#169 - Katherine Eban: COVID-19 Lab Leak: Examining all sides of the debate and discussing barriers to a full investigation
Episode Stats
Length
1 hour and 39 minutes
Words per Minute
146.24268
Summary
In this episode, Catherine Eban joins me to discuss the origins of SARS-CoV-2, the mysterious virus responsible for one of the worst pandemic pandemic in history, COV-19. Catherine is a journalist at Vanity Fair and has previously written a detailed piece on this topic.
Transcript
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Hey, everyone. Welcome to the drive podcast. I'm your host, Peter Atiyah. This podcast,
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head over to peteratiyahmd.com forward slash subscribe. Now, without further delay,
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here's today's episode. My guest this week is Catherine Eban. Catherine is an investigative
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journalist and also a previous guest on the podcast back in September of 2019 when we spoke
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about her book, Bottle of Lies, which dug into the prevalence of fraud in the generic drug
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manufacturing industry. Well, Catherine's back again this time to discuss yet another controversial
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topic, this time around the origins of COVID-19 or the virus responsible for COVID-19, SARS-CoV-2.
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Catherine is one of a number of journalists who has written a detailed piece on this, hers in
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Vanity Fair. And in this episode, we get into a lot of detail about both sides of this.
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I suspect most of you are at least somewhat familiar with this, but if not, let me provide
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a little bit of background. There is a brewing controversy around the origins of the virus
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responsible for COVID-19. Of course, at the time of the pandemic's arrival, it was viewed as a
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largely open and shut case that this was a virus of zoonotic origin, meaning this was a virus that
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occurred in nature. The belief at the time was that this was a virus that originated from bats,
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transferred to an intermediary, a pangolin most likely, before ultimately finding its way into
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humans in the wet markets of Wuhan. While there were some rumblings about the veracity of that theory
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in the early parts of 2020, they were met with the sharpest rebukes from both the scientific community
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and more broadly, just the political community that was viewing such statements as xenophobic
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or otherwise ill-informed and conspiratorial. Since that time, however, there has been a push for
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greater transparency and basically a push to understand what the real origin of this virus
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is. And I think there have been basically two factors that have driven that push. The first
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is that despite the case of SARS-1 and MERS, very similar coronaviruses to the one that resulted in
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COVID-19, there has yet to be any identified species of origin and or intermediary. In other words,
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the bat that would have resulted in this virus ultimately going to humans and or to an intermediary,
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that animal or those animals have not been identified and that has not been due to a lack
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of effort. I think the second factor that has driven this push for greater transparency has been
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effectively the abject lack of transparency to date. Now, part of that can be understood and explained
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by understanding that in an autocratic nation like China, transparency is not the norm and therefore
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would never be the norm under any circumstance, lab leak or otherwise. But I do think that there is
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enough frustration on the parts of people to at least ask the question, why did we not take this
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theory seriously a year ago or 18 months ago when perhaps it would have been easier to gather information
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to examine both of these ideas? The idea that the virus originated in nature or the idea that the virus
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actually escaped from the lab where it was presumably being manipulated for some greater good, such as
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the development of vaccines or disaster preparedness or other things like that. We do not really get into
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radical ideas such as that this virus was developed as a bioweapon and somehow unleashed. So regardless of
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your knowledge level in this space, I think this episode will be interesting and I will allow you to
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obviously draw your own conclusions. So without further delay, please enjoy my conversation with
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Hey, Catherine, great to have you back on the show here.
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Seems we're always discussing something controversial. And by the way, I already know what our third podcast
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will be about based on other controversial work you've done. So yeah, you don't like to write about
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things that are simple. No, I don't seem to. It is the fate of the investigative journalist.
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Well, let's start with a broad question, which is what attracted you in particular to this story?
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And why did you decide that you had something to offer, especially in a story where not to let too
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much out of the bag too soon, but it seems that this is not something that can truly ever be known
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one way or the other. So it seems a bit of a frustrating exercise.
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Yeah. Well, I've been covering the pandemic for a year for Vanity Fair. And, you know, as things have
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come a little bit more under control in the U.S., at least for the time being, my editor and I were
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like, what are the big unanswered questions of the pandemic? And we decided that the biggest
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biggest is what its origin was. Now, one might say, well, that was settled a while ago or seemingly
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settled, right? It came from nature, but we don't know exactly how or where. But it was interesting
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because the head of the World Health Organization himself said, we still don't know. And all hypotheses
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remain on the table. So it seemed that with Trump out of office, with the WHO head himself raising this
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as a question, it was a good time to begin to look into what was the sort of, what's the debate?
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What's the controversy? What are the questions? And what I uncovered was a lot more than I had
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really considered or bargained for when I started my reporting. Maybe for folks, we should give a
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little bit of background on what a lab leak implies. Is there a precedent for such a thing
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in virology? Because at the surface, it certainly sounds nefarious, right? It sounds like, well,
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that must be a deliberate thing. And it immediately falls into the realm of conspiracy theories. But in
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fact, there's quite a precedent for viruses getting out of labs in the modern era. And I would define
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the modern era as the era of microbiology. Obviously, there weren't lab leaks that accounted for the
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Spanish flu. But are there any that come to mind as you began your work here or that you had to learn
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about as a result of your investigation? Yeah. So let me say first that lab leak, as it's understood,
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is not a unitary theory. It ranges all the way from field researchers went into a bat cave,
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brought back natural samples into a laboratory, and that natural sample somehow leaked, or a laboratory
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researcher got infected simply through, you know, aerosol transmission, which is what we're talking
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about. This is not, I mean, the word leak implies like liquid gushing out of a pipe. That's not what
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we're talking about. We're talking about aerosol transmission. But it could have been an infected
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lab worker. It could have been an infected field researcher bringing a sample back. But the phrase lab
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leak sort of runs all the way up to the possibility that someone in a laboratory was manipulating viruses,
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potentially in an experiment to make them more infectious, to see if they would become more
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infectious. And that that new strain, not a natural strain per se, but one that was genetically
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modified, could have leaked from a laboratory. So it really runs the gamut. It's not a single thing.
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This is not like, oh, how could that ever happen? In a way, it's like, how could it not happen? Because
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it's happened over and over and over again. You know, you had very serious lab leak in the Soviet
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Union, which finally became exposed. It was an anthrax leak. You've had SARS leaks. You've had four
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SARS lab escapes since the SARS epidemic of 2002. So this actually is something that happens a lot.
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And it seems that one of the most significant examples of this was this Russian flu in 1977,
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which was an H1N1 flu that had been around in the 40s and 50s. It was being studied in a lab.
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When it reemerged, it seemed to target disproportionately people that were younger than 25,
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which at the time maybe didn't make sense. Although after it was clear that this was the same virus that
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was around sooner, it made sense because obviously the people that were being afflicted were people
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that did not develop natural immunity. Again, there had been no, to my knowledge, of course,
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because you wouldn't have had the tools to have done so, there was no gain of function. Not that they
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could have genetically edited, but I don't believe there was evidence that it had been sort of selectively
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bred or anything like that. It was simply a question of, this is a virus that's being studied in a lab.
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And then somehow that led to it getting out. And as you point out, at least four cases of the early
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SARS-1 virus escaping. And again, when you read the stories of these, which I've read at one point,
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all of them, these are mistakes that people can make. These are perhaps viruses that are not being
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handled with as much care as they should be handled. Some shortcuts are being taken with respect to
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how they could be handled. You know, I think it's important to point out that people talk about
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BSL-4 labs that are studying these incredibly dangerous pathogens. And so those are the most
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protective, highest containment labs where all the researchers are working in spacesuits with
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independent oxygen. But the fact of the matter on the ground is that you have research with incredibly
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dangerous pathogens taking place in laboratories across the world that have much less protection,
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like BSL-2 labs, which are basically the safety standard of an American dentist's office.
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So you've had live SARS viruses being studied in overcrowded laboratories in China and elsewhere
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So there's at least a precedent that a virus that's being studied can make its way out of the lab. In
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fact, there's a great precedent for it. But of course, that alone doesn't explain what could have
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happened here. It's probably worth also explaining for folks who haven't been so steeped in this story,
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or at least reminding people of the typical way in which a virus can be transmitted between animal
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hosts and what it means to have an intermediary hosts and how, for example, those were identified in the
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So it was presumed early on that like other past viruses, SARS-CoV-2 had a zoonotic origin, meaning
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that it spread somehow from an animal and jumped to a human or that there was an intermediary animal.
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So possibly a pangolin, possibly a civet cat, and that it went from a bat reservoir to some intermediary
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animal to humans. So that is believed to be the case with SARS-CoV-1. That is believed to be the case
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with MERS, where there was a dromedary as an intermediate host, with the initial animal
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being presumed to be some sort of bat reservoir. With Ebola, it's believed to have a zoonotic origin,
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either a bat or a chimp. It's not certain yet. But that is the long history of these viruses,
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that it has some kind of natural origin, and then evolves and mutates in such a way that it can
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infect a human. And I think one of the questions here in the case of SARS-1, it didn't take that
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long. I believe it was, you know, in the order of about six months to identify its intermediary,
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which is, what's it called? Like a cavet? Like it's sort of like a little...
