I mean, just a growing awareness of what a colossal spin of the psychological roulette wheel it was.
00:20:20.340 And having had some scary experiences, I decided, you know, meditation was a much more governable game.
00:20:28.960 And so, you know, it wasn't until very recently, about a little over a year ago, that I had my first in several decade significant trip, which I found incredibly useful.
00:20:41.740 But the seriousness of intent that should frame this project is worth emphasizing, because there really is a distinction between a recreational approach to these things.
00:20:54.020 I mean, you're just bored and you want to have fun, and you might do this at a party or do it at a concert or, you know, under conditions where those things exist.
00:21:04.340 Obviously, we're having this conversation during the COVID pandemic, and there's not a lot of either of those things.
00:21:09.360 But people tend to approach this frivolously, and it's not that, you know, that doesn't, certainly doesn't guarantee a bad experience.
00:21:18.800 You can have a great experience doing that, but it's not really the appropriate orientation, in my view.
00:21:27.900 And it sounds like you agree, Jim.
00:21:29.260 It's just that there really is, these are incredibly powerful tools.
00:21:33.560 Well, as my favorite kind of, what, why you have to, why recreational, it may be a little more risky than you think,
00:21:40.120 is my kind of young people who said to me once, we were having this fabulous trip until the car caught on fire.
00:21:49.260 That really shifted everybody's reality in a way that they weren't able to cope.
00:21:53.620 So, we're really looking at something, and actually, in terms of my being conservative,
00:22:00.780 and it's wonderful that psychedelics have moved so far that I'm conservative,
00:22:04.820 is if you're going to have a high-dose experience and you intend to get anything from it,
00:22:11.600 it's very important to have a guide, a companion, a designated driver, so to speak,
00:22:19.020 somebody who knows more than you do and cares about you,
00:22:24.560 that turns out to be a way of preventing almost all strongly negative experiences.
00:22:30.360 Because when you're caught in a negative experience and you're on your own
00:22:33.460 or you're with other people who are off on their own trips, it's very hard to get out.
00:22:39.540 When there's a guide, it's very easy to get out.
00:22:43.000 So, let's talk about that, each of those in chapters.
00:22:46.700 So, I want to talk about the role of a guide here, but this section might be called set and setting.
00:22:54.600 How do you recommend, and again, we're talking about large effective doses here,
00:23:00.000 not micro doses, which we'll talk about later.
00:23:03.080 How do you think about people preparing for a significant trip,
00:23:08.640 whether it's psilocybin or LSD or ayahuasca,
00:23:13.200 or we can talk about specific compounds in a moment.
00:23:16.700 How do you think about the concept of set and setting?
00:23:21.140 Well, what we know is that psychedelics are incredibly sensitive to set or your mental attitude
00:23:28.600 and setting, the literally physical situation you're in,
00:23:32.400 and that includes the other people who are around.
00:23:34.680 And the main reason that I wrote that book, The Psychedelic Explorer's Guide,
00:23:40.780 is for the first two chapters, which detail how to become a good journeyer,
00:23:46.420 how to set yourself up the best way possible,
00:23:50.880 and also how a guide should behave and what knowledge they should have.
00:23:57.780 Because it's not a simple question.
00:24:00.600 But fundamentally, the question is always,
00:24:04.480 do you feel safe?
00:24:05.900 Is it truly safe?
00:24:07.840 Is it private so you won't be disturbed?
00:24:11.160 And do you have some idea of what you,
00:24:14.040 do you understand the substance?
00:24:15.780 Do you understand what the doses are like?
00:24:19.380 And do you have some intentions?
00:24:22.580 And perhaps that's what set is about,
00:24:24.860 which is what do you intend?
00:24:27.220 And it is likely that you will have what you intend,
00:24:32.200 but you'll have something else that goes with it.
00:24:35.880 So all of those are important.
00:24:38.260 And I think the way I've said it is it's set and setting and situation,
00:24:41.600 which is what's your life situation?
00:24:44.020 If your life situation is very difficult,
00:24:46.500 even if you're in a lovely set and setting,
00:24:49.380 it's not going to,
00:24:50.140 your life situation is going to impinge on that
00:24:52.520 and you're going to be in trouble.
00:24:54.060 What's the substance?
00:24:55.300 Do you know what you're taking?
00:24:56.780 If you bought it illegally,
00:24:58.420 has it been tested?
00:25:00.620 The word I use then is sitter,
00:25:02.680 because I'm actually trying just to use S's,
00:25:04.800 because you do that when you write books.
00:25:07.780 But a sitter is almost like a coach.
00:25:11.060 And a coach doesn't bother you
00:25:12.880 unless something is needed to be helped.
00:25:16.980 So if you, for instance,
00:25:18.200 you're lying on a couch,
00:25:20.180 you have music,
00:25:20.980 you take off the headphones,
00:25:22.160 you sit up and you said,
00:25:23.300 I think I'm dying.
00:25:25.520 And you do.
00:25:26.840 You think you're dying
00:25:27.840 and everything in your mind is telling you that.
00:25:32.040 And the guide, friend, sitter,
00:25:34.660 looks over at you and said,
00:25:35.940 oh, that's great.
00:25:37.820 And reaches out his hand or her hand.
00:25:40.320 And part of you says,
00:25:42.800 wait, wait, wait, wait.
00:25:43.420 I just said I'm dying.
00:25:44.500 And this person who I know and love says it's great.
00:25:48.120 And then another part of you said,
00:25:49.260 oh,
00:25:49.600 I took this substance
00:25:51.960 and it's taking me in a different,
00:25:54.380 and I'll just see what,
00:25:56.240 what actually is being,
00:25:58.100 by the notion that I'm dying.
00:25:59.280 And what people then find out,
00:26:01.360 and this is more on reflection later,
00:26:03.240 is as your ego is noticing
00:26:05.560 that it's about to be demoted
00:26:07.320 from amazingly important
00:26:10.000 to something that is useful,
00:26:13.080 it often will come up
00:26:14.960 with these amazing scenarios
00:26:16.580 of what a bad idea it is
00:26:19.060 for the rest of you
00:26:20.740 to discover the correct placement
00:26:23.680 or the correct kind of status
00:26:25.780 of your so-called identity.
00:26:28.420 Remember,
00:26:29.900 Alan Watts had a wonderful comment
00:26:31.560 as he would look in the mirror
00:26:32.640 and he'd say,
00:26:34.280 what percentage of me
00:26:35.800 has ever heard of Alan Watts?
00:26:39.220 If you just look at yourself physiologically,
00:26:41.440 the answer is a tiny amount of your brain
00:26:43.700 has to do with your identity.
00:26:45.400 And the rest of it really has other,
00:26:46.940 other preoccupations.
00:26:49.680 So that's part of what I'm suggesting
00:26:52.980 is why preparation is important.
00:26:55.800 Do you want to say any more
00:26:57.840 about the role of a guide?
00:26:59.160 I mean, can a guide be simply
00:27:01.640 any well-intentioned person
00:27:03.420 who's not tripping along with you
00:27:06.300 or does it require some special experience?
00:27:09.320 Well, the fact of the matter
00:27:11.380 is that most people
00:27:12.440 do not have access
00:27:13.560 to highly trained,
00:27:15.100 sophisticated guides
00:27:16.500 who participated in research studies,
00:27:19.560 et cetera.
00:27:21.020 So the reality of it,
00:27:23.180 what my opinion or not,
00:27:24.520 is that very kind, loving people
00:27:26.840 who've had prior psychedelic experiences
00:27:30.020 that are positive
00:27:30.880 often can be very healthy, safe guides.
00:27:35.600 Again, the term is close
00:27:39.820 to designated driver
00:27:41.100 where you don't need someone
00:27:43.380 who is an auto mechanic
00:27:44.600 and a race car driver
00:27:45.700 to be your designated driver.
00:27:47.160 You need someone
00:27:47.680 who has control of their feelings
00:27:50.060 and emotions,
00:27:51.040 is physiologically sound,
00:27:52.940 and who knows how to drive.
00:27:55.240 So it would be,
00:27:56.680 there is a whole class of people
00:27:59.020 known as guides.
00:28:02.140 According to Michael Pollan
00:28:03.580 in his work for his book,
00:28:05.280 he says there are hundreds of them
00:28:06.440 across the country.
00:28:08.460 There is even an international guild of guides
00:28:11.580 which has been formed
00:28:13.280 in the Netherlands.
00:28:14.760 So there is an occupation
00:28:16.380 where you can actually,
00:28:19.700 in many locations,
00:28:20.960 find people who will,
00:28:23.120 who have a lot of experience
00:28:24.360 in sitting with people.
00:28:25.860 And so that's a kind of in-between place.
00:28:28.600 And I was struck a few years ago
00:28:31.900 in Berkeley on a,
00:28:33.680 you know, on a power pole,
00:28:36.200 there was stapled a little notice
00:28:38.340 that said trip sitter,
00:28:40.180 which is someone who will sit with you
00:28:41.800 while you are tripping.
00:28:43.140 And it basically gave a phone number.
00:28:45.320 And this was someone
00:28:46.500 who you could hire
00:28:47.660 to come to your house
00:28:49.480 and sit with you.
