On this episode of the Joe Rogan Experience podcast, we have Dr. Rhonda Patrick on the show to talk about what antioxidants are, why they are important, and why they should be in your diet. Also, we talk about Ting and how you can save money on your cell phone service using their no nonsense mobile service. We're also joined by Onnit, a company that helps you find the best supplements to help you improve your health, brain health, and overall well-being. Onnit is a company I've been a customer of for a long time, and I think you'll agree that their products are worth the price of admission if you want to get the most out of your day to day life! If you like what you hear, please HIT SUBSCRIBE on Apple Podcasts and leave us a rating and review! You can also join our FB group and join the conversation by using the hashtag on Insta: to be featured on the next episode of . and to become a supporter of the show! and more importantly, share the podcast with your friends, family, and fellow podcasters everywhere! Thank you so much for all the love, support, and support! Peace, Blessings, Cheers! -Jono -Eugene & Aubrey - The Joe Rogans Experience Podcast. -The Rogans Jono & the Rogans Podcast - Jono and The Rogans Family - The Rogan Podcast & Ronna & Ronna ( ) - Ronna and Rachael - Raelynn & Raelin :) -- , is a podcast, R.J. , R.RJ. & R. ( ) - R.A. ( , and R.S. (R.R. & R-RJ) -R.J., R.E. ( ), AND R.P. (RIP R.Y. (S. ) . . , & RODAN AND RYANTHORA ( ) , , AND RENGS (RODANCHOR (R) , etc., ) ( ) & RACHORAJ (RJ & RAYN (R)? ( ) . (RAYN)
00:00:05.000This episode of the Joe Rogan Experience podcast is brought to you by Ting.
00:00:10.000Ting is one of my favorite sponsors on the podcast because I have heard nothing but positive responses from people that have used Ting and have saved money.
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00:02:56.000We're also brought to you by Onnit.com.
00:02:59.000That's O-N-N-I-T. And I'm very excited that we have Dr. Rhonda Patrick on the podcast today because she can explain some of the shit that's in Onnit that confuses me.
00:03:10.000All the baffling stuff about what antioxidants are necessary.
00:03:26.000Onnit.com carries, we essentially try to carry everything that we find beneficial and everything that I use, everything that Aubrey uses, everything that our friends use, athletes, mixed martial arts fighters, jujitsu people, things that would benefit your physical conditioning,
00:03:43.000things that would benefit your cognitive function, things that benefit your immune system, Your endurance.
00:03:49.000What we sell, whether it's our strength and conditioning equipment like kettlebells, battle ropes, steel maces, things along those lines, or whether it's the nutritional supplements like Hemp Force Protein Powder or New Mood or Alpha Brain, we just try to sell you the very best,
00:04:06.000most high-quality supplements that are available in the world.
00:04:10.000Whatever we can find, if we find stuff that's beneficial, we try to sell it to you.
00:04:14.000And because some of the stuff that we sell at Onnit is controversial, we're in the process of running many tests.
00:04:20.000We just got back the results where we actually just started publishing the results of the double-blind placebo test that we did on AlphaBrain.
00:04:28.000If you go to the Onnit website, you can see the results of that test.
00:04:56.000What you're doing when you're taking something like a nootropic is you're giving your brain the building blocks to produce human neurotransmitters, the nutritional aspects of thought.
00:05:07.000If you're just getting that stuff through food, man, you'd have to take a lot of weird food.
00:05:14.000You'd have to take a lot of it in really high doses, a lot of mosses and grasses and weird shit that you're not going to want to eat.
00:05:21.000All of it is very controversial, so we're in the process of continuing even more studies.
00:05:26.000If you go to the Onnit website, you can see the AlphaBrain clinical trial results.
00:05:30.000We have them all posted, and we're in the process of a much larger test right now.
00:05:35.000We're also in the process of tests on several of the other supplements.
00:05:39.000Because they're controversial, even though we 100% back them and support them, we offer a 30-pill, 90-day, 100% money-back guarantee on anything that you buy from Onnit.
00:05:50.000Any of the supplements, if you try them, you don't like them, you feel like AlphaBrain didn't make your brain work any better, you get 100% of your money back.
00:05:58.000You don't even have to send in the pills.
00:07:10.000Dr. Rhonda Patrick reached out to me because she had some things to say about some of the things that other podcast guests had said about nutrition, about health.
00:07:20.000And tell the folks what your credentials are, what you do, who you are, and why you are uniquely qualified to explain nutrition and health to these folks.
00:07:36.000I did my undergraduate work in biochemistry, chemistry.
00:07:40.000And now I'm doing a postdoctoral fellowship on nutrition and metabolism.
00:07:45.000So I started out with synthesizing peptides and doing organic chemistry, and I got really bored with that.
00:07:52.000And I was an undergraduate sort of student research intern.
00:07:58.000So then I decided to try biology out, and I went to the Salk Institute for Biological Sciences in La Jolla, and I did some research on aging biology.
00:08:52.000No, no, I didn't make hybrid mice people.
00:08:55.000But I did a lot of work on mitochondria and mitochondrial metabolism and how that relates to cancer and how cells die and how they don't die and what's going wrong with cancer.
00:09:07.000And I got a really awesome publication out of it in Nature.
00:09:10.000And then I decided that I was really wanting to move on to something different.
00:09:16.000During your PhD, you dig, dig, dig, dig, dig, deep, deep mechanism.
00:09:20.000Finally, you just keep digging deeper.
00:09:23.000I felt like I was lost from what everything meant and what was the significance of it.
00:09:29.000You kind of have to do that in grad school because you're learning the tools, how to use tools to answer questions, what kind of questions and how you answer them.
00:09:41.000Then I decided I wanted to take a step back and look at the big picture and Do some clinical research and apply the tools that I learned in graduate school and try to learn some things looking at people.
00:09:54.000So now I'm at the Children's Hospital Oakland Research Institute working with Bruce Ames, who's pretty famous for his Ames test, carcinogenicity test, where he basically made this test that could help you figure out whether or not a chemical was a mutagen, meaning if it caused cancer.
00:10:11.000And so I'm working with him, and I'm actually looking at...
00:10:17.000What causes, you know, I'm looking at a lot of things, but I'm actually fundamentally looking at people that are obese and how obesity accelerates the aging process.
00:10:26.000People that are, you know, obese die of all sorts of age-related diseases sooner, cardiovascular disease, type 2 diabetes, cancer.
00:10:33.000By the age of 40, there's a 14-year reduction in their lifespan, which is, I think, even greater than smoking cigarettes.
00:10:41.000So I'm trying to understand fundamental mechanisms like why these people are accelerating their aging process.
00:10:49.000And so I'm actually looking at something specifically.
00:10:50.000I'm looking at their DNA. So I'm taking blood cells.
00:10:55.000So we draw blood from people that have a BMI of like 30 or above or 25 and below, which are considered normal or lean.
00:11:20.000So I take their blood cells and I look at their DNA and how much damage is in their DNA. And I kind of want to get into that a little later, kind of explain what that is.
00:12:20.000So that's why I was asking if tryptophan was in your alpha brain, because tryptophan is a rare amino acid that occurs in protein.
00:12:27.000And most people think that, oh, I eat turkey, I'm getting my tryptophan.
00:12:32.000But the thing is that tryptophan, in order to get converted into serotonin, has to get transported into your brain through this transporter.
00:12:43.0005-HTP, and then it converts into serotonin.
00:12:45.000Yeah, that's one of the principal ingredients in NuMood.
00:12:48.000NuMood is 5-HTP and L-tryptophan, and the idea being that there's sort of a slow-release effect.
00:12:54.000The L-tryptophan converts to 5-HTP, and then 5-HTP converts to serotonin.
00:12:59.000Right, so 5-HTP can actually cross the blood-brain barrier.
00:13:02.000So that can already get converted into serotonin in your brain.
00:13:05.000And tryptophan, so tryptophan actually competes with other branched-chain amino acids like leucine and isoleucine to get transported into the brain, and it loses.
00:13:15.000Leucine, these branched-chain amino acids, they're abundant in protein.
00:13:18.000So what ends up happening if you're not taking something like 5-HDP or something else is that most of the time you're not getting enough tryptophan transported into your brain.
00:13:26.000Now, certain things can help alleviate that competition like exercise.
00:13:30.000So exercise, you take up a bunch of branched-chain amino acids to make muscle.
00:13:33.000So exercise actually boosts serotonin in your brain by allowing tryptophan to get transported into your brain.
00:13:59.000You can deplete like 90% of someone's brain serotonin.
00:14:03.000And then they do all these like behavioral tests to see what, you know, what the results are, how not having serotonin in your brain impacts behavior and cognitive function.
00:14:13.000And they found that it really, there's a lot of things that are, you know, sort of messed up.
00:14:17.000If you're not making serotonin, you become impulsive, impulsive behavior, your long-term thinking kind of Like a meth head?
00:14:27.000Actually, there's a study where they compared methamphetamine users, cocaine users, and then they depleted just normal people.
00:14:36.000They depleted their tryptophan by the meth that I just told you about.
00:14:39.000And depleting the tryptophan, so basically depleting the serotonin in your brain, you're scoring just as bad as a meth user.
00:14:47.000And actually methamphetamine does deplete your serotonin.
00:14:54.000You know, the fact that serotonin is affecting our behavior and that it's basically, you know, tryptophan and vitamin D are important for that.
00:15:03.000People don't realize, you know, nutrition affects the way your brain works.
00:15:10.000And when you're a regular person that's trying to go online or read books about health and nutrition and what you need and what you don't need, there's so much contradictory information.
00:15:20.000There's so many people that tell you, you don't need anything, just a balanced diet.
00:15:49.000Yeah, you get getting your nutrition from your diet.
00:15:52.000Well, that would be ideal, but the reality is we have, you know, the National Institute of Medicine that are conducting these surveys every five years.