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Yeah. And obviously in MERS, as you mentioned, a camel. What's relevant about this is that the
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virus can acquire additional tools in that intermediary host before making that final
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leap. And then so the question is, how much of the transmission occurs between, say, the cat and
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the human? Or once that transmission occurs, is most of the transmission occurring human to human?
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And so as of now, which is directionally, call it a year and nine months post the first infection,
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we don't yet have an identified intermediary host, which implies that it exists, but it hasn't yet
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been identified or there wasn't one. And this might've traveled directly from bats to humans,
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for which there's clearly a precedent based on what happened in 2012, right?
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Well, let me just say that we don't yet have a designated animal host and it's not for lack
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of trying to find one. So Chinese authorities have tested up to 80,000 animal samples to see if they
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could find a host animal and have not been able to do so. You could think of it as an international
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bat hunt to find the host animal of this virus. And none has presented itself yet.
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Right. So we have, we haven't identified the potential bat source of it. We haven't identified the
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intermediary of it. There is a close closest relative that has been identified, correct?
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Yeah. So that is a sort of complicated question, but there is a strain RATG13, which was found in an
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abandoned mine shaft in Yunnan province in 2013, which is sort of the closest viral sample to the SARS-CoV-2
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sequence. So it's about 96.2% identical to SARS-CoV-2.
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What do we know about that? I don't want to say accident, but that experience in 2013,
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where the miners were exposed to it, what do we know about their illness and what does that
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So there's a couple of really interesting things about what happened in 2012. First of all,
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that it happened, what happened, but also how it sort of broke into the public domain,
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what happened. So just starting out in 2012, there were six miners who were given this
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very unpleasant assignment, which was to go to this abandoned mine shaft and clean it out because it was
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thick with bat guano, which is bat feces essentially. So they go in there and they dig for days and weeks
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and they become gravely ill. So they become admitted to the hospital, Kunming University Hospital. So they
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get admitted to the hospital. The question is, is it a fungus? Is it a virus? They bring in an expert
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who analyzed this, says it's a virus. They have pneumonia. It's a virus. Their symptoms were
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almost identical to COVID-19. So he asked, what were they doing? They were digging a bat guano.
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What kind of bat? It's this Chinese rufous horseshoe bat, which is the same one that triggered SARS-CoV-1.
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Three of the miners died. Three ultimately recover. So this is a case that should have triggered worldwide
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alarm because it looked like the beginning of an outbreak again. But the Chinese authorities never
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reported this to the World Health Organization. It sort of remained below the radar, except that this
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abandoned mineshaft became a destination for virologists in Asia who were going into this mineshaft and
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getting samples and bringing it back to their laboratories. Probably the most active samplers from this
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mineshaft were members of the Wuhan Institute of Virology in Wuhan. They dug up many samples, brought it back to
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their laboratories, and they sequenced a sample, which they called at the time, 4991. And that was,
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as we would find out later, 96.2% identical to SARS-CoV-2. Except at the beginning of the outbreak,
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nobody knew about this mineshaft. Nobody knew that three miners had died, and no one knew about 4991.
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The only way that we ultimately found out about it is because a very curious unemployed science teacher
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in Eastern India started digging into this database of Chinese master's theses and pulled up an entire
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dissertation about this incident in the mineshaft. Now, to be clear, it would not have been known
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based on the infection of those six mineshaft workers with basically a 50% mortality that there
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was any evidence that that virus could be transmitted human to human. Correct. It could have been simply
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that they acquired it from the bats, which is the most likely scenario, in the presence of an overwhelming
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exposure to the virus, but that the virus would not transmit human to human. Would that have been
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possible? That's right. We have no information that they infected one another. They were all exposed
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to this bat guano. They went to the hospital. It doesn't appear that the hospital workers got sick,
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so it doesn't appear that they spread it to other people, but they were desperately ill. And it's
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interesting to note, the oldest miner died first. He was the most gravely afflicted. He was in his 60s.
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So if we look back at this incident in light of COVID-19, there are a number of aspects of this
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that do look like SARS-CoV-2 in 2012. Though clearly it's a different virus given that, I mean,
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I think for a person listening, maybe not familiar with genetic distance, 96.2% sounds like, oh,
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that's a perfect match. But of course, that's not remotely a match. You know, I've spoken with
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virologists who have said, look, to try to take a virus from 96.2% to 100% would take forever. I mean,
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that would be a very long period of genetic manipulation. So the point being, it seems unlikely,
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at least if that's true, that that virus ultimately became SARS-CoV-2. What did your work uncover with
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respect to that specific concern? The issue is, that is one sample that was taken from that mine
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shaft. But we don't know the whole universe of samples that came from that mine shaft. Now,
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that sample was taken to the Wuhan Institute of Virology, which, you know, just to point out
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is about seven miles away from what was initially identified as the epicenter of the COVID-19 outbreak
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in this Huanan seafood market. But the issue is there were hundreds of samples that were taken
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to the Wuhan Institute of Virology. The database that housed these samples was taken offline,
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weirdly, a couple of months before the known start of the COVID-19 outbreak. So publicly,
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we're not looking at the entire universe of samples that emerged from that mine.
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Now, based on the fact that the Wuhan Institute of Virology collaborated with a number of US
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institutions, most notably, presumably, the University of North Carolina, which I think
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we'll get to, can we look at any of the grants or publications that came out of those jointly and
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surmise just how many samples of coronaviruses were extracted from 2013 until 2019?
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Yeah. I mean, well, we know that there are hundreds of samples that were extracted. And we presume that
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there was, you know, deep sequencing done on these samples. But again, we don't have access to all that
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information. So we don't know if any of those other samples may have closed the gap from 96.2
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to 100%, basically. So again, just to ground everybody in the thought process here,
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if there's an argument to be made that SARS-CoV-2 originated and its final origination came from a
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lab, you basically have a couple of mechanisms that that could have happened. One would be that the
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exact version of SARS-CoV-2 was identified in the wild, potentially in this mine, was brought to the
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lab where it was being studied, but not altered before it infected presumably a lab worker that
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ultimately led to the outbreak. Conversely, a very, very, very close cousin to SARS-CoV-2 was identified
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in the wild, again, potentially in this mine, where it was brought to the lab. And research was done on
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it, which we'll get to, called gain-of-function research. And that closed the genetic gap, so to
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speak, from where it started to where it currently is, and what ultimately led to the outbreak through
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presumably some contamination within the lab. Is that sort of a safe summation of the plausible scenarios?
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That is. And, you know, let me just add that the reason those scenarios exist as questions that
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remain unanswered is because there has been a fundamental lack of transparency that has essentially
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been enforced by the Chinese government. And I mean there to distinguish between the motives of the
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scientists and the motives of the government. We don't know whether the Chinese scientists would
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like a full accounting of everything that happened and are being prevented at giving one because the
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government is restricting it. So the questions can't be resolved because there hasn't been transparency
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So who would be the most preeminent scientist or scientists in China with respect to viruses? There's a pretty
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interesting character who leads the charge there, correct? She even has her own nickname.
00:24:48.260
Yeah. I mean, she does. And, you know, it's one of these stories where as a journalist, you feel like you
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can't even make this stuff up, right? She Zhengli is the lead coronavirus researcher, the foremost
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coronavirus researcher in China. She is a sort of nationally revered, very well-known figure. So she is the
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lead coronavirus researcher at the Wuhan Institute of Virology. And she has this nickname, Batwoman. And that comes from
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her fearless exploration of these bat caves in Southern China. So, you know, when you see her image,
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she's often shown wearing this space suit in the BSL-4 lab at the Wuhan Institute of Virology. And she's,
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you know, she's like among these sort of sparkling firmament of internationally renowned scientists.
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She's, nobody disputes that she's earned her place there. And she's particularly well-known for a key
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discovery from the SARS-CoV-1 outbreak, which is she was the first researcher to figure out the mechanism
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by which humans were infected by that virus, which is through the ACE2 receptors, human lung cells.
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So she identified the mechanism for transmission. How long has the Institute been doing gain-of-function
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research? And maybe even before we answer that question, we could take a moment to explain what
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gain-of-function is. It's actually not perfectly, there isn't an exceptional definition for it, but
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I think we can loosely describe it. Sure. So first of all, there are some people who say that,
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all of virology is gain-of-function research, which is basically when you study a virus,
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you are seeing sort of what functions it gains and what functions it loses. You know, how does it
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infect? Is it going to become more infectious? And by what mechanism is it going to become more
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infectious? So gain-of-function research put simply is this idea that you are trying to test
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whether the pathogen can become more infectious? You're trying to give it attributes that it
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doesn't possess in nature as a way to gauge its infectiousness to humans.