00:28:50.440 So we are creating
00:28:52.240 a kind of new occupational
00:28:54.380 grouping here
00:28:56.800 of people who know
00:28:58.300 not only a lot more than you do,
00:29:00.340 but consider it,
00:29:01.400 consider it usually
00:29:02.760 more than a vocation
00:29:03.880 to help you.
00:29:05.620 And I guess a final question
00:29:06.600 on setting,
00:29:07.800 how do you think about
00:29:08.520 the difference between
00:29:09.680 taking one of these compounds,
00:29:12.760 let's say LSD or psilocybin,
00:29:14.900 out in nature
00:29:16.360 or, you know,
00:29:17.120 with senses directed outward
00:29:19.660 versus an internal journey,
00:29:23.140 whether you're blindfolded
00:29:25.000 or just in a dark room?
00:29:28.420 Well, I think it's the same discussion
00:29:30.560 you have about mysticism.
00:29:32.400 There's internal mysticism
00:29:34.080 where you go inside,
00:29:35.500 then you find that everything
00:29:36.600 in the universe is inside,
00:29:38.300 or you go outside
00:29:40.040 and you find that everything
00:29:41.560 in the universe is outside.
00:29:43.960 The difference is that
00:29:45.880 if you have,
00:29:47.020 if you're interested more
00:29:48.240 in your own psychodynamics
00:29:49.640 and you have, say,
00:29:52.340 therapeutic intentions,
00:29:54.040 probably you will do better
00:29:55.520 staying inside
00:29:57.440 where you are less
00:30:00.300 literally likely
00:30:01.040 to be distracted
00:30:02.180 by the amazing beauty
00:30:04.560 of the 10,000 things.
00:30:06.640 If you wish to blend more,
00:30:11.580 to become more aware
00:30:13.560 of your continuity
00:30:14.840 with the natural world,
00:30:16.180 then outside is fantastic
00:30:18.600 and will give you
00:30:21.040 a recognition
00:30:22.700 of your continuity
00:30:24.600 with the natural world
00:30:25.720 that is not,
00:30:26.920 that you don't lose,
00:30:28.160 you don't forget.
00:30:30.040 Now, let's talk about dosage
00:30:31.900 and here we can talk about
00:30:33.600 microdosing as well.
00:30:35.160 And am I right in thinking
00:30:36.740 that you're essentially
00:30:37.860 the father of microdosing
00:30:39.420 at this point?
00:30:39.920 I think at the moment
00:30:41.920 I'm probably the person
00:30:44.120 who has the largest number
00:30:47.240 of cases in his research base
00:30:50.540 and has talked the most about it
00:30:52.820 and is probably the most quoted.
00:30:55.920 There's a generation
00:30:56.880 of researchers coming up
00:30:58.280 fast behind me
00:30:59.840 and will soon push me aside,
00:31:02.380 but for right now,
00:31:05.100 yeah, I'm probably
00:31:06.440 the most well-known person
00:31:09.900 and has done
00:31:11.360 and has reported
00:31:12.720 on microdoses
00:31:13.580 in ways that other people
00:31:15.080 haven't, yeah.
00:31:16.760 Okay, well,
00:31:17.260 that was a walk around
00:31:18.560 what was an attempt
00:31:20.260 at humility
00:31:20.800 and I think it failed.
00:31:22.700 Well, you're going to have
00:31:24.020 to boost the dosage
00:31:25.120 then, I think, Jim.
00:31:26.540 That's always,
00:31:27.560 that's not necessarily
00:31:29.120 always the best suggestion, Sam.
00:31:31.940 So, let's differentiate
00:31:34.040 these two projects
00:31:35.000 because they really are distinct.
00:31:36.640 So, let's talk about
00:31:37.860 macro dosing first.
00:31:40.240 Yeah, let me just go
00:31:40.940 right up the line.
00:31:42.160 Sure.
00:31:42.600 And let's start
00:31:43.900 at around 25 micrograms
00:31:46.460 where people report
00:31:47.640 some psychedelic effects
00:31:49.900 very mild.
00:31:51.740 Of LSD.
00:31:53.320 We're just talking LSD
00:31:54.740 and I'll do it in micrograms.
00:31:56.240 Okay.
00:31:57.280 Around 50 micrograms
00:31:59.160 is a,
00:32:01.020 what was called
00:32:02.120 originally a museum dose
00:32:03.620 and now is called
00:32:04.460 a concert dose
00:32:05.220 and if you've ever wondered
00:32:07.280 when you go to a concert
00:32:08.260 why there's that
00:32:08.980 unbelievably
00:32:09.720 huge light show,
00:32:11.660 it's because
00:32:12.520 such a large percentage
00:32:13.780 of the patrons
00:32:14.420 have come
00:32:15.120 intending to get
00:32:17.200 as much out of the light show
00:32:18.260 as the music
00:32:18.880 and that maybe
00:32:20.720 is 50
00:32:21.440 to 100.
00:32:24.780 At
00:32:25.340 100 micrograms,
00:32:27.200 one can do
00:32:27.940 very hard-nosed
00:32:28.700 scientific research
00:32:29.780 and there's
00:32:31.540 a great many
00:32:32.160 companies around
00:32:33.020 the world
00:32:33.520 some of which
00:32:34.900 admit to it
00:32:35.660 where
00:32:36.240 a number of
00:32:37.460 breakthroughs
00:32:38.100 are attributed
00:32:38.780 to working in that way
00:32:40.720 with that dosage.
00:32:42.060 When you get into
00:32:43.160 the 100 to 200
00:32:44.280 microgram range,
00:32:45.560 it's
00:32:46.180 psychotherapeutic
00:32:47.380 which is
00:32:48.960 you can
00:32:49.640 work with
00:32:50.560 a therapist
00:32:51.300 somewhat the way
00:32:53.060 the therapist
00:32:53.660 wants to,
00:32:54.700 meaning you're still
00:32:55.380 in communication,
00:32:57.600 you will
00:32:58.180 trip off
00:33:00.100 into
00:33:00.700 kind of
00:33:01.460 thought loops
00:33:02.120 if someone,
00:33:02.920 if your therapist
00:33:03.580 says,
00:33:04.360 do you want to
00:33:04.960 look at the
00:33:05.940 death of your mother?
00:33:07.880 10 minutes later
00:33:08.660 you may return
00:33:09.560 to the room
00:33:10.460 and say,
00:33:11.440 yes,
00:33:11.860 thank you
00:33:12.300 for that,
00:33:14.080 I understand it
00:33:14.780 much better
00:33:15.300 and I understand
00:33:15.960 my reactions.
00:33:17.660 Once you go
00:33:18.440 above 200
00:33:19.300 and
00:33:20.340 up to,
00:33:21.620 say,
00:33:22.080 400,
00:33:23.220 then you're
00:33:23.820 usually talking
00:33:24.660 about what
00:33:26.000 is called
00:33:26.460 a transcendent
00:33:27.260 or a mystical
00:33:27.920 or a unity
00:33:28.660 experience.
00:33:29.760 That's when
00:33:30.480 you
00:33:31.380 lose
00:33:33.100 your primary
00:33:33.940 identification
00:33:34.780 with your
00:33:36.860 own
00:33:37.400 physical
00:33:38.980 identity
00:33:40.360 and your
00:33:40.900 own psychological
00:33:41.840 identity.
00:33:42.560 So you are
00:33:42.940 no longer,
00:33:43.620 if I'm
00:33:43.900 taking
00:33:44.980 400 micrograms,
00:33:47.160 at some point
00:33:48.040 Jim Fadiman
00:33:49.920 becomes
00:33:51.060 a subset
00:33:52.160 of the
00:33:53.260 larger being
00:33:54.260 that I
00:33:55.460 feel myself
00:33:56.020 to be.
00:33:56.980 And in
00:33:57.260 that state
00:33:57.920 people report
00:33:59.060 things like
00:34:01.140 experiencing
00:34:02.600 the birth
00:34:03.120 of the
00:34:03.460 universe
00:34:03.840 or
00:34:05.000 physically
00:34:05.560 their own
00:34:06.280 birth
00:34:06.660 or
00:34:07.480 memories
00:34:08.980 of past
00:34:09.780 identities.