00:15:59.000They call them the Nutrition and Examination Health Surveys.
00:16:02.000It's NHANES. It's very notorious in the nutrition field.
00:16:06.000We consider NHANES surveys to be pretty accurate in determining what people are getting from their diet.
00:16:12.000And these surveys are telling us, no, people are not getting what they need from their diet.
00:16:17.000The majority of Americans are not getting what they need in terms of micronutrients.
00:16:49.000That's something that our lab works on.
00:16:53.000We've got this sort of theory that it's hard to do aging studies in people and particularly looking at different vitamins and minerals and what effects they have long term.
00:17:04.000But that's one of the theories in our lab that We've shown some evidence of it, is that a lot of vitamins and minerals, they're cofactors for many different biochemical pathways in your body.
00:17:20.000If you would just Google biochemical pathways, you'll see this massive image come up and it's just like, holy crap.
00:17:28.000Vitamins and minerals are cofactors for enzymes, meaning they need to be there for the enzyme to work optimally.
00:17:36.000Enzymes and proteins in your body are doing everything.
00:18:42.000It's a hormone that controls the expression of over a thousand different genes in our body, which is literally like one 24th of our human genome, many of them in our brain.
00:18:52.000So what that means is without vitamin D, so vitamin D is so important that we can make it from the sun.
00:18:59.000Problem is we're not, we're not doing that.
00:19:02.000Most of us aren't out in the sun a lot.
00:19:15.000And as a majority of the people from the surveys, if you look at people that supplement and don't supplement in the United States, about 70% don't get adequate levels of vitamin D. And actually, the way we determine what's adequate is based on vitamin D's classical function of bone homeostasis.
00:19:33.000So we know vitamin D is important to make sure that our bones don't start breaking down.
00:19:38.000But in fact, there's a thousand other things it's doing and we don't know how much vitamin D we need to do those other things.
00:19:43.000But to at least maintain that, that's considered adequate.
00:19:46.000And that's like 30 nanograms per milliliter of the precursor of vitamin D called 25-hydroxy vitamin D, which is what most people, when you get your levels measured, that's what they measure.
00:19:57.000So what should you take on a daily basis?
00:19:59.000I would say, you know, definitely you should probably be taking a vitamin D supplement.
00:21:31.000But I can't say that everyone should go out and take 4,000 IUs a day.
00:21:35.000I can say that you should definitely make sure that you have levels in your blood that's higher than 30 nanograms per milliliter, which is above the adequate status.
00:21:44.000And actually, if we look at Studies where they've looked at, for example, all-cause mortality, lowering all-cause mortality, they've shown that huge, large cohort studies they've done, they've looked at the levels of vitamin D and then looked at mortality,
00:22:03.000People with levels of vitamin D between 40 and 60 nanograms per milliliter in their blood had the least amount of all-cause mortality, so basically they were living the longest.
00:22:16.000Maybe you want to have between 40 and 60 nanograms per milliliter based on that study.
00:22:23.000It's important to get the levels tested.
00:22:25.000That's kind of what I like to advocate because it's so cheap and easy.
00:22:46.000I mean, we're going to start to do that.
00:22:48.000Preventative medicine, being able to know if we have adequate amounts of these vitamin minerals, it's going to get easier and easier the next couple of decades, I think.
00:22:56.000Now, you reached out to me because of people on the podcast saying things that you didn't think were accurate, and you got upset and sent me some videos and some different things that sort of describe what disinformation these people were releasing or erroneous information.
00:23:30.000Based on the National Institute of Medicine doing these surveys, we know that's not correct.
00:23:36.000And in fact, they've even done surveys where they've We've looked at people that supplement versus people that don't supplement, and people that supplement have much more adequate levels of these certain vitamins and minerals.
00:23:48.000So that's already the first thing that's not true.
00:23:53.000This recent editorial that came out in the Annals of Internal Medicine It was really upsetting because they were basically saying that multivitamins do nothing, and not only do they do nothing,
00:24:18.000First of all, I think it's one of the most irresponsible studies or the most irresponsible press releases I've ever read because if you actually read what the studies were in comparison to what they're saying, they're saying vitamins don't work, case closed.
00:24:32.000But the studies that they did were on Alzheimer's patients not showing any sort of improvement.
00:24:39.000People over 65 that had heart attacks not showing any improvement.
00:24:43.000I mean, just those two things were Two out of the three tasks that they did, that they're saying that vitamins don't work, when you're talking about a generic multivitamin, too, synthetic multivitamin, like one of those Centrum ones.
00:26:19.000Choose one vitamin that's in your multivitamin concoction and see if what you're giving them actually raises the level of that to show that they're A, compliant, B, that you're giving them a dose that's actually doing something.
00:26:31.000So you're leaving it up to the person to take it as well.
00:26:37.000And also, you say that you take 4,000 units and they had 100. That's not so good.
00:26:44.000The other aspect of the study was that high-dose multivitamins had no effect on the progression of heart disease in heart attack survivors.
00:27:27.00045% of the U.S. population doesn't have adequate levels of magnesium.
00:27:33.000And, you know, I think most people in the fitness community are concerned with magnesium because they're always like, you know, oh my God, I sweated out.
00:27:47.000It's an essential cofactor for DNA repair enzymes.
00:27:52.000So let me explain what that is because it's probably like, well, what's DNA repair enzymes?
00:27:55.000So, you know, everyday just normal metabolism.
00:27:59.000So our mitochondria, they're, you know, taking food that we eat in, whether it's carbohydrates or protein or fat, and they're generating what's called electron-reducing equivalents through this whole Krebs cycle, if you ever learned in biochemistry.
00:28:13.000And those electron-reducing equivalents are really important because they have Hydrogen, which has an electron and a proton.
00:28:20.000And these electrons get passed along inside your mitochondria, these various proteins, and they shoot out protons at the same time.
00:28:27.000And this is basically the way it generates energy to then take the oxygen you breathe in and reduce it to water and couple that to making ATP. Anyways, so these electrons get passed around.
00:28:39.000And what happens is they often, because you're taking oxygen you breathe in and making water to generate The energy you need to make ATP, you start making superoxide anion.
00:28:48.000You start making reactive oxygen species in your mitochondria.
00:29:02.000They react with your DNA. They react with lipids, your cell membranes.
00:29:06.000They react with proteins and they damage them.
00:29:08.000And what happens when you're doing, it's called DNA damage.
00:29:11.000When it reacts with your DNA, You know, sometimes you get like a bulky adduct that's attached on or sometimes you get like an oxidative product, which then can cause a break.
00:29:23.000Your DNA is double-stranded and can cause a break.
00:29:25.000And what happens is, you know, the cells in different organs, like in your kidneys and your liver, these cells have a limited lifespan and so they have to replicate.
00:29:34.000They have to synthesize their DNA, replicate, in order to replace their limited lifespan.
00:29:40.000So when the cell then tries to replicate its DNA and there's this funny stuff there, it's like, what is this?
00:29:47.000And then sometimes it puts another nucleotide, what's not supposed to be there, and it causes a mutation.
00:30:46.000And what happens is, over decades of getting this DNA damage, Because it happens at random places in your genes, eventually you get it in a place that you don't want.
00:30:55.000You get it in a gene that's important for controlling cell cycle or stopping bad cells from, you know, dividing and proliferating.
00:31:03.000These are called tumor suppressor genes.
00:31:05.000And when you get it in one of those, you're screwed because now you got some funky cell that doesn't pass those checkpoints that usually...
00:31:13.000Our genes are making sure they don't pass this checkpoint if they're funny.
00:31:17.000And then they pass it and they start dividing and proliferating and now you've got this clonal population of cancer cells.
00:31:28.000So if you're walking around with not sub-adequate levels of magnesium, you're not going to know anything until you're in your 50s or 60s and you come down with cancer.
00:31:41.000So now when you read something like this, you know, vitamins don't work, case closed, and you find out this is the research that they did, and this is the conclusion that they came to from the research, that's so irresponsible and so infuriating.
00:33:13.000Without folate, you're not making thymine, and you need folate to basically make new DNA for these new cells that you're making in your body every day.
00:33:21.000So when you don't have folate, that can actually cause a single-strand break in your DNA, and it can do the stuff I was telling you about by causing mutations and leading to cancer eventually.
00:33:31.000However, if you already have cancer, everything that's good for you, cancer, it's like cancer is on crack, man.
00:35:24.000So I think in some cases, when you start talking about nutrition and preventative medicine, a lot of people, if you don't know about it, you get kind of threatened and you feel...
00:35:57.000Is that a response to not wanting to delve into the incredibly deep waters of nutrition and figure out what all these mechanisms are?
00:36:06.000I mean, is it just sort of a knee-jerk reaction to, oh, it's a bunch of BS? I think there's two reasons.
00:36:14.000I think one is absolutely it's a visceral response because there is a load of crap out there and it is hard.
00:36:20.000It is hard to differentiate between what's the noise and the signal.
00:36:24.000And so some people are just like, oh, it's all crap, you know.
00:36:27.000But I think there's also people that just, it's just too much work.
00:36:30.000Like, you know, I want to keep eating what I'm eating and I want to believe it's fine and that's what I want to believe and so I'm going to believe it.
00:36:37.000I think that's another really, you know, mindset that needs to be changed.
00:36:41.000And I think, you know, personally, I would love to see people eating more greens, you know, more of these dark green leafy vegetables, which are rich in many different micronutrients, like vitamin K,
00:37:00.000I think, you know, for people that are just, that aren't going to do that, you know, at least give them a vitamin that's going to give them some of these trace elements and minerals and vitamin D and some of these important micronutrients that they really do need.
00:37:14.000Magnesium, you know, so at the very least, it's just, it's an easy way to do it.
00:37:21.000Yeah, it seems to me that in order to really get a grasp on what is required, what is necessary for your body, it takes an incredible amount of study.
00:37:33.000I mean, there's so much information that you have to get, not just as far as dietary information, but supplemental information.