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Look at the surface. I think if you're listening to this and you don't dabble in this world,
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that sounds a bit absurd, right? We're going to take a virus that may have a certain level of either
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virulence or lethality or transmissibility, you know, some feature that makes a virus
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undesirable, and we're going to enhance that. So what's the argument for doing that? What's the
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argument for making a bad virus worse or making a good virus bad? First of all, let me say this is
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hugely controversial and has sort of divided the field of virology because there are people who say
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this is absolutely crazy. As one source said to me, it's like looking for a gas leak with a lighted
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match. And there are other people who say this is absolutely essential. So the argument for why to do
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it is that in order to gauge the risk from viruses that exist in nature, you have to experiment with how
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they become infectious to humans. And one of the ways to do that is essentially to soup up that virus.
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You can, through genetic editing, you can make it more infectious and see if it is, you know, one of
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these things that it's a determination of where we should put our resources. You know, what do we need
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to protect against? There are other people who say, all right, we're going to these very remote areas
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where these viruses are tucked inside these caves. We're taking back samples to laboratories in crowded
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urban areas. We are then altering these pathogens to make them more infectious, right? That is, as one
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person said to me, the definition of insanity. Is there any evidence that gain-of-function research
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has produced victories in the past? And we can even just keep SARS-CoV-2 off the list at the moment,
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because I don't think there's any evidence that's benefited our fight against this virus. But is there
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any evidence that has aided with the creation of flu vaccines or other vaccines?
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So the people who defend it say that you actually do need to do this kind of research in order to
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help with vaccine development. That this is the way that you figure out how to create resistance,
00:30:00.520
is to look at, to experiment with how viruses might mutate. So that, for example, if you wanted to
00:30:10.060
kind of forecast what the variants of SARS-CoV-2 would be like, as I'm sure the audience has heard of
00:30:18.400
the fearsome Delta variant, which is so afflicting many countries in the world and now increasingly our
00:30:24.920
own, part of what gain-of-function research can help do is forecast the mutations. But, you know,
00:30:32.220
there are people who say that there is a lot of other ways to do this kind of research without
00:30:38.320
running the risk of unleashing deadly pathogens that you can't control once they're out in the
00:30:44.620
world. Now, what's the U.S. government's position been on gain-of-function research?
00:30:50.200
Yeah. So this is, let me just say, as a journalist and as an investigative journalist,
00:30:56.500
I had been reporting on the pandemic for a year. And once I got into this question that you just asked,
00:31:04.080
I was like, wow, I can't believe how controversial and yet how under the radar this whole question
00:31:13.440
has been. So just to back up, in 2011, a scientist named Ron Fauchier did gain-of-function research with
00:31:23.900
the H1N1 virus and created a pathogen that he said was the most dangerous and infectious the world has ever
00:31:33.460
known through manipulations. So that sparked this outcry in the scientific community. A group called
00:31:41.440
the Cambridge Working Group was formed, which was basically stood in opposition to this kind of
00:31:47.500
research. And their expressions of concern led the U.S. government to impose a moratorium on funding of
00:31:58.040
any kind of gain-of-function research of SARS and MERS pathogens. So then began a period of review,
00:32:08.080
task forces, reports, analysis. And interestingly, in the very beginning of the Trump administration in
00:32:18.060
January of 2017, that moratorium was lifted. But it was replaced with this framework, which had pretty
00:32:28.120
much enough loopholes to drive a truck through. But it basically said, any agency in the U.S.
00:32:35.260
government that wants to fund this kind of research needs to have its own review process in place and needs
00:32:41.860
to ensure that the entities that are getting U.S. taxpayer dollars are proceeding safely.
00:32:50.720
I know that one of the things that has allowed people to sort of lose faith in the government has
00:32:58.280
been statements that both Francis Collins and Anthony Fauci have made with respect to this when asked.
00:33:03.740
Both of them have been asked if the United States government, or specifically NIH, has funded
00:33:07.960
gain-of-function research. Both have emphatically denied it. I believe the direct quote from Francis
00:33:16.560
Collins, neither NIH nor NIAID have ever approved any grant that would have supported gain-of-function
00:33:22.760
research on coronaviruses that would have increased their transmissibility or lethality for humans.
00:33:28.280
Also, in May of 2021, Anthony Fauci told the Senate hearing that NIH and NIAID categorically have not
00:33:37.400
funded gain-of-function research to be conducted at the Wuhan Institute of Virology. Can you evaluate
00:33:44.420
the veracity of those statements? So here is where we enter this true semantic marshland,
00:33:52.940
because the feeling of, and I'm not talking about sort of wingnuts who want to fire Fauci,
00:34:01.540
credible people who have evaluated this say that there is some sort of rhetorical gray area here.
00:34:12.220
First of all, while they haven't funded research, while the government hasn't funded research at the
00:34:18.160
Wuhan Institute of Virology directly, they have funded basically an intermediary non-profit called
00:34:25.700
EcoHealth Alliance, which in turn has given subgrants to the Wuhan Institute of Virology. So yeah,
00:34:33.200
no direct funding, but yeah, indirect funding. Now, part of the obligation of EcoHealth Alliance
00:34:40.200
was to report back to the NIH and say, here's our progress reports. Here is what the Wuhan Institute
00:34:49.180
of Virology was doing with some of your grant money, and we ensure that they've been doing this
00:34:56.420
safely. We don't know what's in those progress reports because NIH has not released them.
00:35:04.800
Oh, the NIH now is like being buried up to their eyeballs in FOIAs. Absolutely. People want to know,
00:35:13.040
what did they know about this research? There are numerous investigations ongoing into that very
00:35:18.820
question right now, including from the HHS inspector general. So there's a lot of questions around this.
00:35:26.300
And let me just say, part of the reporting effort for me was disentangling conspiracy theories. And
00:35:37.400
there's, you know, they're wall-to-wall conspiracy theories out there, disentangling the ones that have
00:35:42.540
no basis in reality, and then trying to evaluate the credible questions. So in my investigation,
00:35:50.320
there are credible questions, you know, about that funding. I mean, why were we giving taxpayer,
00:35:59.320
why were we allowing taxpayer dollars to a high-level Chinese laboratory where we now believe there was
00:36:09.080
actually military scientists working in there? They're obviously an adversary. As one person said to me,
00:36:16.500
hey, what's wrong with the Louis Pasteur Institute? I mean, maybe we should make more of an effort to
00:36:23.120
restrict our research dollars to the science laboratories of allies and not adversaries.
00:36:31.400
Tell me a little bit about EcoHealth Alliance. Why are they acting as an intermediary? What's their
00:36:36.100
mission? What does this organization exist to do?
00:36:38.400
So EcoHealth Alliance is a nonprofit, which is run by a fellow, a zoologist named Peter Daszak,
00:36:46.560
and has a very laudable goal, which is basically to map the viruses in the natural world and use that
00:36:56.400
information in part to preserve wild spaces. If we continue on the path of habitat destruction,
00:37:03.360
and we end up sort of cheek by jowl close to these viruses like Ebola, it's, you know,
00:37:12.840
we're both extinguishing the natural world and endangering our own health and safety on this
00:37:18.580
planet. So that is the goal of EcoHealth Alliance. But the organization was pushing very,
00:37:26.620
very hard for big funding dollars, not just to fund this research on a small scale, but had their eyes
00:37:35.620
on something called the Global Virome Project, which was basically a massive mapping of the world's
00:37:42.120
viral strains. And as one of my sources said, then it's not just looking for a gas leak with a lighted
00:37:50.180
match, it's looking for a gas leak with a blowtorch, right? If you going into all of these wild spaces,
00:37:56.580
and you're pulling back, bringing back all of these dangerous viruses, and potentially unleashing
00:38:03.120
pathogens, the scientific question here is, do we need to know all the answers to this? Or can we just
00:38:10.940
kind of leave the caves to themselves and make sure that we closely regulate all of this activity?
00:38:19.740
So fast forward to the Trump administration. In the middle of the COVID outbreak, Trump gets
00:38:26.360
asked at a news conference by a journalist from a right-wing media outlet called Newsmax,
00:38:33.320
why is the U.S. government giving money to the Wuhan Institute of Virology? Which was inaccurate,
00:38:41.220
but Trump answered, we know about that and we're going to shut it down. About a week later,
00:38:46.720
the NIH is forced by the White House to sever or to stop the grant to EcoHealth Alliance.
00:38:55.720
So at that moment, it looked very much like, wow, the Trump administration is really interfering with
00:39:01.220
the science. This is critically important research in a time of COVID-19. But as the story has evolved,
00:39:08.400
you know, there are real questions about what was going on in the Wuhan Institute of Virology,
00:39:16.260
what our taxpayer dollars was funding there. And because of the lack of transparency, it's very
00:39:22.820
hard to evaluate that. So let's go back to sort of January 2020, when the virus was identified,
00:39:32.080
sequenced, I think it still looked somewhat contained, at least contained to China, they had shut down
00:39:38.920
Wuhan. You mentioned that in September, I believe, of 2019, the database of all viruses extracted from
00:39:50.300
the mine, presumably the database would have contained all viruses that they had been working on as well,
00:39:58.300
That is right. And we don't know why. And it hasn't been put up since then. So what was presumably
00:40:06.540
this transparent hub of international science with Shenzhen Li doing these research experiments and
00:40:15.880
collaborating with scientists around the world, suddenly it was like the steel doors in front of
00:40:22.000
this institute just were shut tight. And nobody can see into what strains they had.