00:34:11.560 It's what
00:34:12.420 we called
00:34:13.040 in an
00:34:13.340 original
00:34:13.740 report
00:34:15.100 in the
00:34:15.400 60s
00:34:15.840 the
00:34:16.060 psychedelic
00:34:16.740 experience
00:34:17.500 which is
00:34:18.480 experiencing
00:34:19.340 that your
00:34:20.700 that your
00:34:22.340 Alan Watts
00:34:23.140 said it
00:34:23.420 nicely
00:34:23.720 is you
00:34:24.260 exist
00:34:25.080 your body
00:34:25.920 doesn't end
00:34:26.440 at your
00:34:26.680 fingertips
00:34:27.080 and that
00:34:29.140 is a
00:34:30.320 revelation
00:34:30.940 to people
00:34:31.860 and on
00:34:32.820 their return
00:34:33.680 from that
00:34:34.620 higher dose
00:34:35.580 they often
00:34:36.880 will see
00:34:37.680 that parts
00:34:38.540 of their
00:34:38.940 own
00:34:39.420 emotional
00:34:40.600 physical
00:34:41.100 social system
00:34:42.020 are really
00:34:42.500 defective
00:34:43.180 and they
00:34:44.840 make massive
00:34:45.640 change
00:34:46.160 I recall
00:34:47.420 working with
00:34:47.880 several
00:34:48.180 alcoholics
00:34:48.960 and they
00:34:49.940 were referred
00:34:50.820 by the
00:34:51.160 court
00:34:51.360 so they
00:34:51.680 were not
00:34:52.000 exactly
00:34:52.460 eager to
00:34:52.980 have a
00:34:53.240 psychedelic
00:34:53.780 experience
00:34:54.200 this is
00:34:54.600 the early
00:34:54.960 60s
00:34:55.520 and all
00:34:56.600 of this
00:34:56.820 was not
00:34:57.420 known
00:34:57.780 and each
00:34:59.240 one of
00:34:59.580 them a
00:35:00.120 week later
00:35:00.580 went out
00:35:01.040 and drank
00:35:01.540 and then
00:35:02.800 came back
00:35:03.380 to us
00:35:03.820 and said
00:35:04.180 what have
00:35:04.520 you done
00:35:04.860 to me
00:35:05.280 and we
00:35:05.820 said
00:35:06.140 you know
00:35:06.700 we gave
00:35:07.240 you a
00:35:07.480 psychedelic
00:35:08.040 and they
00:35:08.740 said but
00:35:09.040 I don't
00:35:09.860 like drinking
00:35:10.560 it doesn't
00:35:11.920 feel good
00:35:12.520 it feels
00:35:12.980 like it
00:35:13.420 shrinks
00:35:13.840 my
00:35:14.220 expanded
00:35:16.100 awareness
00:35:16.500 so
00:35:18.580 there's a
00:35:19.740 wonderful
00:35:20.140 bit of
00:35:20.760 video footage
00:35:21.940 from some
00:35:22.620 work done
00:35:23.580 at Spring
00:35:24.040 Grove
00:35:24.240 Hospital
00:35:24.680 again in
00:35:25.120 the late
00:35:25.360 60s
00:35:25.880 this was
00:35:26.700 40 years
00:35:27.260 later
00:35:27.640 one of
00:35:28.500 these
00:35:28.880 overnight
00:35:30.060 recovered
00:35:30.540 alcoholics
00:35:31.360 and the
00:35:32.500 filmmaker
00:35:32.980 is saying
00:35:33.600 well
00:35:33.880 can you
00:35:35.320 talk about
00:35:35.760 your
00:35:35.900 drinking
00:35:36.180 he says
00:35:36.420 I haven't
00:35:36.720 had a
00:35:36.980 drink
00:35:37.240 in 40
00:35:38.220 years
00:35:38.600 and the
00:35:39.700 filmmaker
00:35:40.600 talks about
00:35:41.560 willpower
00:35:42.180 and the
00:35:42.940 man laughs
00:35:43.800 and says
00:35:45.240 it has
00:35:45.880 nothing to
00:35:46.180 do with
00:35:46.400 willpower
00:35:46.880 I've
00:35:47.400 never had
00:35:48.140 any interest
00:35:48.720 in drinking
00:35:49.280 ever since
00:35:50.000 so a
00:35:52.100 high dose
00:35:52.760 or a
00:35:53.260 mystical
00:35:53.600 experience
00:35:54.380 level dose
00:35:56.140 has a
00:35:57.300 number of
00:35:57.820 additional
00:35:58.280 effects
00:35:58.820 that will
00:35:59.720 not be
00:36:00.200 found at
00:36:00.840 lower doses
00:36:01.400 and that's
00:36:02.060 pretty much
00:36:02.440 all the way
00:36:02.940 down
00:36:03.720 the 200
00:36:05.000 psychotherapeutic
00:36:06.320 dose
00:36:06.580 you have
00:36:06.780 things
00:36:07.160 what will
00:36:07.540 happen
00:36:07.900 at a
00:36:08.260 lower
00:36:08.440 dose
00:36:08.760 etc
00:36:09.120 does
00:36:10.260 that
00:36:10.480 answer
00:36:11.020 what
00:36:11.460 do you
00:36:12.480 consider
00:36:12.800 an
00:36:12.980 analogous
00:36:13.480 dose
00:36:13.760 of
00:36:14.120 mushrooms
00:36:15.000 and or
00:36:17.100 synthetic
00:36:17.540 psilocybin
00:36:18.160 well
00:36:19.540 yeah
00:36:21.540 in the
00:36:22.000 couple of
00:36:22.500 thousand
00:36:22.940 cases
00:36:23.640 I have
00:36:24.320 we have
00:36:24.860 I think
00:36:25.080 one person
00:36:25.760 with synthetic
00:36:26.480 psilocybin
00:36:27.200 so
00:36:27.520 that's
00:36:28.540 interesting
00:36:28.800 it's
00:36:29.440 well I guess
00:36:31.540 it's coming
00:36:32.060 back now
00:36:32.800 right into
00:36:33.260 the research
00:36:33.960 but it's
00:36:34.760 not
00:36:34.880 coming back
00:36:35.640 because there
00:36:36.160 are a lot
00:36:36.440 of people
00:36:36.900 who can
00:36:37.220 make money
00:36:37.640 from it
00:36:38.080 it's
00:36:38.920 coming
00:36:39.160 back
00:36:39.500 research
00:36:40.180 because
00:36:40.480 researchers
00:36:41.120 who
00:36:42.880 come out
00:36:44.000 of a
00:36:44.460 psychopharmacology
00:36:46.280 model
00:36:46.800 want something
00:36:48.220 that's as
00:36:48.680 close to a
00:36:49.380 normal
00:36:49.880 psychologically
00:36:51.080 active
00:36:51.580 substance
00:36:52.220 as possible
00:36:52.960 and they
00:36:54.220 love to
00:36:54.660 have accurate
00:36:55.200 measurement
00:36:55.700 even though
00:36:56.360 the amount
00:36:57.860 a person
00:36:58.360 should take
00:36:59.040 should be
00:37:00.900 based on
00:37:01.560 what the
00:37:01.900 person
00:37:02.300 actually
00:37:02.820 needs
00:37:03.400 not on
00:37:04.860 their weight
00:37:05.600 or their
00:37:07.140 age
00:37:07.580 it's a
00:37:09.940 little bit
00:37:10.300 as if
00:37:10.680 people
00:37:11.260 came in
00:37:11.740 for meals
00:37:12.360 and you
00:37:12.760 gave everyone
00:37:13.580 the exact
00:37:14.380 amount
00:37:14.920 of each
00:37:15.960 food
00:37:16.400 carefully
00:37:17.320 measured
00:37:17.820 and they
00:37:18.860 said
00:37:19.040 but hey
00:37:19.420 I want
00:37:19.980 more
00:37:20.180 potatoes
00:37:20.580 and they
00:37:21.020 said
00:37:21.220 no
00:37:21.480 the study
00:37:22.460 says
00:37:22.940 everyone
00:37:23.780 has to
00:37:24.280 have the
00:37:24.660 exact
00:37:25.000 amount
00:37:25.320 of
00:37:25.440 potatoes
00:37:25.760 so
00:37:26.380 I have
00:37:27.100 obviously
00:37:27.600 some
00:37:27.940 biases
00:37:28.320 about
00:37:29.100 some
00:37:29.420 of the
00:37:29.600 scientific
00:37:29.980 research
00:37:30.580 even the
00:37:31.340 best
00:37:31.580 of it
00:37:31.860 but what
00:37:33.540 we're
00:37:33.660 looking at
00:37:34.200 with
00:37:34.400 psilocybin
00:37:35.040 is
00:37:36.160 three
00:37:36.540 to five
00:37:37.300 grams
00:37:39.100 of
00:37:40.120 mushroom
00:37:40.620 will
00:37:41.920 give you
00:37:42.520 a fairly
00:37:43.620 expansive
00:37:44.360 trip
00:37:45.220 people have
00:37:46.680 taken much
00:37:47.240 more than
00:37:47.680 that
00:37:48.020 and at
00:37:49.000 some
00:37:49.260 point
00:37:49.720 they
00:37:50.360 stop
00:37:51.560 bringing
00:37:52.020 back
00:37:52.520 useful
00:37:53.040 information
00:37:53.720 and so
00:37:54.560 in my
00:37:55.200 world
00:37:55.560 that's
00:37:56.160 what too
00:37:56.440 much
00:37:56.660 of a
00:37:56.900 dose
00:37:57.160 is
00:37:57.440 each
00:37:58.740 mushroom
00:37:59.140 has
00:37:59.420 its
00:37:59.640 own
00:38:00.100 level
00:38:01.400 its own
00:38:02.380 amount
00:38:03.000 of
00:38:03.200 psilocybin
00:38:03.840 even if
00:38:04.260 you have
00:38:04.600 mushrooms
00:38:05.060 from the
00:38:05.500 same
00:38:05.920 little
00:38:07.480 patch
00:38:07.980 the same
00:38:08.720 species
00:38:09.180 they'll