00:37:59.000Let me push that aside and just fucking have an apple and feel like I'm doing my job.
00:38:03.000You know, one of the reasons why I made a video to this, you know, response to this editorial was because, you know, A, because...
00:38:12.000I could have done some scientific paper and gone through peer review.
00:38:15.000But, you know, I want to get it to the people.
00:38:17.000And it's like, at some level, you know, there's other scientists, they don't really care.
00:38:22.000You know, I want the people to realize that, you know, because these people like my dad, my dad takes a multivitamin and he listens to the news, he gets his information from the TV, like that generation does.
00:38:32.000And, you know, it's just, it's so upsetting that like, all of a sudden, my dad could stop taking his vitamin.
00:38:37.000And I don't want him to stop taking his vitamin because it's You know, it's important that he does take his multivitamin.
00:38:43.000There are certain, you know, components in that multivitamin that I know he's not getting from his diet.
00:38:49.000So, you know, at least let him get it from his multivitamin.
00:38:52.000So this study, there was a meta-analysis that included like 30 different studies, and I really read through them all.
00:39:00.000And there were a lot of methodological errors, and I point them out in the video where people were just – they weren't measuring levels of any vitamins and minerals and saying – they were measuring some outcome like cardiovascular disease or cognitive function without any – There was no biomarkers saying,
00:39:25.000And if you look at some of the studies that did do that, for example, when they were giving them vitamin D, they gave them vitamin D to a severely deficient population, which is like 12 nanograms per mil.
00:40:18.000And like I said, I personally can't tell people how much to take.
00:40:22.000I can tell them what I take, which is 4,000 IUs a day.
00:40:27.000And honestly, I can tell them they should Have levels of vitamin D in their blood greater than 30 nanograms per mil.
00:40:33.000And we should also tell them, if you're not familiar with taking vitamins, that most vitamins need to be taken with food.
00:40:40.000Yeah, I mean, you can definitely get nauseous if you're taking your vitamins on an empty stomach.
00:40:45.000Plus, some vitamins, like vitamin B12, if you don't have an acidic environment in your stomach, if you have too acidic of an environment, then you can't.
00:41:21.000I think there's been research done that shows that your body doesn't really exactly know what to do with vitamins and vitamin form if you take them on an empty stomach with no food attached to them.
00:43:35.000And the other thing was he was saying that it was the vitamin C thing that was getting to me too.
00:43:43.000He was going on about not needing 2,000 milligrams of vitamin C. And then I looked up some of his stuff and he was also talking about vitamin C not being important or not doing anything for immune function.
00:43:55.000And then he started talking about some of Linus Pauling's I can tell you what's wrong with that guy and there's a bunch of things, but one of the main reasons he does what he does is that he grew up Mormon, a very strict Mormon background, and then refuted it and now he's an adult and he's just not gonna take any nonsense.
00:44:14.000He grew up with all nonsense and now he's no nonsense.
00:44:17.000And I have a unique insight into this because I have some friends that grew up Mormon And now they abandoned it actually in their 40s.
00:44:26.000And it's really interesting because they're like children in a lot of ways.
00:44:32.000They're a fundamentalist lifestyle, like growing up in a fundamentalist religion where everything is spelled out for you.
00:44:40.000But you've accepted that your whole life.
00:44:43.000You've accepted and you're told not to question and you're told to follow the rules of this ideology.
00:44:50.000When you get away from that and you try to figure the world out on your own, Your thinking developed in this incredibly fucked up way.
00:44:59.000The way you make your connections to things.
00:45:02.000Like you have this black and white sort of connection thing going on in your head.
00:45:08.000And that's his fundamentalism translated to a fundamental skepticism.
00:45:15.000So his skepticism is his fundamentalism now.
00:45:18.000He automatically is skeptical of anything that might require additional thinking or curiosity or something that's going to counter what a lot of people intuitively think to be true.
00:45:35.000Anything that is bizarre or weird, anything that doesn't seem like you think about someone and then the phone rings and it's them...
00:46:25.000And so people that have that type of thinking that have been trained that way and just like you were saying, you know, they've...
00:46:30.000They've built up these connections where, you know, it's black and white, and if it's not black, then it's definitely white.
00:46:35.000And it's like, that's just not how it works.
00:46:37.000Well, their religion becomes just this skepticism.
00:46:39.000And instead of it being an open-minded, objective analysis of what's at hand, instead, they just want to stuff it into this skepticism box, you know, and immediately debunk things.
00:47:41.000Folate's important to make thymine, you know, nucleotide.
00:47:45.000It's also important to, when you eat protein, you know, methionine and amino acid and protein, it gets converted into homocysteine.
00:47:52.000And you need folate because it's a methyl donor that then gets methylated and reconverted back into methionine because you don't want too much homocysteine around in your body because it does bad things.
00:48:03.000It basically makes proteins start aggregating and it causes vascular disease and cognitive decline.
00:48:08.000Anyways, 40% of North Americans Have a polymorphism in a gene called the methylene tetrahydrate folate reductase, also known as the MTHFR,
00:48:27.000But 40% of North Americans have this polymorphism in this gene that doesn't make it work correctly.
00:48:33.000And so what ends up happening is they can't remethylate this homocysteine to convert it back into methionine.
00:48:38.000So they end up having elevated levels of homocysteine in their blood.
00:48:42.000And unless they take more folic acid to sort of compensate from that, they're going to have higher levels of homocysteine in their blood, which will lead to vascular problems and cognitive decline.
00:50:16.000Even your gut microbiome adapts within 24 hours.
00:50:22.000If you're eating mostly a protein diet, the different interior types that are in your gut, they've shown that people that eat mostly meat and fat, they're bacteria.
00:50:35.000They have bacteria that's We're good to go.
00:51:25.000I work with someone that's doing a lot of research on the gut.
00:51:28.000And so, you know, I get to learn just from, you know, their research and reading on my own About the complexities of it, but it's fascinating how important that bacteria is in our gut and how important certain types are and how that affects the way we respond to disease,
00:52:13.000If you have basically your innate immune system is being active down there because it's unhappy, causing inflammation, things like having high C-reactive protein has been correlated to depression.
00:52:28.000A biomarker that I think could be used with depression is actually C-reactive protein instead of just this vague kind of, okay, I feel this, I feel that.
00:52:38.000Well, let's measure your C-reactive protein levels.
00:52:43.000They've even done some studies where they've They've gotten depressed patients, found that they had high C-reactive protein, gave them like two grams of EPA. EPA is the omega-3 fatty acid that's important for – it's like anti-inflammatory as opposed to DHA,
00:52:58.000which is most of your brain lipids are DHA. But two grams of EPA a day, I forgot for how long, but they lowered their C-reactive protein and helped with their depression.
00:53:13.000The connection between the human body and depression is such a weird one because for so many folks, they go to a doctor, they don't feel good, the doctor gives them an antidepressant, they feel better, and then that's it.
00:53:26.000But there could have been so many other factors that could have been manipulated.
00:53:32.000Either their diet, their exercise routine, hydrating.
00:53:35.000I mean, how many people are fucking just dehydrated and they feel like shit?
00:53:39.000How many people get out of a bad relationship and they feel like shit?
00:53:57.000And then consider what's the stimulation that your brain is receiving every day.
00:54:02.000Well, you're driving in traffic in fucking pollution to a cubicle where you sit and do shit that you don't want to do all day.
00:54:08.000You get home and then you force feed yourself, you know, some terrible foods because you're depressed and you're, you know, just sort of indulging, giving yourself some pleasure and fucking shitty macaroni and cheese or whatever you're stuffing down your face.
00:54:22.000And then you wonder why you're depressed.
00:55:15.000Meditation, they've shown that meditation, there's actually an enzyme that can rebuild your telomeres, but we don't express it in high levels.
00:55:24.000But meditation can actually boost the expression of telomerase.
00:55:29.000And cause your telomeres to get longer.
00:55:31.000So there's really something to that, you know, having a more relaxed, being able to meditate, not having a lot of stress, you know, affecting the way you age, literally, and we have a biological marker for it.
00:55:45.000It's another thing, vitamin D, I wanted to, vitamin D affects the telomere length also.
00:55:50.000If you Google vitamin D receptor mice and pull up this image with the, there's mice, aging mice, So vitamin D actually does affect the way we age.
00:56:02.000And they did this study in twins where they looked at their vitamin D levels.
00:56:06.000They measured their vitamin D levels and they looked at their telomere length.
00:56:09.000And they found that those twins with the highest levels of vitamin D also had the longest telomeres that corresponded to actually five years, being five years younger, even though they were twins, their same chronological age.
00:56:22.000Their telomeres looked like they were five years younger if they had higher levels of vitamin D. Do you know anything about TA65? This is some sort of a supplement that's supposed to enhance your telomere lengths?
00:56:42.000But vitamin D exercise is another one that does.
00:56:46.000They've done studies showing, again in twins, those that exercise the most actually had telomere length that corresponded to being 10 years younger.
00:56:56.000And those that exercise sort of like average compared to those that didn't had an average of like I think four years.
00:57:02.000So there's things that affect the way you age and we have markers for that, biological markers like telomere length that proves your lifestyle is indeed affecting the way you age.
00:57:15.000Yeah, I'd read this telomere study, and I had seen the ads for this supplement.
00:57:23.000So those two mice, these are the same age mouse.
00:57:26.000The top panel, these mice are about four and a half months old.
00:57:29.000And the one on the left is a vitamin D receptor knockout mouse, which means it can't respond to vitamin D. So it's like not having any vitamin D. If you look at the lower panel, those are the same age four months later.
00:57:43.000Look how rapidly that mouse is aging without having vitamin D. I mean, there's lots of things going wrong.
00:57:49.000I mean, I told you that vitamin D is regulating over a thousand different genes in your body.
00:57:52.000So inflammation, I mean, cognitive function.