00:40:31.400
What, I mean, there was a Lancet paper that came out in February of 2020, that very aggressively made
00:40:38.860
the case that any suggestion that this didn't originate in nature was ridiculous. Was that a peer
00:40:48.780
reviewed paper? Was it, was it an editorial? What, what was the nature of that paper? Was it an opinion
00:40:53.540
Yeah. Yeah. So, you know, it's important to note, it was not a peer reviewed paper. It was a statement,
00:40:59.640
which was published by 27 scientists who said, basically anybody who is saying that this could
00:41:08.580
have had a lab origin is siding with, is trafficking in conspiracy theories. And we stand with our fellow
00:41:17.140
scientists in China to say that this had a natural origin. So it was a big piece of branding that
00:41:26.500
suddenly raising the question of the lab leak was aiding and abetting Donald Trump's xenophobic agenda,
00:41:34.720
aiding and abetting conspiracy theorists. And as one of my sources said, it was like it was nailed
00:41:41.260
to the church door. It became the orthodoxy and it really shut down debate, but there was something
00:41:48.160
more consequential that emerged from that Lancet statement. The scientists who signed it asserted
00:41:54.960
that they had no conflicts of interest. The problem was the person who had sort of designed and
00:42:02.460
orchestrated the statement was Peter Daszak, who was the president of EcoHealth Alliance.
00:42:08.200
A number of the scientists who also signed were either employees of him or had received grant money.
00:42:15.660
And even though he's saying that he has no conflicts of interest, he was providing money to the Wuhan
00:42:21.360
Institute of Virology. So it was not a kind of neutral value free assertion. He has a stake in this.
00:42:29.840
He definitely has a stake in this. As somebody pointed out, if it turns out to have been a lab
00:42:36.800
leak, it could do to the field of virology what Chernobyl did to the world of nuclear science
00:42:44.340
research, right? Transform the whole thing, shutdowns, restrictions, moratoriums. So Peter Daszak as the
00:42:52.920
recipient of million, well, not personally, but EcoHealth Alliance as the recipient of millions
00:42:59.440
of dollars in grant money, definitely had a horse in this race. Besides NIH, who else would be funding
00:43:07.860
this type of research? Would the DOD be funding any of this research? It has. DOD gave grants to
00:43:14.500
EcoHealth Alliance. So as I spoke with investigators inside the U.S. government who were looking at COVID
00:43:24.420
origins over the last year, what they found is that there is a big, they called it gain of function
00:43:32.500
bureaucracy inside the federal government. There are a lot of people who are invested in this kind of
00:43:38.440
research who are giving grant money for this kind of research. So they have committed to this kind of
00:43:45.740
very aggressive viral research. And so they have an interest in the outcome of this question. And
00:43:54.020
as these investigators told me, it had an enormous impact on their ability to just
00:44:01.360
neutrally evaluate the question of origin. This is more of a question of speculation,
00:44:07.560
but do you think that had all of this taken place in a world where it had not been politicized,
00:44:14.200
in other words, if politicians, including the president of the United States, had never weighed
00:44:18.060
in on this, if this were a discussion that were only going to take place in the scientific community,
00:44:24.520
do you think the reaction would have been as polarizing?
00:44:27.720
It would have made a huge difference. I mean, partly this became so polarized because
00:44:37.560
President Trump, at that point, lacking a lot of evidence in April, 2020, announced it was a lab leak,
00:44:47.580
that he was certain it was a lab leak. Is there any evidence that he had intelligence
00:44:52.640
to suggest that? Or was this simply an off the cuff statement?
00:44:57.720
Right. So according to my sources, the most significant information that the U.S. government
00:45:05.600
obtained came in the fall of 2020, late summer or fall of 2020. So April of 2020 really predates
00:45:16.520
a lot of the significant information that the government collected. Couple that with the fact
00:45:22.320
that on the same day that he declared he was certain it was a lab leak, hours earlier, his own intelligence
00:45:30.000
agencies put out a statement saying, we are certain that this was not genetically modified. As it turns out,
00:45:38.820
they didn't particularly have evidence for that either. But, you know, it's clear that elements of the U.S.
00:45:47.040
government were sort of ping ponging off of these xenophobic declarations that President Trump was making.
00:45:56.920
Not necessarily as a good faith effort to get to the bottom of it, but more as a way to bludgeon China.
00:46:06.340
And as you know, he, he labeled the COVID-19 kung flu. He made a lot of very sort of negative assertions
00:46:16.100
and it had this tremendous effect. It created, as one source told me, an antibody response within the
00:46:24.940
federal government to the idea that it was a lab leak.
00:46:28.380
So was there censoring for these ideas or questions on social media? I wasn't particularly paying
00:46:34.480
attention in the spring of 2020 to this, but was this the type of thing that if you had posted
00:46:41.860
something about this on Facebook, where is it going to be taken down? I mean, what was the,
00:46:45.400
what was the level of curiosity around this and how much was, was, was being explored?
00:46:51.780
Well, it's interesting because some social media sites, I believe, including Facebook were labeling
00:46:58.520
posts like this as conspiracy theories. And there has been some reversal since then, you know, also
00:47:04.640
in the media where you have now sites like Vox that were posting disclaimers about conspiracy theories
00:47:13.400
are now lifting those statements as the idea of a lab leak has gained in some credibility.
00:47:20.200
So let's march through the government a little bit more here in terms of the efforts that were made
00:47:27.940
to sort of try to get to the bottom of this, because really everything we're talking about
00:47:33.320
is not really front and center, right? I mean, front and center is containing this virus,
00:47:37.980
vaccine development. I mean, there are real crises going on here and presumably one could argue,
00:47:45.020
we'll look at this point. And by this point, I mean, say in the spring and early summer of 2020,
00:47:49.620
2020, it doesn't as much matter what the origin of this virus is as what our response is going to be.
00:47:56.820
And obviously a year, over a year ago, there was great uncertainty about that. Is the window missed
00:48:03.120
even by that point? Do we have evidence that things that records were destroyed, were attempts made
00:48:08.820
to go and do site visits, collect antibodies? Because to me, it seems like the most interesting
00:48:15.300
thing you'd want to do is gather serum samples and understand the seropositivity of people within
00:48:22.540
that vicinity and try to get a signature that way. Any efforts made by the WHO or others to do that or
00:48:28.900
the CDC in China? You know, this is very interesting because I interviewed Dr. Robert Redfield for this
00:48:35.680
story and he was the head of the US CDC. He said to me that from minute one of his learning of this
00:48:45.720
virus, he began thinking about the Wuhan Institute of Virology because he knew of this risky gain of
00:48:53.700
function research they were doing and wanted to rule them out as a potential source. And he offered to
00:49:01.780
send in a team of experts to do exactly what you're saying, you know, to do this widespread testing,
00:49:07.420
to do antibody testing of all the researchers there. As he said to me, had we sent in a team of
00:49:15.440
experts, I could have presumably, if the laboratory was not a source, I could have ruled it out in a
00:49:21.120
couple of weeks. But China, whether they were covering up a lab leak or because they were just reacting
00:49:27.800
the way an authoritarian government does, they immediately circled the wagons, they refused to
00:49:33.520
let in a team of experts, and they did start destroying records. That is absolutely part of
00:49:39.500
what they did. So there is no question that we have lost massive ground in our ability to understand
00:49:46.800
the origin. And has the Chinese government allowed anyone to go back to the caves in Wuhan where the
00:49:54.840
original samples were identified, where RATG13 was found to continue bioprospecting?
00:50:02.920
Yeah. I mean, not only have they not allowed it, they have actively arrested journalists who have
00:50:07.820
tried to go there. The BBC sent a team of journalists there in December of 2020. They were tailed by Chinese
00:50:14.720
police. They found a big truck blocking access to the mineshaft. The Wall Street Journal sent a reporter
00:50:23.040
in on a bicycle, and he was detained by Chinese police and questioned for about five hours.
00:50:29.840
His notes were confiscated. So the Chinese government has been blocking access to this mineshaft.
00:50:37.060
Let's talk about some of the lines of evidence, both for and against this. I mean, I think what's clear
00:50:43.860
here is, one, there's a precedent for this happening, right? So it's an absolutely plausible scenario.
00:50:50.280
Two, unfortunately, because of the nature of the Chinese government's behavior, and by extension,
00:50:58.680
the US government's behavior, there's ample reason to believe in a conspiracy, but by no means is that
00:51:07.220
necessary. In other words, this virus could have completely occurred in nature, and the Chinese
00:51:13.740
government would probably still behave the exact way it did, and the US government would have behaved
00:51:18.480
exactly the same way it did. So, you know, unfortunately, those things don't really, I think,
00:51:24.680
move the thinking or the evidence one way or the other more than the other. But now let's talk about
00:51:31.100
some of the features of the virus, because I think this is where it gets very, I mean, not that what we've
00:51:37.900
said hasn't gotten interesting, but the biology of this is also quite interesting, right?