00:38:09.500 be
00:38:09.660 different
00:38:10.000 so it's
00:38:11.400 much
00:38:11.580 harder
00:38:12.020 when you
00:38:12.320 get into
00:38:12.720 natural
00:38:13.100 substances
00:38:13.720 and for
00:38:15.120 example
00:38:15.560 what I
00:38:16.040 know
00:38:16.320 is
00:38:16.640 in
00:38:16.980 ayahuasca
00:38:17.920 the
00:38:19.460 ayahuasquero
00:38:20.100 the
00:38:20.480 shaman
00:38:21.680 who's
00:38:22.060 giving
00:38:22.460 the medicine
00:38:24.960 whether
00:38:25.920 they're
00:38:26.260 trained
00:38:26.700 in
00:38:26.880 South
00:38:27.100 America
00:38:27.540 or
00:38:27.940 one
00:38:28.940 of
00:38:29.040 the
00:38:29.180 hundred
00:38:29.480 or so
00:38:29.860 in
00:38:29.980 Los
00:38:30.180 Angeles
00:38:30.580 they'll
00:38:31.660 give
00:38:31.920 you
00:38:32.060 what
00:38:32.280 they
00:38:32.440 think
00:38:32.720 is
00:38:32.880 a
00:38:33.020 good
00:38:33.200 amount
00:38:33.660 and
00:38:34.580 then
00:38:34.800 later
00:38:35.160 on
00:38:35.680 they
00:38:36.520 will
00:38:36.700 give
00:38:36.960 you
00:38:37.120 more
00:38:37.480 if
00:38:37.720 that
00:38:37.900 seems
00:38:38.200 to
00:38:38.420 be
00:38:38.740 useful
00:38:39.480 now
00:38:40.280 how
00:38:40.480 much
00:38:40.840 is
00:38:40.960 a
00:38:41.100 good
00:38:41.260 amount
00:38:41.680 okay
00:38:42.340 it's
00:38:43.120 a
00:38:43.280 quarter
00:38:43.560 cup
00:38:43.900 it's
00:38:44.100 a
00:38:44.200 half
00:38:44.460 cup
00:38:44.780 they're
00:38:46.540 using
00:38:47.020 their
00:38:47.460 clinical
00:38:47.980 their
00:38:48.540 kind
00:38:48.760 of
00:38:48.880 intuitive
00:38:49.300 knowledge
00:38:50.040 rather
00:38:51.160 than
00:38:51.640 a
00:38:52.080 scale
00:38:52.400 so
00:38:53.400 once
00:38:53.660 you
00:38:53.800 get
00:38:53.980 into
00:38:54.200 organics
00:38:54.720 it's
00:38:54.960 much
00:38:55.300 harder
00:38:55.620 to
00:38:55.840 say
00:38:55.980 what's
00:38:56.280 the
00:38:56.420 right
00:38:56.640 amount
00:38:57.000 when
00:38:57.820 you
00:38:57.960 get
00:38:58.520 into
00:38:58.660 micro
00:38:58.940 dosing
00:38:59.380 it's
00:38:59.660 much
00:38:59.840 easier
00:39:00.180 question
00:39:01.380 of
00:39:01.580 dose
00:39:01.900 has
00:39:02.100 always
00:39:02.540 been
00:39:02.960 subjective
00:39:03.860 and
00:39:05.180 the
00:39:05.320 people
00:39:05.660 that
00:39:05.880 I
00:39:06.000 worked
00:39:06.200 with
00:39:06.360 clinically
00:39:06.700 I
00:39:07.500 gave
00:39:07.680 you
00:39:07.760 those
00:39:07.940 numbers
00:39:08.340 but
00:39:08.880 let
00:39:09.180 me
00:39:09.320 show
00:39:10.700 you
00:39:10.880 how
00:39:11.360 it
00:39:11.520 works
00:39:11.960 400
00:39:13.100 micrograms
00:39:14.000 is
00:39:14.300 an
00:39:14.820 amazing
00:39:15.240 amount
00:39:15.680 of
00:39:16.140 psychedelic
00:39:16.780 however
00:39:18.480 when
00:39:20.000 you
00:39:20.180 have
00:39:20.420 an
00:39:20.560 alcoholic
00:39:21.140 you
00:39:22.960 give
00:39:23.180 them
00:39:23.380 400
00:39:23.860 micrograms
00:39:24.780 and
00:39:24.940 an
00:39:25.220 hour
00:39:25.400 and
00:39:25.520 a
00:39:25.580 half
00:39:25.780 later
00:39:26.100 they're
00:39:26.380 walking
00:39:26.720 around
00:39:27.120 the
00:39:27.300 room
00:39:27.540 and
00:39:27.660 saying
00:39:27.960 man
00:39:28.680 something's
00:39:29.040 going
00:39:29.220 on
00:39:29.440 but
00:39:29.560 I
00:39:29.680 don't
00:39:29.820 feel
00:39:30.020 comfortable
00:39:30.460 and
00:39:30.780 what
00:39:31.400 are
00:39:31.480 you
00:39:31.600 guys
00:39:31.880 doing
00:39:32.120 anyway
00:39:32.460 anyone
00:39:33.800 else
00:39:34.180 at
00:39:34.440 that
00:39:34.620 point
00:39:34.920 is
00:39:35.200 on
00:39:35.600 the
00:39:35.760 couch
00:39:36.120 voluntarily
00:39:36.900 asking
00:39:37.760 for
00:39:38.120 headphones
00:39:38.560 and
00:39:39.520 a
00:39:39.900 blindfold
00:39:40.340 because
00:39:40.920 the
00:39:41.540 input
00:39:42.080 is
00:39:42.320 so
00:39:42.500 overwhelming
00:39:42.980 well
00:39:44.260 when
00:39:44.540 you
00:39:44.800 add
00:39:46.140 to
00:39:46.500 the
00:39:46.740 alcoholics
00:39:47.620 cocktail
00:39:48.500 another
00:39:49.020 400
00:39:49.480 micrograms
00:39:50.320 so
00:39:50.420 they're
00:39:50.540 now
00:39:51.140 800
00:39:51.560 micrograms
00:39:52.260 which
00:39:52.400 I
00:39:52.500 don't
00:39:52.640 recommend
00:39:52.960 to
00:39:53.120 anybody
00:39:53.500 they
00:39:54.640 settle
00:39:55.000 down
00:39:55.320 and
00:39:56.360 again
00:39:56.740 behave
00:39:58.000 exactly
00:39:58.620 the way
00:39:59.040 everyone
00:39:59.400 else
00:39:59.660 does
00:39:59.980 on a
00:40:00.280 much
00:40:00.440 lower
00:40:00.680 dose
00:40:01.060 and
00:40:02.900 I
00:40:03.000 looked
00:40:03.220 at that
00:40:03.520 for a
00:40:03.780 long
00:40:03.960 time
00:40:04.280 I
00:40:04.400 actually
00:40:04.620 studied
00:40:05.480 alcoholism
00:40:06.780 and
00:40:07.060 why
00:40:07.580 most
00:40:07.900 treatments
00:40:08.220 don't
00:40:08.500 work
00:40:08.780 and
00:40:10.480 what
00:40:10.620 I
00:40:10.760 realized
00:40:11.200 with
00:40:11.440 psychedelics
00:40:12.140 is
00:40:12.320 alcoholics
00:40:13.120 have
00:40:13.440 learned
00:40:14.180 and
00:40:14.500 have
00:40:14.720 a
00:40:14.900 physiology
00:40:15.380 that
00:40:15.840 cooperates
00:40:16.620 to
00:40:17.420 handle
00:40:18.080 very
00:40:19.000 large
00:40:19.420 doses
00:40:19.840 of
00:40:20.120 substances
00:40:20.680 that
00:40:21.660 distort
00:40:22.060 consciousness
00:40:22.640 so
00:40:23.620 in a
00:40:24.240 sense
00:40:24.460 their
00:40:24.720 ability
00:40:25.120 to
00:40:25.340 hold
00:40:25.660 on
00:40:26.060 and
00:40:26.340 to
00:40:26.600 hang
00:40:27.200 on
00:40:27.420 to
00:40:27.520 their
00:40:27.680 defenses
00:40:28.200 is
00:40:29.120 far
00:40:29.460 more
00:40:29.740 developed
00:40:30.320 than
00:40:31.140 for
00:40:31.320 the
00:40:31.440 rest
00:40:31.640 of
00:40:31.780 us
00:40:32.020 so
00:40:33.720 so
00:40:33.740 I
00:40:34.000 I'm
00:40:34.180 dancing
00:40:34.940 around
00:40:35.360 the
00:40:35.560 dosage
00:40:35.980 question
00:40:36.500 because
00:40:37.120 it's
00:40:38.100 not
00:40:38.260 quite
00:40:38.640 the
00:40:38.840 appropriate
00:40:39.260 question
00:40:39.780 the
00:40:39.940 appropriate
00:40:40.360 question
00:40:40.880 is
00:40:41.080 what
00:40:41.260 is
00:40:41.420 the
00:40:41.580 correct
00:40:41.940 amount
00:40:42.300 for
00:40:42.520 this
00:40:42.780 person
00:40:43.180 on
00:40:43.440 this
00:40:43.700 day
00:40:44.060 for
00:40:44.780 this
00:40:45.120 intention
00:40:45.640 and
00:40:47.620 that
00:40:47.760 of
00:40:47.920 course
00:40:48.120 is
00:40:48.300 an
00:40:48.420 individual
00:40:48.860 question
00:40:49.400 is
00:40:50.300 there
00:40:50.400 anything
00:40:50.760 in
00:40:51.780 your
00:40:51.920 mind
00:40:52.140 that
00:40:52.360 significantly
00:40:53.540 differentiates
00:40:55.080 the
00:40:55.500 experience
00:40:56.900 on
00:40:57.800 a high
00:40:58.380 dose
00:40:58.620 of
00:40:58.760 LSD
00:40:59.240 versus
00:41:00.500 a high
00:41:00.900 dose
00:41:01.160 of
00:41:01.500 psilocybin
00:41:02.200 that is
00:41:03.680 mushrooms
00:41:04.080 in most
00:41:04.740 cases
00:41:05.060 well
00:41:06.220 the
00:41:07.080 feeling
00:41:07.580 in
00:41:07.980 the
00:41:08.400 underground
00:41:09.680 who takes
00:41:10.280 a lot
00:41:10.540 more drugs
00:41:11.000 than I
00:41:11.320 do
00:41:11.540 is
00:41:12.880 that
00:41:13.120 psilocybin
00:41:13.880 is a
00:41:14.340 kinder
00:41:14.940 experience
00:41:15.460 it's a
00:41:15.940 more
00:41:16.200 emotionally
00:41:16.880 gentle
00:41:17.620 experience
