#294 ‒ Peak athletic performance: How to measure it and how to train for it from the coach of the most elite athletes on earth | Olav Aleksander Bu
Episode Stats
Length
2 hours and 33 minutes
Words per Minute
191.97012
Summary
In this episode, I sit down with Olav Alexander Bu, Head of Performance for the Norwegian Olympic Triathlon Team, to talk about the relationship between VO2 max and performance. We cover a variety of topics, including: how to improve your VO2max, why weight matters, and why we should pay more attention to the absolute numbers rather than the relative ones. We also discuss the role of lactate testing and its role in performance.
Transcript
00:00:00.000
Hey, everyone. Welcome to the Drive podcast. I'm your host, Peter Atiyah. This podcast,
00:00:16.540
my website, and my weekly newsletter all focus on the goal of translating the science of longevity
00:00:21.520
into something accessible for everyone. Our goal is to provide the best content in health and
00:00:26.720
wellness, and we've established a great team of analysts to make this happen. It is extremely
00:00:31.660
important to me to provide all of this content without relying on paid ads. To do this, our work
00:00:36.960
is made entirely possible by our members, and in return, we offer exclusive member-only content
00:00:42.700
and benefits above and beyond what is available for free. If you want to take your knowledge of
00:00:47.940
this space to the next level, it's our goal to ensure members get back much more than the price
00:00:53.200
of a subscription. If you want to learn more about the benefits of our premium membership,
00:00:58.020
head over to peteratiyahmd.com forward slash subscribe. My guest this week is Olav Alexander
00:01:06.980
Bu. Olav is an endurance coach, exercise scientist, engineer, and physiologist. He is the head of
00:01:14.380
performance for Norway triathlon and is best known for coaching two of the world's greatest triathletes,
00:01:20.840
Christian Blumenfeldt and Gustav Eden. And he coaches the Norwegian Olympic sailing team and
00:01:27.920
consults for multiple world tour cycling and elite track and field teams. In this episode, we were only
00:01:34.140
able to cover a fraction of what I was hoping to cover as we ended up going so deep on VO2 max and
00:01:41.660
performance. Safe to say this will be the first of several interviews that I do with Olav. In this
00:01:48.100
interview, we look at the relationship between VO2 max and ATP production, efficiency, energy,
00:01:54.520
and power. We speak about the quality of low intensity training as it relates to VO2 max,
00:02:00.560
how weight impacts VO2 max, absolute versus relative VO2 max values, and why we maybe ought to pay a little
00:02:08.700
more attention to the absolute numbers than just the relative as I have typically done, the different
00:02:13.520
ways to test for VO2 max, and the different ways to train to improve your VO2 max, and of course,
00:02:19.320
Olav's work with his athletes. We also have a pretty deep discussion around the role of lactate testing
00:02:25.960
and its role in performance. So a couple things I want to say just to put this into context. Of course,
00:02:31.720
if you're listening to this podcast, you have heard me go on and on about the importance of VO2 max. And so
00:02:37.100
to really have the masterclass in VO2 max here alone is worth the price of admission. But there
00:02:43.660
are so many other nuances we get into here around different terms that people have heard and sometimes
00:02:49.600
confused. So what's the difference between lactate threshold one, lactate threshold two, LT1, LT2,
00:02:54.900
and zone two? How are these actually measured? And even if you think, well, gosh, I really have no interest
00:03:01.860
in doing the kind of deep testing that Olav does, or even the stuff that Peter does on himself. You're still going
00:03:07.420
to learn a lot about the physiology of this stuff here. One final thing I'll say. During the course of this
00:03:12.760
discussion, I learned about something called the VO2 master, which is a portable VO2 max unit that Olav uses
00:03:20.980
extensively with his athletes. Now, I've certainly heard of these types of devices in the past, though not
00:03:27.040
specifically the VO2 master. So it's always with a bit of skepticism that I assume that these
00:03:31.740
things can't be that accurate. But during the course of the podcast, and then after the podcast,
00:03:37.000
Olav and I got talking about it, and my curiosity was piqued so much that I actually got one of these
00:03:41.600
devices. Needless to say, I have been blown away by this device. I consider it the single best
00:03:49.020
investment I've made in tracking, and the accuracy is staggering. It's really remarkable that I can put
00:03:56.900
this thing on and go outside and do a workout on my bike or do a workout on my Stairmaster. Basically,
00:04:02.560
I can test my VO2 max on my own. And again, this is just one of the many nuggets that came out of
00:04:08.140
this podcast. I'm not suggesting you have to go out and buy a VO2 master, though if you're like me,
00:04:13.000
I would highly recommend it. So anyway, without further delay,
00:04:15.680
please enjoy my conversation with Olav Alexander-Boo.
00:04:24.020
Olav, thank you so much for making time to sit down with me today. I'm really excited about this
00:04:30.040
episode, and I'm going to try to contain my own enthusiasm such that the people listening to this
00:04:36.960
will understand what we're talking about because the topic we're going to go into today is really
00:04:42.440
one that fascinates me to no end. But more than that, you are someone who brings a level of
00:04:48.160
expertise that is so high that it really allows me to engage at a level of curiosity that I rarely
00:04:55.820
get to engage in. And I don't think I've taken more notes coming into a podcast than I have for this
00:05:02.680
one. I fully expect we will not get through half of what I've written down in terms of topics that I
00:05:09.580
want to explore. But nevertheless, I'm going to apologize in advance to you and to everybody else
00:05:15.520
for just how enthusiastically I want to address the subject matter of human performance. Perhaps
00:05:23.180
before we get into that, though, maybe you could just tell folks, let's assume people don't know
00:05:28.560
anything about you and who you are, Olav. Just tell them who you are, what you do, and the types of
00:05:33.240
athletes that you work with? To try to make a liner story, I actually grew up on a farm on the west
00:05:40.540
coast of Norway. I had to participate in a lot of work at the farm when I was a kid against my will
00:05:48.480
because I saw my neighbors and others were playing and I would very much like to do that as well. But I
00:05:54.800
think for sure in my now today and already a long time ago, I already started to really appreciate all the
00:06:03.900
hardship, more or less. Fast forward, I already developed a very keen interest for technology already as a
00:06:11.720
kid, and I was extremely curious. I liked to really pick things apart and understand how things were put
00:06:17.240
together, fascinated about everything from the universe and rockets and so on. And of course, living at the farm,
00:06:23.860
you also get the possibility to pick apart a lot of machineries and other things and see how this is
00:06:28.920
working. And so being with animals, I have a very strong connection with animals. I also started to
00:06:35.000
develop as I started to grow a little older, I started to get very interested in more things that
00:06:39.700
were more extreme. I had an attraction towards things that were extreme. So extreme sports typically
00:06:44.100
were a thing that resonates a lot with me. There are probably no extreme sports I haven't
00:06:49.840
participated in, call it on a okay level. Yeah, and then I took my degree in electrotechnics,
00:06:57.640
went on to engineering, found out that I was not cut for the eight to four working style. For me,
00:07:04.020
it was more about entrepreneurship. I like to build things, innovate new things, solve things that
00:07:09.420
nobody has solved before. Those again, a little bit extreme things that basically are abstract,
00:07:14.800
really, really fascinates me. So in 2011, there was an event happening in my life. This was after I
00:07:21.860
actually started my second company, we were into the mountains, we had to use helicopter to get into
00:07:26.480
the mountains. There was a big, or basically half my family died on this trip into the mountains.
00:07:36.020
And again, it made a shift in my life. And I decided to, for various reasons, I got even more
00:07:44.600
into sports. So I was then asked to start to combine the field of exercise physiology and technology,
00:07:51.300
or my strength in technology and see whether we could start to take more of, let's say more research,
00:07:56.980
a lot of research that typically happens in laboratory settings, or even in microbiology,
00:08:01.220
where you're taking out components and looking at how does it react. But we very rarely are able to
00:08:06.540
transform that back into humans in a way that makes us the same difference. So how could we now
00:08:12.480
study people, use technology to study people, especially elites, for example, in the setting
00:08:19.280
where they normally exercise and even use that to continue to drive performance. And then,
00:08:25.180
of course, today, two of my personal, at least three of my personal athletes,
00:08:29.140
Christian Blumenfeld, Gustav Yedin, Ken Janina, they hold all the records that are in triathlon,
00:08:36.120
short course, long course, Olympic medal, world championship medal, short course,
00:08:41.680
the Ironman world, world championship 70.3 and full distance from Kona and St. George last year.
00:08:48.300
And yeah, it's been an incredible journey because I, one thing is, of course, what I have contributed to
00:08:53.400
with them, but I really like a collaborative way of working. So I learn always from them as well,
00:08:58.220
because I'm very curious about how they feel, what they see, how they perceive different things,
00:09:02.840
because there's a lot of things we can measure with data and there's a lot of things we can't
00:09:06.220
measure with data still. So you need also to that context as well. And mainly today, we are actually
00:09:12.260
building a company where we are scaling these companies using AI, so numerical models, large
00:09:17.420
language models into a company called enthalpy, like physics, of course. So enthalpy and thermodynamics
00:09:23.160
are some fundamental laws, humans can't escape no matter how we think we are. And then on the other
00:09:28.920
side, I work also as a coach for coaches mainly. So I'm more coaching coaches at Olympic level,
00:09:34.900
world tour level, racing at the highest levels. So yeah, that's a long introduction on me.
00:09:43.820
Well, let's start with some fundamentals, because we're going to spend a lot of time today talking
00:09:48.340
about extreme performance and peak performance around the types of sports in which you're coaching
00:09:56.140
athletes. So the triathlete is kind of a remarkable athlete in several levels. The first being that he
00:10:03.500
or she must be very good in three disciplines that are related, but quite distinct, different body types.
00:10:11.740
If you look at the world's best swimmers, the world's best cyclists, and the world's best runners,
00:10:15.500
they actually have quite different physiology depending on the distances they race, and certainly
00:10:20.300
different methods of training. And the triathlete therefore has to be really respected because they
00:10:25.900
have to be almost world-class in each of those things to be world-class in their sport. And their
00:10:32.240
physiology as a result of that is remarkable. And there are so many things that we're going to talk
00:10:37.000
about today, including temperature management, energy expenditure, energy consumption, all these
00:10:41.380
things. That said, I want to make sure that the listener is able to follow where we go. And we're
00:10:47.540
going to get into some really serious weeds, right? We're going to talk about MCT transporters for
00:10:52.880
shuttling lactate out of cells and all of those things, because that's where I want to go. But I want
00:10:59.020
to make sure people understand the fundamentals, the very basics. So humor me as we go through kind of
00:11:05.980
the 101 of ATP production and utilization. So you and I are sitting here right now having a
00:11:13.740
discussion. And of course, our body is converting all the while chemical energy into electrical energy,
00:11:22.880
back into chemical energy, and it requires the substrates of oxygen and hydrocarbons to do that.
00:11:31.060
Can you explain, you know, in a little bit of detail, exactly what that process looks like for
00:11:36.260
us right now, as we're sitting here under obviously a very low physiologic demand?
00:11:42.220
On a very deep level, or do you want more like a high level?
00:11:46.760
Okay. I think one of the things, Roche, there's a really beautiful map, call it a map,
00:11:54.140
made by Roche. I think it's called Roche. They are a medical supplier.
00:11:57.940
In the Swiss pharmaceutical company, R-O-C-H-E. Yeah, exactly.
00:12:03.140
They made a really beautiful map, which is still not exhausted. We are continuously learning new
00:12:10.860
things that we can add to this map. And this map is called, there are two maps they basically
00:12:16.440
distinguish between, and there's one that they call the metabolic pathways, another one they call
00:12:20.300
the signaling pathways. And on the metabolic pathways, we have, of course, many ways that we
00:12:26.740
can convert energy from mainly, of course, its proteins, its fats, its carbohydrates that we
00:12:34.760
are converting basically from a substrate or from the food that we ingest and we store in our body
00:12:39.200
to then basically ATP, which is the main fuel source that the muscles, different muscles in the body
00:12:45.900
are using or different functions in our body is using in order to survive. And of course, to convert
00:12:51.500
those substrates also into ATP, also there's oxygen required, but there are many, many different
00:12:56.680
pathways. And the problem a little bit with this as well is that even though this is a field which
00:13:04.160
we have studied quite a lot, we are still learning more and we don't fully understand it still either.
00:13:13.060
And that's why very often actually to bring it up maybe to where I think is more useful very often
00:13:18.480
to work on this is that if you dig too much into some of these different things that you lose track,
00:13:24.080
you start to lose track exactly of how do you increase performance of somebody as well.
00:13:30.560
To use another example, today we have, for example, smartwatches and other things as well that are
00:13:35.680
trying to say something about a sleep. It's derived or inferred basically from movement from your wrist,
00:13:41.480
for example, and it's based on HRV. But the problem is also when you're looking at, okay, what is
00:13:46.220
performance? So if we say the calamity, so again, back to thermodynamics or fundamental laws,
00:13:51.220
on the one side, humans need to move. That's what we do. So we're sitting here now in the chairs,
00:13:55.960
we're moving around, we're gesticulating with my hands and these kinds of things,
00:13:58.780
we are nodding with our heads. And all this requires energy in order to do that. And that's
00:14:03.820
movement. You can track this movement. You could even have quantified it in centimeters or meters or
00:14:08.980
whatever over a day for each of our components or globally when we are running, for example,
00:14:14.020
the distance we cover. But in order to do so, we need an energy source. We need energy from
00:14:19.700
somewhere. And of course, the currency for the muscles or for anything in our body is basically
00:14:23.940
ATP. But in order to create ATPs, then basically we need a different substrate to be broken down.
00:14:29.980
And in order for combustion to take place, we need oxygen. This is the most people probably remember
00:14:34.720
the fire triangle where basically you need oxygen, you need temperature, and then we need something to
00:14:39.720
combust. And of course, oxygen is probably the most practical way today, of course, to measure exactly
00:14:45.860
how much energy are we using at any given time. And then, of course, we can always start to break
00:14:53.440
this down and try to understand how much ATPs this release or what is the energy yield from that amount
00:14:59.540
of oxygen. But this is also highly different also in humans. Some humans will be more efficient.
00:15:04.340
Typically, elites are very efficient at this, while normal population would probably be less
00:15:10.000
efficient at this to create energy. So typically then to round that up, I would say that the way
00:15:16.340
that I very often work today is to not lose track. On one side, of course, I have a large team around
00:15:22.600
with people that are extremely good at this. One of the researchers that I work with, he was just
00:15:29.200
actually now recognized as the number one researcher in the cycling world this year. And they are
00:15:35.640
digging a lot into everything from enzymatic activities to how energy is being released and so
00:15:40.740
on. How can we do this better? But one thing that I found very much more useful is actually that we
00:15:46.160
need sometimes just to black boxes. And we have to remember what is important there. We know movement
00:15:51.460
is the most important part to humanity. So being able to move. If we can sit at work, we can sit there
00:15:56.820
in the podcast. But then basically afterwards, this, we still have an energy surplus that allows
00:16:01.840
us to come home and move around with our kids and play and be kind to our wives and help them out at
00:16:07.740
home and so on. That's a situation we all feel good with. That's what we all want. So then the question
00:16:12.580
is, how do we do that? So how can we track different parameters to understand how we can get there?
00:16:17.340
And this is where I think very often that looking at more of, let's say, humans as an engine,
00:16:22.680
as a machine, there's a fuel and an energy input. So you look at oxygen consumption, for example,
00:16:27.580
because this you can do with the cars. And then you look at, okay, you have power. So most people
00:16:31.780
will probably have a power meter, but if they are cycling and a little bit more, if you don't have,
00:16:36.080
it really is not that important because anyway, the output from this process will be distance per
00:16:41.080
time. And one thing that we see also between, let's say, less trained people, or to put another way,
00:16:47.640
people are putting in less volume into their training is also that very often in order to do
00:16:53.340
a certain amount of work, or let's say moving a certain distance has a higher oxygen cost or
00:16:59.480
basically a higher calorie cost for them to move that distance as well. So I think on the one side,
00:17:05.140
I'm very fascinated about breaking down things into the, let's say, the smaller details. But the
00:17:09.840
problem is that we have a limit to how much time we have available and how do we then make sure that
00:17:14.140
we get the best or how can we then make sure that the things that we do, the interventions we plan,
00:17:20.720
the changes we make to our lives, how can we then quantify what it has an effect? One, of course,
00:17:27.560
is the ultimate measurement of this is ultimately distance per time. But in order to understand what
00:17:32.780
mechanisms are actually happening here now, we can measure, of course, if you have a power meter or
00:17:37.040
power meter technology, we can start, is it biomechanically driven? So are you improving your
00:17:41.020
biomechanics? Or we can look between power, so work basically, and calometry, is it the biochemical
00:17:47.020
part that is improving? And we can even then decide just to say, okay, we black box it. We don't
00:17:53.060
necessarily need to understand it because we can see whether things are improving or not improving.
00:17:57.260
If it does improve, continue to do more of it. If it doesn't improve, then we basically say, okay,
00:18:02.480
fine, we can dig more deeper into it. And that's where, of course, we have specialists and others around
00:18:07.700
us that basically are trying to understand exactly what is happening on a deeper level.
00:18:12.200
Let's use some real examples on that. And I want to just synthesize what you said a little bit,
00:18:16.380
because it's very interesting. One of the first things you said is, look, the metric that matters
00:18:20.520
is velocity. You described it as distance per unit time, but of course, that's velocity. So if you're a
00:18:25.980
runner, if you're a cyclist, if you're a swimmer, if you're a triathlete, the winner and loser is
00:18:30.480
determined by velocity, not power output, not any other metric. Obviously, there's a very strong
00:18:35.740
correlation between power normalized to weight and velocity, but it is not one-to-one. I'll use an
00:18:41.640
example, especially in a triathlon or a time trial where aerodynamics matters significantly. You can
00:18:48.840
have people that put out more power, but they create more drag. And obviously that's very true
00:18:53.600
in swimming as well. In running, obviously there's running efficiency that can speak to energy
00:18:58.780
expenditure versus velocity. So velocity is king. I like the way you kind of broke it down into two
00:19:04.980
drivers. You can have, how efficient are you at using the energy source to make the ATP? What is
00:19:14.280
your loss ratio there? So presumably majority of that energy is lost in the form of heat.
00:19:20.660
We typically, I remember, used to use like a one to five ratio. So you could sort of
00:19:24.720
take the number of kilojoules, divide by five. That was approximately going to be your energy
00:19:30.240
expenditure. But let's come back to that because that's obviously very crude. But then you said,
00:19:34.320
no, no, no, look, you also have to be equally focused on your mechanical efficiency. That gets
00:19:38.600
to what I just talked about. First of all, is that a reasonable synthesis of what you just said?