00:58:21.000I've got this assay where I can actually measure DNA damage in your body from your blood.
00:58:26.000And that's also a marker for age because, you know, the older you are, the more DNA damage you have, and I can measure that clinically.
00:58:33.000So what we're thinking is, like, giving people magnesium and seeing if we can, you know, lessen that damage because their DNA repair is working better.
00:58:44.000Another thing would be vitamin D, measuring, doing the vitamin D, magnesium.
00:58:48.000Yeah, I think there's a few micronutrients that we know of that are really important for long-term effects.
00:58:57.000You know, like I was saying, there's often this trade-off where, okay, let's say you're getting some vitamin K, but you don't have enough.
00:59:05.000In fact, 35% of the U.S. population doesn't get enough vitamin K. Vitamin K is found in plants because it's a part of their – they need it for photosynthesis.
00:59:14.000So if you're not eating a lot of green plants, then you might not be getting enough vitamin K. But vitamin K is often known for being part of coagulation, being important to make your blood clot right.
00:59:28.000So I'm sure any vitamin K you're getting is going towards that because you want your blood to clot right.
00:59:33.000You don't want to bleed out and have a hemorrhage, right?
00:59:35.000But there's other important functions of vitamin K. Vitamin K also prevents the calcification of your arteries.
00:59:41.000And so if all your vitamin K is going towards the proteins that are important for clotting, then the proteins that are important for not having calcification in your arteries aren't getting any.
00:59:51.000And then, you know, two, three decades later, you start to see this calcification in the arteries.
00:59:56.000And in fact, people that are given warfarin, which is a really common drug for inhibiting vitamin K, they end up having problems with calcification in their arteries and stuff.
01:00:12.000I think there's a lot to understanding how these micronutrients work that we don't know yet, and we're starting to try to be able to do some experiments to understand them, but the bottom line is that Your body's smart,
01:00:27.000and if you don't have enough of a certain vitamin or mineral, it's going to shunt it to the one that's going to help you survive now and help you reproduce, because that's what it wants to do.
01:00:37.000And these other things, like repairing damaged DNA or having your brain work optimally, you don't have to be that smart to survive.
01:00:46.000These things, they probably get the short end.
01:00:51.000Vitamins, in my mind, are sort of like a long-term thinking.
01:00:55.000It's like, yeah, okay, well, I'm not walking around with any acute deficiencies, which is what most people think when they're thinking, oh, I have enough vitamins and minerals because I don't have beriberi.
01:01:04.000I don't have, you know, these problems that are severe deficiencies.
01:01:08.000It's like if you're severely deficient, you're going to have some symptoms that you'll notice.
01:01:12.000But most of these symptoms you're not going to notice.
01:01:22.000It's amazing to me that there's not a center where you could go and get a full workup done and they provide you with a recipe for your vitamin supplementation needs.
01:01:37.000We want to get it to where we can just get a finger prick of blood.
01:01:41.000And we'll know different proteins we can measure that we know are involved in long-term functions versus the short-term functions of these vitamins.
01:01:49.000And we can say, based on looking at these proteins, we can say, okay, you need more of this and this and this vitamin.
01:02:08.000The idea of going to someone who measures your blood and finds out what you're lacking in your diet, that's not normal.
01:02:16.000You know, I think instead of going to a doctor to try to find a quick fix to get some, you know, you're depressed, so they give you an SSRI. Well, you know, we don't know what the long-term effects of some of these pharmaceutical drugs are in our brain.
01:02:28.000Like, they just had this study that came out a couple months ago on antipsychotics.
01:02:33.000Which they routinely give people with schizophrenia.
01:02:36.000And they found that these antipsychotics, in a dose-dependent manner, cause brain atrophy.
01:02:42.000And they followed these people over 15 years.
01:02:45.000This is the first long-term effect of antipsychotics that came out.
01:02:52.000And they showed that these schizophrenic patients, the higher the dose of antipsychotic they were on, the more brain atrophy.
01:02:59.000You know, it's like, so here you are giving these people antipsychotics and, you know, 15 years from now, their brain is like literally, it's like atrophying at a rapid rate.
01:03:10.000So that's just a classic example of us not knowing what some of these long-term effects of some of these pharmacological drugs that we're doing, especially when it comes to the brain.
01:03:47.000But it's, have they exhausted all the other possible options?
01:03:51.000I have a friend who's on an SSRI, and he recently found out that he had been taking Propecia, and he recently found out that Propecia actually caused depression in some people.
01:04:05.000It can cause depression in some people.
01:04:45.000I mean, omega-3 fatty acids, you know, 30% of your brain is made of DHA, which is an omega-3 fatty acid.
01:04:53.000And they've shown that actually DHA affects...
01:04:55.000The way dopamine is signaling in your brain.
01:04:58.000So, you know, in terms of like back to the schizophrenia, people with schizophrenia, you make dopamine in this frontal part of your cortex.
01:05:06.000And the dopamine that you make there negatively feeds back on this dopamine that you make in the back part of your brain.
01:05:12.000And if you don't have that negative feedback, what happens is that you start making more dopamine in that back part of your brain.
01:05:18.000You start to have like negative things like hallucinations and paranoia and things like that.
01:05:22.000Yeah, and so they've shown that omega-3, they've actually given omega-3 fatty acids, DHA, to schizophrenics and shown that it actually elevates the dopamine in the frontal part of the brain and helps regulate some of that negative feedback.
01:05:39.000How many people are getting their eating fish every single day or getting their omega-3 fatty acids for their brain every single day?
01:05:46.000I mean, I know I am, but I'm pretty much an exception.
01:05:50.000You know, a lot of people that are depressed, like I said, the EPA is another big thing because inflammation has been shown to be correlated with depression.
01:06:19.000Yeah, I've seen some studies on how EPA, like giving even like higher doses of EPA to people with like arthritis, you know, they're inhibiting some of the production of like arachnidonic acid and some of these prostaglandins and things that are involved in inflammation, which a lot of people are getting because they're eating,
01:06:35.000you know, they're getting a lot of omega-6 fatty acids too.
01:06:37.000So yeah, I've seen studies where it's been shown to improve it, you know.
01:06:41.000Now, you were looking at this MCT oil over here, and you were saying that it's lacking something.
01:09:06.000And what are the benefits of lauric acid, again, specifically for combining it with MCT oil or making sure that it's in MCT oil?
01:09:13.000Well, it is an MCT, but the benefits is, one, is appetite suppressing, and two, it's a very strong antimicrobial, so it's good for your gut.
01:09:59.000Another thing that someone said to me that they were concerned about was that it's stored in plastic.
01:10:05.000Is there an issue with plastic leaching chemicals into things like MCT oil?
01:10:11.000I mean, they've shown that certain chemicals, you know, especially in the presence of heat, can leach chemicals into whatever is in the plastic container.
01:10:20.000So if, like, that plastic container sits in the backseat of your car and your windows are rolled down or something along those lines?
01:10:26.000I always try to keep oils at 4 degrees in the refrigerator because it slows that, you know, obviously the oxidation process and all those, the heat, you know, is slowed down, so...
01:10:37.000Ideally, though, what should that be stored in?
01:10:39.000It shouldn't ideally be stored in plastic.
01:10:45.000You know, it's not a real big concern of mine, so I haven't really put any thought into it, no.
01:10:49.000So as long as it's just not allowed to be exposed to heat, and as long as you're reasonably sure that the process from the storage in the plant, you know, the canning, the bottling, whatever it is, to storage to store, that it's not sitting out in the sun.
01:11:29.000Is that something you, I mean, if you have a bottle of water and it's sitting in your car and it's a hot day, should you not drink that bottle of water because it's been sitting in your car?
01:11:36.000It's probably not going to kill you to drink it, you know, once.
01:11:39.000But, you know, I wouldn't do it all the time.
01:11:43.000I mean, the bottle, like, heats up and then the plastics leach out into the water and then it affects hormones in some sort of a way, right?
01:11:51.000Yeah, I mean, they've shown that, you know, I'm not an expert on...
01:11:54.000I've done a little bit of reading on this, so, you know, I'm not going to claim to be any expert here.
01:12:24.000I'm emailing you that right now because I had a friend who asked me about it and I didn't know and I felt like you were the perfect person to throw this by.
01:13:41.000I've done a little bit of research and I plan on doing more and actually coming out with a report on this, but I'll just talk about what I've done.
01:13:48.000I like to dig, really dig, and make sure I'm comprehensive.
01:13:51.000When you digest fats, you have to make bile acids to basically be able to absorb them.
01:14:02.000Some of these bile acids that you make when you digest fat are carcinogenic.
01:14:10.000Deoxycholic acid, DCA, is one that I'm talking about in particular.
01:14:14.000So that's kind of like, you know, every time you're eating fat, your body's making this DCA, which damages DNA, damages DNA in your epithelial cells, lining your intestine.
01:14:24.000So, you know, that's sort of a drawback, but it doesn't mean you should stop eating fat.
01:14:28.000It just means you should be aware if you're eating 60 or 70% fat diet that you might want to consider some of these long-term effects that could rear their head later in life.
01:14:39.000Also, eating fat increases IGF-1 because IGF-1 is a growth factor.
01:14:47.000You probably have heard of it because in the fitness community, it's sort of like a downstream media or growth hormone.
01:14:52.000People are always really excited about having more IGF-1 because it helps you bulk on muscle.
01:15:01.000But also, if you have too much of it that you're making over a lifetime, it's a growth signal that tells cells to overcome the checkpoints I was talking about earlier where you have these checkpoints where if you have some damaged DNA that has a mutation, then...
01:15:17.000The cell goes, okay, it's time to die.
01:15:19.000But lots of IGF-1 there says, oh, I don't have to die.
01:15:42.000They must have an issue with this, right?
01:15:44.000Like, that's people that have, like, they have tumors in the pituitary gland.