00:41:18.420 and
00:41:19.640 that's
00:41:19.960 partly
00:41:20.360 it is
00:41:21.240 said
00:41:21.480 because
00:41:21.860 there is
00:41:22.220 a plant
00:41:22.620 spirit
00:41:23.080 behind
00:41:23.560 it
00:41:23.940 LSD
00:41:25.240 is
00:41:25.520 considered
00:41:26.020 a little
00:41:26.820 colder
00:41:27.360 a little
00:41:27.900 more
00:41:28.280 powerful
00:41:29.720 it doesn't
00:41:31.620 let you
00:41:32.000 off
00:41:32.300 easy
00:41:32.640 and I
00:41:34.740 know
00:41:34.920 these are
00:41:35.340 all
00:41:35.700 very vague
00:41:36.460 terms
00:41:36.900 unless you
00:41:37.560 know what
00:41:37.780 I'm
00:41:37.920 talking
00:41:38.280 about
00:41:38.700 my
00:41:40.020 research
00:41:40.460 associate
00:41:41.040 doctors
00:41:41.740 fire
00:41:42.060 corb
00:41:42.640 at one
00:41:42.940 point
00:41:43.340 set up
00:41:44.580 a little
00:41:44.860 bot
00:41:45.260 and it
00:41:45.940 asked the
00:41:46.460 little
00:41:46.640 bot
00:41:46.940 to say
00:41:47.460 here's
00:41:48.000 a hundred
00:41:48.780 reports
00:41:49.460 from
00:41:49.760 erowid
00:41:50.240 about
00:41:50.560 psilocybin
00:41:51.220 experiences
00:41:51.920 here are
00:41:52.780 a hundred
00:41:53.040 reports
00:41:53.660 of LSD
00:41:54.280 experiences
00:41:55.140 can you
00:41:56.720 this little
00:41:57.440 learning bot
00:41:58.200 distinguish
00:41:58.960 the two
00:41:59.760 if you
00:42:00.940 can't be
00:42:02.060 told which
00:42:02.560 substance
00:42:02.940 it is
00:42:03.260 so it
00:42:03.460 kind of
00:42:04.120 blinded
00:42:04.920 artificial
00:42:05.740 intelligence
00:42:06.420 and the
00:42:08.380 AI
00:42:08.860 robot
00:42:09.560 said no
00:42:10.160 I actually
00:42:10.680 can't tell
00:42:11.220 the difference
00:42:11.800 between
00:42:12.200 those
00:42:12.520 experiences
00:42:13.220 there's
00:42:14.660 another
00:42:15.080 group
00:42:15.500 of people
00:42:16.060 who are
00:42:17.120 saying
00:42:17.460 the difference
00:42:18.120 between a
00:42:18.640 synthetic
00:42:19.100 psilocybin
00:42:19.940 and a
00:42:20.380 mushroom
00:42:20.800 is also
00:42:22.560 a great
00:42:22.920 difference
00:42:23.420 and
00:42:24.360 that is
00:42:26.260 also not
00:42:27.020 yet
00:42:27.360 particularly
00:42:28.160 we don't
00:42:29.180 know quite
00:42:29.540 what that
00:42:29.940 means
00:42:30.240 but it's
00:42:30.680 probably
00:42:31.160 true
00:42:31.640 since
00:42:32.080 a mushroom
00:42:33.360 has a
00:42:33.820 whole
00:42:33.980 other set
00:42:34.620 of alkaloids
00:42:35.460 in it
00:42:35.800 so it
00:42:36.340 should have
00:42:36.720 a slightly
00:42:37.060 different
00:42:37.400 effect
00:42:37.780 than just
00:42:38.720 the
00:42:38.960 psilocybin
00:42:39.500 molecule
00:42:39.980 yeah
00:42:41.280 but one
00:42:41.840 obvious
00:42:42.620 difference
00:42:42.940 is just
00:42:43.540 the time
00:42:44.040 course
00:42:44.420 of the
00:42:44.840 trip
00:42:45.380 an LSD
00:42:46.060 trip
00:42:46.400 lasts
00:42:46.920 about
00:42:47.600 twice
00:42:47.960 as long
00:42:48.360 as a
00:42:48.580 mushroom
00:42:48.800 trip
00:42:49.100 that's
00:42:50.160 important
00:42:50.740 because
00:42:51.740 that's
00:42:52.040 one of
00:42:52.320 the reasons
00:42:52.780 that the
00:42:53.380 research
00:42:53.700 has gone
00:42:54.000 the way
00:42:54.200 it has
00:42:54.520 one of the
00:42:55.800 questions
00:42:56.160 is
00:42:56.520 with the
00:42:57.720 psychedelic
00:42:58.240 renaissance
00:42:58.620 why
00:42:59.340 are most
00:43:00.520 of these
00:43:00.820 studies
00:43:01.160 psilocybin
00:43:01.780 why not
00:43:03.060 LSD
00:43:03.540 because
00:43:04.080 with LSD
00:43:04.760 we have
00:43:05.220 a couple
00:43:05.680 of thousand
00:43:06.260 research
00:43:06.840 papers
00:43:07.360 you know
00:43:08.500 to start
00:43:08.960 with
00:43:09.980 and I
00:43:10.640 asked
00:43:10.980 one of
00:43:11.300 the
00:43:11.480 senior
00:43:11.820 researchers
00:43:12.320 and this
00:43:14.140 comes on
00:43:15.720 as a little
00:43:16.460 ridiculous
00:43:17.100 but it's
00:43:17.740 actually quite
00:43:18.380 subtle and
00:43:18.980 sensible
00:43:19.360 he said
00:43:20.580 there are
00:43:20.840 several
00:43:21.300 reasons
00:43:21.760 one is
00:43:23.820 psilocybin
00:43:24.840 will give
00:43:25.800 the same
00:43:26.240 experience
00:43:26.840 but in a
00:43:27.340 shorter amount
00:43:27.880 of time
00:43:28.340 four to six
00:43:29.160 hours
00:43:29.540 LSD
00:43:31.400 eight to
00:43:31.840 twelve
00:43:32.140 if you're
00:43:32.840 working with
00:43:33.460 someone
00:43:33.840 eight to
00:43:34.640 twelve
00:43:34.920 hours
00:43:35.380 in a research
00:43:36.380 setting
00:43:36.780 that's
00:43:37.160 two
00:43:37.480 shifts
00:43:37.980 of
00:43:38.220 personnel
00:43:38.620 that
00:43:39.800 doubles
00:43:40.360 your
00:43:40.760 personnel
00:43:41.180 cost
00:43:41.660 so
00:43:42.700 there's
00:43:43.020 a
00:43:43.300 motive
00:43:44.760 I said
00:43:46.480 there's
00:43:46.820 two
00:43:47.000 things
00:43:47.300 about
00:43:47.580 psilocybin
00:43:48.240 one is
00:43:49.900 it's not
00:43:50.400 called
00:43:50.840 LSD
00:43:51.420 meaning
00:43:52.840 it doesn't
00:43:53.440 there's not
00:43:53.940 a lot
00:43:54.140 of press
00:43:54.500 about it
00:43:54.880 not a lot
00:43:55.180 of research
00:43:55.560 not a lot
00:43:55.980 of
00:43:56.160 not a lot
00:43:57.620 of negative
00:43:58.000 press
00:43:58.460 from the
00:43:59.120 60s
00:43:59.900 yeah
00:44:00.200 the other
00:44:01.780 and this
00:44:02.240 is my
00:44:02.560 favorite
00:44:02.940 is
00:44:03.120 psilocybin
00:44:03.700 is hard
00:44:04.040 to spell
00:44:04.540 what they're
00:44:05.740 saying is
00:44:06.780 that just
00:44:07.780 because it's
00:44:08.540 more
00:44:08.840 sounds more
00:44:09.540 like a
00:44:09.940 scientific
00:44:10.420 term
00:44:11.120 people are
00:44:12.460 more comfortable
00:44:13.060 with it
00:44:14.000 which makes me
00:44:15.960 wonder why
00:44:16.460 there isn't
00:44:16.920 more research
00:44:17.580 on DMT
00:44:18.400 because that's
00:44:19.360 that's over
00:44:19.940 in 15 minutes
00:44:20.780 and dimethyltryptamine
00:44:22.560 is also hard
00:44:23.320 to spell
00:44:23.700 DMT is not
00:44:25.500 on DMT
00:44:28.120 have you
00:44:28.560 do you have
00:44:28.920 experience
00:44:29.540 with
00:44:30.580 pure DMT
00:44:32.220 as opposed
00:44:32.620 to
00:44:32.940 DMT
00:44:34.000 is the
00:44:34.340 one of the
00:44:34.800 active ingredients
00:44:36.100 in ayahuasca
00:44:36.860 as well
00:44:37.440 but
00:44:37.660 that's a
00:44:39.020 very different
00:44:39.600 experience
00:44:40.120 apparently
00:44:40.480 do you have
00:44:41.780 the smokable
00:44:43.280 very short
00:44:44.020 acting experience
00:44:44.820 or the injectable
00:44:45.680 very short
00:44:46.240 acting experience
00:44:46.920 although I may
00:44:48.240 now lose
00:44:48.820 at least
00:44:49.200 half of your
00:44:49.720 audience
00:44:50.060 I have
00:44:50.580 not a
00:44:51.280 great
00:44:51.540 many
00:44:52.100 experiences
00:44:52.920 and I
00:44:54.060 don't
00:44:54.620 seek out
00:44:55.340 new substances
00:44:56.340 to experience
00:44:57.520 it's kind of
00:44:58.880 like people
00:44:59.440 who like
00:44:59.900 wine
00:45:00.340 some people
00:45:01.320 like wine
00:45:01.820 to drink
00:45:02.240 some people
00:45:02.780 like wine
00:45:03.580 to find
00:45:04.780 interesting
00:45:05.540 difficult
00:45:06.040 rare
00:45:06.640 amazing
00:45:07.680 wines
00:45:08.260 the question
00:45:09.880 always for me
00:45:10.760 is what is
00:45:11.520 the take home
00:45:12.280 value
00:45:12.840 now