00:19:43.620
Yeah. And you can split that also into, because here it helps to, when you look at mechanical part,
00:19:47.880
it's also when you look between power and velocity, then you can of course say that one component is
00:19:53.240
of course the biomechanical part, but another part of it is also the work economy or where you basically
00:19:58.020
look at equipment, for example. So aerodynamics and other things as well. So there are two components,
00:20:02.180
but purely if you look at the human locomotion, then basically it's exactly like you break it down.
00:20:07.200
I'm going to share with you one really funny example before we come back to this. So 10 years
00:20:11.120
ago, back when I used to ride a bike and the only thing I would do was time trial. That was my favorite
00:20:15.520
event to do. I had two partners that I trained with who were both much better than me, collegiate
00:20:20.660
cyclists. And we used to do this workout every Saturday, which was an 80 kilometer ride on a time
00:20:28.480
trial circuit, closed off. It's flat. Each loop was maybe seven or eight kilometers, but here was the
00:20:34.440
thing we used to do. We used to not allow ourselves to go over 200 Watts. So we had a power meter and
00:20:41.780
the SRM will tell you exactly what your wattage and your average wattage is. So you had to keep that
00:20:46.800
average watt at 200, not 201, not 199. And each week we would see if we could get faster and faster
00:20:54.540
while keeping the wattage at 200. And as you know, 200 Watts is not a lot of Watts, of course.
00:21:00.900
So it was not hard to hold that for the 80 kilometers, but over the span of a year, I think
00:21:07.700
if I remember correctly, we were able to increase our velocity from maybe, I want to say like 20 and a
00:21:16.160
half miles per hour to maybe 22 miles per hour, which is a very significant improvement in efficiency.
00:21:23.420
And I'm curious, how much of that do you think we did by getting better in our CDA, our coefficient
00:21:31.120
of drag times frontal surface area, didn't require new equipment. And then how much of that do you think
00:21:36.600
we did metabolically? In other words, that we metabolically got better at turning energy into
00:21:46.460
So first of all, of course, when you have a power meter, you don't know how much the metabolic
00:21:50.360
efficiency. We missed the VO2 data. We have no idea what oxygen consumption did in that year.
00:21:56.360
Exactly. So that part is not a part of the equation, but if you look at a work economy,
00:22:01.820
then I think there are a couple of things that mainly, of course, since a power meter on a bike,
00:22:06.760
like the SRM only measures, let's say the net mechanical power. So it basically only measures
00:22:12.520
the component of power that actually goes in the direction that you are actually moving the crank
00:22:18.940
arm. And of course, already there are two components. We don't have to focus on that here,
00:22:23.460
but that's where the difference between net mechanical power and gross mechanical power comes
00:22:26.920
in, of course. I don't know, maybe we touch even further on this because there are also several ways
00:22:31.300
to produce 200 watts as well, because you can also have a very large intracyclic power also true.
00:22:36.380
Sorry, I should make this point. The goal was to keep average power and normalize power the same.
00:22:43.700
Yeah. But even there, actually what most people don't realize is that when basically your power
00:22:47.960
meter shows 200 watts and you keep it super steady around 200 watts as well, you'll actually have
00:22:54.000
inside one second or one revolution, for example, you already there have a variation of power.
00:23:00.520
Let's say it's 200 watts. You will have a peak power production, I would say probably for you
00:23:05.080
because of your focus and how determined you were there. Probably you were sitting on the nicer side
00:23:09.340
of it, but I wouldn't be surprised for some people riding 200 watts to be pushing 1,200 watts,
00:23:15.920
for example, peak throughout every single revolution. Wow.
00:23:20.400
This is something we already quantify by the power meters. But since we don't have to focus on that
00:23:24.640
part here, because you're measuring the locomotive part of the power component, then I would say there
00:23:29.800
is a couple of things that is very interesting. One is, of course, that you say that you are already
00:23:33.520
riding at the power output, which is very comfortable. And I think that is important
00:23:38.060
in many senses when you really want to work on your work economy for it, because here we
00:23:42.400
are mainly, we have already excluded the biomechanical part of it, because since you are not looking
00:23:47.060
at the difference between gross mechanical power and net mechanical power, then we are already
00:23:51.180
said that, OK, we don't care even about the biomechanical part. We are only looking now basically
00:23:55.340
on, let's say, what is transferred into forward propulsion or velocity.
00:23:59.820
But when you're riding 2,000, what I think is really important and undervalued is that
00:24:04.900
the harder we go, more of our oxygen and blood will basically be prioritized towards, one,
00:24:12.100
driving the muscles forward. Secondly, also, even more for cooling. You hit it pretty spot on
00:24:17.860
when you say there's a 20% efficiency, 80% heat, 20%. That's what we see pretty much for elites,
00:24:23.700
not for people. As you said, we'll come back to that probably.
00:24:26.080
So then basically, when you are focused on this, I think that there are no better setting
00:24:31.760
when you ride at a little bit lower power. It allows you to be very mindful and cognitive
00:24:37.800
present to your movement and how you are in the bike there and everything there. And this
00:24:43.240
is some things that I see very often is a difference between also the specialists and the triathletes
00:24:47.880
as well, because the triathletes are much more inclined to solve tasks brute force than
00:24:53.860
the specialists. The specialists are, because they simply have more time on lower intensity,
00:24:59.860
medium intensity, and high intensities, or let's say especially lower intensities,
00:25:04.060
they tend very often exactly to build a better feeling for how they are moving through the
00:25:10.900
landscape more efficiently by doing exactly like you say. You look at the 200 watts and it becomes so
00:25:16.360
measurable because you can start to evaluate what is happening with your velocity as a function of
00:25:22.240
that. You just see that, okay, I'm creeping down with my head a little bit and you start to feel
00:25:26.200
these nuances. Because to maybe end it a little bit here is that when you go to a wind tunnel,
00:25:32.260
one of the problems with going to a wind tunnel is that you go in there and you do something that is
00:25:36.340
like a spot. It's a spot picture exactly of the position that you're holding for the moment.
00:25:41.500
I don't know how many hours is spent in the wind tunnel, but for various purposes, but obviously
00:25:45.480
a part of that has been looking at aerodynamics of an athlete. The problem is that the moment you take
00:25:49.860
the athlete off the bike and you put him on the chair and you ask him to go back into the position
00:25:53.400
there, if he doesn't have an outline in front of him that tells him exactly the position to be in,
00:25:58.620
that can already start to offset any other margins that you're looking to gain from, for example,
00:26:03.560
clothing and other things. So in order now to re-evaluate clothing on an athlete and not on a
00:26:08.060
dummy or a doll, but basically on a live athlete, the problem with that is exactly if you go off the
00:26:13.760
bike, come back on again, you won't have the same position unless you have an outline that you see
00:26:17.940
that you're fitting yourself into. And the problem with that is exactly that you haven't gotten the
00:26:22.720
time to rehearse your position and actually start to feel and get aware about your whole body position
00:26:28.120
in exactly that position there, which is completely the contrary to when you're riding 200 watts.
00:26:33.820
You're riding at a power output that allows you exactly to have that cognitive access to evaluate
00:26:38.880
yourself, feel yourself, be aware of the surroundings and everything there. And you are basically
00:26:43.820
programming that into your, basically your backbone for that. This is the position there. So when you
00:26:48.640
go out, let's say in a race, you have trained that position so deep into your body that you can almost
00:26:56.460
do it blind. I think you're spot on here, Olive, now that we discussed it. I actually think that that
00:27:01.980
whatever it is, 5% improvement came almost entirely through frontal surface area. And as you said,
00:27:09.700
it's so relaxed. I mean, we're talking as we're doing this ride. It's not a hard ride, which meant
00:27:15.960
all of your cognitive reserve goes into wiggling your way into how narrow can I get my shoulders?
00:27:23.960
What's the best position of my knees on the top tube? All of that kind of stuff. So that's very
00:27:29.340
interesting. And it's also interesting that you point out that it's a luxury that the one sport athlete
00:27:35.760
has, because at the time that was the only thing, I mean, I swam, but most of my energy was on the
00:27:40.820
bike. And yes, I think a triathlete would have a harder time maybe justifying that. Do you think
00:27:46.800
a triathlete would benefit, however, from doing some of that kind of training that seems sort of like
00:27:55.620
So this is where I would differ because it becomes junk mileage when you're not mindful
00:28:00.060
about that. So of course, this is also where, for example, I know that a lot of
00:28:03.700
people talk about when you do a quality or high quality or quality workout is a high intensity
00:28:08.640
workout. But basically how I basically see it instead is that low intensity, medium intensity
00:28:13.400
and high intensity should all be high quality. All of them should be mindful workouts because you can
00:28:18.480
use them for different purposes. Exactly when you're doing the lower intensity, it allows you
00:28:22.920
exactly to have that cognitive reserve to basically use your senses to give you better biofeedback
00:28:30.340
and learn better what you can improve, which you don't will have the cognitive reserve to do
00:28:35.160
when you do the higher intensity workouts, because then you are exactly focusing more on surviving
00:28:40.220
instead. So yes, absolutely. This, I think, becomes most evident in swimming. In cycling, we actually do
00:28:48.160
see that the triathletes, because the movement pattern and other things, there are very, very few
00:28:54.140
degrees of freedom when you're sitting on a bike. So in cycling, we see that, for example, the best
00:29:00.320
triathletes in the world are on par, close to or on par with actually the best cyclists in the world.
00:29:06.920
In running, this, of course, starts to become a little bit bigger difference between them, simply
00:29:11.480
because now you start to allow for a little bit more degrees of freedom. And swimming is, of course,
00:29:15.860
the worst. This is where you have so many degrees of freedom and so poor feedback values. You need to have a
00:29:21.620
very good spatial awareness of your body and what you're doing there in order to allow you to have
00:29:28.180
or to utilize your oxygen for maximum propulsion. To give you an example, we were in the flume at
00:29:35.080
Tenerife tea tree. This is not like a counter current pool where there's a jet sitting in front of you and
00:29:40.960
pumping some water today. This is a full-fledged wind tunnel. Basically, water is circulated full
00:29:46.580
cross-sectional area around in a huge circle. And there is basically a three times, three meters
00:29:52.720
wide, one and a half meter deep, five meter, five, six meter long cross-sectional area of water just
00:29:59.400
passing over or past you like you were in an endless ocean, swimming in an ocean. Water quality
00:30:05.120
is perfect. There's no turbulence, no nutter, just pure water running past.
00:30:09.720
But sorry, the athlete is able to swim in place. So it's not like, you know, an endless pool where
00:30:15.100
you're being blasted with a five mile per hour current two feet from your face. You're out far
00:30:21.120
enough in the pool that it just feels like you're in the ocean and you're not moving, but you're using
00:30:26.700
a natural stroke. It looks very similar to a wind tunnel. It has the honeycomb structure on both on
00:30:33.620
the front and the back here. And then basically there are some huge fans pumped sitting in another
00:30:38.180
part of there. So it's not sitting where you are swimming, but basically sitting on a return section
00:30:42.640
instead there. So basically what happens here is that you're laying in this tank and the water is
00:30:47.420
just passing. So you can just set the speed here in the same way as you do with an endless pool or
00:30:50.720
counter current pool. So you set the speed to, for example, 1.5 meter per second, and you just jump
00:30:56.380
in and you're just swimming there. And you want, whether you go left or whether you go right or forward
00:31:00.740
or back, the current is exactly the same here. There is no turbulence anymore. So the interesting thing
00:31:06.500
now is that we built, we took a gold standard metabolic cart and then basically we made hoses and
00:31:11.560
everything in an apparatus that allows them to use this while they are swimming.
00:31:15.740
So meaning you are able to measure the ventilatory rate of oxygen consumption, carbon dioxide
00:31:21.720
Everything. So the input, basically you're measuring the fuel consumption of the car and you're looking
00:31:27.960
Yes, exactly. Yeah. Not the only exhaust, but the exhaust is measured, but also the back wheels
00:31:32.700
basically of your car. So then basically when they are in the flume there, we know that Christian
00:31:37.560
and Gustav, for example, have a equally high or higher view to max than the elite swimmers in the
00:31:42.800
world. And now I'm not talking about where you're comparing running with swimming. We are taking them
00:31:47.440
and measured it in swimming. And the same thing I've done also on elite swimmers. And basically where
00:31:51.880
we say Christian and Gustav has a higher view to max. So a bigger engine than the best swimmers in the
00:31:58.720
world. The people that are winning gold in the Olympics.
00:32:01.260
Yep. So in other words, when you push the speed high enough to the point where they reach the
00:32:07.680
maximum amount of oxygen that they're going to be able to consume, which is equivalent to,
00:32:13.180
or linearly equivalent to, the maximum energy expenditure. And we always know that the bigger
00:32:18.660
that number, the bigger the engine. They do more. They are able to consume more oxygen and put more
00:32:25.020
calories to work than the world's best swimmers. But of course, you're about to tell us they're not as fast.
00:32:30.080
Exactly. And the difference is so big, you don't even want to know it. So for example, we had the
00:32:36.600
bronze medalist from the Olympics swimming in the flume there. He is 195, 195 tall. He weighs more
00:32:44.100
than I think, let's say around 90 kilograms or more. Massive guy, a lot of muscles. He goes into the
00:32:50.640
flume, swims at the same velocity as Christian is doing, and is using almost a liter less of oxygen.
00:32:58.540
At that point, that was close to 25% less oxygen. And what we also do know, the more muscles you have
00:33:05.160
in the body, the more oxygen you can also consume. Because you have almost no muscles, obviously there
00:33:09.800
won't be a lot of oxygen consumption because it's the muscles mainly that are using oxygen during
00:33:14.360
basically exercising. So now when you have an athlete that is this massive, obviously you would
00:33:18.980
assume that, okay, he is using also a lot of oxygen because there's a lot of muscles involved.
00:33:22.800
But because he is so efficient, he actually swam at the same velocity with almost 25% less oxygen
00:33:30.620
consumption than the best triathletes in the world is doing. And that is a little bit mind-boggling,
00:33:37.580
but it just tells how important also efficiency or movement efficiency is into this whole equation as
00:33:44.500
well. I would argue that is only mind-boggling to someone who has not swum. But as a former swimmer
00:33:52.380
myself, this doesn't surprise me one bit, not one iota. Because I came to swimming late in life. I'm
00:34:01.620
an adult onset swimmer. So I didn't swim until I was 31 years old. This is almost 20 years ago.
00:34:07.480
And it never ceased to amaze me. Even when I was at my absolute fittest on the bike,
00:34:15.100
when my VO2 max was more than five liters, how people with seemingly such a lack of fitness
00:34:22.200
could destroy me in a swimming pool. These people were technically so superior that I could consume
00:34:29.700
five liters of oxygen. They would consume three, no comparison.
00:34:33.460
And that's where exactly being mindful, using that cognitive reserve, not to do junk miles,
00:34:39.780
but doing really mindful miles in the pool, on the bike, exactly like you did. It's so important,
00:34:46.540
but very undervalued. And it could have been used so much better.
00:34:51.720
Super interesting. Well, let's start talking about some of these things. We've already alluded to VO2
00:34:55.700
and VO2 max, and you've already made a very bold claim, which in the pool is easier to accept,
00:35:02.740
but let's extend it now. And let's talk about what it means on the bike and on the run, because
00:35:07.700
people who listen to this podcast have heard me say over and over again, that VO2 max is the greatest
00:35:13.960
predictor of lifespan. This is kind of a remarkable statement, and I'll repeat it because it is so
00:35:19.940
profound. Whether you smoke or don't smoke, whether you have diabetes or don't have diabetes, whether
00:35:26.800
you have end-stage kidney disease or don't, heart disease not, hypertension or not, all of those
00:35:32.400
things play an important role in predicting the length of your life, but not as much as having a very
00:35:38.800
high VO2 max. This rises above every other biomarker we have to predict the length of life. And the reason I
00:35:48.680
argue that that's probably the case is that VO2 max is an exceptional integrator of work that is done.
00:35:58.280
So for the few times I have patients that will tolerate the mathematical equation, I would say, loosely
00:36:04.060
speaking, VO2 max equals the integral from T1 to T2 of work as a function of time DT. And we know that that
00:36:13.420
work is very valuable for your health, right? We can quantify why it is that exercise helps you live
00:36:20.420
longer. Why is it good for the brain? Why is it good for the heart? Why is it good for the immune
00:36:25.400
system? And therefore VO2 max becomes a very reproducible way to document that work. And it can't
00:36:33.740
be changed quickly. So it's not a cheap biomarker like vitamin D where you can just take a bunch of
00:36:40.440
vitamin D supplements and immediately change your vitamin D level. So with all of that said,
00:36:46.520
when we get into the minutiae of exceptional human performance, VO2 max is not the best predictor.
00:36:54.140
So let's put swimming aside because it's so obvious there, but why would it not be the best predictor of
00:37:02.000
performance in something like cycling, for example, or running where the aerodynamic contribution
00:37:10.040
in the case of cycling is easier to mitigate still nowhere near as bad as swimming and where the
00:37:16.480
efficiency maybe isn't as important. So where do we see VO2 max not become the most important driver
00:37:24.120
of endurance performance? So first of all, I would not agree more with you on that VO2 max is
00:37:32.840
probably or still today the holy grail for understanding basically longevity or let's say
00:37:41.540
the best marker or metric we have in order to quantify it. Because to just elaborate a little
00:37:47.320
bit further on that, you can also say that, well, VO2 max is a measure of something. So we are measuring
00:37:51.900
something in the end there. And to be a little bit crude, you could say that, okay, fine. Some people
00:37:58.680
could say, well, having a good heart is a good predictor of longevity, for example. But I'm pretty
00:38:04.460
sure we can find people that are in the bed and they are really sick that still have a really good
00:38:10.640
heart. You understand that, well, there has to be more nuances to this than just the heart itself.
00:38:15.600
You can have people that has a great heart, everything looks good, lungs perfect, everything like this,
00:38:20.780
but they have neurological diseases, for example. All of these will limit you from reaching a high
00:38:29.160
VO2 max, which is again, so integral. It basically just encompasses all this kind of thing because you
00:38:34.560
can't reach a high VO2 max if any of these functions here are not good. I couldn't agree more with you.
00:38:42.040
VO2 max is the absolute best predictor of mostly everything just because that it encompasses all these
00:38:49.320
things. Then on to why doesn't VO2 max become a very good predictor of performance in cycling? I would
00:38:55.980
argue it does, but then we are also starting to reach some more limitations as well. You want to
00:39:01.700
have as a high VO2 max as possible, even as a cyclist. The only problem is that we are now facing some
00:39:08.880
other problems as well when you are an elite athlete, and that is something we call maximum sustainable
00:39:13.320
energy expenditure. So obviously, to turn around more calories per time, that obviously means also
00:39:20.560
that over time, you will use more calories as well. And this, in order now to support growth,
00:39:25.540
you obviously have to input more calories also. Because you're burning more, you need to bring
00:39:29.840
more in. Otherwise, you are starting to run into deficit, and you, worst case, end up with problems.