01:15:48.000We've had a few of those guys in mixed martial arts that had cancer of the pituitary gland, and then they had the tumor removed so that they could compete in the United States.
01:15:57.000They were competing overseas in other organizations, like in Pride.
01:16:01.000They used to allow these guys to fight.
01:16:03.000And they would be fucking these literally giants.
01:17:03.000Actually, some people that are making...
01:17:06.000When your pituitary makes growth hormone and then stimulates the liver to make IGF-1, that IGF-1 negatively feeds back on the pituitary to shut it off.
01:17:15.000But people that have that sort of problem don't have that negative feedback, and they end up having all sorts of problems.
01:17:21.000For one, even though IGF-1 can actually make your muscle cells insulin-sensitive, which is good, growth hormone...
01:20:20.000Yeah, so I haven't done a ton of research on, like, the differences between just a normal dry sauna, which most of the studies that I read, they're using normal dry saunas.
01:23:31.000And so in people, actually in people, people that have polymorphisms in the IGF-1 receptor, it's associated with like centenarians, like living to be 92 and 100. And that's mostly mediated through not getting cancer.
01:23:48.000But there is an interesting tradeoff, and I think that...
01:23:54.000In lower organisms, the reason is that having that reduced insulin signaling helps them deal with stress.
01:24:00.000They have an increase in gene expression for various different genes that are antioxidant genes, like glutathione reductase and things like that.
01:24:11.000And also in genes that help them take care of proteins and increasing neurotrophic factors.
01:24:18.000I'm not sure if the same benefits are true in humans.
01:24:21.000In humans, mostly, I think they're not getting cancer because of having lower IGF-1.
01:24:27.000Well, here's the answer about amino acids and growth hormone.
01:24:32.000Apparently, there's a PubMed study on it.
01:24:35.000And they're saying that specific amino acids such as arginine, lysine, and orathine can stimulate growth hormone release when infused intravenously or administered orally.
01:24:49.000Many individuals consume amino acids before strength training, workouts, Believing that this practice accentuates the exercise-induced growth hormone release, thereby promoting greater gains in muscle mass and strength, the growth hormone response to amino acid administration has a high degree of Interindividual variability.
01:25:13.000That's the first time I've ever read that.
01:26:41.000During exercise, intensity is also a major determinant of growth hormone release.
01:26:45.000Although one study showed that arginine infusion can heighten the growth hormone response to exercise, no studies found that pre-exercise oral amino acid supplementation augments growth hormone release.
01:26:57.000Further, no appropriately conducted scientific studies found that oral supplementation with amino acids which are capable of inducing growth hormone release before strength training increases muscle mass Hmm.
01:27:50.000That's where it gets confusing, whether they know that it increases strength or muscle mass to a greater extent than the strength training alone.
01:27:56.000Because a lot of that is variable individually as well.
01:28:00.000You have to do the person itself and do their baseline and then what they would do without the amino acid and then do what they do with it.
01:28:09.000So you'd have to compare each person to their own self.
01:28:12.000Yeah, that's the only way to do it, right?
01:28:14.000Because I've had friends that can just...
01:28:16.000I know, I have a friend who just can't fucking pack on muscle.
01:28:19.000The guy will lift weights all the time, he lifts heavy, he can't gain weight, he gets a little stronger, but he just can't pack on muscle.
01:28:26.000Then I have other friends that they just look at weights and they're...
01:28:31.000It's like some people, they just have that mesomorphic body structure, and they start lifting weights, and their muscles just start expanding and growing, and they just start getting bigger.
01:28:38.000And other people, they have that ectomorphic thing going on, and they just can't pack it on.
01:29:17.000So it's an interesting trade-off because oftentimes growth hormones are associated with what you want more of it because your growth hormone levels go down as you age and It causes muscle atrophy and your brain atrophy in a sense too.
01:29:39.000I think it has to do with more of supra-physiological levels of growth hormone, like people that are injecting growth hormone.
01:29:46.000Like people that are bodybuilders that are taking like 10 units a day.
01:29:58.000When you make growth hormone from your pituitary and then that stimulates IGF-1 to be made in liver, that then inhibits the production of more growth hormone.
01:30:06.000I mean, that feedback's there for a reason.
01:30:08.000And so if you just keep injecting it, you're sort of overcoming that feedback because...
01:30:12.000Well, your body, you're giving it growth hormone.
01:30:19.000I wonder if there's ever been any studies on people like bodybuilders that are taking massive amounts of growth hormone over long periods of time.
01:30:25.000Because I read this thing, Dorian, look at that guy.
01:30:41.000And I think he probably takes a truckload of pharmaceutical drugs every day in order to achieve that physique.
01:30:48.000But his stomach, that's like apparently one of the things that happens when you take massive amounts of growth hormone is they literally bulge out like they're pregnant.
01:30:59.000I would love to see someone study that, to see what happens to those guys when they do that over long periods of time.
01:31:04.000That would be a really interesting study.
01:31:05.000Well, the bodybuilding industry or the bodybuilding as a sport is so fascinating to me because essentially you're dealing with these chemical projects.
01:31:35.000And, you know, I used to think that that was just big stomach muscles.
01:31:38.000I used to think that he did a lot of abs, so his stomach muscles were huge, until I actually read that their organs grow because of all the hormones that they're on.
01:31:55.000Yeah, like I said, I know it can cause insulin resistance in the liver.
01:31:59.000Yeah, well, people get diabetes from it, from overuse of growth hormone.
01:32:02.000Now, the idea that there's a whole sport dedicated to shooting as many chemicals into your body and turn you into some freak of science, that's a strange sport.
01:35:00.000Yeah, there's apparently, there's quite a few studies that have been done, not just on the mice, but also on dogs and cattle to try to figure this stuff out.
01:35:16.000If you do a Wikipedia, just like, what is the myostatin research?
01:35:23.000Okay, yeah, I'll just do it on Wikipedia here.
01:35:26.000Okay, abbreviated myostatin, also known as growth differentiation factor VIII, abbreviated GDFVIII, is a protein that in humans is encoded by the MSTN gene Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family that inhibits muscle differentiation and growth in the process known as myogenesis.
01:35:55.000Myostatin is produced primarily in skeletal muscle cells, circulates in the blood, and acts on muscle tissue by binding cells.
01:36:04.000A cell-bound receptor called the activin type 2 receptor and animals lacking myostatin or animals treated with substances that block the activity of myostatin have significantly larger muscles.
01:36:18.000And this could be of economic benefit to the livestock industry.
01:36:21.000However, these animals require special care and feeding which offsets the potential economic advantage.
01:37:09.000I'm going to have to dig into that because it's really interesting.
01:37:11.000I'd like to understand some of the mechanisms.
01:37:13.000Yeah, so a gene-encoded myostatin was discovered in 1997 by geneticists Dr. Sei Jin Lee and Alexander McFerron, who also produced a strain of mutant mice that lack the gene.
01:37:26.000And these mice have approximately twice as much muscle as normal mice.
01:39:47.000There's been a couple cases where they've documented children have it.
01:39:51.000In 2004, a German boy was diagnosed with a mutation in both copies of the myostatin-producing gene, making him considerably stronger than his peers.
01:40:00.000His mother has a mutation in one copy of the gene.
01:40:03.000And then in 2005, an American boy was diagnosed with a clinically similar condition but with somewhat different cause.
01:40:10.000His body produces a normal level of functional myostatin, but because he is stronger and more muscular than most others his age, the doctors believe that a defect in his myostatin receptors prevents his muscle cells from responding normally to myostatin.
01:40:24.000And that is what I've heard that they are trying to develop.
01:40:30.000And that myostatin, producing myostatin, regulating the size of your muscle tissue, if they could come up with a myostatin inhibitor, it would increase the size of your muscles.
01:40:53.000It's going to be really interesting, though, that when they start coming up with gene doping...
01:40:58.000And they start giving it to wrestlers or football players or things along those lines.
01:41:03.000Because it seems like anything that affects the body so significantly, as you see with those mice or those dogs, someone's going to take that shit.
01:41:17.000With his wee willy in his pants, and he's ready to just shoot that in there and make up for everything.
01:41:22.000And there's going to be a trade-off, but, you know, who cares?
01:41:27.000Well, do you follow genetic manipulation or studies on genetic manipulation and the potential for what they're figuring out these days?
01:41:35.000Because it seems incredible, and it seems that the...
01:41:39.000The future is going to be so bizarre when you deal with the idea that the exponential increase in the ability to change things and to alter the human body is just going to continue.
01:41:53.000As long as society allows this research to continue, as long as we don't blow ourselves up, this work is going to continue to go on.
01:42:02.000There's going to be more breakthroughs.
01:42:03.000There's going to be more significant increases in the capacity for change.
01:42:08.000I mean, who knows what the fuck it's going to be like just a decade, two decades from now.
01:42:14.000We've already made some major advances in the stem cell research, which to me is one of the most important, you know, because if we can get to the point where we can replace our damaged motor neurons or, you know...
01:42:26.000Make sure we're not getting Parkinson's disease.
01:42:28.000I mean, I think that's a huge, you know, that's a huge thing in helping us, you know, extend the quality of our life.
01:42:42.000You know, that's something you don't...
01:42:44.000I mean, there's certain things you can do in your lifestyle to try to not get one.
01:42:49.000But it'd be pretty sweet to have some genetic breakthroughs in these stem cell...
01:42:58.000I would like to see a study on someone who follows the exact protocol that science, that someone like you would prescribe to him or her, and that they do it over a long period of time and they have a twin that doesn't do it.
01:43:15.000And they do some of those studies where they're looking at specific, you know, things like specific vitamins or exercise or things like that.
01:43:22.000But a long-term study where you're looking at multiple changes, I would love to see that as well.
01:43:28.000Yeah, one person drinks, one person doesn't, one person smokes.
01:43:32.000They did it in monkeys, you know, and it was like a...