00:45:14.640 that's a little
00:45:15.820 bit as if
00:45:16.440 someone
00:45:17.100 I say
00:45:17.560 well you went
00:45:18.120 to a concert
00:45:18.780 what's the
00:45:19.200 take home
00:45:19.540 value
00:45:19.880 they said
00:45:20.240 don't be
00:45:20.640 ridiculous
00:45:21.160 I went to
00:45:21.580 the concert
00:45:22.100 for the
00:45:23.060 being there
00:45:24.300 at the
00:45:24.760 time
00:45:25.160 well I
00:45:26.800 have nothing
00:45:27.220 nothing wrong
00:45:28.160 with that
00:45:28.460 and of course
00:45:28.960 do the same
00:45:29.500 thing
00:45:29.900 but because
00:45:31.660 of my
00:45:32.160 background
00:45:32.740 I probably
00:45:33.840 take psychedelics
00:45:34.840 more seriously
00:45:35.700 than most
00:45:36.240 people
00:45:36.620 so the
00:45:38.540 question
00:45:39.060 of all
00:45:41.120 these different
00:45:41.700 substances
00:45:42.300 and all
00:45:42.780 these different
00:45:43.320 forms
00:45:43.920 doesn't
00:45:45.680 it doesn't
00:45:46.640 resonate
00:45:47.000 and I
00:45:47.880 remember
00:45:48.220 when I
00:45:49.140 was sending
00:45:50.320 out little
00:45:50.760 I gave a
00:45:51.300 talk at
00:45:51.680 Santa Cruz
00:45:52.280 UC Santa
00:45:53.240 Cruz
00:45:53.480 some years
00:45:53.900 ago
00:45:54.140 and I
00:45:54.460 asked each
00:45:55.100 of the
00:45:55.280 people there
00:45:55.680 to fill
00:45:56.040 out a
00:45:56.280 little
00:45:56.400 form
00:45:56.780 what's
00:45:58.400 your best
00:45:58.760 trip
00:45:59.000 what's
00:45:59.260 your worst
00:45:59.620 trip
00:45:59.880 why did
00:46:00.340 you come
00:46:00.680 here tonight
00:46:01.320 and what
00:46:02.480 have you
00:46:02.760 used
00:46:03.200 and these
00:46:04.400 were all
00:46:04.820 undergraduates
00:46:05.640 and there
00:46:07.260 was one
00:46:07.720 young man
00:46:08.300 who had
00:46:08.720 tried 24
00:46:09.980 different
00:46:11.160 psychedelic
00:46:12.080 substances
00:46:12.800 and I
00:46:14.420 thought
00:46:14.740 he probably
00:46:16.440 doesn't get
00:46:17.120 much out
00:46:17.640 of it
00:46:18.000 he's a
00:46:19.060 collector
00:46:19.620 of having
00:46:22.340 done
00:46:22.880 experiences
00:46:23.700 and that's
00:46:25.120 very different
00:46:25.820 the other
00:46:27.440 side of that
00:46:28.060 the other
00:46:28.320 way of
00:46:28.620 arguing
00:46:29.060 that is
00:46:29.600 the notion
00:46:30.720 is
00:46:31.160 and this
00:46:31.440 is I
00:46:31.740 think
00:46:31.880 from
00:46:32.140 Jean-Paul
00:46:32.720 Sartre
00:46:33.220 or Camus
00:46:34.440 which is
00:46:35.280 when you
00:46:35.940 ask God
00:46:36.540 a question
00:46:37.200 and he
00:46:38.700 answers it
00:46:39.460 you hang
00:46:40.080 up the
00:46:40.400 phone
00:46:40.660 so for a
00:46:43.800 lot of
00:46:44.100 people
00:46:44.360 they say
00:46:45.760 well I
00:46:46.360 learned what
00:46:47.600 psychedelics
00:46:48.340 had to teach
00:46:49.340 me
00:46:49.620 and my
00:46:51.500 interest then
00:46:52.100 diminished
00:46:52.580 yeah
00:46:54.260 yeah
00:46:54.300 yeah
00:46:55.120 well that's
00:46:56.140 certainly
00:46:57.820 resonates with
00:46:58.480 me
00:46:58.660 I mean I
00:46:59.120 certainly
00:46:59.520 felt that
00:47:00.020 for 25
00:47:00.840 years
00:47:01.260 and it's
00:47:02.220 not something
00:47:02.940 that I
00:47:03.340 imagine doing
00:47:04.800 with any
00:47:05.440 frequency
00:47:05.860 at high
00:47:07.020 doses
00:47:07.340 certainly
00:47:08.000 but
00:47:08.920 I've never
00:47:10.080 taken ayahuasca
00:47:10.880 I've never
00:47:11.300 smoked DMT
00:47:12.420 and I just
00:47:13.160 hearing about
00:47:14.160 the
00:47:14.580 phenomenology
00:47:16.120 of those
00:47:16.420 experiences
00:47:16.900 they sound
00:47:18.000 like they
00:47:19.280 are certainly
00:47:20.560 opening different
00:47:21.960 doors in
00:47:22.920 the mansion
00:47:23.780 of the
00:47:24.860 mind
00:47:25.240 and I'm
00:47:25.900 I do feel
00:47:27.160 like I
00:47:28.240 can attest
00:47:28.840 to a
00:47:29.920 somewhat
00:47:30.180 significant
00:47:30.700 difference
00:47:31.100 between
00:47:31.700 psilocybin
00:47:32.880 and LSD
00:47:33.600 at higher
00:47:34.800 doses
00:47:35.200 what you
00:47:36.240 said about
00:47:36.820 the difference
00:47:37.700 does resonate
00:47:39.160 with me
00:47:39.520 there's always
00:47:39.840 LSD has a
00:47:41.980 kind of metallic
00:47:43.000 quality to it
00:47:44.580 compared to
00:47:45.160 psilocybin
00:47:45.880 that not to
00:47:46.960 say that it's
00:47:47.420 bad but
00:47:48.000 it's it
00:47:49.380 is different
00:47:49.900 and then of
00:47:51.100 course there's
00:47:51.600 the there's
00:47:52.560 MDMA
00:47:53.120 ecstasy which
00:47:54.140 is not
00:47:54.760 classically a
00:47:55.440 psychedelic
00:47:56.040 which in
00:47:57.380 terms of
00:47:57.680 take-home
00:47:58.140 value you
00:47:59.560 know has
00:47:59.840 offered a
00:48:00.300 tremendous
00:48:00.640 amount to
00:48:01.220 people
00:48:01.500 where do
00:48:02.460 you put
00:48:02.940 MDMA in
00:48:04.020 this
00:48:04.280 conversation
00:48:05.060 well the
00:48:06.140 reason MDMA
00:48:07.100 there are two
00:48:08.220 reasons MDMA
00:48:08.860 isn't a
00:48:09.240 psychedelic one
00:48:09.960 is biochemical
00:48:10.760 which is
00:48:11.280 the other is
00:48:12.880 that you do
00:48:13.400 not go beyond
00:48:14.200 yourself your
00:48:15.320 psyche
00:48:15.660 without the
00:48:17.160 experience
00:48:18.260 only you're
00:48:19.640 you in an
00:48:20.200 incredibly
00:48:20.720 inner safe
00:48:21.440 place where
00:48:22.480 all the parts
00:48:23.120 of you that
00:48:23.660 are awful
00:48:24.320 to consider
00:48:25.080 or terrible
00:48:26.320 events or
00:48:27.160 traumas or
00:48:29.080 worse you
00:48:30.920 can objectively
00:48:32.480 look at and
00:48:34.060 move them from
00:48:35.020 the part of
00:48:35.660 your brain that
00:48:36.220 holds them as
00:48:36.940 terrible trauma
00:48:38.240 and disturbs or
00:48:39.980 destroys your
00:48:40.620 life and
00:48:41.820 puts them into
00:48:43.080 conventional
00:48:44.080 memory where
00:48:45.300 you can
00:48:45.780 remember that
00:48:46.540 you did
00:48:46.900 terrible things
00:48:47.720 but it
00:48:48.060 doesn't
00:48:48.440 dominate your
00:48:49.180 presence so
00:48:50.620 it's a
00:48:51.060 totally different
00:48:51.920 set of
00:48:52.440 experiences and
00:48:54.460 however the
00:48:56.860 way it's
00:48:57.560 given is
00:48:58.360 exactly the
00:48:59.200 way we
00:48:59.640 developed it
00:49:00.400 in the
00:49:00.760 60s with
00:49:02.000 the comfortable
00:49:03.260 room and the
00:49:04.280 music and the
00:49:05.180 headphones and
00:49:06.600 the male and
00:49:07.840 female guide
00:49:08.820 all of which
00:49:11.100 are to make
00:49:11.860 it easier for
00:49:13.060 people to look
00:49:14.140 at traumatic
00:49:15.500 experience if
00:49:17.240 you give the
00:49:18.020 same person a
00:49:20.880 very very high
00:49:21.700 dose of lsd
00:49:22.520 they will they
00:49:23.640 will pass right
00:49:24.560 through the
00:49:25.300 trauma area and
00:49:26.960 have perhaps
00:49:27.780 again one of
00:49:28.700 these transcendent
00:49:29.520 experiences which
00:49:30.780 may or may not
00:49:31.980 affect the
00:49:33.420 trauma we
00:49:34.360 haven't really
00:49:34.820 done that kind
00:49:35.540 of research so
00:49:37.020 mdma in a
00:49:38.000 sense is
00:49:38.440 psychologically
00:49:39.140 less threatening
00:49:40.660 because you
00:49:41.300 don't go beyond
00:49:42.420 your own
00:49:43.200 identity and
00:49:44.460 that's a real
00:49:45.560 difference