00:39:35.620
So feeding that, let's say, calorie consumption becomes crucial.
00:39:38.700
Further, the problem is that VO2 max is closely related. So if we wanted to have a surrogate
00:39:45.340
metric for VO2 max, we typically do make an athlete run all out for, let's say, a couple of minutes,
00:39:51.860
one to five minutes, let's say three minutes to make it simple. Or we can have cyclists do a three
00:39:57.200
minute or four, five minutes, but something short. Not too short, but absolutely not too long.
00:40:04.620
Exactly. Yes, exactly. This is, again, a very good proxy to understand, or as a surrogate,
00:40:10.060
to understand, of course, what is your VO2 max as well. But then what we have to understand as well,
00:40:15.220
that this is not necessarily what you need in Tour de France. You don't need to be the best four-minute
00:40:20.040
athlete. This is more important for a track cyclist. A track cyclist that has the working time for four
00:40:24.820
hours, for four minutes, then VO2 max becomes maybe the best predictor of performance again. So it's a
00:40:30.360
little bit depending on context. But because we already said now there's another limitation here
00:40:34.860
as well, and that is the maximum sustainable energy expenditure. How much energy can you expend on
00:40:40.300
different, let's say, intensities in order to increase, let's say, the speciality of what you're
00:40:45.340
going to be good at? So if you are going to be best in the world riding 160 kilometers and then
00:40:51.120
sprinting towards the finish line over a couple of hundred meters, you can even not argue that it's a
00:40:56.340
sprint even. But let's say you are really going fast the last kilometers. The problem with this
00:41:01.860
is that if you spend most of that energy that you have available now to increase your VO2 max,
00:41:07.660
you're spending obviously less time on specializing what you're really going to be good at. And you
00:41:12.800
won't find a track cyclist that you can put into Tour de France and think that he will win Tour de
00:41:17.340
France. And you won't find a Tour de France rider that you can put on a track and become the one
00:41:21.320
kilometer winner there. Obviously, because they are specializing on two different durations. So
00:41:26.940
simply because we have a limitation for how much energy that we can turn around per day, per week,
00:41:33.860
and so on, sustainably, because that's the key here, sustainably, it basically means also that we
00:41:39.180
have to focus more on that exactly specificity that we're looking to excel in. And then, yes,
00:41:45.140
VO2 max will still be the best predictor, but not necessarily having the highest number.
00:41:53.420
Yeah. And let's stay with cycling and even keep it simple and just talk about not include the track,
00:42:00.820
which is far closer to an anaerobic effort. It's sort of on the anaerobic side of a peak aerobic
00:42:07.820
effort. But even if you think about, let's go back to the distance of the 112 mile time trial
00:42:14.920
that a triathlete is doing in an Ironman. So for the most part, I mean,
00:42:19.920
there's no sprinting in there. He's not sprinting at the very end. In fact, he's probably trying to
00:42:25.720
keep that relatively constant in effort to prepare himself or herself to do the marathon run that's
00:42:32.380
following. Even in that system, let's go back and talk about two athletes. If there are two athletes
00:42:38.040
that have the same VO2 max, does power at VO2 max give you another layer of insight? Let's just say
00:42:47.220
Christian and Gustav each have a VO2 max of 80 milliliters per minute per kilogram. But one of
00:42:55.740
them is doing that at 450 watts and one of them is doing it at 425 watts. Does that give you a new
00:43:05.420
piece of information or is it still limited because that's really only speaking to a four minute,
00:43:10.560
five minute effort? Yes and no. That is of course where you can black box, of course, a little bit.
00:43:16.900
Now we just talked purely about VO2 max, my focus on that. But of course, there will be a fairly good
00:43:21.480
correlation also between oxygen consumption, let's say, at VO2 max because you could argue that
00:43:28.020
there's really no power at VO2 max as long as you are above what we call VO2 steady state. So you have
00:43:34.780
a couple of different steady state scenarios. You have typically one that a lot of people knows about
00:43:39.260
which is the maximum like the steady state. But then of course, above there again, you have something
00:43:43.480
called VO2 steady state. And at the moment you start to exceed over VO2 steady state, then basically it's
00:43:48.920
just a matter of duration before you will basically elicit VO2 max. But obviously, the closer you stay
00:43:54.580
to your VO2 steady state, the lower the power you will basically outputting. If you put out a too high
00:43:59.920
power, obviously you won't be able to reach VO2 max because you will not be able to contract your muscles
00:44:04.240
efficiently anymore and you won't be able to bring your ventilation or oxygen consumption up to a max.
00:44:09.620
But there's a sweet spot there, more or less, where basically any power that sits between, let's say,
00:44:14.740
VO2 steady state and a higher power number will elicit VO2 max. It's just the amount of duration that is needed
00:44:22.000
in order to get there. So of course, this adds uncertainty because you need to know this. You need to know this.
00:44:28.020
I think it's important just so the listener understands that you can't necessarily just go out and people start
00:44:32.860
talking about power at VO2 max and their VO2 max because then suddenly people will get confused because you have to know
00:44:38.740
also then what was the duration of it as well. How did you get there? And yeah, yeah, exactly.
00:44:45.080
Yep. Yep. Yeah. Yeah. Maybe let's take a quick aside because you and I are speaking about this with
00:44:49.340
such a degree of familiarity. I want to make sure the listener understands how you're measuring VO2 max
00:44:55.160
in the lab. This is a test that I believe every human being, athlete and non-athlete should have done
00:45:01.260
because everybody needs to know their number and everybody needs to know where they stack up against
00:45:07.060
people, their age and their sex. Because again, it is one of the most important, if not the most
00:45:13.200
important modifiable metric we have to speak to both the length and quality of life. So if I came
00:45:20.080
into your lab tomorrow to have my VO2 max measured, tell me what we would do. So the good thing now,
00:45:27.400
of course, is that also VO2 max is being, or let's say metabolic measurements are being democratized as
00:45:32.540
well. For example, we work very closely with a Canadian company called VO2 master that allows you
00:45:37.920
basically to put now a mask. So it's like the old age, basically, when you have these big computer
00:45:42.500
towers and everything. Today, we have iPhones and Androids that basically have computational power
00:45:47.640
that exceeds millions of times, even what the Apollo 11 expedition had.
00:45:52.100
Yeah. So the same thing is, of course, happening also to metabolic analyzers as well,
00:45:57.440
from basically being these huge towers that were basically exclusive to labs to basically where
00:46:01.600
it's now being democratized. And you basically have like this super portable analyzer just sitting on
00:46:06.120
your face, meshing your oxygen uptake. But to bring it to the lab setting, what happens there is that
00:46:11.820
you come into the laboratory setting. I don't work so much with relative values, but a lot of people
00:46:16.900
will do. So obviously, we've got to measure your weight. So we get your weight there.
00:46:20.560
You mentioned Christian, or let's say an elite athlete, you said 80 milliliters per minute per
00:46:25.760
kilogram. So we have normalized this to kilogram. That's why we need to measure your weight.
00:46:30.440
So what we do is that depending on what kind of modality that's important to you,
00:46:33.800
so let's say that it's running, for example, what you'll do is that you get on a treadmill.
00:46:38.520
And basically, there's a couple of different ways to do this. Whereas the method is pretty much the
00:46:44.820
same, but it can be a little bit of a different gear. Some people will use something that we call
00:46:49.440
mixing chamber system, and some people will use what we call the breath systems. But it would
00:46:54.200
basically involve basically you having either a mouthpiece in your mouth, where there sits a
00:46:59.140
turbine with a sample line from it. Basically, when you're exhaling in this mask there, or through
00:47:04.540
this mouthpiece, we are measuring the flow or how much air you are breathing in and out per time.
00:47:12.940
If it's a turbine, then basically we correlate it to how many RPMs this turbine is spinning. So now we know
00:47:17.700
whether you are breathing, for example, 50 liters or 100 liters, 150 liters per minute.
00:47:22.920
But then, of course, now we only measure your ventilation. We don't know anything about your
00:47:26.680
oxygen consumption yet. We only know something about your ventilation. So then what we also have
00:47:31.300
to do is we need a sample line that sticks in there as well, that basically collects now the
00:47:35.840
concentration of oxygen and carbon dioxide as well. So what we then do is that because we know that
00:47:43.400
the ambient oxygen condition and ambient CO2 conditions is basically, let's say, 20.9% oxygen
00:47:50.420
and then 0.05% CO2 more or less, roughly speaking. While you are now running and you're breathing,
00:47:59.040
you are obviously breathing in a certain amount of oxygen into your lungs, and then you're consuming
00:48:03.360
some of the air into your lungs, which contains basically 20.9% oxygen. When that comes into your lungs,
00:48:10.500
parts of that oxygen, far from all of it, actually only closer to 25% of the oxygen, you are actually
00:48:16.740
taking up in your lungs, and it's being now transported through your body, and you're exhaling
00:48:21.220
actually 75%, roughly speaking, 75% oxygen. You actually exhale out again now. Since we are
00:48:27.360
measuring now the oxygen concentration with this device, we can measure, we know now the delta
00:48:31.740
concentration that sits between what is the oxygen concentration when it goes in, how much is oxygen
00:48:36.560
concentration that goes out. Since we also measure the volume of air, we know we can now extrapolate
00:48:42.140
that and say, okay, this is the amount of oxygen you're actually extracting from there, and this
00:48:46.260
is how we know your oxygen consumption. So why is oxygen consumption important? Well, this comes back
00:48:52.120
to basically calamity. Calimetry actually is very often people think then immediately of nutrition and
00:48:58.400
foods and these kind of things, but it's actually just a unit. It's actually just a unit,
00:49:03.460
a scientific unit, actually, for knowing how much energy is needed to heat water from 14 to 15
00:49:09.840
degrees, for example, a certain amount of that, and then how much calories is needed. So we could
00:49:13.680
even use gasoline for this. But it basically comes back to the fire triangle. You need something to
00:49:18.860
combust, you need oxygen, and you need temperature. And basically, when we know, when you combust,
00:49:23.620
there's a field, now I'm getting really nerdy here, but there's a field, so there's a field in
00:49:27.380
biochemistry, which is called, or actually not only biochem, yeah, well, biochemistry,
00:49:31.540
about chemistry in general, which is called stoichiometry. So in stoichiometry, there we can
00:49:36.940
basically look at, so when we have, like you mentioned initially in the call as well, you talk
00:49:41.340
about hydrocarbons, for example, but let's say carbohydrate, carbon, hydrogen, and oxygen, and then
00:49:46.240
we know how many atoms there are of each of these in that molecule there. And then basically, when we
00:49:51.340
want to convert this into ATPs, for example, then we are breaking this down. So for example, if you look
00:49:56.300
at the glycolysis, we are taking, for example, glucose, which is C6H12O6, and we are breaking
00:50:01.980
that down into two pyruvids, or basically C3H5O3. But we've got two of them now. But in this process
00:50:10.240
of releasing ATPs there, at the same time, what happens is also we are releasing hydrogen ions.
00:50:15.220
And this is actually, when you feel a burning sensation in your muscles, this is actually,
00:50:18.860
it's not the lactate, it's actually this that you are feeling in your muscles. Lactate is actually
00:50:22.340
a superfuel. If the muscles get access to both lactate and glucose, it will actually use
00:50:27.780
lactate as a preferred source before even glucose. But then basically, because C3H5O3 basically lacks
00:50:35.820
one hydrogen molecule now, as long as you have an excess of this, then basically you are able to
00:50:40.040
bind back that hydrogen molecule in there, and you get C3H6O3, which is lactate molecule. We've got
00:50:46.220
two of them. So you split one glucose molecules effectively now down to two lactate molecules.
00:50:52.360
When you're looking now at the energy yield here, basically we know that when you burn,
00:50:56.560
when you convert from glucose to lactate, for example, there is a certain amount of
00:51:00.420
energy or joules that is released in this process. We can even say, okay, let's forget about even ATPs and
00:51:06.000
make it even a little bit simpler. What is the potential joules that sits in a glucose molecule?
00:51:11.260
And then when we split this glucose molecule, how many joules are we releasing in this process?
00:51:15.940
And basically, because it says C3, or basically C6H12O6, we know there are six oxygen molecules there.
00:51:23.520
And now we can actually calculate, or we can know actually from your oxygen consumption,
00:51:28.380
because that's O2 molecules going in, and then there comes out CO2 molecules,
00:51:32.500
or both O2 molecules, but also CO2 molecules. But what we can know now is that we can know exactly,
00:51:38.080
because we can use stoichiometry, and we can basically calculate how much joules has been
00:51:42.680
released in this process. And that ties back to VO2 max. The more oxygen you are capable of turning
00:51:47.860
around per time, the more calories, or let's say the more fats, proteins, carbohydrates, you are able
00:51:54.120
to break down and release energy that you can use for the propulsion in the process. And that's why
00:52:00.460
VO2 measurements is a holy grail metric. We can always talk about direct calimetry, but that's so,
00:52:06.480
let's say, call it intrusive into a process, and so little practical to do.
00:52:11.560
So indirect calimetry measured with VO2 max, or VO2 and VO2 max, is a superior method to understand
00:52:19.200
how much energy are you able to release in this process. And also then, just to come back a little
00:52:24.640
bit to your field as well, medicine. If you have a low VO2 max, it basically means also at the moment
00:52:30.680
you start to have stress in your lives, you have infections in your lives, anything like this,
00:52:34.480
you are utilizing a much higher percentage of that ability. Because to get healthy as well,
00:52:41.960
you need energy to get healthy as well, to do whatever, transporting blood around in your body
00:52:46.800
or whatever. So an athlete that has a huge VO2 max that becomes sick, there's a fractional change,
00:52:53.700
basically, or relatively small change of their capacity or reserve that is utilized now in this
00:53:00.080
process. So at the moment they release basically their training, or they reduce the training volume,
00:53:04.680
they get a huge excess of energy or ability to recover now. And if you're quick enough to do it,
00:53:11.740
you won't almost increase in infection at all, because the body gets so much energy excess to help
00:53:18.860
aid in the recovery process now, compared to a person which has a solo VO2 max that even walking up the
00:53:25.440
stairs. I think that's such a great point. And I don't think people fully appreciate what a
00:53:30.360
physiologic stress significant illness is. So I won't bore people with all of the details,
00:53:36.040
but if you go and do the chemistry on what it takes to raise the body's temperature from 98 Fahrenheit
00:53:41.820
to 103 Fahrenheit, that is an enormous energy cost. When we look at cardiac patients, when we look at
00:53:49.800
any patients in the ICU, and you look at the change in cardiac output that might be required to support
00:53:57.440
a systemic inflammatory response syndrome, it is profound. So I think this is absolutely spot on,
00:54:03.840
and it really comes down to just having more reserve. I want to ask you several questions. Let
00:54:08.700
me try to take them in order. First, you mentioned that you prefer to look at VO2 max in absolute terms.
00:54:15.440
So how much does Christian and Gustav weigh? Those guys probably weigh 75 kilos.
00:54:21.200
So the funny thing is that leading into the Olympics, one of the things we actually looked
00:54:24.500
even at is basically what happens, because we have tried to reduce the weight very conservatively by
00:54:29.920
global standards, even in sports, to reduce the weight, because we had already ingrained in our
00:54:35.880
heads from basically a past and other people saying that, well, you need to bring up your relative
00:54:40.060
VO2 max. And that is done very simply by reducing the weight. The interesting thing was we found
00:54:45.420
after we had done this a couple of times, and a little bit by accident, because we do so much
00:54:49.500
measurements, is that we saw actually that, well, the relative VO2 max didn't come up, and the absolute
00:54:54.520
VO2 max came down even more than the weight came down. So let's just make sure people understand exactly
00:55:00.220
what you said. It's very important. And we should use some numbers so people understand. So I'm making
00:55:05.080
this up, but if they weigh 80 kilograms, their maximal oxygen consumption is six liters, you take six
00:55:10.940
liters or 6,000 milliliters divided by 80, and you're going to get a big number. And you're saying,
00:55:16.420
well, gosh, I mean, the tried and true method here is we have to lower that body weight. Why don't we
00:55:21.820
take that body weight from 80 kilos to 75 kilos? And now 6,000 divided by 75 is a much bigger number.
00:55:29.020
All things equal, we're much better. The problem is it's not all things equal, because that 6,000
00:55:34.040
milliliters of oxygen might have come down to 5,500 milliliters per oxygen. And now that ratio
00:55:40.820
has actually gone down. Exactly. So both absolute have gone down and also relative have actually gone
00:55:46.500
down. It's a little bit, I think, shocking, because most people, we of course have a lot of theories of
00:55:54.820
why. One, why this is happening, but also why do people still cling to the idea of reducing? So you
00:56:03.000
come up to a certain level. Let's say that you had hundreds of athletes through your program,
00:56:07.540
suddenly comes this really good, like this guy that just responds, a girl that just responds to
00:56:11.920
your training. He goes to junior level, starts to win, senior level, starts to win, starts to go to
00:56:16.940
the championships and whatever. But now you're starting to really have to fight for the sports.
00:56:22.280
Okay, what do you do? Okay, my training program is perfect. That's something that's very easy to
00:56:27.940
sometimes think, or you're afraid of making changes to the program, because you don't necessarily
00:56:31.840
understand exactly why you got there. But we have got ingrained with that, okay, fine, let's reduce
00:56:36.620
the weight now, because that will be the next step now, because we are not able to make you
00:56:40.060
more powerful. So let's start now to reduce your weight. There are two things happening now.
00:56:44.880
One thing is, of course, the things we have observed, the view to max starts to come down,
00:56:48.440
absolute and relative value starts to come down.
00:56:51.180
Does that happen because you're unable to control where you're taking the weight off? So
00:56:56.620
for example, are you losing disproportionately lower body muscle mass, which is, I think,
00:57:03.840
disproportionately contributing to VO2 max relative to upper body?
00:57:07.980
No, unfortunately, it is more complicated than that, because it is without even losing muscle mass.
00:57:13.960
So it is related then to basal energy expenditure. If your total body mass is coming down,
00:57:19.800
your basal energy expenditure is coming down, that is probably altering fundamental metabolic
00:57:26.280
pathways at rest that must be translating to what's happening under stress.
00:57:31.220
Most probably, yes. This is, of course, something I haven't had enough time to dive into,
00:57:36.220
because on the one side, I'm looking more to drive performance. There are some findings that
00:57:40.340
we really want to understand better, but we have to say, okay, that's going to happen in the next life
00:57:46.920
I mean, an interesting experiment to do here, sorry to interrupt, would be
00:57:50.480
to actually use doubly labeled water under the weight reduced setting compared to the previous
00:57:58.360
setting. Obviously, you could do indirect calorimetry during rest. You wouldn't be able
00:58:02.900
to get total energy expenditure, which is what you want, and see if that drop proportionately
00:58:08.860
corresponds to the drop you saw in VO2 max absolute.