01:43:35.00027 year experiment, I think, where they, so caliwork restriction is known to extend lifespan in lower organisms and also in this monkey, monkeys they did, where if you give a monkey 30% less food than it would normally eat.
01:43:52.000So you basically let the monkey decide what it would eat.
01:43:55.000And then you say, okay, I'm going to give them 30% less of that every day.
01:45:07.000It's actually, he looks more muscular.
01:45:09.000Yeah, so he looks like he's lost less muscle, less muscle atrophy.
01:45:14.000I mean, so what they found, they've done, like, these gene profiling expression arrays where they can measure, like, thousands of different genes at once.
01:45:21.000And they've seen that caloric restricting actually changes the expression in, like, thousands of genes.
01:45:27.000And so it helps, like, you know, genes that are involved in, you know, protein degradation, protein synthesis, like, all these things are changed in these caloric restriction monkeys.
01:45:37.000Genes that are involved in, like, you know...
01:45:39.000Growth factors in the brain, those are upregulated.
01:45:42.000Inflammatory genes are downregulated, so it's like, you know, 27 years less of constant inflammation going on.
01:45:48.000And so it's very interesting how—and there's a couple of theories as to why these monkeys age better, why caloric restriction, you know, can help the way you age.
01:46:00.000And one of the big theories out there is that there's sort of like a hormetic response.
01:46:04.000So hormesis is basically where you have like a low level of stress, like a little bit of stress.
01:46:09.000And that stress then helps you Changes the expression of genes that are involved in stress, and so you basically can then deal with stress later.
01:46:17.000So it's kind of like conditioning your body to deal with stress by giving it a little bit of stress.
01:46:22.000And this is kind of the same thing with a lot of xenobiotics, like plant polyphenols, catechins, these sorts of things.
01:46:31.000They actually induce this hormetic response where they increase the expression of stress-resistant genes that we have in our body that help us deal with We're good to go.
01:46:56.000And this whole idea of hormesis is very interesting where you're sort of giving your body a little bit of stress.
01:47:01.000Like exercise is stress and it's a little bit of stress and it does the same thing.
01:47:04.000But that whole field of epigenetics is just so fascinating how, you know, things that you eat, what you do can actually change the expression of genes and this actually affects the way you age.
01:47:16.000And really what's interesting, not only does it affect the way you age, it affects the way your children that you haven't had yet age.
01:48:42.000There's been a few of them that have been done where in Sweden they keep like extensive records of people's – there's records of what they eat.
01:48:54.000What diseases they've had throughout their life when they were born, if they were depressed, what they died of.
01:48:58.000I mean, they're very extensive, like, records on people and also they have extensive, like, agricultural records.
01:49:04.000So they can say, like, during this part of, you know, the country at this time of the year there was a lot of famine or there was a lot of, you know, there was a great crop harvest.
01:49:13.000And so particularly this northern part of Sweden called Norbutyn, Sweden, back in, I think it was like the 1800s, they looked back.
01:49:22.000During this period of time, for whatever reason, it was hard to get in and out of there.
01:49:25.000And so people were really dependent on the crops that were there.
01:49:29.000So if there was a lot of crops and it was a good harvest, people really gorged themselves.
01:49:34.000And if the harvest was bad, there was a famine and people really, they sort of were calorically restricted.
01:49:40.000They basically didn't get to eat as much.
01:49:43.000And so a lot of these Swedish scientists decided to look back and see, well, what effects did that have on future generations?
01:49:50.000So it's kind of like Is there a transgenerational, you know, epigenetic effect on longevity?
01:49:57.000So let's look at these people that grew up during the famine versus feast years and let's look at their children and their grandchildren and see what diseases they had or how long they lived.
01:50:06.000And, you know, it's not like It's not like a controlled study.
01:50:10.000I mean, it's very correlative and there's a lot of factors missing, but it's still very interesting.
01:50:14.000What they found is that males that were between the ages of 9 and 12, and if they were 9 and 12 during the famine years, they had children and grandchildren that lived on average about seven years longer than the grandchildren of those that grew up during the abundance years.
01:50:34.000And when they corrected for socioeconomic status, meaning, okay, rich people kind of ate well no matter what.
01:50:40.000When you correct for that, when you have people from the same socioeconomic status, those grandchildren of the men that were between the ages of 9 to 12 during famine years lived 32 years longer, which is like crazy increase in lifespan.
01:50:54.000And they also, they had more studies coming out where those grandchildren were one-fourth less likely to get type 2 diabetes and also cardiovascular diseases.
01:51:02.000So it was like, why do you have to be between the age of 9 and 12 and a male?
01:51:09.000Why growing up during that part of the famine, how does that affect your grandchildren's lifespan?
01:51:16.000And we can't really tell you why, but there's some sort of theories as to why.
01:51:21.000During that time period, there's something, you know, you're prepubescent right before you actually get that growth spurt.
01:51:27.000And they think there's something to do with the sperm DNA that gets changed.
01:51:31.000A little bit of stress, a little bit of hormesis possibly, a little bit of stress changes the expression in your sperm genes, and that gets passed on.
01:52:55.000Back to the epigenetics study, something even as complex as, like, learning and memory can be modulated by your environment.
01:53:04.000This was a mouse study where they took mice that were transgenically...
01:53:08.000I'm modulated to get neurodegenerative disease.
01:53:11.000And so they put these mice, usually when we work with mice, they're in this cage that has bedding, it has some food and water, and that's about it.
01:53:19.000There's not a lot of stimulation, not a lot of exercise.
01:53:24.000But they took these mice and they put them in what we call an enriched environment.
01:53:27.000So they gave them all these toys that stimulated various regions in their brain, like the cognitive region, motor region, somatosensory regions.
01:53:36.000And what they found was that these mice scored better on learning and memory tests.
01:53:40.000And not only did they score better on learning and memory tests, they increased the expression of a gene that's involved in long-term potentiation.
01:53:47.000Long-term potentiation is a signal that you're making when you're learning.
01:53:53.000But the really interesting thing about this study was that these mice that were genetically engineered to get neurodegenerative disease had offspring mice that were also Genetically engineered to get neurodegenerative disease, but were not put in an enriched environment.
01:54:06.000So they were put in that boring cage where they had no stimulation.
01:54:09.000But they had still increased that long-term potentiation gene.
01:54:16.000In this case, it was through the egg, through the female line, to the offspring mice, which had the same learning memory benefits, even though they weren't exposed to that environment.
01:54:26.000So, I mean, just having cognitive stimulation, just using your brain more and exercising more, Can affect the expression of your genes and that can actually get passed on.
01:54:52.000I mean, certainly, you know, the environment plays a component in those things, but, you know, the epigenetics, we're just sort of starting to understand epigenetics and how it works, and it's complicated.
01:55:24.000You just think of the potential for re-engineering the human body.
01:55:29.000I mean, it seems like we're going to be able to do all these things we're doing to mice, giving them double muscles and making them fucking smarter.
01:55:36.000We're going to be able to do that to people.
01:55:38.000We're going to make a Dr. Manhattan, you know?
01:55:40.000Remember from that movie, The Watchman?
01:55:43.000There's going to be a guy one day that's the omnipresent super being that becomes a god.
01:55:50.000We're going to fuck up and make a god.
01:55:53.000I try to do what I can to make myself work better, cognitive-wise, and also try to basically age better.
01:56:05.000You know, it's certainly, like, we can do things, like, now.
01:56:08.000But just, yeah, like you were saying, genetically changing someone's, like, literally, like, you know, making someone's muscle grow like that by, like, giving them an inhibitor of a certain myostatin receptor.
01:56:19.000I mean, that's, like, hardcore stuff that, you know, we don't really know what the effects are going to be of doing things like that long term.
01:56:45.000So intelligent that he sort of, like, factored in a lot of things like, well, you know, people live, people die, you know, remorse and guilt and all these things are really just byproducts of human culture and our correlation to, you know, cause and effect and our reactions to each other.
01:57:02.000I mean, he took away all the joy and fun, the zest of life.
01:57:38.000You've got to be smart enough to realize that this is all silly.
01:57:41.000Yeah, thinking about the things you can't control.
01:57:43.000Sometimes I get these what I call OCD spikes where if I'm driving on the highway, I start to imagine all the possibilities that can happen, like all the things that can happen with all the cars.
01:57:57.000And there's moments where it's so overwhelming where I just can't drive.
01:58:12.000What I often do is I like to live five minutes from where I work.
01:58:16.000That way I don't ever have to get on the highway because I don't have to think about all the things that can happen when I'm on the highway.
01:58:28.000I sometimes obsess over what I can't control and the fact that there's all these people and I'm like, they're doing all these things and all this could happen and all these possibilities and then it's like, okay, it's like overload.
01:58:39.000I had a moment when my first daughter was born where when I was in the hospital in the moment she came out of the box I was thinking like how many different people are being born right now simultaneously all around the world and if you could see that on a giant screen I mean,
01:59:01.000it would look like an invasion of babies.
01:59:03.000If you could see the millions of people, no doubt, being born all over the world at the same moment, just...
01:59:27.000Isn't that sort of the issue with – one of the main issues with paying attention too much to bad things in the news?
01:59:37.000And I've talked about this many times.
01:59:39.000I think we have a real problem with digesting 7 billion people's worth of problems because – Anytime something spectacular or horrific comes up from all over the world, we get it and we absorb it.
01:59:52.000And it sort of alters our idea of what the world is.
01:59:55.000Oh, the world is a scary place and it's filled with evil.
02:00:00.000Really, the numbers are pretty against that.
02:00:04.000The numbers, like, throughout your day, you experience very little violence.
02:00:08.000Throughout your day, you experience very little horrific crime.
02:00:11.000It's very, very rare in most parts of America, unless you live in a terrible neighborhood, to experience the kind of shit that you see on your news feed or your Twitter feed.
02:00:22.000It's not an accurate expression because it's based on such an insane number that you're not supposed to be correlating.