00:49:46.060 actually this
00:49:47.080 brings up an
00:49:47.580 interesting point
00:49:48.660 about which there
00:49:50.120 may be research
00:49:50.880 that I'm
00:49:51.340 unfamiliar with but
00:49:52.280 just based on my
00:49:53.800 own experience
00:49:54.520 it's often felt to
00:49:56.160 me that not
00:49:57.860 taking enough of
00:49:59.780 a psychedelic is
00:50:01.380 as much of a
00:50:03.700 risk factor in
00:50:05.280 determining having
00:50:06.160 a bad trip
00:50:07.640 we'll talk about
00:50:08.820 good and bad
00:50:09.300 trips next but
00:50:11.160 you know here
00:50:13.100 we're talking about
00:50:13.640 dosage not
00:50:15.260 taking enough not
00:50:16.240 not achieving you
00:50:17.480 know escape
00:50:17.960 velocity of some
00:50:19.020 kind can doom
00:50:20.980 you to an
00:50:22.520 unpleasant experience
00:50:23.580 as much as
00:50:25.060 taking too much
00:50:26.860 if taking too
00:50:27.740 much is in fact a
00:50:28.740 liability I mean
00:50:29.520 there's I've had
00:50:30.480 trips where it's
00:50:31.140 felt like I took
00:50:32.760 just enough to
00:50:34.580 have in my
00:50:35.940 ordinary mental
00:50:37.400 reality good and
00:50:39.000 scrambled or I
00:50:40.480 took just enough
00:50:41.380 to be given an
00:50:43.420 unusual mental
00:50:45.520 energy with which
00:50:46.960 to fixate on my
00:50:48.680 psychological
00:50:49.340 problems but not
00:50:51.040 given enough to
00:50:52.060 fly clear of them
00:50:54.160 for any span of
00:50:55.400 time and so the
00:50:56.900 net result was
00:50:57.820 there was a
00:50:58.280 something considerably
00:50:59.800 more than a
00:51:00.320 micro dose that
00:51:02.100 potentiated my
00:51:04.100 capacity for
00:51:04.840 unhappiness and
00:51:06.720 I believe I
00:51:07.920 believe I've
00:51:08.380 noticed this from
00:51:10.020 both sides because
00:51:11.620 you know I've had
00:51:13.020 trips where you
00:51:13.880 know I've gone
00:51:15.040 you know very far
00:51:16.520 out well beyond
00:51:17.960 any personal
00:51:18.860 reference point to
00:51:19.900 my life and my
00:51:20.820 psychology and then
00:51:22.600 it's only upon
00:51:23.360 re-entry you know
00:51:25.020 as I'm coming
00:51:25.560 down that you
00:51:26.940 begin to punch
00:51:28.500 into the atmosphere
00:51:29.340 of the familiar
00:51:30.320 and begin thinking
00:51:31.940 about your life
00:51:32.760 is it that strata
00:51:34.800 of the mind that
00:51:35.920 there's a sort of
00:51:37.560 a new capacity
00:51:38.600 for chaos and
00:51:39.980 complication and
00:51:40.900 neurosis
00:51:42.080 you're kind of a
00:51:44.060 commercial for
00:51:45.420 guides at this
00:51:46.560 point yeah look
00:51:48.080 at that particular
00:51:49.320 event that happens
00:51:50.980 in a high dose
00:51:51.720 which is you have
00:51:53.540 found that you
00:51:54.560 are immortal or
00:51:56.760 that you are one
00:51:57.780 with whatever your
00:51:59.020 religious tradition
00:51:59.840 teaches you is the
00:52:00.760 highest or you've
00:52:02.480 gone past that
00:52:03.700 into feeling that
00:52:06.700 everything is
00:52:08.480 interconnected and
00:52:09.420 it's all the same
00:52:10.120 stuff and then you
00:52:11.660 come down and you
00:52:12.620 find that there you
00:52:13.860 are there you are a
00:52:15.480 kind of middle-aged
00:52:16.720 physician in a
00:52:18.880 difficult marriage and
00:52:20.180 one of your kids is
00:52:21.380 has some kind of
00:52:22.820 illness and you have
00:52:23.900 economic problems and
00:52:25.860 you love kite surfing
00:52:27.440 that person can
00:52:30.900 with a little bit
00:52:32.180 right into the heart
00:52:35.480 of their issues
00:52:36.540 coming down than
00:52:37.720 they could coming
00:52:38.740 up and one of the
00:52:41.520 methods that we use
00:52:42.780 when we're doing this
00:52:43.620 clinical work this
00:52:44.260 was with a couple of
00:52:44.860 hundred people is we
00:52:46.700 ask them to bring in
00:52:47.660 important photographs
00:52:48.780 again notice this is
00:52:49.820 visual we also ask
00:52:51.760 them to have a list of
00:52:52.580 questions and I'll
00:52:53.400 mention that but we
00:52:54.980 ask them to bring in
00:52:55.660 important photographs
00:52:56.660 and this usually
00:52:57.280 would be of important
00:52:58.480 human beings in their
00:52:59.320 lives and we would
00:53:01.920 say would you like to
00:53:02.680 look at your
00:53:03.160 photographs and they
00:53:04.280 would look at us like
00:53:05.880 what's a photograph and
00:53:07.240 who are you but then
00:53:09.300 you hand them a
00:53:10.080 photograph and say it's
00:53:11.540 their it's their spouse
00:53:14.300 now again these are
00:53:16.760 trained guides and what
00:53:18.300 do they do they do
00:53:19.600 nothing the person
00:53:22.460 looks at this
00:53:23.380 photograph and they
00:53:24.200 may look at it for a
00:53:25.520 minute and put it
00:53:26.200 aside they may look at
00:53:27.380 it for 45 minutes and
00:53:30.100 then they say okay I'd
00:53:31.420 like another photograph
00:53:32.200 and you don't know
00:53:34.120 what's going on but when
00:53:35.400 they write a report a few
00:53:36.560 weeks later you find out
00:53:37.820 they spent a huge amount
00:53:39.140 of time therapeutically
00:53:41.780 reworking a lot of their
00:53:44.120 issues around that
00:53:45.460 particular person so it's a
00:53:48.760 method of depth
00:53:50.380 psychological work
00:53:52.060 without form without
00:53:54.600 vocabulary and without
00:53:56.080 theory
00:53:56.620 that was we also gave
00:54:00.740 them a a rose bud
00:54:02.680 a rose just starting to
00:54:04.540 open and almost every
00:54:06.520 religious tradition that
00:54:07.620 had access to roses
00:54:08.820 makes them an important
00:54:10.880 either symbol or active
00:54:12.900 force and we found
00:54:15.020 again that people would
00:54:16.740 have an experience of
00:54:18.940 working with a living
00:54:20.820 expanding beautiful
00:54:23.240 piece of nature that
00:54:26.260 they felt was important
00:54:27.760 and again people would
00:54:28.900 take a long time just
00:54:31.160 looking into that rose
00:54:32.160 indicating how it opened
00:54:33.160 and they went inside it
00:54:34.480 and how they became a
00:54:36.080 rose and how that that
00:54:38.080 made sense to them in
00:54:39.580 their usual life so as
00:54:42.600 as one comes down but
00:54:44.220 one is coming down aware
00:54:46.240 that one is more than
00:54:47.720 one's identity and when
00:54:49.660 you had those high
00:54:50.600 experiences Sam the
00:54:52.400 ones as you said coming
00:54:53.720 back into being you
00:54:55.300 it's always a little
00:54:56.660 puzzling like I'm part
00:54:59.340 of everything there is
00:55:00.380 why did I come back into
00:55:01.740 a Sam Harris of all
00:55:03.400 people that's where you
00:55:05.580 then get an opportunity
00:55:07.320 to say probably I came
00:55:09.000 back into the Sam
00:55:09.940 Harris to clean him up a
00:55:12.440 little bit so that he
00:55:13.940 would get more benefit
00:55:15.080 out of being in this
00:55:15.980 lifetime so let's talk
00:55:19.140 about microdosing which
00:55:20.760 superficially seems like
00:55:24.160 a similar project because
00:55:26.080 we again we're talking
00:55:27.500 about taking LSD or
00:55:30.100 psilocybin generally but
00:55:32.560 the dosage being dialed
00:55:36.500 down as much as you're
00:55:37.980 about to describe really
00:55:39.780 does change things what
00:55:42.820 constitutes a microdose and
00:55:44.400 and what are people