00:51:42.360
Yeah. So there is no information that is in the public domain, either regarding the viral sequence
00:51:53.640
and the sort of oddities of the viral sequence, or regarding other circumstantial evidence that can
00:52:00.100
answer this question one way or another. When I started reporting this, there was, you know, there were
00:52:05.600
plenty of articles that were like, well, maybe this and maybe that, but the information that is in the
00:52:11.380
public domain doesn't get you there. Some attention or a lot of attention has been focused on what is
00:52:19.380
called a furin cleavage site in the sequence. And that is part of the strain that one virologist told me
00:52:30.200
is a sort of signature of genetic editing of the Wuhan Institute of Virology, that in a number of the
00:52:39.120
strains they've worked on and manipulated and published papers about, you see the insertion
00:52:45.460
of a furin cleavage site in the viral sequence. And that is the spot on the sequence that makes it
00:52:54.380
more infectious to humans. So Nick Wade, who's a former New York Times reporter, he published a long
00:53:02.980
piece sort of analyzing the question of the science and the lab leak. And he quoted, you know, this
00:53:08.440
incredibly famous scientist, David Baltimore, saying, as soon as he heard about the furin cleavage
00:53:14.360
site, he told his wife that was the smoking gun. And then he knew it was genetically edited.
00:53:21.360
Since Nick Wade's piece came out and got a lot of attention, David Baltimore sort of walked that back
00:53:26.380
and said, well, not really. And then other people have come out and said, well, you find furin cleavage
00:53:32.660
sites and sequences in nature, and it doesn't necessarily have to be reflective of genetic
00:53:37.860
editing. That's been my find as well. I mean, I've spent far more time on this than I wanted to,
00:53:46.540
Yeah. It's one of those things you sort of think, well, look, I'm going to just read these three
00:53:50.200
articles, but then you have to read every single reference to those articles. And truthfully,
00:53:57.820
I'm going out of my mind at this point, and I don't want to read any more on this because it's
00:54:03.120
too much. But that's one of the rabbit holes I went incredibly far down. And there's just outright
00:54:10.220
contradictory information there. Now, I haven't spoken to Nicholas Wade, but in his piece, he says,
00:54:15.420
there is no evidence of furin cleavage sites in any beta coronaviruses that are SARS-like. And yet
00:54:24.640
I actually found several references for papers that contradict that, including a paper published in
00:54:31.040
2018 that found a furin cleavage site in MERS, which is a SARS-like beta coronavirus. So to me,
00:54:41.600
the presence of the furin cleavage site, which to your point makes this much more infectious than SARS-1,
00:54:50.140
you had commented that SARS-1, it transmits through the ACE2 receptor. Well, this is on the order of
00:54:58.360
like an order of magnitude more transmissible because that S1, S2 subunit is cleaved and now it
00:55:04.240
has an enormous affinity for that ACE2 receptor. So a more interesting question to me is the nature of
00:55:11.500
the codons that exist there. So the furin cleavage site, actually, I believe it is exclusively a
00:55:18.480
proline, arginine, arginine, alanine sequence, and not to bore people with too much biochemistry,
00:55:25.380
but you have three nucleotides that make up each codon. So you have redundancy in the system because
00:55:32.200
there's only 20 amino acids, but you have 64 combinations with all of the nucleotides.
00:55:38.880
You have more than one way to get an amino acid. So what I think also got a lot of attention in
00:55:47.540
Nick Wade's piece was the, I think it's a CGG arginine. And that is a very unusual arginine. It's
00:55:57.960
only typically present in 5% of coronaviruses, meaning only 5% of the time when in a coronavirus
00:56:04.920
needs to make an arginine, does it use a, I think it's CCG or CGG. Okay. But when you go and look
00:56:13.500
more deeply in the literature, it turns out that you saw that in other furin cleavage sites of other
00:56:20.640
coronaviruses that also had very little of that. In other words, there was another coronavirus that I
00:56:26.120
saw that only had 3% of its arginines being either CCG or CGG, but it still showed up in its furin
00:56:33.660
cleavage site. And there's no ambiguity about whether that was naturally occurring or not. So
00:56:37.440
does that mean it occurred in nature? Does that mean it was manipulated in a lab? It's still very hard to
00:56:43.260
know. So I don't think really in any dimension of this, there is no smoking gun per se. What there is
00:56:56.080
is smoke coming out of a lot of windows. That's what I saw as I was reporting. There is enough smoke
00:57:05.860
coming out of enough windows that we cannot take the lab leak hypothesis off the table. And so for me,
00:57:16.420
the most credible people on this, they're not saying it was a lab leak. What they're saying is,
00:57:23.760
why can't we have a full investigation? That's what we don't have. We have not had a forensic
00:57:31.500
investigation. And so if we haven't had a forensic investigation, why are the scientists acting so
00:57:39.160
unscientific by saying it wasn't a lab leak? How do they know? They don't actually know.
00:57:46.800
Just like we don't know, we don't know that it was or it wasn't. But there's enough of a suspicious
00:57:53.920
fact pattern that it requires investigation. Yeah. Of all the things that I have read,
00:58:02.560
and I think at this point, I don't know what I haven't read. I feel like it's just so overwhelming.
00:58:09.640
Welcome to the club. Yes. Yeah. I think the most compelling
00:58:13.460
mechanistic answer. So there's lots of circumstantial reasons, right? The Occam's razor says,
00:58:20.860
in the middle of fall slash winter, so in Q4 of 2019, when there are no bats, they're all hibernating,
00:58:30.820
you have a breakout in a major population center that's doing research on it. All of those things
00:58:37.040
aside, from a purely biological mechanistic standpoint, I think the most convincing piece
00:58:42.160
of evidence for a lab leak is that for about a year post this virus being in humans, it didn't
00:58:52.040
change. We're only now seeing variants of this virus, right? Like the Delta variant you mentioned
00:58:57.700
earlier. That strikes me as interesting, given the ubiquity of this virus, so how many people were
00:59:05.120
infected? Suggesting just how stable this thing was by the time it got into humans, meaning a lot of the
00:59:13.340
tinkering got taken out of it sooner. So one argument would be if this were a virus that got
00:59:19.500
manipulated and naturally selected through humanized mice, which is to say mice that have ACE2 receptors in
00:59:27.460
their lungs, which are the exact mice you would use to do this type of research. In fact, the mice,
00:59:31.920
which we know were being used for this type of research, that makes sense to me that, you know,
00:59:38.220
you could easily have a virus that has now reached its state of maturation. It gets out now into the
00:59:46.100
wild and it takes quite a while to evolve into its new variant. What about you? Like where does that
00:59:53.220
stack up in terms of biological reasoning in favor of a lab leak versus not?
01:00:04.620
Yeah, she's at the Broad Institute. And she has really advanced that idea and had a preprint paper
01:00:09.600
to that effect, which is the idea that this virus seemed immediately ready to infect humans
01:00:18.540
and didn't appear to undergo the sort of all the early mutations that you saw in SARS-CoV-1.
01:00:26.240
So it seemed sort of primed for human transmission, which in her view argued for a lab leak.
01:00:33.620
But then you have scientists on the other side of that who say, actually, if you look at this strain,
01:00:40.000
this is not maximized for human infectivity. If you were going to set out to create this in a laboratory
01:00:48.140
to maximize human infectivity, this isn't it. So I think those are, again, two competing versions of
01:00:58.020
But they're saying very different things. Like I don't think that Elisa, is it Elisa Chen is her name?
01:01:05.180
I don't think her argument is that it's maximized in its potential. I think if I'm understanding her
01:01:11.860
argument correctly, it's that it's reached a steady state. It's in an equilibrium. And I think
01:01:17.740
that's a very different argument to the one that's being posed in the other direction, which is that,
01:01:23.940
oh, well, if you were going to make this, you could make a much better job. I think that maybe
01:01:29.060
gives a little too much credit to scientists. That's sort of like saying, well, when those
01:01:34.500
bombs dropped on Hiroshima, I mean, they were good, but they weren't as good as they could
01:01:38.640
have been. I mean, come on. They could have been way more lethal.
01:01:42.300
You know, I have to say, it is sort of a red herring argument because, okay, so let's say it's
01:01:49.120
not like the perfect bioweapon to infect all of humanity overnight.
01:01:55.420
Right. The credible people who talk about a lab leak are not necessarily saying it was a
01:02:00.160
bioweapon. It could be the accident of a sloppy, you know, a moment of a momentary lapse.
01:02:07.240
Yeah. So again, I've always found that argument to be completely nonsensical because one,
01:02:13.120
if we believe in the broad idea of gain of function research, it's not bioweaponry. Two,
01:02:20.340
even if you say, well, no, but if you're going to go to the trouble of doing gain of function
01:02:24.900
research, you should try to make the most virulent, deadly strain imaginable. Okay. But are you going
01:02:33.340
to make that in the first, you know, let's assume it takes a hundred steps to make that. And what
01:02:38.520
happened if we were at step 60 when this leak occurred? Does that mean we weren't on a path
01:02:44.080
to making it better? So, so again, to me, that argument is meaningless actually.
01:02:47.540
Right. There are a lot of red herrings in this debate.