00:58:12.980
Yeah. So this is also something, because you can think of it, and maybe this is just a
00:58:16.020
temporary phase. So maybe this is a temporary phase before you stabilize the weight, and then
00:58:19.960
at some point, it will start to come up again as well, but it doesn't either. So that's a little
00:58:24.260
bit of the thing here. Also, we can venture a little bit into double labeled water because we spent
00:58:28.240
a fortune on doing several double labeled water or blocks. And this, it's a nice method, but it also
00:58:35.480
has several pitfalls. So actually, what we have started to do much more of lately is exactly
00:58:41.460
doing resting metabolic rates. So again, having the portable metabolic analyzer
00:58:45.600
like the VO2 master, it allows us basically, we do measurements before dinner, we do it after
00:58:50.220
dinner just to look at the foods, for example. We do after training to see basically what happens
00:58:55.620
there. And we even see that it even sometimes dips below normal resting levels, for example,
00:59:01.660
even. We can only theorize on why that is happening. But the thing is that there's a couple of
00:59:06.380
mechanisms that we just need to control, and we need to become even better at it.
00:59:10.520
But back to a little bit to VO2 max and ESA. So why do I work on absolute values versus relative
00:59:15.340
values? One of the things that we do see is that, first of all, Christian and Gustav now,
00:59:20.120
they weigh 73, 74 for Gustav and 80 kilograms for Christian. And he's 175 tall. You would almost
00:59:30.420
say that, hey. He's stocky, right? 175 centimeters at 80 kilos. He looks like a muscular guy. He's not
00:59:36.620
a beanpole. Exactly. But you'll also see that he has a little bit of extra fat on his body compared
00:59:41.760
to what you would expect to have from an independent. But we can't look at it that way because I'm not
00:59:46.460
looking to build aesthetic machines. No, no, no. It's performance. Philosophy matters.
00:59:51.020
Exactly. Exactly. When you make things relative, because if you look at a power number,
00:59:55.580
so you can have two guys, for example, that has, let's say, five watts per kilogram. They are
01:00:00.280
producing five watts per kilogram over a certain distance. But one of the guys is just moving much
01:00:05.920
faster, everything equal. So aerodynamics would be equal, everything like that. But the problem is
01:00:10.340
only that the raw power from a bigger guy that has five watts per kilogram is much higher power,
01:00:16.580
which basically then with aerodynamics are the same. He will move much faster for this. And this goes
01:00:21.600
the same also with VO2 max as well. If you look at relative values, okay, there's nice,
01:00:25.460
to have an idea of what kind of level people are at. But if you just want to look now purely at
01:00:30.600
propulsion, then basically you have to look at it in absolute terms instead. Because most of the
01:00:34.780
racing that is being done today is not very hilly. There are very few sports that are very hilly.
01:00:40.080
And of course, if it starts to become very hilly, then of course, then you can start to say,
01:00:43.240
okay, fine. Now relative values will maybe give you a better predictor of the performance
01:00:48.040
necessarily than absolute values would give. Yeah. So that's the main reason.
01:00:51.680
That's very interesting. So again, a couple of things. One is, yeah, in cycling, especially in
01:00:56.700
the Tour de France, I've heard it stated. And the data for this are a bit confounded because
01:01:04.440
they were based on the two decades of cycling when EPO was widely used. Every single top cyclist was
01:01:13.000
using EPO. But that said, I think that still normalizes it and makes it clear. And basically,
01:01:18.400
you could look at predictions of who would win the Tour absent a strategic blunder or an accident.
01:01:25.500
And it was all predicated by functional threshold power in watts per kilo.
01:01:31.020
So if you could know how many watts a cyclist could hold for 60 minutes divided by their weight,
01:01:39.200
and you line those up in descending order, all things equal, that was going to be your
01:01:44.760
championship finish. And of course, it's never exactly equal because as I said,
01:01:48.780
you can make a strategic blunder, there can be an accident, lots of things can happen.
01:01:52.720
But I suppose that that doesn't surprise you given the vertical nature of the Tour de France. It is
01:01:58.120
mostly one in vertical distance, not horizontal distance.
01:02:02.460
Exactly. Just to add to that also, I think one problem there is a little bit when you talk about
01:02:07.060
60-minute power. So you take 60-minute power and you divide it by kilograms to make it relative.
01:02:11.740
I think that then you are starting to get a fairly robust metric for it. The problem very often is
01:02:16.340
that people use much shorter durations. Right. They use 8-minute power, 10-minute power,
01:02:23.360
And then the problem, if you now extrapolate that, then you still call that functional threshold
01:02:27.020
power, for example, and you divide it by your weight. What you don't know when you're looking at it
01:02:31.840
this way is how much of energy comes from oxidative phosphorylation and how much comes from the
01:02:36.500
glycolysis, for example. And the shorter the duration is, and you're extrapolating that up to
01:02:40.840
a larger value. The more dangerous it is metabolically. Yeah. Let's actually make sure people
01:02:45.120
understand why. If you're doing this analysis based on five minutes, to your point, what if during that
01:02:51.440
five minutes, 80% of the energy was glycolytic, which is producing a lot of lactate? And we've just
01:02:57.520
described, and we're going to come back to lactate. Lactate's great. It's the hydrogen that comes
01:03:01.740
with it that's going to paralyze you. And so your 80% of that energy source, you will not be able to
01:03:07.880
do that for 90 minutes or 60 minutes. But if you push the test out to 60 minutes, you can't fake it,
01:03:13.780
basically. You will not be able to do an 80% glycolytic effort for 60 minutes.
01:03:19.200
Exactly. There, it becomes a really good predictor. But that's what I also like when people talk about,
01:03:23.620
okay, my 60-minute power, this is my 60-minute power. That's extremely precise way of describing
01:03:29.700
your capabilities. Because then at least you have a single point, or you have two points. You have a
01:03:34.200
power, and you have a duration that you're capable of holding in. And that gives you already a fairly
01:03:38.580
good idea of the level of the athlete. Of course, if you start to have two data points now, so of
01:03:43.160
course, now maybe they are, you asked him also, what's your five-minute power?
01:03:47.740
Yeah, yeah, or five-minute power, for example. Because then you're already starting to get a slope as well.
01:03:52.000
So you can start to even understand a little bit what kind of characteristics that is behind
01:03:55.620
this athlete. So typically, a sprinter will have a higher ratio between the five-minute and 60-minute
01:04:00.420
power, while a TT specialist will typically have a lower ratio between the five-minute power and 60-minute
01:04:04.720
power. Obviously, back a little bit to the maximum sustainable energy expenditure and VO2 max, why
01:04:09.320
it's not necessarily a good predictor always of performance when you look at these long or these
01:04:13.580
endurance events, simply because specificity becomes so important there as well. But this is again,
01:04:20.020
yes, I agree. When you talk about 60-minute power, and you divide it by kilogram, and you're using
01:04:24.760
that to compare it across athletes in Tour de France, then it starts to become at least a pretty
01:04:29.620
good metric to understand, or at least if I'm going to bet my money, it's a safer bet where you
01:04:35.340
would go with the money looking at a higher number. Yeah.
01:04:38.560
Yeah. When you go back to, again, because the data are most available when you actually go now and
01:04:43.140
talk to cyclists like Lance Armstrong and Jan Ulrich and these guys, and they'll tell you. I mean,
01:04:47.920
again, I think today cyclists are very guarded of those data. But back in the heyday of oxygenated
01:04:54.740
performance enhancing drugs, these guys were able to put out six and a half watts per kilo for 60
01:05:01.540
minutes. I think today people believe that they're only able only they're able to do five and a half
01:05:08.460
watts per kilo for 60 minutes. So that's giving you a relative sense of the difference on and off these
01:05:14.940
agents. I want to come back to another thing you said twice. Now you've alluded to less technical,
01:05:21.540
more portable, indirect calorimetry devices than what I'm used to in the lab if I'm doing a VO2 max
01:05:30.280
test. Now I was under the impression, and I'd love to be corrected here, that these portable devices
01:05:37.120
are probably decent for measuring VO2, i.e. the consumption of oxygen, but their accuracy is
01:05:45.520
sorely lacking for measuring VCO2, the production of carbon dioxide. And therefore, it might be a good
01:05:53.360
tool for estimating VO2 max, but it's not a great tool for estimating total energy expenditure,
01:06:00.680
which is calculated by using VO2 and VCO2, and nor is it a great tool for measuring fat oxidation,
01:06:09.300
because there you must be able to look at a very accurate ratio of VCO2 and VO2. So are there devices
01:06:17.880
out there that we could be buying, that we could be testing ourselves on every month at home, that would
01:06:25.000
meet the criteria of being accurate enough in those domains?
01:06:29.240
Yes. So I think the accuracy of the devices are starting to become fairly good. We do very often back-to-back
01:06:36.240
testing between the devices. So of course, in a laboratory setting, we are using mixing chamber
01:06:40.040
system, which is, of course, is validated against many different methods.
01:06:46.140
So I am actually sticking still to an old system.
01:06:50.040
No, actually, no, not the Parvo. I'm actually using a Jager Oxycon Pro with a mixing chamber system.
01:06:55.520
But I also really like the AEI Moxus as well, simply because it has some superior technologies
01:07:03.820
in it compared to most of the other devices on the market. Most of the devices on the market,
01:07:08.920
we're not going to go into this, most of them are using galvanic fuel cells to measure oxygen and
01:07:14.300
then use infrared sensors to measure the CO2. But one of the things that, for example, the AEI
01:07:19.460
Moxus is doing is that it actually measures it using a zirconia cell instead. And zirconia cell is
01:07:24.540
actually one of the most sensitive cells that we have. For example, if you want to look at the
01:07:28.200
photosynthesis, for example, you can't use a galvanic fuel cell because it's not sensitive enough.
01:07:32.680
While a zirconia cell is sensitive enough. But nevertheless, the same technology now sits
01:07:38.560
in the portable devices. So it's still using, also the portable devices now are using galvanic
01:07:43.540
fuel cells. We, of course, I mentioned the view to master. One of the benefits we have had is that
01:07:49.040
we enter into a partnership with them to advance the technology. Several years back, I did a screening
01:07:55.120
on the market of all kinds of different metabolic or portable metabolic devices. What I am in need of
01:08:00.940
is that I need to find a compromise. It doesn't help me necessarily to find a device that is a
01:08:05.240
little bit more accurate than the view to master, for example, if the athlete doesn't want to use
01:08:08.960
it because it has a rucksack and it has a lot of procedures, it is a horrible user interface and all
01:08:14.340
this kind of thing. Then basically, I bought a super nice device. I'm able to get the athletes to
01:08:18.260
measure it one or twice a time, but that's not where the strength of data comes. The strength of
01:08:22.940
data comes exactly from what you say. You need to measure regularly all the time there,
01:08:26.960
and it has to be done in a way that the athlete doesn't feel it as intrusive or invasive into
01:08:31.740
their lives. Tell me a little bit about the VO2 master because I'm aware of some of the other
01:08:35.740
portable devices, but not this one. Obviously, the hallmark of this is you're going to be plugging
01:08:41.320
the nose. You've got a mask that creates a perfect seal and therefore very clearly at a minimum can
01:08:48.640
measure the airflow rate in and out, correct? Yeah. The thing is actually you don't need to plug your
01:08:54.760
nose. It actually uses a Hans Rudolf mask. Most labs you'll very often see at least are using
01:08:59.780
these blue masks, more or less. The cool thing is that what they did is that they actually designed
01:09:04.720
a device that sits, actually mounts on this Hans Rudolf mask that is around in the labs.
01:09:10.740
Then basically, what it does is the same as you do with a metabolic card that sits in the laboratories.
01:09:15.540
It has galvanic fuel cells because this is made by maybe there are five manufacturers of galvanic
01:09:20.360
fuel cells in the world. Basically, everybody purchases from more or less these five different
01:09:25.380
manufacturers. It's the same galvanic fuel cells that sits in the VO2 master. Then basically,
01:09:29.980
the main differences between this device is that they have removed the turbine and they're using
01:09:33.920
the same way of measuring flow that you do in Formula One and aerospace. They use differential
01:09:38.900
pressure instead to quantify the flow of what you're doing. Basically, this is a device that just sits
01:09:43.940
here. It's a headgear. There's no wires. There's no nothing. It basically connects to your phone,
01:09:47.880
watch, whatever that you have. Then basically, this is how you now collect your oxygen consumption.
01:09:52.580
I could go out for a bike ride. If I'm going to go and do VO2 max intervals and hill repeats,
01:09:57.940
my favorite workout is the four to five minute hill repeat. I could be wearing this thing and that's it.
01:10:05.420
I come home and it's going to say, if I did 10 sets, it's going to tell me peak oxygen consumption
01:10:11.500
per each set. You can even connect it to your garment computer and you go into your garment account and you
01:10:17.000
can see it there, all the views. You can see your breathing frequency, tidal volume. You can see
01:10:22.040
your fraction of expired O2, your VO2, all the values basically combined there in the same together
01:10:28.540
with your power, with your velocity, with your position, everything there, like in one place.
01:10:33.600
You don't need to look at one separate report for your VO2 numbers and then basically looking at
01:10:39.740
So it's going to show me heart rate versus power versus VO2 at every moment in time.
01:10:46.800
And how accurately is it measuring VO2 relative to what you can do in the lab? And how about VCO2?
01:10:52.820
So VCO2 is, of course, that's a place where we have been very fortunate because we are a little
01:10:57.640
bit ahead of the curve there. So we have had their device that has CO2 now for this must be soon
01:11:07.600
Yeah, in the prototype, this is probably going to be released to the market sometimes during
01:11:12.660
next year. Then basically the whole market will have access to it. So we also have the
01:11:17.080
CO2 capabilities as well. But yes, basically you can go out and how it compares with basically
01:11:23.220
a metabolic card. I think here there are two things to keep in mind. One is, of course,
01:11:27.600
that measure of VO2 is a measure of VO2. So obviously they should on one side be the same.
01:11:31.980
But one thing also, we know that between different devices, so the Oxycontro, for example,
01:11:36.640
we have the option to basically use it as a breath-to-breath device, or we can use it as
01:11:40.640
a mixing chamber device. If it uses a breath-to-breath device, then basically you're breathing
01:11:44.620
straight through the turbine. That's it. So there's minimal resistance.
01:11:48.740
Then, of course, on the other side, we can use the mixing chamber system. And then you
01:11:51.520
have a 2.7 meter long hose. If you want to know, I can come back why it's 2.7 meters
01:11:56.040
later on. But anyway, it's connected to a mixing chamber. And then basically what happens
01:12:00.060
here is the breathing resistance now goes up a little bit. And as we know also, breathing is
01:12:04.300
not free either. Your lungs, in order to breathe, they also need energy. They need
01:12:08.620
ATPs to contract or basically breathe. Simple as that. And basically, the more resistance
01:12:14.560
there is to the breathing, the higher the oxygen consumption obviously will be. So you will
01:12:18.840
actually see now for the exact same device, the exact same sensor, but just depending on
01:12:23.100
the method they're using, that there will be differences between the two machines. Simple
01:12:26.800
as that. Further, when you go out and you actually do biking, one thing that is important
01:12:31.440
to keep in mind there is that you are creating a very high headwind, most likely when you
01:12:35.880
are going fast. Of course, you can go in a hill or these kind of things and you bring
01:12:39.120
down the velocity to very low velocities, but you put out big power there. But what we
01:12:44.140
have to remember is that any system that is based on measuring flow, and you now have an
01:12:48.880
interference from basically flow reaching or hitting the turbine, hitting the VO2 master
01:12:54.540
or any metabolic device there, will most likely also start to influence a little bit
01:12:59.500
the numbers there. Because we have to remember also that we are not really measuring the flow,
01:13:04.560
and we are not really measuring total oxygen consumption. We are inferring it based on methods
01:13:10.860
that are basically saying that when we see that the turbine is rotating at this many RPMs per
01:13:16.720
minute, for example, then basically we know that that correlates to a certain thing. So there
01:13:22.840
will always be a little bit of uncertainty. And that's why, for example, when you're in a lab setting
01:13:26.260
where basically you have no headwind, you have very controlled conditions and all these kind of
01:13:29.500
things, the ability to get a higher accuracy will always be higher than it is out in the field.
01:13:35.060
But then we know that what you do in the laboratory is still quite far from what you do out in the
01:13:40.800
field because you're already starting to limit the way that you're moving, the cooling. Yes,
01:13:45.320
maybe you have a fan of this, but cooling will be different. There are a lot of things that already
01:13:48.920
are different there. So the question is always, do you want accuracy of what really you are looking at,
01:13:55.540
or do you are just looking at oxygen consumption and then you create an artificial setting,
01:14:00.920
which is not necessarily representable for what you're doing? So it is a little bit of a give
01:14:05.060
and take where basically, yes, you give a little bit in one place, you lose maybe a little bit of,
01:14:09.300
let's say, absolute accuracy from the device because you're introducing some more unknown variables
01:14:13.920
there. But at the same time, you're looking at it now in real life conditions where you want to see,
01:14:19.740
okay, what is it looking like here? And you get that accuracy in there,
01:14:23.460
but on a compromise of absolutely as a measurement.
01:14:27.040
And how much of a difference are you seeing in one of your athletes between what you're doing
01:14:32.220
gold standard on an ergometer in a lab versus if you put the mask on them and you make them go and
01:14:40.100
do four minute hill repeats where the velocity is not that high, but they're probably still going
01:14:44.540
18 to 20 miles an hour up a hill, pushing a massive gear to hit that VO2 max.
01:14:50.420
How much of a difference are you seeing in the VO2 and the VCO2?
01:14:55.640
Between the two devices. So between the lab and the portable, the VO2 master.
01:15:00.060
Typically when we do back-to-back testing there between the two devices, we would see
01:15:04.780
normally for Christian and Gustav, let's say difference of maybe 50 milliliters between the
01:15:16.300
I thought you were going to say 500 milliliters.
01:15:19.040
No, then we could just throw the device out the window. Then it has no value anymore.
01:15:25.020
Okay, okay, okay. But 50 milliliters of oxygen, you guys are putting out probably,
01:15:30.220
you guys have an absolute of probably six liters.