02:00:28.000You're not supposed to be looking at a 7 billion people number.
02:00:31.000You're supposed to be looking at a tribe of 150 people.
02:00:34.000I mean, that's what our brain, that's what the Dunbar's number is.
02:00:38.000We don't really know what the fuck to do with 7 billion people's worth of information.
02:00:43.000So we become these paranoid messes when we start thinking about all this horrible shit that's happening, but you're talking about a A fucking planet worth.
02:01:04.000Is it possible that the epigenetics of living in this life will alter our genes and our expression of our genes so that we can accept this kind of information?
02:01:30.000You know, I don't listen to tabloids, but yeah, I'm sure they are...
02:01:34.000Or even just fear-mongering, you know, just going on the Alex Jones website, just paying attention to all these people that are doom and gloom, new world order, they're fucking chemtrails, they're Putting caskets out in the FEMA camps and getting ready to mass kill people.
02:04:01.000They're not thinking about any of these things.
02:04:02.000They don't have anything other than immediate concerns, which is kind of what we're designed for, right?
02:04:09.000I mean, when you look at the genes of human beings and the amount of time that we've been in this particular type of a society and the amount of time that we've been essentially hunter-gatherers, I mean, there's no comparison.
02:04:21.000We have just a long stretch of time where we were just living a very specific way.
02:04:27.000And then over the last couple of hundred years, things radically shift in a very strange and new direction.
02:04:33.000And then we find ourselves where we are now, from the invention of the printing press to the fucking Twitter feeds and internets and Facebook.
02:07:24.000It's so endlessly fascinating when you find out what has been learned about the body, how many studies have been done, what information is out there, and then yet how much we need to learn, how much there is to know, how much there is to discover.
02:08:10.000False claims that this company has or that company has or these pills have.
02:08:15.000We hear about things all the time when it comes to nutrition and supplementation, especially when it comes to athletic supplementation, things that are purported to deliver amazing muscle growth.
02:08:28.000They've found that a lot of those things that are purported to give muscle growth were erection pills.
02:09:30.000People are just putting some other plant in there, and it's like you think you're getting echinacea, and it's some other crap.
02:09:38.000I think there's a whole opening for people to actually do some DNA barcoding where you can actually test what's in a supplement and start a company where it's like, I've tested these supplements, and they're actually what they're saying they're supposed to be.
02:09:54.000Because it's like you've got a huge...
02:09:57.000When people are trying to buy certain supplements and then they're not even getting...
02:10:01.000What they think they're buying, regardless of whether or not there's any science to back up with what they think they're buying isn't doing anything.
02:10:06.000I mean, the point is they should be getting what they think they're getting.
02:10:09.000And then, of course, there's a huge issue of homeopathic cures, which are mostly nonsense.
02:10:14.000There's a huge homeopathic industry that's essentially selling you sugar.
02:10:42.000It affects all these different things.
02:10:44.000And then taking all this other crap that I don't know...
02:10:47.000People like the idea of some exotic thing isolated from somewhere.
02:10:51.000And it's like, oh, it does this because it's exotic.
02:10:53.000And, you know, the reality is people...
02:10:56.000They should be focusing on what they're not getting that's essential for, you know, things that we know that's essential for the, you know, proteins in their body to work.
02:11:03.000And so a lot of that homeopathic stuff, it gets mixed in with the vitamins and minerals too, and that's really irritating because it's really, they're two different things.
02:11:20.000If you're interested in that, just Google homeopathic medicine sugar pills, and there's studies, there's a lot of different stuff on sugar pills.
02:11:30.000Well, actually, they've shown, they've done placebo effect studies using sugar pills, where they've published, like, they've given someone a placebo.
02:11:39.000I mean, the whole point of the study was not for the Yeah.
02:12:27.000I mean, I haven't really done a ton of research into understanding why, but yeah, it's interesting how your brain can make yourself think that something's working and you actually can force yourself to be healthier.
02:12:48.000I mean, the human being is like, a human body is to me essentially like the most incredibly complex computer ever and we don't have a guidebook for it.
02:13:10.000I mean, when I started researching these studies on the effects of depleting tryptophan from your brain and how normal people all of a sudden become impulsive violence and impulsive behaviors and recidivism.
02:13:25.000So they'll do these tests where they're punished for doing something wrong and they'll keep repeating the same thing.
02:13:30.000I mean, I was like, I can't believe you can change someone's behavior by depleting tryptophan.
02:13:35.000Like, that was really, you know, amazing to me.
02:13:39.000And, you know, the way that nutrition affects your brain function in general and behavior is really interesting to me because it suggests that we have to some degree some control over our cognitive function and behavior.
02:13:49.000And I think that we should be optimizing that as much as we can.
02:14:19.000There's been studies showing that giving these people multivitamin and omega-3 fatty acids, so it's hard to pinpoint what's specifically in it, but I think it's a combination of everything.
02:14:52.000Omega-3 fatty acids, and it affected their aggressive outbursts.
02:14:57.000You know, because that's a whole other topic.
02:14:59.000You know, you've got a population of people that's incarcerated and knows what they're getting fed, probably deficient in multiple micronutrients, including omega-3 fatty acids and vitamin D. Unquestionably.
02:15:11.000We had a guy on recently, his kid, War Machine, an MMA fighter.
02:15:15.000John Copenhaver's his real name, War Machines' fighting name.
02:15:20.000And he was talking about a year that he did in prison where they gave him 1500 calories a day and it was horrible nutrition and just how his body just felt like it was wasting away because of it.
02:15:29.000Yeah, see, this is, I would like to see, you know, we're spending money to keep people in prison, you know?
02:16:33.000I see your point of view, but I see how people are going to say, if you're going to start somewhere, don't start with people that have already fucked up.
02:16:40.000Yeah, we should definitely give them to poor people also.
02:17:45.000I listened to the podcast that you had some time ago, and he's got good information.
02:17:51.000I don't want to say otherwise, but I wanted to correct that because he had said that the children from the well-fed population The ones that were grandchildren of the well-fed children got type 2 diabetes less.
02:18:57.000This guy is selling coffee, and now we're selling this coffee through Onnit that was...
02:19:03.000Supposed to be the cure to this issue of mycotoxins.
02:19:07.000No, you're actually drinking Hawaiian Kona coffee that I started drinking right after we got our results back on the mycotoxin tests.
02:19:18.000His contention was that 70 plus percent, whatever it was, of all coffee is infected with mycotoxins and they make you sick, they make the coffee taste bitter, they make you feel bad.
02:19:29.000I took too much of this at face value and He parroted a lot of the things that he said.
02:19:34.000And then we decided to start looking into it ourselves.
02:19:36.000Well, they've known about mycotoxins in coffee for a long time.
02:19:40.000There's a PubMed study from 1980 about mycotoxins in coffee.
02:19:59.000One Starbucks, one random bag from Whole Foods, One coffee that we sell, which is the upgraded coffee that Dave produces, which is good coffee, good single-source coffee, and another one called caveman coffee.
02:20:12.000None of them tested positive for mycotoxins.
02:20:14.000And so if 70% of all coffee has mycotoxins, and we had three bags other than the upgraded coffee, none of them are taking his upgraded quote-unquote bulletproof process Which he won't reveal what this process is publicly.
02:20:31.000And so I kind of feel like there's some bullshit there, for sure.
02:20:37.000There's no way we're just going to find four bags of coffee and test them.
02:20:42.000So our friend Tate, who runs Bulletproof Coffee, he tested two bags, and his coffee and this upgraded coffee, and allegedly he found below threshold levels of mycotoxins in Dave's coffee.
02:20:56.000So I didn't, you know, I didn't conduct that test.
02:21:00.000I don't know if it's right, but what the fuck, you know?
02:21:04.000Like, I feel like when you're a guy who's running on and doing these kind of interviews and spewing out all these facts, you have to be really fucking careful, you know?
02:21:15.000You have to be really fucking careful that what you're saying is true.
02:21:18.000And if what you're saying turns out to not be accurate and I find out you're profiting from what you're saying, It becomes bad.
02:21:29.000And that's where we are with this upgraded coffee thing.
02:21:32.000We still sell it at Onnit because it is really good coffee, but we've removed all the literature on the mycotoxin issue, all the literature on that.
02:21:43.000Because when you talk to the people that are in the know in the coffee industry, coffee growers, people who grade coffee and rate coffee, they actually have a rating system that is, you know, like you get a 94, 95 if you have excellent coffee.
02:21:58.000Well, your coffee loses points if it tests positive for mycotoxins.
02:22:41.000Like I said, aflatoxin is one thing that certainly can cause cancer.
02:22:47.000I've never really been that concerned about mycotoxins in my coffee being a carcinogen.
02:22:53.000I'm more concerned about my own metabolism generating reactive oxygen species because that's generating more You know, reactive oxygen species than some mycotoxins in the coffee, and that's, you know...
02:23:06.000Well, mycotoxins most certainly exist.
02:23:47.000And, you know, he claims that he's telling the truth and he claims that, you know, if you sign a non-disclosure agreement, he'll show you all his, you know, all his testing methods.
02:23:55.000Like, But it seems to be bullshit, and I feel bad because I like the guy, and I think that, first of all, he's a collector of ideas.
02:24:05.000He doesn't have a formal education in nutrition.
02:24:09.000This is not something that he's got a PhD in.
02:24:12.000He's not you, essentially, is what I'm saying.
02:24:15.000So, you know, when I talk to you about it, I'm getting it from someone who went to really good schools and you do research every day for a fucking living.
02:24:24.000And like I said, I'm not an expert in mycotoxin, but I've sort of not really been worried about it in coffee just based on the little bit of reading that I've done.
02:24:35.000Well, it seems like it can be an issue if you have mycotoxin-infected coffee.
02:24:52.000But what Tate, my friend Tate in Caveman Coffee, found in his is below threshold levels of two different types of mycotoxins, which is not going to affect you at all.