01:02:51.540
On both sides. Yeah. So given all this sort of loose smoke, that's sort of diffusing from the
01:03:01.480
ground out of windows here and there, how would you think about trying to synthesize the arguments that
01:03:08.640
most favor the consensus view that this virus occurred naturally versus the contrarian view,
01:03:17.660
for lack of a better word, that this virus emerged from a lab? What would you say are the
01:03:23.460
most compelling features that favor the former? First, let me just say that I actually don't think
01:03:30.160
there is a consensus view at this time. I think the consensus has been shattered and the scientific
01:03:38.060
community is really divided. That said, I think the strongest argument for a zoonotic origin is the
01:03:48.660
precedent of previous SARS outbreaks, you know, SARS-CoV-1 and MERS. And you look at those and yeah,
01:03:57.300
those are SARS outbreaks that have a zoonotic origin that has been identified. So it would make perfect
01:04:07.600
sense that this is the big one. This has come on the heels of those outbreaks. And you add into that,
01:04:16.440
you don't have any specific smoking gun evidence to contradict that, even though a host animal has not
01:04:25.660
been found, an intermediate animal has not been found. So I think that in and of itself is sort of
01:04:32.280
the most basic argument for it. And to build on that really, SARS-1 traveled something like 900 to
01:04:41.460
1,000 miles from its original site using two intermediary hosts. So to your point, the argument
01:04:48.080
that, well, if this originated in a bat in a cave 1,000 miles away, there's no way it could make it to
01:04:54.800
this populated area. No, that's not true. It certainly happened in the past, right?
01:04:59.940
It certainly has happened in the past. But let me just say that is added to the mystery here,
01:05:04.800
because what people are saying is, well, if it started in Southern China in Yunnan province,
01:05:12.680
why don't we see a trail of infections up to Wuhan? We don't. So it looks like Wuhan in Central China
01:05:20.880
is the origin of this outbreak. Why? So the original theory was there is a host animal and
01:05:30.820
it could have been a sample at the seafood market in Wuhan, but no, you know, all of this testing has
01:05:38.840
not turned that up. So in order to account for a natural origin, you have to find a way to argue
01:05:46.940
how in the dead of winter in Central China, in a market that didn't sell bats, didn't have bats,
01:05:55.800
at a time when most bats are hibernating, how do you have this outbreak? And then Chinese scientists
01:06:02.640
themselves were like, oh, we know where it came from. It came from these labs. Two Chinese scientists
01:06:08.040
very early on in the outbreak posted a preprint paper saying, well, we surveyed the area around the
01:06:16.380
seafood market and there are these two laboratories that have all these bat samples. So we think it
01:06:22.140
came from them. And that preprint paper was immediately taken down. But you have this problem
01:06:28.140
of how to account for how it started in Wuhan. Now, again, to go back to evidence in favor of
01:06:36.340
the zoonotic origin, because I don't think anybody disputes that the bats weren't transmitting it to
01:06:41.900
people in the fall or winter. I think everybody agrees that by the time September, October,
01:06:48.400
November rolled around, the bats themselves would have been in hibernation. So the probability that
01:06:53.080
a bat directly transmitted it to a human in, say, November, December, exceedingly low. Of course,
01:07:00.360
the bats could have passed it on to intermediaries before then, and or the bats could have transmitted
01:07:06.300
it on to a person or persons before then who didn't really become that ill, but somehow managed
01:07:12.820
to make their way to Wuhan, correct? Yes. Although there is a wild card in this, which is that the
01:07:20.180
virus in many cases is asymptomatic. So there are people who are arguing for an even earlier origin than
01:07:27.680
we knew. Such as the summer of 2019. Right. They're like Dr. Redfield is one of those people who has said
01:07:34.520
that he thinks the origin is actually a lot earlier, and that it's very hard to pinpoint a date because
01:07:40.880
of the problem of asymptomatic transmission. Right. And, you know, you got to take a step back and
01:07:46.560
remember what it was like circa May of 2020, when the very first papers were coming out looking at
01:07:56.680
zero positivity, suggesting that the case fatality rate was infinitely lower than it had been previously
01:08:07.220
identified. So, you know, when we were first thinking about this as, oh my gosh, like 2% of
01:08:15.000
people or 8% of people who are getting this are dying. And it's, you know, the realization was, no,
01:08:20.360
it's, you know, 8% of people who are wildly symptomatic are dying or, and then the more we began
01:08:25.960
to test people, the more that number began to fall. But it wasn't until serology was being done on
01:08:31.620
asymptomatic people. This was done in Santa Clara, a very controversial study by John Ioannidis. It was
01:08:36.880
done in New York. You, you basically began to see, look, this has got a lethality of about one in a
01:08:42.020
thousand people infected. So if you then extract that back to China, I think there's a scenario in
01:08:48.600
which 500 people are infected, none of whom really gets sick or think anything of it beyond, you know,
01:08:57.020
it's just a, it's a regular cold, but someone threads that needle of getting up to Wuhan. So
01:09:02.640
that there's at least a plausibility of bat to human to Wuhan in that timeframe, correct?
01:09:12.320
If that were the case, it's, would still be interesting to identify the bat of origin,
01:09:18.300
but it sounds like that's not happening yet. So let's chalk that up to first on our, our wish
01:09:23.520
list, right? So if we were creating a wish list of how one would get to the bottom of this,
01:09:27.680
it would be a full court press to identify, to do basically an amazing prospecting exercise to look
01:09:36.020
for the bat host potentially. But just to say that in a way has been done.
01:09:42.320
Right. That's potentially what's in the database that was taken out in September of 2019.
01:09:46.660
But even since the COVID outbreak, and so that is post-dating what was in the database,
01:09:53.960
there has been a huge hunt and widespread testing of wildlife samples. I mean, there has been a big,
01:10:00.680
big hunt for the host animal, which has not been found.
01:10:05.340
And has that hunt been carried out mostly by Chinese scientists or has been a worldwide effort?
01:10:10.680
I mean, it's been a worldwide effort, but you know, the Chinese authorities have tested, I mean,
01:10:15.960
the, the count and, and the WHO report talks about this, something like 80,000 animal samples have been
01:10:24.360
tested in search of a point of origin and it has not been found.
01:10:30.160
Okay. So then on the heels of that, another scenario is that a bat infected an intermediary,
01:10:40.400
which either infected humans or another intermediary, which ultimately infected humans,
01:10:45.320
several of those animals have been proposed and several of those animals could have existed at the
01:10:50.240
Wuhan market in the winter, still alive, not necessarily kept in the most sanitary conditions.
01:10:56.120
That seems like a very viable scenario. And the biggest challenge to that is that
01:11:03.720
very few stones have been left unturned in the search for what those animals might be.
01:11:10.240
And yet that has turned up empty handed. That's exactly right. That is a very logical scenario,
01:11:17.020
except that there's no evidence for it. That's the problem.
01:11:22.940
So I just want to make sure I'm not missing a scenario. Is there any other scenario that involves
01:11:29.900
this virus infecting people having not been to a lab first?
01:11:35.700
You know, one thing that has been talked about is the people who live around these bat caves,
01:11:43.300
who have had exposure, who have tested positive and larger numbers previously for SARS antibodies.
01:11:52.280
But you still have the same problem of if that is a possible origin, is a natural escape
01:12:01.160
in location in Southern China to villagers who live around those mines,
01:12:07.960
how does it get up to Wuhan without leaving a trail of infection that could be documented?
01:12:17.280
So then on the other side, we have a scenario where researchers are identifying this virus
01:12:29.340
by identifying its original host and themselves get infected through that, bring the bats or the
01:12:39.920
virus itself into the lab. And early in their tenure with these animals or with the virus, rather,
01:12:46.460
there's a contamination. I mean, I really think of these as two sides of the same coin, which is
01:12:52.420
gain of function versus no gain of function research. But nevertheless, the virus has been
01:12:56.860
brought into the lab. I mean, that's basically the other side of this coin. The most compelling
01:13:02.480
argument for that appears to be, at least to my reading, the contrapositive of what we just said,
01:13:09.640
i.e., it's the absence of either the original bat or the intermediary host, coupled with the argument
01:13:19.160
made earlier about the relative lack of genetic drift or mutation once the virus took hold in late 2019.
01:13:36.640
First of all, there is a lot of precedent for a lab leak, as we've seen. I mean, there is a long
01:13:42.840
history of this. There is a proximity argument, which is, why Wuhan? Well, here are these laboratories
01:13:52.720
that have the largest collection of bat samples really in the world who are doing some of the
01:14:00.780
most aggressive testing. So there's that smoke coming out of that window. We know that they were
01:14:08.260
doing aggressive gain of function research in which they were manipulating pathogens. And we also know
01:14:14.980
that they were doing it not just in a BSL-4 setting, but in a BSL-2 setting. And then you do have the
01:14:23.420
Alina Chen argument that you do not see the sort of wide range of mutations initially in transmission
01:14:33.040
that you did with SARS-CoV-1. So I think there's those arguments.