01:15:33.280
Seven liters. Oh my God. So understandably, it makes a difference at their level,
01:15:38.600
but for someone at my level and for most of the people listening here,
01:15:41.540
a 50 milliliter difference is nothing. It's less than nothing. This is so exciting to me because
01:15:48.120
I was under the impression that these devices were still so far away that they were not even worth
01:15:56.480
No. One thing that, of course, you also start, which is a little bit interesting there,
01:16:00.980
obviously because we use mixing chamber system, that's where we come from. You'll ask the question
01:16:05.820
if you think it's interesting to your listeners, whether they want to understand why there are mixing
01:16:09.140
chamber systems and so on. But to spare them for that for now, basically what we do know is that
01:16:15.160
when you have a mixing chamber system, just because you have a little bit of the higher resistance in
01:16:20.120
a system like that, typically we see also a more stable breathing pattern just because they're
01:16:25.700
actually being reminded more about exactly how they're breathing because they feel a little bit
01:16:30.320
more of the resistance. What you do see is as a system gets less resistance, you naturally also
01:16:37.040
start to see a little bit of more variation going up and down and these kind of things.
01:16:41.540
Because even though, if you look at a power meter, people that are not used to ride with a power
01:16:46.220
meter, they're only used to use heart rate and you give them suddenly a power meter. The first time
01:16:50.200
they get a power meter, they don't understand anything because power goes all over the place
01:16:53.900
there because they are not used to focus on a power and it becomes almost like they're chasing a
01:16:58.320
number that they don't have. They don't have the coordination or the skills to basically keep it
01:17:03.220
or relax around that very stable power and how to basically read it. Breathing is even worse.
01:17:10.140
Breathing is even worse than power because now you're even one order further away from performance.
01:17:16.440
So velocity obviously is first principle, first order. That's where exactly the performance
01:17:20.920
happened. Power, you're one step further away. And this is of course a system that is very responsive
01:17:25.980
as well to what you do. You won't necessarily see if you suddenly get a spike, let's say you're riding
01:17:31.640
200 watts. If you went to 210 watts for a second and back down to 190 to 200 watts, your speed wouldn't
01:17:37.460
change at all. Your velocity would be the same more or less. But still you have the volatility there.
01:17:41.360
So if you now are using velocity as the gauge for whether a system is correct or not, you will always
01:17:45.820
say, hey, this cannot be correct. I went to 210 watts, it should be immediately giving me this. But again,
01:17:51.080
the sensitivity to velocity, how the velocity is measured, is not good enough necessarily to capture
01:17:56.280
the small changes that are happening intra-cyclic in the power production there, in between there.
01:18:01.400
It's being smoothed out because of inertia, measurement, weaknesses, and so on. This gets
01:18:07.120
even worse when you get to velocity because what we know is the body, exactly because of when we get
01:18:12.340
to ventilation. Yeah, ventilation, yeah. Good clarification because exactly we are meshing on
01:18:16.900
the exhaust even here. And between basically where we are doing work and basically when we are breathing
01:18:22.100
in and we are exhaling out again, there are so many compensating regulatory mechanisms in the body
01:18:26.980
that are compensating for the lack in one place and here back and forth all the time, more or less,
01:18:31.740
to make sure that we deliver energy as efficiently as possible to sustain that propulsion that we are
01:18:36.900
doing. And now when you are measuring VO2 here, you can have quite a bit of fluctuation in this and
01:18:42.820
there are, let's say, kinetics involved here. To give an example, if you are running at, let's say,
01:18:49.020
you're running 15 kilometers power and you have a certain oxygen consumption now at 15. So I'm just
01:18:53.760
making up a number. Let's say that you are, or to use power, you're riding at a constant power to
01:18:58.660
make a simple constant power of 300 watts. And you're consuming now four and a half liters of
01:19:05.260
oxygen. So you can still output those 300 watts there. But if you hold your breath now, what happens?
01:19:10.500
VO2 comes down, ventilation comes down, or tidal volume and breathing frequency comes down.
01:19:14.900
But you start to feel that something builds up in your body. You're still able to output
01:19:19.140
those 300 watts there. At the moment you start, at some point, you either are forced now to stop,
01:19:23.880
or you have to start breathing and you're forced to start breathing again.
01:19:27.120
And at the moment you start breathing again now, you have a huge depth in your body. And what will
01:19:30.820
happen is that basically you get a huge spike in ventilation, huge spike in VO2. But what you also
01:19:36.400
see is that when you break this down, is that obviously the big spike comes from both that you're
01:19:40.960
driving a much larger tide volume. Breathing frequency goes up a lot, but also your fraction
01:19:45.400
of expired O2. So the delta between how much of the oxygen you are consuming now, you are going
01:19:50.100
much deeper than the 25% we said initially. But then basically, because there are, things are not
01:19:56.020
reacting extremely quickly on the exhaust part here, you'll see basically that here is almost like a
01:20:01.260
regulator, like a PAD regulator that are trying to bring this back to that stable settings there.
01:20:06.520
And it happens, okay, yes, your breathing comes down again, but still maybe you have a high VO2 and
01:20:11.480
then suddenly VO2 undershoots a little bit because fraction of expired O2 comes up a little bit higher,
01:20:15.840
but then says, oh, this is not enough. This is too little oxygen, so I need to increase the extraction
01:20:19.820
a little bit again before it comes back again. And this just tells to basically that yes, 300 watts
01:20:24.900
there, but you can still have a lot of variations there. Just by the fact that you're sitting on the bike
01:20:29.500
and you're sipping that bottle there, you're holding your breath when you're sipping that bottle there,
01:20:32.940
that will already influence your breathing and your VO2 for the next half minute on there.
01:20:38.080
If you are swallowing, just the fact that if you start to have a lot of spit, for example,
01:20:41.980
in your mouth and you're swallowing there, you are building a miniature debt there now that you
01:20:46.000
have to pay for again afterwards there. What one has to be careful about there,
01:20:50.940
I don't like standardized and say, you can't drink, you can't swallow, you can't do it,
01:20:54.620
you have to be a machine because that's not who we are. We have to learn to look past the noise of
01:20:59.640
the data by collecting a lot of data and knowing exactly that we are not machines. Well, you could
01:21:05.100
maybe say that we are machines as well, but there are so many things happening in between here that
01:21:10.160
you can't necessarily, exactly like you also say, you can't want one ratio.
01:21:15.920
You've alluded to F1 twice now, that happens to be my favorite sport. And as much as we can look at
01:21:21.780
those cars and say, they are the most remarkably engineered things with wheels that have ever been
01:21:30.420
produced. Everything from the engines that they build, these hybrid internal combustion engines
01:21:38.000
through the chassis and the aerodynamics. Again, most people are shocked to learn that the aerodynamics of
01:21:44.280
that car are such that it can drive upside down at a hundred KPH. All of those things are remarkable.
01:21:49.780
I still think we're far more complex. I mean, hands down, because every element of that car
01:21:55.360
can be modeled. There is an equation that explains every piece of it. Whereas there is no equation to
01:22:02.740
explain what you just described. And by the way, there's an element of chaos in that system.
01:22:08.520
One thing that I'll suggest listeners try if they have power meters, it's just a great example of what
01:22:14.120
you said. So if you have a heart rate monitor and a power meter, next time you're on your bike,
01:22:18.540
make a deliberate effort to change your ventilatory rate. Vent a lot and vent a little and watch what
01:22:26.920
the heart rate does, even as you hold the power constant. And of course, this is because that CO2 is
01:22:33.300
very soluble and CO2 is tracked by the brain very closely as a proxy for pH. And the body is very
01:22:44.020
particular about keeping the pH at 7.4. As you slow down your ventilation rate and hold your breath
01:22:50.740
and your carbon dioxide levels rise and your pH falls, you will see that heart rate start to spike
01:22:58.020
with no additional input in power output. And of course the reverse is true. It's just a great example
01:23:03.800
of what you said, but it's one where you can sort of be the guinea pig and watch it. I still to this day
01:23:08.900
get a kick out of playing that game to see how much I can move my heart rate just by interfering
01:23:14.240
with my ventilatory rate. But I can say that I think that that's also why some people become
01:23:20.860
better also and others not. Because I think that one thing that we very often tend to lose as we get
01:23:26.740
older or we go through, for example, different training is that we lose that ability to play.
01:23:32.220
And exactly going out and playing is one of the best ways to learn actually what influences and
01:23:38.380
increase our awareness of that. Because one of the things is that I've learned also with elites is
01:23:43.660
that elites are not necessarily perfectly calibrated either. They need to actually be calibrated because
01:23:49.940
you have some athletes that typically, if you ask them to go out and do call it a threshold workout,
01:23:54.420
or let's say a workout that has, let's say intervals, a combined duration of intervals that are
01:23:59.220
between 60 to 80 minutes and that should be fairly close to all out, or let's say to bring it to
01:24:03.820
exhaustion on the last interval. You'll see that some athletes, elite athletes, they are ending up
01:24:09.720
going out too hard and they end up dropping the power towards the end. Some athletes, they go out a
01:24:15.320
little bit too light and they have to go really hard towards the end to bring it up there. But both
01:24:20.500
scenarios, if you were able to keep it at a very calibrated or accurate level there, you would see that
01:24:26.640
the total amount of kilojoules you were able to accumulate on those 80 minutes or 60 or 80 minutes
01:24:31.560
or whatever the length there would be, would be higher than if you ended up going progressive or
01:24:36.040
worst case, you end up ending up going regressive because you go too hard in the beginning and
01:24:40.620
forced to come down towards the end there. What standard do you use, by the way? So let's use
01:24:44.960
that as a quick example. So again, I said I'll use myself because I'm trying to get as much free
01:24:49.440
coaching as I can here. So if I love doing my VO2 max sets on a bike, on a hill, I have a fixed
01:24:56.200
distance that I ride. So it really depends on the wind. So if I have a headwind, it'll take about
01:25:00.820
five minutes. And if I have a tailwind, it could take 345. That's how much the wind can play a role
01:25:06.840
on this hill. But basically it's not an all out effort because you want to be able to do it multiple
01:25:13.080
times. But it's a very hard effort followed by about a one-to-one ratio of recovery. And that's
01:25:20.100
the workout. After a warmup, it's over and over and over and over again. It's like an hour of doing
01:25:25.320
that. Now, I typically, and I think this is because I've become softer in my old age, I typically ascend
01:25:35.300
in power. So I will typically start out at a very conservative power where at the very end,
01:25:43.100
I am not dead. But by the end, by the last one, I might be doing 10% more power than on the first
01:25:52.760
set. And I'm absolutely at my limit. How would you recommend I change that? You want that to be
01:26:00.220
within 5% the whole way through? Or how would you recommend that? If again, the goal is maximizing
01:26:07.480
that workout to maximize VO2 max and to increase the engine size? Maybe we should add one more
01:26:13.180
dimension to this now, because I think that very often we confuse, for example, also when we talk
01:26:17.980
about FTP, just FTP, and we black box a metric as FTP instead of saying 60 minute power or 20 minute
01:26:24.360
power, whatever. What's really accurate with the 20, when you say 20 minute power, 60 minute power,
01:26:28.500
you basically know that, okay, you can hold that power for that duration. That's the maximum,
01:26:32.260
for example, before you basically end up dropping too much and you just call it David. Very often
01:26:37.080
when we talk about VO2 max, it's very often confused with aerobic capacity, while in reality, it's not.
01:26:42.100
It's aerobic power. You're measuring how much oxygen for undefined time. Yes, we have normalized it as
01:26:48.540
milliliters per minute, but you can have a big range between athletes that has the same VO2 max. Some can do
01:26:53.320
that for several minutes. Some can only do that for, let's say, one minute, for example.
01:26:57.100
And this is where the important is, because we're looking for to provide signal, signaling and or
01:27:02.120
stimulus to the body. If you go out and you do one five minute interval, more or less,
01:27:07.460
then basically, okay, fine. That's the stimulus that you're providing yourself there. So this is
01:27:11.340
about how, okay, you've got a certain amount of time available to go out and do that VO2 max session
01:27:16.380
today, for example. Let's say there's 90 minutes. Then basically, of course, now this is one dimensional
01:27:21.320
because we're not talking only about a single workout as well. I think the most undervalued
01:27:27.160
thing, which is not very sexy to talk about, and also the most undervalued thing is that basically
01:27:32.180
it's consistency. Consistency in the training over time. And that means that you need to leave a little
01:27:38.140
bit in reserve there. And we haven't even touched on the topic of psychology yet either, because we are
01:27:42.860
very much not talking about the things in physiology that we are good at measuring and these kinds of
01:27:46.780
things, but there are also plenty of things that we are not able to measure. And even the things that
01:27:51.020
we like to say that we, oh, we are so good in stoichiometry or are so good in understanding
01:27:55.000
metabolic pathways or signaling pathways, there are still things added to this where we basically
01:27:59.340
understand that no, we don't. And then we haven't even dived into the topic of microbiome. It's a world,
01:28:05.560
undiscovered world that we are basically taking on now. So one of the things that is that when you're
01:28:10.800
doing this exercise, but a good thing with VO2 is that, of course, that we're measuring a quantity.
01:28:14.980
We're measuring a volume of something. It's much in the same way when we talk about power versus
01:28:18.860
work. So you talk about work, for example, to make this a little bit more practical. So when you say,
01:28:23.580
okay, I want to basically do my VO2 max workouts and go a little bit progressive, I would normally
01:28:27.640
say that's a good thing to do. Because also what happens is there is a priming effect also happening
01:28:32.800
in the body as well. So if you go out like where you think that you maybe would be able to sustain
01:28:36.960
throughout the workout, you might figure out that you still are able to go a little bit higher.
01:28:40.900
At some point, it's the opposite. One thing that we have done multiple times over the last half
01:28:46.140
decade is that very often people think that, okay, when I've done a VO2 max effort, then basically
01:28:50.800
I'm done. I won't be able to repeat that. I need two days of rest or maybe a week of rest or whatever
01:28:55.580
before I can do that. That's not true either. We know that, for example, if you do a VO2 max effort,
01:29:01.300
and then basically you give an adequate time of rest in between, you are able to go even harder on the
01:29:06.020
next one now, even though that was completely to exhaustion on the first one.
01:29:11.700
Say more about that. So put some time and numbers to it so I can understand what you're saying. So
01:29:16.400
you could take one of your athletes and what duration of an interval would you have them push to?
01:29:22.760
So for example, here, let's say that we are using an old-fashioned way of quantifying VO2 max. You
01:29:27.420
say that you do a graded exercise test. So you increase the power by 5%, for example, every minute that
01:29:33.480
goes there until you basically come to exhaustion. Let's say that now that it finishes around 500
01:29:39.420
watts and around seven liters of oxygen. For the listener, those are world-class numbers that are
01:29:45.400
obscene. You're not running into people on the street that can do that, but carry on.
01:29:49.320
Yeah. And here already, I haven't told what's happening before there as well, because if I only
01:29:54.160
took them fresh during this, then the power number would be different. So again, this comes back a
01:29:58.080
little bit to talking about power at VO2 max, where this is already manipulated depending on what
01:30:03.180
you've done before this as well. So now basically they do this. So let's say that they last for six
01:30:08.440
minutes and then finish the last one on, let's say, 500 watts, 500, last minute on 500 watts. Maybe
01:30:13.340
they go a couple of seconds longer into the next one. And this is also important. So when you do a
01:30:18.140
graded exercise test, if you come to the next step now and you feel that, oh, this is too hard,
01:30:22.600
push as long as you can, because every second counter, because it's more work, it's more work,
01:30:27.900
it's more oxygen consumed. They're a strong stimulus, more or less. I wouldn't advise doing this very
01:30:32.820
often, but we can come back to that a little bit later because I'm not a big fan of doing very
01:30:36.620
often two exhaustion workouts that you should put them in very sparingly into your program.
01:30:41.540
And that ties back to consistency. But anyways, now given in between, let's say if we give 10 minutes
01:30:47.540
of rest in between and a little bit more rest in between there, then basically if you do now a new
01:30:51.860
VO2 max, the same athlete, we bring now to more than seven liters or 7.1, or maybe even a little bit
01:30:59.520
higher and power output is also now, for example, comes up now maybe one more minute at one higher
01:31:05.660
power output. So now we are already at maybe 525 watts for one minute as well.
01:31:11.380
You're saying that that's happening because they've been primed by the first set to be able
01:31:18.660
If it goes too long rest in between there, then basically you start to lose the effects.
01:31:23.000
If the duration or the rest in between there, then you are not able to draw the effect of that
01:31:27.060
anymore. That can be, I think you could probably extend it up to 15 or maybe 20 minutes. But when
01:31:32.620
you get past 20 minutes, I'm not so sure whether that would hold true anymore. So it needs to be
01:31:37.720
short. And this can also come back to because we know also that oxygen, when we think about
01:31:41.920
hemoglobin as well, the affinity for oxygen and CO2 to the hemoglobin is also affected by the
01:31:48.040
temperature of the blood or the body and the hemoglobin as well. So this is also improving
01:31:53.060
actually with a higher temperature than it is at a cola. So when you get 20 minutes, obviously
01:31:58.140
temperature of your body will also come further down, come longer down than it is at 10 minutes.
01:32:03.260
10 minutes, it will also come down, but maybe not as much. But the most interesting thing that
01:32:07.220
happens also now is that our R value is heavily skewed towards oxygen consumption and less carbon
01:32:15.260
dioxide production. Even when you do this, you would even say that this doesn't qualify for a
01:32:20.240
VO2 max set. So the VO2 numbers now are equally high or higher, but the carbon dioxide production
01:32:25.280
is actually now just maybe a little bit higher than one in RR value. And normally we would say that
01:32:31.140
if you just went by the papers or the old school books, you would say that, okay, in order for
01:32:35.560
to qualify a VO2 max set, you should, for example, one of the criteria is often they say that you need
01:32:40.360
to exceed an RR value of 1.1, for example, for it to be valid. Of course, what are you going to say?
01:32:46.120
The VO2 max value was higher. Are we not going to disqualify it? It was a higher oxygen
01:32:49.500
consumption than it was in the previous one. It's also equally more now. Let's explain this to
01:32:53.980
people. You and I already alluded to this very briefly, but we didn't make a big point of it. So
01:32:58.280
the RER is calculated instantaneously at any moment in time as the ratio of VCO2 to VO2. So
01:33:05.620
let's go back to, you're going to put one of your athletes on the bike and he starts riding really
01:33:11.480
slowly. In that moment, he's at a hundred watts. So he's not even breaking a sweat. What is his RER at
01:33:17.300
that moment? The thing is that this is actually a little bit funny because here it's very easy when
01:33:21.580
we look at the values, when you look at RER, we typically look at the ratio of concentration and
01:33:25.920
we already exclude a little bit of volume of oxygen and volume of CO2 that is there. And of course,
01:33:30.960
there is a requirement for a certain amount of energy to be turned around per time. That's why,
01:33:35.580
for example, if you look at lactate as a surrogate, again, if you go back all the way to stoichiometry and
01:33:41.080
we'd said, we already said C6, H12, O6, glucose broken down to lactate and this kind of thing,
01:33:46.300
we already know here how much CO2 that is being produced in this process there of certain ratios.