00:55:46.240 microdosing well I have
00:55:49.320 to make this super clear
00:55:50.640 imagine that microdoses
00:55:52.700 have no psychedelic
00:55:54.540 effect so they are not a
00:55:56.620 little bitty high maybe
00:55:59.600 they're the difference
00:56:00.460 between an M dial you're
00:56:01.520 still you know there's
00:56:02.660 still radio frequencies but
00:56:03.860 the microdose is one
00:56:04.900 tenths to one twentieth of
00:56:06.320 what is called a
00:56:06.900 recreational dose with LSD
00:56:09.060 for the original work I did
00:56:12.660 some years ago we it was
00:56:14.840 ten micrograms that seemed
00:56:16.160 to be an appropriate
00:56:17.500 amount for people to have
00:56:20.260 the experiences that I'll
00:56:22.380 talk about a little bit
00:56:23.340 more without having to
00:56:26.940 stop or disturb their life
00:56:29.360 they had their normal day
00:56:31.080 normal activities normal
00:56:33.400 work normal driving normal
00:56:36.260 time with their family etc
00:56:39.560 the dose for mushrooms
00:56:43.540 was about was then about
00:56:46.800 0.2 grams to 0.5 grams
00:56:49.420 now when I say the doses
00:56:52.340 again what we found after you
00:56:55.260 you get a few hundred reports
00:56:57.120 is people say gee 10
00:56:59.900 micrograms was too much I'm
00:57:01.900 taking seven 0.2 was too
00:57:07.000 much I'm taking one tenth of a
00:57:09.140 gram
00:57:09.560 what we found is that
00:57:10.780 people would correct the
00:57:12.400 dose so to speak for their
00:57:13.660 own understanding and
00:57:15.320 experience and we also found
00:57:17.760 in terms of taking it how
00:57:19.880 often which is a huge
00:57:21.400 difference between
00:57:22.280 psychedelics and microdosing
00:57:23.540 microdosing is done
00:57:25.580 repeatedly people found that
00:57:28.160 after taking it one day on
00:57:30.040 and two days off over a full
00:57:31.700 month that's about ten times
00:57:33.760 over a month most people
00:57:36.600 ended up taking it less often
00:57:39.560 so it looked like it was it was
00:57:41.960 not addictive just as all other
00:57:43.500 psychedelics but whatever value
00:57:46.020 it had people seem to to gain
00:57:49.020 basic benefits within the first
00:57:51.400 month and then allow it to
00:57:53.840 continue at its own pace now what
00:57:56.080 are basic benefits okay it's very
00:57:58.940 hard to make this easy to understand
00:58:02.940 but
00:58:03.940 Ailet Waldman did a book called a
00:58:06.560 really good day and it's about her
00:58:08.660 month of microdosing and the best
00:58:11.280 definition of microdosing that I've
00:58:13.080 come across again from one of our
00:58:14.700 people
00:58:15.040 is I did better work than I usually
00:58:21.000 do I made a few more cold calls that
00:58:23.500 were successful I had a few ideas in
00:58:26.640 the meeting that I usually have no
00:58:28.320 ideas when I went to the gym I did
00:58:31.980 one more set of reps and I enjoyed
00:58:35.660 being with my family more than
00:58:37.500 usual and I forgot that I'd taken a
00:58:39.840 microdose one never says at the end of
00:58:44.540 a high-dose session I forgot I took a
00:58:46.600 psychedelic okay well actually that's
00:58:49.080 not quite true if if it's a
00:58:50.640 sufficiently high dose you can
00:58:52.620 completely forget you've taken a
00:58:54.020 psychedelic but then you eventually
00:58:55.280 remember as reality and you've taken
00:58:59.120 a sufficiently high dose you forget
00:59:00.580 that you're a human being on this
00:59:02.940 planet yeah because when you come
00:59:05.960 down you're very surprised to find
00:59:07.500 out that that's true and hopefully
00:59:09.080 you're not attempting any reps at the
00:59:10.740 gym no let alone driving to it oh so
00:59:15.720 a microdose seems to improve the
00:59:19.720 overall function of the organism and I'm
00:59:23.760 being kind of vague and scientificy
00:59:26.160 because there are so many people who've
00:59:30.160 reported different benefits or different
00:59:32.900 improvements in using microdosing that
00:59:36.240 it's very hard to categorize and we can
00:59:39.360 look at some of the details of that as
00:59:42.560 much as you wish yeah I guess so let me
00:59:45.480 just give you some anecdotal experience
00:59:47.080 here and and then get your reaction so I
00:59:50.320 only have experience microdosing LSD and
00:59:53.980 so I guess first question is is there any
00:59:58.160 reason to differentiate the effects of
01:00:01.220 taking psilocybin versus LSD or are they
01:00:04.580 essentially indistinguishable I mean
01:00:07.620 given the given that a microdose is as
01:00:09.860 close to subliminal as you can get I can't
01:00:14.260 imagine there's much to say about the
01:00:16.280 difference there but well when I was
01:00:18.320 giving the differences in kindness and
01:00:20.880 coldness I was actually quoting someone
01:00:24.340 who said in our microdose community in
01:00:26.740 Los Angeles we've come to that conclusion
01:00:29.360 that psilocybin is a little nicer
01:00:32.020 interesting the important question is how
01:00:35.640 long is it effective and this is where it
01:00:37.600 gets interesting we know that LSD has
01:00:40.480 major effects 10 to 12 hours and and we
01:00:43.780 all say as if that as if it stops at that
01:00:46.480 point we forget that with high doses
01:00:49.460 there's also what's called an afterglow of
01:00:52.460 four to six weeks where you feel better
01:00:55.800 about everything in many ways and you're
01:00:57.840 more creative and and so forth with
01:01:00.220 microdosing very early on what I discovered
01:01:03.940 was what I called a two-day effect which is if
01:01:07.260 it's psilocybin or LSD there's at least a
01:01:11.580 two-day effect and great many people say I
01:01:15.100 actually prefer the second day it's better
01:01:17.740 so we're dealing with something which
01:01:21.520 isn't distinguished in the easy sense of
01:01:24.860 time it may be distinguished in terms of
01:01:28.520 its emotional warmth but because you're
01:01:31.080 taking it as part of your normal life
01:01:33.380 you'll you know if you feel better and
01:01:37.740 you're more effective it's hard to say
01:01:39.660 is that analytic or is that emotional
01:01:41.800 it's simply that my goodness I hadn't
01:01:46.500 noticed a way to work that little niche
01:01:52.340 at the bank that always I'm walking to
01:01:54.500 work I look forward to the flowers
01:01:56.200 particularly on days when I microdosed
01:01:57.760 yeah as far as the emotional valence as
01:02:02.880 far as how microdosing might be recommended
01:02:06.300 or contraindicated for any person I can
01:02:09.320 well imagine that microdosing would have
01:02:12.440 would have antidepressant effects it seems
01:02:15.620 to increase arousal generally it's it may
01:02:19.800 as you say it kind of brightens your
01:02:22.060 attention and it would surprise me if it
01:02:25.440 wasn't functioning as a kind of cognitive
01:02:28.200 enhancer and antidepressant but I could
01:02:30.480 also see that it might be contraindicated
01:02:33.500 for somebody with any kind of anxiety
01:02:35.600 disorder I mean it seems to me that there
01:02:37.640 is a kind of anxiety like valence to mere
01:02:41.040 arousal well I would say Sam as an N of
01:02:46.160 one you have hit on both of the most
01:02:49.800 important aspects positive and negative
01:02:52.340 that people are aware of and let me let me
01:02:55.280 break that down let's look at depression
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