01:14:38.780
Yeah. And I guess you could almost break this down into two arguments, which is,
01:14:42.660
what's the likelihood that this virus was brought into or created in a lab versus what's the
01:14:51.160
likelihood it escaped? So you could break this down into two probabilities, probability that this
01:14:58.620
virus was brought into a lab, and then really a third one, probability that this was manipulated in
01:15:04.300
a lab, and then probability that this thing escaped or could have escaped. So if that's P1, P2,
01:15:10.180
P3, P3 is like close to one. That could be taken as a foregone conclusion, meaning the probability
01:15:17.000
that a virus in a lab can get out is very high. We know about the bad ones that have happened,
01:15:24.220
but what we don't know is how many times has research been done on a virus in a lab that is
01:15:29.960
of totally no consequence to humans and it gets out. We wouldn't know about it, but that could happen
01:15:35.960
all the time. So if you're supposed to be functioning at BSL-4, and by the way, I'm not
01:15:42.820
saying this to sort of pick on the people doing it. BSL-4 is a miserable environment. You couldn't
01:15:48.580
pay me enough to be a viral researcher working in a BSL-4 environment. I would rather be painting
01:15:56.580
roofs with tar in July than I would be working in a BSL-4 lab. So can totally understand why
01:16:05.900
there's a natural human inclination to take shortcuts with procedure there.
01:16:11.360
So I almost think of like that third step of could this have escaped the lab as of course it could
01:16:16.300
have. So it's really just a question of what's the likelihood that this thing made its way into a
01:16:21.360
lab and got tweaked. And that's where you get into these other questions of, boy, the people who
01:16:28.120
claim it didn't aren't doing themselves any favors in the way they're acting. You know, the EcoHealth
01:16:34.700
Alliance, the Lancet paper doesn't look good in the light of day. No, it does not look good,
01:16:41.260
which is back to one of the groups that I talk about in my Vanity Fair article is this group that
01:16:48.060
calls themselves drastic, which are these scientists who are independent researchers
01:16:53.780
scattered around the globe who became curious about this, obsessed by this, wanted to get to
01:17:00.800
the bottom of it. And I interviewed a number of them. How many of them are anonymous versus
01:17:05.540
identified, by the way? There's a handful who are anonymous and I did not write about any of those
01:17:11.880
who were anonymous who I didn't speak with because you really cannot assess the agenda of someone who
01:17:20.560
is anonymous and you're not interviewing. I mean, you don't know whether it's Steve Bannon hiding behind
01:17:25.360
a pseudonym. But for example, the Indian researcher who calls himself the seeker on Twitter, he's a science
01:17:33.240
teacher in Eastern India who was the one who uncovered this Chinese master's thesis. I was able to
01:17:39.700
interview him. A lot of those people I interviewed, they said the same thing to me. I got into this
01:17:47.420
because I wanted to know why the scientists were acting so unscientific. Why do you take a hypothesis
01:17:56.020
off the table without evidence? If you're having an investigation, don't you pursue all hypotheses in an
01:18:03.700
equal fashion until you have real evidence? And in fact, the World Health Organization partnered with
01:18:12.460
a group of experts who went to China and were basically sort of led on this highly restricted
01:18:19.720
tour by the Chinese authorities and issued a report in which they said, oh, the lab leak hypothesis is
01:18:27.680
highly unlikely. I obtained a U.S. government analysis of that report, which said the report
01:18:35.180
is essentially ridiculous. It concludes that on the basis of no evidence. And in fact, one of the lead
01:18:41.820
researchers on that expedition was Peter Daszak of EcoHealth Alliance. Wasn't Peter Daszak the only
01:18:47.900
American brought in? Wasn't he the only American scientist brought in? Yes, he was. So there has not been
01:18:54.480
a neutral, conflict-free, forensic evaluation of all possibilities of origin at this time.
01:19:05.280
Do you have confidence that such a thing will happen? The Biden administration recently requested
01:19:11.400
such a report to be delivered within no less than 90 days, if I'm not mistaken?
01:19:15.860
Yeah. It is going to take a huge act of political will and really unity by many, many different
01:19:27.040
countries to essentially force the Chinese to be more transparent. It's not necessarily a fight that
01:19:36.240
the Biden administration wants to have. It's really inconvenient. I think it would be a whole lot
01:19:43.460
easier to say, well, it must be zoonotic and we can't find the animal host. Bummer. So I don't know
01:19:51.100
if we're going to be able to surmount all of the political hurdles and the evidentiary hurdles
01:19:57.780
that lay in our way to have a real investigation into this.
01:20:05.180
What would be required of full transparency? What would be asked for that would demonstrate
01:20:10.260
conclusively one way or the other? Well, part of that is what probably will never happen.
01:20:17.020
China says, you know what? We're changing our minds, full transparency. We're putting back the
01:20:23.840
database. Here's a record of all the samples. Here are the lab notebooks. Come do a tour. Here's the
01:20:31.240
medical records of all the researchers who were in the laboratory. That is very, very unlikely to happen.
01:20:37.640
We, by the way, have no serology on the three people who worked in the lab who got sick in the
01:20:43.900
late summer, early fall of 2019, correct? My understanding is that we don't, or if we do,
01:20:50.400
if our intelligence agencies have something more definitive, it's definitely not in the public domain.
01:20:56.540
So that information is not available. But plan B, assuming that China is not going to be more
01:21:04.340
more forthcoming, is for the countries of the world to basically look in their own research files,
01:21:11.600
you know, that there is a lot of information that is potentially available to us if we are really to
01:21:19.000
dig into our own filing cabinets. That is essentially what Joe Biden has called for.
01:21:25.120
He's told the intelligence agencies to go back to the drawing board,
01:21:28.600
inventory, what they have, and see if they can't come to some sort of closer conclusion. You know,
01:21:38.000
there was recently an important paper put forth by Jesse Bloom, who is an esteemed virologist,
01:21:45.620
who said that there were sequences that were in an NIH database that were taken offline at the request
01:21:52.780
of Chinese scientists that had some early sequences from Wuhan. So potentially, you know, there is
01:22:00.880
information that our own government, for whatever reason, has either buried or ignored or removed,
01:22:07.740
which can be analyzed. So given all the time you've spent on this so far, how has your own
01:22:15.640
probability shifted from zoonotic versus lab origin over the past year?
01:22:25.300
Starting out, when anybody mentioned the possibility of a lab leak, I was very dismissive because it
01:22:32.300
sounded to me just like conspiracy theories. And there were a lot of conspiracy theories associated
01:22:38.040
with that. But I think what's happened is as time has gone on and no host animal has been found
01:22:46.160
and Trump has been removed. And so there is a sort of space to ask this question without necessarily
01:22:54.720
aiding a, what's viewed as a racist agenda. And China has failed to be transparent
01:23:03.600
and conflicts of interest have been exposed. And from my own reporting now, I understand that a
01:23:12.840
full investigation within the U.S. government was essentially blocked or restricted. I kind of give
01:23:21.540
it even odds at this point. I think it's a possibility. I don't have a definite conclusion. If a host animal
01:23:29.580
was found tomorrow, I would be like, okay. But I think there are just too many questions to be
01:23:36.080
ignored right now. One of the things about conspiracy theories is they require cover-ups.
01:23:42.720
One of the conspiracy theories that's always obsessed me is the Kennedy assassination ever
01:23:46.900
since I was a kid. And I don't know, probably by the time I was in my mid thirties, I'd seen enough,
01:23:54.380
read enough that I concluded there's simply no way it was anything other than Lee Harvey Oswald.
01:23:59.580
Like I really just decided, despite what Oliver Stone would have you believe,
01:24:05.460
Lee Harvey Oswald acted alone. And there are many reasons I could bore you with that include
01:24:10.920
a more accurate look at the forensics of the ballistics and things like that. But a big part
01:24:16.280
of it is how hard would it be to keep everybody quiet if this were some CIA plot or some mob plot
01:24:25.040
or one of the other crazy ideas that's put forth. And I guess that's one of the things that kind of
01:24:32.200
nags at me here a little bit with this one, which is if this in fact came from a lab,
01:24:39.000
how many people have to know that? It's not the case by the way that Peter Dasher would necessarily
01:24:45.420
know that, right? He wouldn't necessarily know that. I mean, he might have a huge incentive to hope
01:24:51.520
that it's not happened, but he wouldn't necessarily know that. But presumably more than one person
01:24:57.000
would be covering this up. And I guess that speaks to the bigger that number of people,
01:25:04.160
the harder this thing becomes over time, if indeed that's the case.
01:25:08.600
So let me say a couple of things about this. First of all, the question of COVID origin
01:25:14.340
is the ultimate grassy knoll, right? This is one for the ages. I think the question of a cover-up,
01:25:22.400
you know, it's very different to consider a cover-up in the U.S. with a tradition of freedom
01:25:28.080
of speech and protection of whistleblowers and to consider a cover-up in China with an authoritarian
01:25:35.560
government that has control over everybody's lives and can absolutely wreak havoc, not just on a
01:25:44.240
whistleblower, but on a whistleblower's family. So for example, the anthrax lab leak in the Soviet
01:25:52.040
Union in the 70s only became disclosed after the fall of the Soviet Union. Once this sort of
01:26:00.320
authoritarian structure around it crumbled, then it could be disclosed. But China has incredible control
01:26:08.760
over its citizens and could, even if, let's say, Shi Zhengli thinks it was a lab leak or
01:26:16.520
knows it was a lab leak, is she free to say that? Well, certainly not while in China and not while
01:26:24.040
her family's in China. Right. So that said, I'm always mindful of this expression we have in
01:26:31.440
investigative journalism. Never assume conspiracy when incompetence is an option. In other words,
01:26:39.040
it's easy to say conspiracy, but that's always a more unlikely possibility.