01:33:51.980
But since we also know the ratio between glucose and lactate as well, we can use that also surrogate
01:33:58.180
to have more or less the same confirmations as well, or the same indications as well. The
01:34:02.760
difference is only that VCO2 is a volumetric measurement, while lactate is a concentration metric
01:34:07.060
and concentration metrics are influenced by many other factors as well. So that's why lactate can
01:34:12.140
be a little bit more unpredictable, and it's not as a good indicator as VCO2 is. But coming back to
01:34:18.700
that, basically at 100, typically there, you won't see necessarily a very good ratio between VO2 and
01:34:23.720
VCO2. So RER value there can actually be quite high, because two things that are playing into account
01:34:28.380
there. Your resting metabolic rate already plays a much bigger factor or a relatively larger percent
01:34:34.020
of the total oxygen consumption and a carbon dioxide production now, as opposed to when you
01:34:39.580
start to go to a higher number. So the higher the number are, the smaller the percentage of the
01:34:44.320
resting. Because when we measure VO2 and VCO2, we measure actually the gross oxygen and gross CO2
01:34:50.800
production. We're not measuring only oxygen as a function of exercise, but actually of both exercise.
01:34:56.480
Yes, and basal resting. Okay, so now this, of course, is going to be heavily influenced by their diet and
01:35:01.400
the carbohydrate content of their diet. But I'm assuming your athletes are on a pretty high
01:35:05.360
carbohydrate diet. Oh, yeah. Yeah. So that means that their resting RER is probably 0.85 to 0.9.
01:35:14.680
Or higher. Okay. So that means that they get a nadir in their RER when energy expenditure gets high
01:35:24.420
enough that it starts to dwarf basal energy expenditure. And you're really achieving maximal
01:35:31.140
fat oxidation, which is probably occurring at, I don't know, about, at a wattage that probably
01:35:41.240
corresponds to 75 or 80% of their best one-hour power. I'm guessing that in and about that wattage,
01:35:49.000
they are at maximum fat oxidation and they probably are at minimum RER.
01:35:54.560
Actually, it's even higher for endurance athletes or especially triathletes or long course triathletes,
01:35:59.560
because this comes back also a little bit to, now we are getting a little bit deeper into it,
01:36:03.340
but this also comes back to why it's not necessarily VU2MAX a good predictor of performance,
01:36:07.760
especially the longer the events becomes. So for example, to let people in on a little bit of our,
01:36:14.840
Yeah. Not secret sauce, but secret. And that is that actually for Christian and Gustav to win the
01:36:20.320
world championships, so last year, basically we had a consequence of the specialization we did.
01:36:26.920
VU2MAX came down significantly. From them, basically racing in the Olympics,
01:36:32.440
clocking in, so using relative values, which is maybe a little bit more easier to relate to,
01:36:37.720
both Christian and Gustav would typically test in around, let's say, close to 90 milliliters per
01:36:42.460
minute per kilogram. But at Ironman, in order to set new records in Ironman, we had to bring it down
01:36:51.620
to actually below 80 milliliters per minute per kilogram.
01:36:56.880
And you did this purely because of energy demand and energy consumption?
01:37:02.260
Purely because you can't sustain, because think of it more like a curve.
01:37:06.240
You had to detune the engine, basically. You had to bring the fuel flow rate and oxygen flow rate in
01:37:12.980
the engine down to do Le Mans versus do a Formula One race.
01:37:17.940
Exactly. Because you can't now prioritize keeping doing those five-minute power surges
01:37:23.160
or microintervals anymore, because it's too far away from basically what you need in an Ironman.
01:37:28.700
And you need to build more, let's say, towards the higher energy demands or, let's say, higher
01:37:32.960
power outputs in an Ironman, the lower ones or the sustainable ones and so on, and maybe even
01:37:37.160
building a little bit longer as well. You basically don't have the time anymore. Basically,
01:37:41.420
that's not right. You have the time, but you actually are not able to consume enough energy
01:37:46.840
over weeks and months to sustain a program that allows you to both increase your V2MX at the same
01:37:53.880
time as you're building up that long-duration power output. Let's say the four-hour power as well
01:37:59.580
at the same time. I think what would be interesting for folks to understand is, so there's something
01:38:04.260
called the WIC equation, which tells us the relationship between energy consumed
01:38:11.180
and oxygen consumed and CO2 produced. I used to know it off by heart, but I think it's basically
01:38:16.740
energy expenditure is 3.75 times VO2 in liters per minute, plus 1.25 times VCO2 in liters per minute.
01:38:28.100
Actually, I would make it even simpler, because basically, we know that from one milliliter
01:38:32.080
of oxygen, basically, there's 20 joules. There are 20 joules of energy being there. And then we know
01:38:37.040
already, as you said, you already said that, well, the efficiency of the body is approximately 20%
01:38:42.200
propulsive and 80% are thermal. So you can actually do this far simpler in that sense that
01:38:47.060
you can just look at, okay, how many milliliters of oxygen you're consuming and multiply it actually
01:38:53.600
At six liters per minute of VO2. And I guess the reason you can make that simplification is by the
01:39:01.500
time you're at six liters of VO2, you can assume what VCO2 is. You don't have to measure it.
01:39:07.380
The approximate, let me just do the math. So that's about, that's 30 calories per minute
01:39:15.060
of energy consumption. 1,800 calories per hour of energy consumption at six liters per minute.
01:39:26.260
And at that point, you now exceed the capacity of the human digestive system.
01:39:32.160
There is no means by which a human in any form can ingest 1,800 calories in an hour and actually
01:39:41.860
get those calories out of the gastrointestinal system, into the circulatory system, into the
01:39:48.360
muscles. So really at this level, it becomes an energetic problem as much as a problem of stroke
01:39:56.440
volume, heart rate, and capillary efficiencies. You can even say that you don't even care about
01:40:03.360
heart rate or stroke volume or cardiac output anyway, because that's what you even started with,
01:40:07.580
which also resonates so well with me. VO2 encompasses exactly that stroke volume because
01:40:13.300
cardiac output is just a function of VO2 in the end anyway, because what you really need,
01:40:19.660
the cardiac output is just to supply you with oxygen. Really it's the oxygen, which is the key
01:40:24.860
metric here. So again, yes, the energetic demand becomes so crazy that you just have to start to
01:40:30.760
prioritize and you just say that, okay, how important is it for you to be able to do like super high
01:40:35.660
five-minute watt surges in Ironman? Not important at all. Yeah, never. Exactly. So you can't spend time
01:40:41.340
on training it. If you could feed more energy, so if you somehow would be able to even feed more energy,
01:40:46.620
yes, then you can definitely uphold more of that. And that's, of course, what we did there. We looked
01:40:51.880
exactly at how can we stay in this perfect balance there, living at the edge where we can keep the
01:40:56.980
VO2 max as high as possible, or let's say the whole curve as high as possible, because that in the end
01:41:02.120
will give us a better ability to race than necessarily our competitors setting records.
01:41:08.420
Now, given these huge energetic differences, let's just make sure people understand the
01:41:13.220
distances we're talking about. At the Olympics in Paris next July or August, it's an Olympic
01:41:18.880
distance triathlon, so we won't need to go into the distances, but let's just tell people a world-class
01:41:24.100
athlete is doing that in what, an hour and 40 minutes or maybe even less at this point? Where are they?
01:41:29.480
140, 145 is basically where you need to be. And that's basically 51.5 kilometers,
01:41:35.460
1500 meters swimming, 40 kilometers biking, and then basically 10 kilometers running.
01:41:39.900
Conversely, if you look at Ironman distance at the other end of the spectrum,
01:41:43.720
we're 2.4 miles in the water, 112 on the bike, full marathon run. The world-class
01:41:50.200
guys are doing that in what, seven and a half hours, 740-ish?
01:41:55.780
Yeah, seven and a half. Christian went 721, one of the fastest.
01:42:00.400
Again, it's simply unfathomable to anybody who's done any of those things that they're going that
01:42:05.780
fast. But the energy demand, if you're trying to do something all out for an hour and 40,
01:42:13.360
that is a much easier fueling strategy than if you have to go at a sub-maximal effort for seven and a
01:42:20.860
half hours. So is it surprising to you that you can have one athlete who can be exceptional and
01:42:29.260
world-class at both? Because I have to be honest with you, it's a little counterintuitive to me
01:42:34.180
based on this discussion that you could be the best in the world at both of those.
01:42:38.980
Is there another sport where we would see such disparity? Like we wouldn't expect that the best
01:42:44.080
400-meter runner is also going to be the best 10K runner. And we wouldn't expect that the best 5K
01:42:53.360
This is where I think that we have hugely benefited from using science because it allowed us to break
01:42:59.740
down the arm and distance and understand where basically we could gain much more time than what
01:43:04.900
had been done before. Because what we have to think is that the training, let's say the method for
01:43:09.760
training, we can come back to it because you mentioned the five-minute intervals and how you
01:43:14.120
were executing this to basically do your view to max session. We can come back to that because
01:43:17.680
if you're thinking of it, we are organic creatures. So we respond to stress by normally getting stronger,
01:43:23.920
given that we are providing the conditions to allow it to grow stronger. So now basically when you are out
01:43:30.080
and you are doing your five-minute efforts, you have a finite amount of time that you can do this
01:43:35.660
exercise. So let's say you had 90 minutes. You can twist this around instead and say that in the same
01:43:40.040
way that you go out and you play a little bit with your breathing to see what you can do with your
01:43:44.200
heart rate at a certain power. Now you can just say that, okay, fine. I'm actually now looking to
01:43:48.560
provide the maximum amount of stimulus to increase my view to max. We already said that, for example,
01:43:54.520
five-minute power or three-minute power is a good proxy or surrogate to understand how high your view to max
01:43:59.980
is. Now think of it this way instead, that when you go out, you're looking actually to
01:44:04.340
accumulate the maximum amount of work that you can do at a certain output. That is actually a better
01:44:11.080
way of looking at how can I actually here provide the best possible stimulus for me now to grow my
01:44:17.460
engine, to grow my view to max. Sorry, just to be clear, you're saying you might go out and say for
01:44:22.940
an hour, what's the most number of kilojoules that I can expend as opposed to what's the highest VO2 max
01:44:32.240
I could sustain for that period of time? Are you basically saying we should just use kilojoules
01:44:39.140
Yeah, because you can think of it this way, that the further away we are from, because in the end,
01:44:43.240
you can say that, okay, velocity is the ultimate measurement of form. And the further away we move
01:44:47.660
from this, the more gray it becomes because there are more mechanisms compensating and that has an
01:44:52.620
influence on what is happening there. So we can think of it this way, that, okay, the reason why we want
01:44:56.980
to grow an engine is because we want to become faster on the one side. But then when you go out,
01:45:02.300
you are not measuring VO2 max. You're not measuring milliliters per minute or how much oxygen you're
01:45:07.200
consuming when you're doing your exercise now. But we know that the higher intensity you go,
01:45:13.100
the more oxygen you will consume per time. So then we are saying that now we are providing a stimulus
01:45:18.340
to the body to say that we need more oxygen. You need to respond to this and basically facilitate
01:45:23.340
this moving forward. Because this guy, he might be crazy enough to go out and do this session again
01:45:28.420
next week or something like this. So again, the theory of supercompensation, that's why normally
01:45:32.980
we would say that, okay, the reason why we get stronger is because we exercise or we provide a
01:45:36.820
controlled stress to the body that the body is able to respond to and grow from. So now when you're
01:45:42.860
out and exercising and you're doing this hill repeats there, now you can instead think of it this
01:45:47.200
way. Okay, so when I did my five minutes, my five minute efforts, let's say you accumulated,
01:45:51.800
how many repeats would you do during an hour? Or let's say how many repeats would you do during
01:45:55.600
the session? Six to 10. Six to 10. So then basically when you do six to 10, that means
01:46:00.400
basically then you are accumulating between 30 to 50 minutes of, let's say, that high intensity.
01:46:05.100
Of work, yes, that's right. Of work there. So of course you do more work, but you do that specific
01:46:09.460
work there with the idea of that this will give you a bigger engine. But ultimately, actually what
01:46:14.140
you're really looking for is to become faster. That's what you're really looking for. And that can be done
01:46:18.640
like we also mentioned initially as well. And in one sense, you can say you don't really care
01:46:22.220
either. If your VO2 max comes down, but you just come faster, okay, well, efficiency have increased,
01:46:26.600
but okay, that's most likely not going to be the race. The outcome of it, it will probably be a mix
01:46:30.480
between a lot of things there. But now you can think of it this way. And that is that when you go
01:46:35.340
out and you do, so let's say that you ride now at 400 watts and you accumulate 30 minutes at 400
01:46:43.420
Those days are over, by the way. That used to be the case. I wish I could still do 400 watts for
01:46:53.700
Let's say 300 watts. It doesn't matter. It doesn't matter. 300 watts and this is close to exhaustion.
01:46:58.860
Close to exhaustion. You have a little bit of reserve so you can repeat this. Like you say,
01:47:02.000
you have enough even in reserve that you even are able to progress throughout the session a little
01:47:05.540
bit of this. So let's say that now you're accumulating in average at 310 watts, you accumulate 30
01:47:11.800
minutes, 30 minutes of work around there. Because if you go to 50 minutes, a normal consequence of
01:47:17.380
this would normally be that either now you have gotten fitter or you just had a lot more in reserve
01:47:22.180
when you do the 30 minutes and you really didn't bring yourself close to exhaustion at all. So then
01:47:26.040
the stimulus and then the stress on the body is also much less. Worst case, if you were capable of
01:47:31.840
doing now 50 minutes, accumulating 50 minutes at 300 watts or 310 watts, for example, two weeks ago,
01:47:39.200
if you now do it only for 30 minutes, that's already detraining of the ability to stay at
01:47:45.500
300 watts if you do too many of these sessions now moving forward. Unless you only use this one as a
01:47:50.680
way to just provide some adaptation or make yourself ready for something bigger to come forward.
01:47:56.640
But now you can look at it another way. So let's say again, 300 watts, 30 minutes, that's approximately
01:48:00.860
where you're sitting or 310 watts, 30 minutes, that's approximately where you're sitting, then you're
01:48:04.700
close to exhaustion. The time you have got available for this training that you had there now, maybe that
01:48:09.600
was 60 minutes or less. How long are these sessions lasting typically from basically when you start
01:48:14.260
until you stop the session in total? Not that much longer because the warm-up and the cool-down
01:48:19.100
is 20 minutes in total. So most of the set, I could be door-to-door from my house in 75 to 90 minutes
01:48:26.540
easily. Okay, but brilliant. So basically here we're talking about 75 to 90 minutes in total of a
01:48:32.060
training time available. It's very different. So just to be clear, when I used to train,
01:48:37.080
I exercise now, I don't train. When I used to train, my coach on the really big days would sometimes
01:48:43.660
want me to not begin the VO2 max set until I had done 2,000 kilojoules. So I would go out and do
01:48:53.620
a relatively easy, like a 200 watt, 2,000 kilojoule ride, and then finish with a very big main set
01:49:05.900
of hill repeats, short hill repeats. So six minute hill repeats. And so that was an enormous total
01:49:12.800
amount of energy expenditure, but most of it was actually at zone one to zone two, pure aerobic
01:49:21.260
efficiency, and then finishing with the VO2 max. Again, I don't remember what the rationale was
01:49:27.620
for where the, get those 2,000 kilojoules of work in before you go there. But those were much longer
01:49:33.580
days, obviously. Again, today, because I'm not training, for me personally, velocity doesn't
01:49:39.340
matter anymore, nor does power. Frankly, I'm only training for the conditioning of it. I'm basically
01:49:46.520
asking the question, how long can I keep my VO2 max high? One of the things I think about is,
01:49:54.880
at what age will my VO2 max in relative terms, mils per kilogram per minute, be smaller than my age
01:50:03.820
in numbers? It's an interesting question. Where do we make that crossover?
01:50:08.160
I think this is also something that we will probably have a completely new picture of also over the next
01:50:13.300
five to 10 years as well, just because a lot of measurement equipment that we have available
01:50:17.720
becomes more democratized. One thing I can also say is that from all the data, I collect so much
01:50:22.600
data on my athletes as well. And also many of the coaches I work with, they collect so much data on
01:50:27.240
the athletes. But the problem is that we even see that we can use the data to even make the athletes
01:50:31.840
faster. So we even haven't gone as fast as it is possible to do yet. But the time that is available
01:50:37.220
to basically analyze all these metrics and bring it back into our sound program is so time consuming
01:50:43.700
to do that you sometimes just have to skip this and you have to focus on the more important part
01:50:47.940
of it. So one of the things that we are doing is we have a company called Enthalpy and where we
01:50:53.020
basically are building AI, but of course, LLMs or natural language processing systems and numerical
01:50:58.840
models where we basically allow us to start to utilize even more of this data in order to provide even
01:51:05.460
more deeper individualization for athletes. But even when you go out and basically exercising and
01:51:10.560
you're looking at it, because we can break this even further down, because again, your ability to
01:51:14.820
put out 300 watts, for example, is also a function of force and circumferential velocity, or let's say
01:51:20.700
torque and cadence. Because it's very easy sometimes when you go out and you're thinking that, okay, now I'm
01:51:25.600
going to go max. What you feel is the torque. You don't feel the power in the same way. You feel really the
01:51:30.860
torque. But if you aim for something that really feels like super heavy, that's a big
01:51:35.340
torque, but it doesn't necessarily yield a very high power output at all. And power is basically
01:51:40.200
what drives the energy demand for the body. It's not the torque. Of course, it's not entirely. It's
01:51:44.620
a mix of a little bit of the two. But do you subscribe to the idea, again, using this example,
01:51:49.140
where if you shift more towards higher torque, lower velocity, you're putting more of the stress
01:51:54.900
on the musculature of the legs. If you switch more towards a higher velocity by velocity, I mean crank
01:52:00.280
velocity, lower torque, you're switching more of the demand in the direction of the cardiovascular
01:52:05.880
system. I mean, remember, people used to talk about this all the time between Lance and Jan,
01:52:10.320
right? One was pushing 95 to 100 RPM. The other was pushing 65 to 70 RPM. They're putting out the same
01:52:16.480
power, but two different strategies. Do you think about that distinction for the cyclist?
01:52:21.620
Well, yes, I do. And this is also something that's very easy to measure. So for example, if you're out and
01:52:26.500
you put on a view to master and you go for a certain power output and you drop, for example,
01:52:30.440
that cadence, so you bring up the torque. Yeah, you can basically make VO2 the metric
01:52:34.760
that helps you decide, and that should correspond most to fatigue. Well, actually, the interesting
01:52:39.940
thing is that what you're seeing now is that you might actually bring down the VO2 as a function of
01:52:45.080
that you're increasing the torque. So you get a little bit better ratio there. But what can happen
01:52:49.600
actually as a functional is that you also see that CO2 comes up a little bit more. So you actually
01:52:53.800
are shifting a little bit to substrate. That's right. Yes, exactly. And of course,
01:52:57.700
the mechanism behind this is probably also like, it's fairly easy to rationalize. And simply because
01:53:03.720
when you are starting to use a higher torque, you are activating a larger cross-sectional area of your
01:53:07.980
muscles. So you're also recruiting more type 2 fibers versus only type 1 fibers as well.