02:25:41.000And it's like, oh, you can't eat beans because beans have lectins, and lectins cause an immune response in your gut, and this is going to cause leaky gut.
02:25:53.000Lectins are inactivated by heat, and so unless you're chewing raw kidney beans or raw lentils, you're probably not activating an immune response in your gut.
02:26:02.000And actually, beans are really high in fiber, and fiber gets broken down into short-chain fatty acids, which actually prevents the immune response in your gut.
02:26:49.000So it's another one of those cases where there's too much to know, there's too much to learn, and I have a guy on who says he's an expert, and some of the things that he says seem to be bullshit.
02:26:57.000And that's the big one, that everyone has mold in their coffee except me.
02:27:01.000I know how my super secret way of getting rid of it, but I fucking bought it.
02:27:06.000So here we have a problem that we've allowed to be created, but I'm not drinking it anymore because of that, just out of general principle.
02:27:15.000We'll probably eventually stop selling it.
02:27:29.000Well, not only that, a lot of people buy it based on this premise that has not been proven, that most coffee has mold in it, with no fucking evidence whatsoever to back that up.
02:27:38.000I haven't seen any evidence that most coffee has mycotoxin, and I haven't seen evidence that it has levels of mycotoxins that are harmful.
02:27:48.000There was one test that showed that in the bitterness area, there was one test that showed that mice, when they were given saccharin infused with mycotoxins, tended to avoid that saccharin with mycotoxins.
02:29:15.000This one guy who's not even a fucking nutrition expert, doesn't have a PhD in nutrition, He comes along with these incredible claims and also has this incredible method to alleviate this ailment.
02:29:35.000It seems to be what's been done here, whether or not it's intentional or not.
02:29:39.000I don't even think it was intentional, but I think that he's one of those guys that once he goes down a path To say he was wrong or to try to...
02:29:49.000Once you have a product on something, it's hard to then say you were wrong.
02:29:52.000Yeah, you're fucking profiting off of it.
02:29:53.000You put yourself in a situation where it's...
02:29:55.000And it's tricky because it's not bad coffee.
02:30:39.000I have children and jobs and things to do.
02:30:43.000I don't have time to deal with this shit, but I'm obligated now because I got thrust into this situation.
02:30:50.000It's nice to talk to someone like you to clear up some of the misconceptions of health and nutrition and to find out what's real and what's not and what are issues.
02:31:01.000When I talk to a guy like Brian Dunning who's like, you don't need vitamin C. You don't need this.
02:31:09.000He's fat and just not taking care of his body.
02:31:11.000He's a no-nonsense guy who got fucked because he was a kid and he was raised a Mormon and now he's trying to counteract that by being a skeptic.
02:31:19.000I mean, that's really essentially what's going on.
02:31:20.000But that guy can fuck with people's heads because he's not an expert.
02:31:24.000He's clearly not an expert in a lot of things.
02:31:28.000So, he really shouldn't be reviewing scientific literature, in my opinion.
02:31:33.000He needs to get some people that really know how to do that if he's going to start trying to critically analyze science.
02:31:40.000That's my opinion because I've read some of his stuff where he's trying to critically analyze it.
02:31:44.000For example, this Linus Pauling, he's got something on his website talking about how vitamin C has no effect on cancer incidents or can help, if you already have cancer, can help kill the cancer cells.
02:32:00.000And he puts up these studies by the MyoClinic That, you know, couldn't repeat these early studies that were done by Linus Pauling and Cameron, I forgot his name, anyways, in the late 70s.
02:32:12.000But, you know, anyone that's a scientist will look at that and go, oh, Pauling and Cameron gave their patients, their cancer patients, vitamin C intravenously.
02:32:22.000And they did that for a reason, because you can only horribly absorb so much vitamin C and it'll get into your bloodstream.
02:32:28.000But intravenously, you can, like, You know, raise it to like millimolar, you know, concentrations.
02:32:33.000And so the two myoclinic studies that repeated it, repeated it in quotations, gave them orally.
02:32:40.000And so, you know, you can't repeat a study and change the method of administration from oral to intravenous and say, oh yeah, we repeated the study and it didn't work.
02:32:51.000So when you're critically analyzing data, you need to focus on those sort of details because they're actually really important.
02:32:57.000And a recent study just came out like two weeks ago where they took patients, female patients that had ovarian cancer, and they gave them vitamin C intravenously, and they were doing their standard chemo.
02:33:10.000It's really hard nowadays to do any sort of unconventional cancer treatment.
02:33:16.000That's not, you know, because it's like you don't want to just kill someone.
02:33:21.000So anyways, they did it with the chemotherapy, and it actually...
02:33:24.000It killed the cancer cells better, and it also alleviated a lot of the negative symptoms associated with the chemo.
02:33:30.000And this was published in Science Translational Medicine, which is a pretty good journal for translational research, in fact.
02:33:38.000Well, Brian has several problems with some of the things he puts out.
02:33:42.000You know, he's accused me of being a pseudoscience shill.
02:33:46.000And even after the podcast, where he came on and had all these...
02:33:52.000Really ridiculous accusations that he threw at me on his website, and we talked about them one by one, what I believed and what I actually didn't believe, what I said and what I didn't say.
02:35:41.000It's not a problem if the well is properly vented.
02:35:44.000Theirs wasn't, so gas got into their water.
02:35:48.000How do we know it had nothing to do with fracking?
02:35:51.000Water wells range in depth from a few meters to a few hundred at the very deepest, but fracking takes place kilometers deeper, past numerous layers of bedrock.
02:36:01.000Years of study have proven what geologists have always known.
02:36:05.000There's just too much distance of solid rock between the two regions for any seepage to take place.
02:36:24.000These piss-poor studies, these people that have been documented on all these various documentaries.
02:36:31.000There's the two ones on the Gasland 1 and Gasland 2, but then there's also people that have done interviews and showing how they can light their fucking water on fire now and showing how their wells are poisoned.
02:36:42.000People who have been really made deathly ill by drinking what they thought was filtered water, but it's not filtered enough because some of the chemicals from fracking got into the water.
02:36:52.000Proven that those are the specific chemicals that are in their water that got there from fracking.
02:36:59.000He's just one of those fucking guys, those no-nonsense guys.
02:39:07.000I mean, it's like, okay, well, everything that I was told throughout my life is wrong.
02:39:10.000So then everything else must be wrong.
02:39:12.000If you just Google dangers of fracking, there is a tremendous amount of information out there about fracking, about what's bad about fracking, about the dangers.
02:39:23.000And I had Peter Schiff on the podcast, who's an economic genius, very smart guy.
02:39:58.000Yes, we could use the natural resources.
02:40:01.000Yes, it would be nice to not be dependent on foreign oil.
02:40:04.000However, if you really are destroying thousands of wells, if that really is documented, if really people are getting sick from drinking water that's contaminated with the very chemicals that they use for fracking...
02:40:17.000You know, that doesn't seem like it's good.
02:40:19.000That seems like that's something that most people are not aware of.
02:40:22.000And when you find out who are the people that are funding these studies that are saying it's safe and where's the money all coming from, a lot of it's coming from these oil companies.
02:40:31.000A lot of it is coming from these oil companies.
02:40:33.000And the reason why these laws are in place in the first place, a lot of it is because people have been greased.
02:40:38.000A lot of it is people have been paid off.
02:40:40.000They understand that there's a lot of money to be made in this.
02:40:42.000And they've allowed the doors to be open for these companies to come in and fuck up giant parts of the country forever.
02:41:07.000But, you know, he said after the podcast, he said he would remove me from his list.
02:41:12.000He said, you've convinced me I'm going to remove you from my list.
02:41:14.000Then, from just getting crushed by people online, the poor guy got destroyed on Twitter.
02:41:20.000Because people who listened to the podcast were so frustrated by him and the ridiculous way he thinks and the ridiculous things that he was saying.
02:43:51.000Well, and the people like that, along with people like Dave Asprey who got the information on the study, the dietary study incorrect, it's a real problem with those guys because they're not a guy like me who's not a fucking expert in anything.
02:44:04.000Look, if you ask me questions about martial arts, If you ask me questions about stand-up comedy, I can give you the opinion of an expert.
02:44:11.000I'm a true expert in those very small areas.
02:45:45.000They don't understand enough of the science behind it.
02:45:47.000And so then you get everyone following this, this big following, and it's like, you know, like, how do you come in and say, okay, look, this is how it's really happening.
02:45:55.000And that's kind of what I'm trying to do in some degree.
02:46:12.000Well, listen, I've really enjoyed this conversation.
02:46:14.000I think you've opened up a lot of people's eyes and you've educated a lot of people and provided a lot of information, almost too much information.
02:46:20.000I'm definitely seeing people writing down all these different things and Googling all these different things that you've said.
02:47:04.000That's kind of like a Kickstarter, but you can contribute like 25 cents a month, and that's to help me pay for my podcasting, like to host my podcasting.
02:47:12.000And it's really just to help me continue doing what I'm doing, like on weekends and in my free time.
02:47:19.000And lastly is signing up for my newsletter.
02:47:21.000I know that's not that cool these days, but I actually put a lot of good information in my newsletter.
02:47:25.000I'm going to put this link to this new study on Absolutely.
02:47:50.000That can separate and clear the fog on a lot of these issues.
02:47:54.000And I'm fucking not tolerating this anymore.
02:47:58.000If someone comes in and they have all these claims and they don't have information to back up their claims, I'm just going to fucking kick them out.
02:49:09.000Next week though, lots of cool people coming in, ladies and gentlemen.
02:49:13.000We got a lot of shit happening and thank you for all the love.
02:49:16.000All the love on Twitter, all the love on Facebook and all the positive responses that we get and all the cool people that I meet that tell me how much this podcast enhances your life.
02:49:25.000It enhances mine too and it would be nothing without you guys.