01:26:47.240
Yeah. Conspiracy doesn't make a lot of sense here. And I think it detracts from an honest look at the
01:26:53.520
facts. It should really be viewed as two competing hypotheses. And one of them that got largely
01:27:01.100
ignored because it was politically inconvenient to consider. Yes, that's right. I side with that
01:27:08.240
analysis 100%. Are you optimistic that a year from now we're going to have much more insight? Because
01:27:14.780
the reality of it is if you look at what we know today versus what we knew six months ago, virtually
01:27:21.480
nothing new, right? Very little new information. There's just been more attention paid to old
01:27:27.220
information, which is always concerning when you're trying to think about this, right? Because
01:27:32.300
it's more interesting if, oh my goodness, there is more information that is emerging here. We are
01:27:38.200
learning more, but that's not really the case. We're learning more on the basis of old information.
01:27:43.020
And at some point we're going to saturate our knowledge based on that. Are you optimistic that
01:27:47.440
we're going to learn more in the next year? Or is this going to become simply more of a polarizing
01:27:52.980
discussion? Well, I have no doubt that it will be a polarizing discussion and continue to be one.
01:27:59.900
I think the real question, the way I see it, is how much political capital does the Biden
01:28:08.040
administration want to spend on this? The Biden administration and the other powerful governments
01:28:14.060
of the world. How far are they willing to push China to demand answers? Look, someone in China
01:28:22.400
knows some answer, presumably, like they know it was or wasn't a lab leak, or they can guess that.
01:28:30.960
How far are the governments of the world prepared to go to push for an answer for this?
01:28:36.340
Besides the United States, which governments would have the most persuasion?
01:28:40.100
Well, you know, a lot of this is going to be fought economically. So for example, originally,
01:28:47.940
the government of Australia, of Scott Morrison, was pushing to have the question of a lab leak as
01:28:56.020
part of one of the facets of the World Health Organization inquiry into this. They wanted to make
01:29:02.640
sure that that possibility got on the agenda. China's retaliation was very swift. And
01:29:09.800
they were immediately blocked. I believe it was import of Australian goods into China. So there is a
01:29:18.180
lot of economic retaliation that can occur in the push for answers. And as we've already kind of
01:29:26.320
identified, there's no scenario under which a lab leak occurred and the United States doesn't have
01:29:32.500
blood on its hands as well, through both direct contribution of funding and also collaboration from
01:29:38.920
a research perspective, correct? I mean, in other words, if there's a lab leak, you can't just say,
01:29:44.700
well, it's just the fault of the Wuhan Institute of Virology, because it's just bad luck that it
01:29:49.380
occurred there. The reality of it is this could have easily taken place at the University of North
01:29:52.800
Carolina or the University of Galveston in Texas, where similar research goes on. The bigger issue
01:29:58.160
is this was in some ways a joint effort between the United States and China, correct?
01:30:03.840
Well, let me just say, there is one other laboratory that is right near the Huanan seafood market,
01:30:11.360
which is the Chinese Centers for Disease Control and Prevention, which had moved right next to the
01:30:18.040
seafood market shortly before the outbreak began. They had a coronavirus researcher who was very gung-ho,
01:30:25.620
had collected a lot of viral samples. So I guess in theory, it is possible that this came from a
01:30:32.720
laboratory that had nothing to do with U.S. funding. But I would say, regardless, I still take
01:30:39.780
your point that the lab leak scenario raises a lot of thorny questions for the National Institutes of
01:30:48.440
Health, for how scientific research is funded. It would be hell to pay in the field of virology
01:30:57.360
if the effort to identify viruses ended up unleashing them. Yeah, it's interesting to think how this will
01:31:04.440
unfold over the coming decade, the economic damage, the loss of life, etc. Do you get a sense of how
01:31:12.600
this will impact gain-of-function research, at least in the United States? It's interesting because this
01:31:19.900
whole debate has spotlighted this kind of tucked away corner of scientific research that the public
01:31:29.180
really didn't know anything about. And so I certainly think that any agency now prepared to give a grant to
01:31:38.100
this research is really going to think carefully about this, going to think about who are they giving
01:31:45.320
grants to, who are the sub-grantees downstream, what are the hazards, the dangers of the kind of research
01:31:53.400
they're doing. So this really has been spotlighted, and I think it will, even without a definitive
01:31:59.520
answer, I think it will have an impact on this kind of research. Yeah, it's certainly clear that
01:32:06.160
gain-of-function research didn't help here. Even if this was of zoonotic origin, it's not like gain-of-function
01:32:11.240
did anything to prevent it or more rapidly thwart it. Let me just say this, which is, you know,
01:32:18.280
EcoHealth Alliance's whole argument for existence is, if we partner with these far-flung laboratories
01:32:25.700
and we go out to these remote bat caves and we find these samples and we bring it in and we do this
01:32:31.440
research, we are going to have a way to potentially prevent outbreaks. Okay, we spent millions, you know,
01:32:39.660
the U.S. government spent millions of dollars on that argument. What did we gain? Didn't prevent
01:32:46.360
COVID-19, right? So where's the benefit? What's the upside? What's the argument for the continuation
01:32:52.840
of this? That's a question that has not been answered. Well, I wish I had a stronger point of
01:32:59.340
view on this, but I think I'm in your camp, Catherine. I can talk myself into both of these
01:33:05.980
scenarios. And the only thing I find myself really hoping for is the open and honest evaluation of
01:33:13.560
this, which unfortunately requires getting new information. And I think the majority of that
01:33:20.220
information probably lies outside of our borders and therefore is going to be limited. So I'm not sure
01:33:27.500
if we're going to be any further along in a year. I do believe that eventually one day we will know.
01:33:35.360
Is it going to be in our lifetime? Not sure about that. Well, it's funny, right? At some point,
01:33:41.280
if no intermediary host and or species of origin is ever identified, like, is there some asymptote to
01:33:49.320
that or tale where you say, well, gosh, if it hasn't been found in like a hundred years, it really
01:33:54.800
doesn't exist. Or in theory, you would imagine even if this was all done through gain of function
01:34:01.400
research, you'd need to find something in nature that was 99.8% close to it. And then you would say
01:34:09.940
that that last 0.2% had to be done in the lab. But then you could probably equally convince yourself
01:34:16.040
that no, that 0.2, that variation of 0.2% took place in the first few people that were never
01:34:23.020
identified. So again, I go back and forth and I talk to myself in and out of this. And I'm frustrated
01:34:28.780
that this is something that should be knowable and is not known, which is generally more frustrating to
01:34:34.620
me that things that are unknown that maybe can't be knowable. For example, I have no idea if there
01:34:40.820
is life beyond earth. But I'm not as frustrated by that because that seems a lot harder to know.
01:34:47.660
This seems like something that is knowable and I probably will never know it.
01:34:51.900
Well, let's put it this way. Regardless of whether there is life beyond earth,
01:34:57.920
the answer to that didn't force you to stay inside for a year and not see friends and family.
01:35:05.180
So this one for all of us, and I'm really struck by this, feels so personal, of course, because it
01:35:11.700
is. And so people are obsessed with this question. And once you start looking into it, as you've
01:35:18.000
experienced and as I did reporting it, you just go down this rabbit hole in which like night is day
01:35:24.720
and day is night and you cannot get to the bottom of it, no matter how many rocks you turn over.
01:35:32.100
Well, Catherine, maybe the next time we get together, we can talk about the consultants that
01:35:36.340
unleashed torture upon the US government and the CIA and their efforts in Iraq. Would that be a great
01:35:43.080
follow-up discussion? Sure. I'll do that one. Yeah. My goodness. Do you ever write about things
01:35:49.320
that aren't upsetting? Do you ever write happy stories? You can guess from my silence, I have to
01:35:57.240
really think about that. It's not a lot of unicorns and rainbows over here, no. But I tend to gravitate
01:36:05.260
towards the things that fascinate me. And you're fascinated by the macabre. You really don't like good
01:36:11.820
things, do you? In my own life, I do. But I do set out to try to get to the bottom of things that
01:36:21.900
do not have easy answers. And sometimes those can be quite dark. Well, Catherine, if it wasn't bad
01:36:29.820
enough to talk about generic drugs and the corruption that goes on there, you put a bow on it this time.
01:36:37.140
Thank you. And again, I think the bow is less about whether or not this did or did not come
01:36:42.780
from a lab, but more about the fact that there has been and likely will be forever an enormous
01:36:48.780
obstruction to get to the truth about it. Yes. Unfortunately, that is absolutely true. Yep.
01:36:55.460
Well, thank you very much for your work on this and for making time to chat about it today.
01:37:01.800
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