01:53:13.780
So you're becoming much more glycogen dependent as you make that recruitment.
01:53:18.520
It's not entirely black-white like that, but in general, yes. But also here,
01:53:23.100
you can say that because then we're thinking, okay, but we have heard about the expression slow
01:53:27.060
twitch and fast twitch fibers. And should more of that be activated when you start to pedal
01:53:30.980
faster? Well, yes, but you're not even approaching the limit of basically a slow twitch
01:53:36.300
fiber or type 1 fiber contractile velocity when you're at 90 or 100 or 110. It's more a pure
01:53:44.540
limitation of coordination or being able to coordinate your pedaling motion in order to have a better
01:53:50.480
balance between your gross power and your net power. And this is basically where people sometimes
01:53:56.960
they forget this, that what happens, you start to go at a higher cadence. If you now actually measure
01:54:02.280
your gross power and your net power, you start to see that, yes, the net power is the same, but the
01:54:07.920
gross power actually starts to go up when you're starting to bring up your cadence as well, which tells
01:54:13.480
why the VO2 now also starts to go up. The VO2 or the oxygen consumption doesn't care about your
01:54:19.240
propulsive power. It cares about how much power is required now. It's counting both the usable and
01:54:26.780
wasted energy. Exactly. So this is one thing that you see is if you go with a little bit lower cadence,
01:54:32.860
typically what happens is that you have a bed that is easier to coordinate your pedaling motion versus,
01:54:38.360
for example, when you start to go with a higher cadence. Let's say you do a graded exercise test.
01:54:43.160
If you aim for a low torque, the problem is there as the ergometer basically now starts to force you
01:54:48.260
to go to higher power, higher power, higher power, higher power, and you go with a low cadence. This
01:54:53.820
will basically start to increase the motor unit activations. You're recruiting more and more of
01:54:59.480
muscle fibers, and you won't be able to get up to an equally high power output simply because the
01:55:05.540
limitation that comes in now is that you have no more motor units, you have no more muscles to
01:55:10.040
recruit anymore, and you are forced to stop. The only way now to compensate for this is that you
01:55:15.500
have to bring up your cadence instead as a function because if there's no more muscles to recruit there,
01:55:21.200
well, then only thing you can do is start to work faster instead or bring you up the cadence faster.
01:55:26.080
So to bring it back again to your question a little bit about, okay, so you're looking to
01:55:30.200
conditioning or creating the ability to put out a big power there. Again, we know that there's a
01:55:36.200
very good correlation between power and VO2. Obviously, more work, more oxygen consumption,
01:55:41.160
simple as that. You can almost say it's a linear relationship. So if you increase your power by 10%,
01:55:46.180
you will no more increase your oxygen consumption by 10% as well. For those people that are really into
01:55:51.580
the pudding here, of course, they understand that this is not entirely the case. This is a curve
01:55:55.460
linear relationship, but for the simplicity, we keep it this way for now. And just to complete that,
01:56:00.400
you will not increase velocity by 10% in that situation because of the relationship,
01:56:06.340
the square relationship between velocity and drag. So just so folks understand,
01:56:10.020
while those two things are moving up in a curvilinear relationship, the velocity relationship
01:56:14.480
is actually a squared or a power relationship. And therefore, it gets harder and harder when you're
01:56:20.400
talking about athletes at the level that you're coaching to eke out an additional kilometer per
01:56:25.860
hour. When they're already going 48 kilometers per hour, it becomes seismic to try to add 5% to that.
01:56:35.920
Yeah, exactly. So then back to your question. Here, you can think of it this way. Since we know that
01:56:41.460
there is a fairly good correlation between or not a fairly good, it's an extreme good correlation between
01:56:47.020
power and oxygen consumption. Now you can think of it this way. Okay, so how can I then increase my
01:56:52.360
oxygen consumption? Because now we're not talking about milliliters per minute. Now we are talking
01:56:56.620
about milliliters accumulated. So in the same way we talk about power and the relationship between
01:57:02.240
power and work, we could talk about also the difference between milliliters per minute and
01:57:06.720
milliliters per, let's say, session, for example. So then we can think of it this way. Okay, so how do I
01:57:12.120
provide a stronger stimulus, let's say, to the cardiovascular system, respiratory system, to everything,
01:57:17.020
so to basically I get a higher view to max? Well, I would then say that you have already a power
01:57:22.400
meter. So you already have something that we know have an extremely close relationship with oxygen.
01:57:28.020
So how can we now increase the total oxygen consumption during that session there?
01:57:32.700
Then basically, I would probably argue that saying doing five minutes on, five minutes off,
01:57:37.500
for example, will not necessarily yield the maximum work that you can do at that. Because we're not
01:57:43.300
looking at total work during the session, because obviously that would be better if you brought
01:57:46.780
down the intensity in total. But now you're looking for the specific, you want to increase
01:57:51.180
the maximum oxygen output. So we're now looking at something that sits in this range there,
01:57:54.880
there's high intensity. So I would rather here look at it more like go out and play a little bit and
01:57:59.880
look a little bit, okay, what kind of intervals do I have to do here to pack as much as possible
01:58:05.260
kilojoules of work here? At that power outputs during that session that you got available.
01:58:11.820
And I'm pretty sure if you do this over a month, and you go back into the lab and you test your view
01:58:16.560
to max, you'll already see now that you have a higher view to max than what you did have before.
01:58:22.420
And just to give a sense of what some of those games could look like, again, I used to experiment with
01:58:27.300
every type of interval from 30 seconds on to 30 seconds off up to eight minutes on eight minutes
01:58:34.900
off. The only thing that was constant was the one to one work to rest ratio. But as I just alluded
01:58:41.380
to, right, the work to rest could be as little as 30 seconds, one minute, two minutes. Even less.
01:58:47.580
And so what is your intuition? Because again, the classic thinking, classic cycling physiology
01:58:54.180
is maximizing VO2 max and maximizing PVO2 max, powered VO2 max, critical power, for example,
01:59:03.540
is going to be attained at three to eight minute intervals. Now, it doesn't mean you don't improve
01:59:09.280
the engine size when you're doing intervals less than three minutes or more than eight minutes,
01:59:13.460
but you're most efficient in your training time at those intervals. Are you arguing? That's not
01:59:19.680
necessarily true. There could be gains outside of that if you're using maximum kilojoules per unit
01:59:27.100
time as your metric. Yeah. Accumulated inside a session. Think of it this way. We are looking
01:59:32.320
for a stimulus. So to again, make it or to be a little bit blunt, rude, you can think of it if you
01:59:37.600
do one minute. No, if you do five minute interval, and that's the only thing you do, the stimulus that
01:59:42.400
you are providing now at, let's say, PVO2 max or power at VO2 max, for example, or let's say you
01:59:48.260
had an oxygen mask and you could measure now your oxygen up, you will see that the total accumulated
01:59:52.500
oxygen that you have been using now during that session is very, very little. So the reason for
01:59:57.360
why you do intervals and you don't try to do, for example, if you try to do it even as intervals,
02:00:02.000
you even try to just combine those 30 minutes into one power output at all, you won't be able to put
02:00:07.480
out the same amount of power. If you just did it in one go, 30 minutes there, probably then you
02:00:12.540
would be forced to do maybe to bring it down to 280, 270. If it was 300, for example, what's when
02:00:18.480
you did it as five minute intervals, maybe even more down. Now we can think of it this way in the
02:00:23.580
same way. We can just bring it down. So why five minutes? Why did you land on five minutes? Could
02:00:27.420
it also be four, for example? Could it be three? Could it be two? Because what we're really looking at
02:00:31.900
here is the maximum. But we want to make sure we don't make the interval too small that we're
02:00:37.240
cheating and using pure glycolytic power, which obviously has its benefits, but won't necessarily
02:00:44.460
increase, presumably at some level, mitochondrial function and mitochondrial throughput. I mean,
02:00:50.780
because we're so focused on VO2 max here, we want to make sure we're increasing an energy system that
02:00:56.260
is flexible enough to oxidize both glucose and fatty acid through the mitochondria and therefore
02:01:04.160
with oxygen. So at some level, don't those interval durations get so short that we can be misled by
02:01:11.040
what we're seeing, assuming we don't have the oxygen mask. So if we have the oxygen mask, of course,
02:01:16.080
we'll notice that. But if we're only relying on power, that correlation between power and VO2,
02:01:22.920
that linear curve starts to separate in lower durations, doesn't it?
02:01:28.180
One thing to bring in here, so disclaimer, which is very important to think, I think that there's no
02:01:33.040
single workout that is the golden workout. We need different kinds of stimulus. When you do different
02:01:38.980
kind of intervals at VO2 max, they will elicit different functions in your body or different
02:01:44.820
benefits in your body. For example, if you do micro intervals, micro intervals, one of the things
02:01:49.800
that might be there is that you won't necessarily bring your core temperature as high up as you would
02:01:55.180
do if you do a long workout, for example. And we know that also, for example, one thing that's very
02:01:59.720
beneficial to our body is to have more plasma. More plasma is good for us. And we also know that
02:02:05.440
that also has an influence on VO2 max as well, for example. So bringing up the core temperature,
02:02:11.060
let's say also like working on fatigue or being able to focus on relaxing when you get more fatigue in
02:02:16.860
your body as you're doing longer intervals. There are many benefits of doing longer intervals as
02:02:21.200
well. But now we are purely looking at one thing here. So we just said, okay, fine, let's see how
02:02:25.580
can we bring the VO2 max the highest. We disregard everything else. We don't talk about necessarily
02:02:30.620
about endurance, fatigue resistance, all these kinds of things that we just neglect that for now.
02:02:36.380
So now you can think of it this way. What is it that causes us to bring up the oxygen? Why does it
02:02:43.180
come up? Here, I think it is useful to think of also what is the measurement method that we're using
02:02:48.580
as well, very often to quantify this. We have to remember that this oxygen apparatus, when we are
02:02:54.000
measuring oxygen consumption, we are not measuring what's happening inside the muscle. We are measuring
02:02:57.840
what comes out in the exhaust here. And then we are quantifying VO2 max as a function of that.
02:03:03.880
If we go into, so for example, if you do mitochondrial respirations, if you take the mitochondria,
02:03:08.560
you do a biopsy, you take out now the mitochondria, and you put it into chambers,
02:03:13.840
specific chambers there to measure now the mitochondrial respiration, we are not talking
02:03:18.260
about 90 milliliters per minute per kilogram anymore. Even for not well-trained athletes,
02:03:24.120
you're already at 200 milliliters per minute per kilogram. We know that for elites, you are more
02:03:28.660
than 300 to 500 milliliters per minute per kilogram if you go into what the mitochondria is capable
02:03:34.240
of using of oxygen there. Just to make sure we understand that, Olav, what you're saying is
02:03:40.140
we are never limited at the level of the mitochondria. I would say statistically speaking,
02:03:46.900
so if you're not talking about... I mean, not talking about people with mitochondrial disease,
02:03:50.100
but if you're talking about you and me and your athletes and most of the people listening to this,
02:03:55.360
when we ask the question, where is the rate limiting step in oxygen consumption or more to the
02:04:02.520
point oxygen utilization, it is not at the mitochondria. It's not that we are unable to
02:04:08.880
put more oxygen through the system at the final point where it is needed for combustion.
02:04:14.980
By the way, I've always thought it's at the level of stroke volume, that it's actually at
02:04:21.200
getting the plasma to the muscle. Is that what you believe? Getting the oxygen, getting the hemoglobin
02:04:27.960
transported to the cells is the most important thing, more or less. It's more of a central limitation
02:04:32.800
than a peripheral limitation we're talking about there. Because the peripheries, if you look at it,
02:04:37.200
for example, from a mitochondrial perspective, the ratio between what it can use is so extreme
02:04:42.600
compared to what we are able to pump around or take up in our lungs and pump around to the body
02:04:48.120
compared to what we can use. Without touching into that, that actually goes also from when we look
02:04:53.800
at it. For example, you mentioned that my athletes are using a lot of carbohydrates for fueling and so
02:04:59.780
on. We also know that basically the 60 to 90 grams per hour, that's not a limitation either. It's
02:05:06.600
much, much, much higher than that. How do we quantify this? We use isotope traces. So we add
02:05:12.680
isotope traces to the carbohydrate and then basically we similar concept as double label water. But here we
02:05:17.500
add it actually to the carbon instead to look at the carbohydrate uptake. So we know that that's also
02:05:21.920
much higher. This is a lot of research that we have done with Morton, specifically on Christian
02:05:26.920
and Gustav. And we know that, again, if you do muscle biopsies, then we see basically that the
02:05:31.420
carbohydrate is so much higher than what we are able to supply to our system. So again...
02:05:37.200
Sorry, meaning you're limited in what the gastrointestinal tract can tolerate,
02:05:41.760
not at the substrate utilization in the mitochondria.
02:05:46.300
Exactly. Now I'm going to be very crude there. Put it this way. What brings us to VO2 max? It's not
02:05:53.360
because we're thinking that we want to have a high VO2 max. Oh, now I want to. You can start to
02:05:57.180
breathe. Increase your ventilation now as high as you want. Yes, you will increase your oxygen...
02:06:01.880
Right, but you'll never get to your maximum level without sufficient work. You need work.
02:06:05.900
Exactly. Not even close to it. You will bring it up because you're breathing more and you're
02:06:09.720
working more when you're doing that. But then coming back to microintervals and whether this is
02:06:14.580
glycolytic or not, I think that if you go into the muscles and you measure in the muscles, you'll see
02:06:19.400
that basically what happens there is that basically the muscles are trying to use all, absolutely all,
02:06:25.800
basically energy systems immediately, instantly. But because we have a lot of buffer mechanisms in
02:06:32.360
our body, if the burst is short enough, then basically it won't show up as something here because
02:06:38.460
you are basically just feeding it to our body. And then basically you have a long taper or let's say
02:06:42.760
you will never get the spike in VO2, but you can see that you have an elevated VO2 consumption
02:06:47.720
over a little bit longer time. If you just measure during the interval, it won't show up on the
02:06:52.820
exhaust because you take off the mask before it basically shows up there. But if you keep the
02:06:56.760
mask on now and you keep it on there for, let's say, a couple of minutes after, you will see that
02:07:00.640
now that basically you have an elevated oxygen consumption compared to before you did that
02:07:04.700
interval there. So basically we can say that when you do a burst, it will use most likely all
02:07:10.620
energy systems instantaneously, all of them as much as possible. If you say that, okay, now it's
02:07:16.380
first we use stored ATPs and then we shift to PCR and then it becomes glycolytic. And then basically
02:07:21.420
we go off to beta oxidation. I think the more correct way to view this, basically the reason
02:07:25.740
why you can have a high power output, short and high power output is because you are able to supply
02:07:30.360
from all the energy systems instantaneously, but then you're depleting the different energies.
02:07:35.400
Yeah. And then all of a sudden the phospholated creatine comes down immediately and then the
02:07:39.460
glycolytic and then, yeah, yeah, yeah. That makes sense.
02:07:42.640
Yeah. So now basically coming back then to microintervals versus longer intervals,
02:07:46.520
as long as you start to accumulate enough work during that session, because we also talk about
02:07:52.060
VO2 and VCO2. VCO2 is really useful for, you get an instantaneous picture of, of course,
02:07:57.920
what kind of substrates are you using? And whether you are at an RIR value of, let's say,
02:08:02.160
0.8 or even, let's say, below 0.8, for example, but let's say that you are 0.8 or you're 0.9 or
02:08:08.040
you're 1 in RIR value. Basically, it doesn't make that much of a difference in your energy yield. So
02:08:14.080
one milliliter of oxygen, if you use 20 joules of energy, 20 joules as a number to basically
02:08:20.640
understand your energy demand there, you won't go very wrong whether you had been using. So if you put
02:08:25.940
this into the formula and you start to look, okay, how much big of a difference it is there,
02:08:29.960
is not a massive difference. Yes, there is a difference, but it's not massive. So if you
02:08:33.880
want to be accurate, obviously you want to do this. But if you want to understand more of a
02:08:37.460
fueling strategy perspective, then of course you need CO2 to better understand, okay, where are you?
02:08:42.060
How are you using fuels at different times? But here also, we have to remember now that when we
02:08:45.860
go into a lab and we test there as well, this is a completely different picture than what it would
02:08:50.500
be if you brought somebody into the lab at the moment they went over the finish line in a race,
02:08:54.240
because now you would basically see that the velocity that they hold there at the end or the power they
02:08:58.020
hold at the end there, even though maybe it's much lower, it's still very close to their VO2 max,
02:09:04.200
because basically they are not able. So the VO2 max, anything have come down, yeah. So there's a
02:09:08.800
missing time component into this very often when we look at research papers, when we talk about this,
02:09:13.540
because we talk about it very often as a spot picture of something that happened in a fresh state,
02:09:18.240
rested state or whatever, yeah, ideal state. Then coming back to the question and to round that up,
02:09:23.460
I think exactly that when you do microintervals and so on, we talk about glycolitting and so on,
02:09:28.920
basically you can use here also your heart rate as a gauge. If you start to see that when you do
02:09:33.180
microintervals and you're packing in, let's say that you did 310 watts and you were able to accumulate
02:09:38.240
30 minutes of that during that session there. If you now do microintervals, so let's say you're able
02:09:43.680
now to bring it to 330 watts, for example, and you do 30 minutes of that, maybe you're able to do 330
02:09:49.320
watts average and you even accumulated now, for example, 35 minutes of that. What you'll see
02:09:55.340
there, because now it starts to become quite a lot of them there, is that most likely you'll see that
02:09:59.520
you also have a very high heart rate and maybe equally high heart rate as you did when you did
02:10:03.980
the five minute intervals, unless you look at accumulated heart rate there. Because you can
02:10:08.620
here also use heart rates as an indicator of how much time you have accumulated close to VO2 max.
02:10:14.660
Because we know that one of the conditions that has to be met also for you to reach VO2 max
02:10:19.100
is that you also are thinking then you need to pump as a maximum amount of oxygen around in your
02:10:23.480
body in order to do that. And we do know that that is a combination of a very, very high heart
02:10:28.980
rate, close to maximum heart rate and stroke volume as well. So it's just occurred to me that I've got
02:10:36.320
eight pages of notes here of things I want to talk about with you. And we are halfway through the
02:10:42.460
first page. So clearly this is part one of many podcasts we're going to have to do together.
02:10:48.640
Hopefully the next one will be in person. There are, however, a few things I want to discuss
02:10:53.320
before we part today. We have yet to do kind of a more thorough discussion around lactate. And if I
02:11:00.280
can only discuss one more thing with you for maybe another 15 to 30 minutes before we go, I'd like to do
02:11:07.520
a little bit of a deep dive into lactate. Now for some background, since I kind of abandoned any
02:11:14.320
athletic goals and the only thing I train for now is my health, right? It's for my longevity. It's for
02:11:22.060
something I call the centenarian decathlon. So being as fit and strong as I can be in my eighties and
02:11:28.520
nineties without necessarily worrying about what I'm doing today in terms of trying to maximize my
02:11:35.040
performance today, I'm trying to maximize my performance tomorrow. A very important part of my
02:11:39.600
training because my training volume is now so much lower than it used to be when I lived on a bike
02:11:46.420
or lived in the water. I'm trying to be maximally efficient, which is always risky because sometimes
02:11:52.440
you just have to put the miles in. But what I do spend is about three hours a week in zone two. And
02:11:59.900
again, there's so many different ways to describe zones. So I'm not doing this in terms of heart rate.
02:12:03.960
I'm really defining this in terms of mitochondria. So zone two is my highest power output where my
02:12:11.060
lactate stays below two millimole. So this is very sustainable from an RPE perspective. It's RPE six
02:12:21.220
to seven. I can talk, but I'm not comfortable talking, but I can talk. It's definitely below my
02:12:28.180
one hour functional threshold power, but it's more challenging than that 200 Watts riding around in
02:12:35.340
circles, having fun, trying to just purely focus on position. And I do use my lactate. I do check my
02:12:44.060
lactate constantly to make sure that I'm really hitting that spot. Now, what's the rationale for
02:12:51.080
that? Well, the rationale for that is that two millimole is about the tipping point about which you can be in a
02:12:57.580
steady state of producing lactate, clearing lactate. And once lactate starts to get into the three and
02:13:02.960
four millimole range, you wouldn't have indefinite access to that energy system. You're going to start
02:13:08.820
accumulating so much hydrogen that at some point your physics of performance are going to be compromised.
02:13:15.240
So let's now talk about this in terms of world-class athletes. So if you had a continuous lactate
02:13:21.120
sensor on an Ironman in his seven hours and 30 minutes, give me a sense of what his lactate tracing
02:13:29.140
looks like. So this is where I differentiate between volumetric measurements and concentration
02:13:36.560
metrics. Lactate is a concentration metrics. We don't measure the volume of lactate. And the plasma
02:13:42.140
volume is decreasing as the athlete is running. So you would expect the lactate concentration to go
02:13:49.180
up slightly even if the production of lactate is constant. Yeah. Also further here is that we have
02:13:57.720
made some discoveries over the last years as well, which is when we start to do Ironman training,
02:14:05.040
for example, which also are very different from a lot of the understanding that currently is there.
02:14:13.880
There are some things there that are changing and we will definitely touch on this in, let's say,
02:14:19.880
an upcoming podcast. But to give you the trace now, first of all, I think that two millimoles,
02:14:26.100
when you have little time to train during a week. For me, if, for example, you came to me and say,
02:14:31.420
hey, Olaf, I need some training advice. For me, longevity, that's the most important for you or
02:14:36.580
wellness. But we can always say that, well, in the end, it's about whether you have a high view to max
02:14:41.200
really doesn't matter if you're not capable of moving very efficiently around just because you're
02:14:45.620
wasting energy. So we can say that universally, maybe more universally, it's about being able to
02:14:51.080
move more per time. Like we said in the beginning, even moving your head is movement. It's just better
02:14:56.540
if we break it down to a global movement of the body or we break it down to basically, let's say,
02:15:00.940
local movements of parts of our body. But movement is actually the most important thing in the end
02:15:07.240
here for all of us. If you came to me, I would very much look at, okay, most important thing would
02:15:12.860
be to bring joy of exercising and sense of achievement into your training moving forward,
02:15:17.960
because that's what's going to get you out in the day. That's what's going to get you out of the bed.
02:15:21.280
If you look forward to exercising, because you find it enjoyable, you'll do more of it. That's the
02:15:26.280
easier way to get you out. And even where you would start to prioritize it over other things you
02:15:30.320
are doing, instead of pushing it always in front of you. And then finally, you get out and exercise
02:15:34.220
because you know you should do exercising exactly to meet your expectations. So that would be the
02:15:40.780
most important thing. But if we look away from that, the differences between riding also at one
02:15:46.100
millimoles versus two millimoles, as long as one millimole is more sustainable for you, let's say
02:15:51.800
over months and years, because it brings more joy to you, it allows you to maybe be more present or
02:15:56.520
let's say almost use it as a mindfulness session. If that becomes more sustainable, you can think about
02:16:01.960
what you accumulate. Because we very often, again, this is a problem very often with research and
02:16:05.720
many things, is that we give a spot picture of something. We look at something in one session
02:16:09.580
over a couple of sessions, instead of actually looking at over a lifespan or over a long, long
02:16:14.520
period. And then this is where I think exactly that we very often, we undervalue the joy of exercising
02:16:21.600
because we go out with an expectation that, okay, I have to go hard, I have to go all out and this
02:16:26.780
kind of thing, which is very demanding and taxing on the body, especially if you're not prepared for this.
02:16:31.960
I'll interject there that I can completely relate to that. And I've accepted that as a part of the
02:16:40.260
transition in my life. So there was a day, there were many days, there were many years where I had
02:16:46.480
a belief system that said every single day, without exception, you must burn the pack of matches fully
02:16:54.620
at least once. So it didn't matter what the workout was. There was still an all out effort of
02:17:01.840
about three to five minutes somewhere in the day that would probably when I measured it, I wouldn't
02:17:08.440
always measure it, but it would take lactate into the 16 to 18 millimole range, like incredible pain.
02:17:16.360
And truthfully, I can't do that anymore, because I don't have the mental fortitude for that much
02:17:25.520
suffering anymore. I love to exercise, there's never a day that I don't want to. But I also don't have to look
02:17:32.800
forward to that degree of suffering anymore. And I think that that's okay. That's the difference between being
02:17:38.580
50 and being 30. And I also don't think I need to suffer that much, certainly on a daily basis, maybe once in a
02:17:47.520
while. But that said, I still really enjoy quantifying my training. And I know that there are many people
02:17:56.780
who don't. For example, most of my patients are absolutely not measuring their lactate levels during
02:18:04.320
their cardio training. If 2% or 5% are, that would probably be accurate. And for most people, it's what you
02:18:12.600
say. It's, what do I need to do to make you enjoy this? And use your rate of perceived exertion as the
02:18:21.060
guide tool. But look, I still have a little bit of a data person in me. And I like using this metric
02:18:29.340
to maximize the efficiency. And it's a great way for me to track my progress. Am I able to get watts
02:18:35.620
higher and higher and higher, while keeping heart rate and lactate more or less the same? And so I'm just
02:18:42.360
guessing that at your level, this must be a relatively important metric, right? I mean,
02:18:48.080
in terms of, first of all, maybe just define for folks what a lactate threshold is. We haven't even
02:18:53.080
talked about it. It's not something I particularly care about anymore. But talk about what a lactate
02:18:58.180
threshold is, how it's measured. Do you guys even still do lactate performance curves?
02:19:02.800
Yeah, more as a function of other metrics that I collect. Lactate for me, again, is a concentration
02:19:08.600
metric is a marker of something. And for me, it's a marker more of substrate utilization. Not an
02:19:13.900
extremely accurate one, but it's a good one. So I would say that lactate for me is a way that allows
02:19:19.780
me to collect, this is a redundant metric to other metrics as well, to basically be more precise in the
02:19:26.240
way that I would prescribe or change even the training on a session. So I would say that there are
02:19:31.380
plenty of good surrogates or proxies that you can use instead to do the exact same thing without
02:19:38.360
lactate. But if you're looking more, let's say, for example, you want to know better now,
02:19:42.720
for example, your subsidization or have an idea of that, I would say even argue that you can't
02:19:47.740
necessarily only do one measurement. You have to do a little bit of couple of, let's say,
02:19:51.140
little bit change in intensities, not much, but a small range there with a couple of measurements
02:19:55.820
to get an idea because your, let's say, call it your lactate or your maximum lactate steady state
02:20:01.440
concentration, for example, in a session can also vary based on, for example, dehydration.
02:20:06.560
So for example, if you go out, you have one lactate concentration today, this might already change
02:20:11.380
in two days time, for example. That's one. I mean, I'll tell you how we used to do it,
02:20:16.780
and it was probably much cruder than what you would do, but we would do repeated intervals
02:20:23.220
at descending pace. So ascending effort, descending pace. So if it was in the pool,
02:20:28.260
we would swim 100s or 200s. That changed the pace. So you'd go out pretty easy for the first one,
02:20:35.160
check the lactate, fully recover, repeat it, fully recover, repeat it, and you're getting faster and
02:20:40.740
faster and faster. So then you make a graph. The x-axis is the speed. We would note heart rate as
02:20:46.520
well, but we would really focus on speed. And then the y-axis was the lactate concentration,
02:20:51.200
and it becomes a power curve. And again, this is very crude, so I can imagine that now the methods
02:20:57.900
are much better, but you can eyeball them as sort of two separate linear curves, and their intersection
02:21:03.600
becomes the inflection point at which you go from kind of sustainable to unsustainable lactate
02:21:09.420
production, or non-linear parabolic lactate production. And we would sort of say, look,
02:21:14.760
let's just assume that that intersection occurred at 3.5 millimole concentration of lactate. And we
02:21:22.000
would note what the pace was there. We would say to that athlete, you have to be mindful of exceeding
02:21:28.480
that pace. Now, this speaks to everything you just said. I mean, that pace is going to change depending
02:21:34.440
on your hydration, depending on your energy reserves, depending on your fatigue. So of course,
02:21:40.100
it's crude, but directionally, that's what we thought about as you have to be very careful every
02:21:46.180
time you exceed that pace in a race, because you're now tapping into a very finite reserve.
02:21:52.120
Is that kind of how you still do it, albeit probably with much more accuracy?
02:21:56.700
What I really like with what you say is, one, you talk about the infliction point,
02:22:00.700
because this is very misunderstood. Some people still today go by fixed blood lactate accumulation
02:22:06.240
values or concentration values. So they stick, for example, to four millimoles or something like
02:22:11.020
this. And okay, if you're going to publish a paper and you want it to be able to compare with other
02:22:16.120
papers that are out there, that's fine. But already here, the problem with that is that four millimoles
02:22:21.440
can be accumulated in a whole range of different ways. You can go just above your second infliction
02:22:27.180
point, or just above maximum like this day, and then you creep up towards four millimoles,
02:22:31.460
meaning that now you have to have a smaller power output in order to get there. Or you can go with a
02:22:36.040
very high power output, and it will take a short time for you to reach that four millimoles there.
02:22:40.240
So how do you now go backwards and say that, okay, well, four millimoles should correlate to this
02:22:44.100
power. It's highly dependent on the protocol that you're doing there already. The way that you
02:22:49.280
described that you basically said it is something I would say that this is fine, because the two most
02:22:54.140
important things, if you want to use it as a way to control your intensity, so you want to,
02:22:58.300
let's say, a different way of controlling intensity, as opposed to, for example, heart rate or other
02:23:02.640
things. And we know, of course, again, heart rate, again, also influenced by hydration,
02:23:06.100
and other stressors and other things as well. So when you are using lactate now, one, I like the
02:23:11.880
way that you describe it. You talk about the infliction points perfectly, and make it as simple
02:23:15.460
as you said as well. Depending on how long your protocol is now, you can draw three lines. You're
02:23:19.720
looking at basically drawing one line that goes through the flat section of your profile more,
02:23:23.440
or let's say, of the lactate. Then you get one that goes more on, let's say, on the liner increase
02:23:27.300
for every step you increase in pace. Then basically, you also see there's an increase in lactate. But at some
02:23:31.900
point, you see there's a complete departure between increase in pace and lactate, and it goes
02:23:38.940
Yeah. So this is where you could say that also then talking back to, for example, metabolism,
02:23:43.480
you could say that the first infliction point is not too far off where normally where you would see
02:23:47.300
your fat max is. And the second one is typically where you would see your maximum lactate steady state
02:23:52.420
And some people, I think, in the nomenclature call that LT1, LT2?
02:23:57.260
Yes. We use that very much. I like to be specific in this sense, because when you talk about LT
02:24:02.180
and LT2, then you already have distinguished it away from, for example, MLSS.
02:24:09.240
Yeah. Because if you talk about MLSS, this actually normally requires you to do a very specific profile.
02:24:14.840
So you would do, for example, longer interval. So you could, for example, do 30-minute or 20-minute
02:24:20.660
rolling effort, for example, and you're looking at lactate as a function of, let's say,
02:24:25.240
every five minutes to see whether the lactate value is stable or whether it starts to increase.
02:24:30.020
So maximum lactate steady state is basically what it says in the names is the highest lactate
02:24:36.560
value that you're able to sustain steady state. If you go now a little bit higher in effort or in
02:24:43.480
intensity, or let's say you are accumulating a little bit more fatigue, then basically you already
02:24:47.880
start to see that now lactate is not stable anymore. For the same power output down, it
02:24:51.920
will actually start to see that lactate starts to accumulate up, going upwards. So it's not steady
02:24:57.580
And what capacity or duration is built into that assumption of LT2? Because again, LT2 cannot
02:25:04.760
be sustained indefinitely. So there's some point at which it ceases to be a true steady state.
02:25:12.040
So this, again, depends a little bit because at maximum lactate steady state, depending on how
02:25:17.620
powerful the athlete is, and here is also a misconception, a lot of people think that maximum
02:25:22.060
lactate steady state is the equivalent of RR value of one. This is not correct.
02:25:27.340
So one thing you very often see is that for, actually, this is something that we discovered
02:25:31.900
with our athletes through different when we went Ironman and when we went Olympic racing,
02:25:37.320
so short, long, and other athletes as well. And that is that what you'll see is that the maximum
02:25:41.620
molecular steady state typically occurs at the lower RR value, depending on the distance you're
02:25:46.460
doing. So the longer the distance you do, you'll actually find that that sits at the lower RR value.
02:25:51.200
It is logical. If you look at it from a physics perspective, or let's say you were talking about
02:25:55.680
stationary action principle, for example, or thermodynamics, then basically how do you supply
02:26:01.060
the bodies with the most sustainable energy, the simplest possible way? Yeah, it comes back to that.
02:26:05.860
At an Olympic distance, are they able to hold LT2 for the whole race? Whereas at the Ironman,
02:26:17.520
The problem with very powerful athletes is that already, because now this is the problem where
02:26:22.720
lactate comes in, because lactate only looks at concentration, it doesn't look at volume.
02:26:26.820
So the problem is that the LT1 will already occur. So very high utilization of VO2 max for an
02:26:34.080
Ironman athlete. How high? Just give us a sense.
02:26:37.240
Well, I have to sit down now because now it's more than a year ago since we did Ironman.
02:26:42.200
Roughly speaking, I would say that it sits in at around close to 80% of VO2 max.
02:26:48.120
That's right. So if the VO2 max is six liters per minute, at 80% of that at 4.8 liters per minute,
02:26:58.980
Yeah. And that you already do know that that's not sustainable because you're already now turning
02:27:03.500
around so much carbs per hour that this doesn't work anymore. So you have to-
02:27:07.400
Well, but hang on, hang on. It depends a little bit on the RER, right? Because you're now at maximum
02:27:12.860
And so what are your athletes? Now, your athletes have one thing working for them and one thing
02:27:18.260
working against them. The thing that they have working for them is they have the healthiest
02:27:22.340
mitochondria on the planet. But the thing they have working against them is they're on a very
02:27:27.120
high carbohydrate diet. And I'm saying for and against them in terms of fuel utilization.
02:27:31.700
So they actually have the capacity for insane fat oxidation, but their system is tuned towards
02:27:41.160
a faster fuel, not a more energy dense fuel. So let me guess, would they hit 0.8 grams per minute
02:27:50.240
of fat ox? Are they getting that high? Put it this way, we have had blocks where we just have been
02:27:56.320
looking at how high we can get them in fat ox and it's extremely high, but I have to go back.
02:28:00.560
You're probably getting close to one gram per minute then.
02:28:07.900
It's absurd to me that we are out of time here. And if it weren't for the fact that I had a hundred
02:28:11.960
patient calls today that I can't just cancel, we would just continue to do this.
02:28:16.340
So we have officially covered two thirds of one page out of eight pages. We have not yet talked
02:28:23.020
about what I want to discuss around muscle biopsies. We have not talked about getting into
02:28:28.680
anaerobic threshold, a term that I don't pay any attention to, but I think we should talk
02:28:32.140
about. We haven't talked about the use of temperature probes and understanding the effect
02:28:37.700
of cooling during both competition and training. We haven't talked about heart rate, heart rate
02:28:42.180
variability, training desire, performance, and recovery. We have not talked about some questions
02:28:47.380
I have about the use of PEDs and why they don't seem as prevalent in triathlon as they do
02:28:53.380
in other endurance sports. I could go on and on. That's just finishing what's on the first
02:28:56.760
page. I wanted to really get into MCT density. I wanted to talk about too many things for me to
02:29:02.200
even rattle off now. So you said you're going to be in the U S at some point. I hope we could do
02:29:06.980
round two of this in person. Would be fantastic. All right. Yeah. This has been really cool for me
02:29:12.720
as well. I want to say also one final thing here. We, of course, we talk very much about terminology
02:29:17.440
and how we see things and so on. One thing that is important for me to be very clear on is that
02:29:22.720
terminology is one thing, but we have to remember also that people might use these terminologies
02:29:27.580
also differently as well. And as long as a coach and an athlete, for example, have an understanding
02:29:33.100
of something and that works for them, don't get discouraged or don't start quarreling over
02:29:38.280
definitions and these kinds of things. Because the most important thing is exactly that you have a
02:29:42.020
language and it does work for you. And that's most important. People like us come and hammer them
02:29:46.420
with a lot of terminologies and a lot of definitions. They obviously have gotten something
02:29:51.320
right. And it's important to have respect for that. And it's also a lot of things that we don't
02:29:54.860
know. There's a reason why we are continuing to do all this research as well, because we are so
02:29:59.920
curious. We want to understand more and we understand that there's so much still to discover
02:30:04.480
as well about everything we even covered now during this call. Well, thank you, Olaf. That was really
02:30:10.320
wonderful. I very much look forward to round two. The same. Thank you so much.
02:30:14.580
Thank you for listening to this week's episode of The Drive. It's extremely important to me to
02:30:20.040
provide all of this content without relying on paid ads. To do this, our work is made entirely
02:30:25.020
possible by our members. And in return, we offer exclusive member-only content and benefits above and
02:30:31.660
beyond what is available for free. So if you want to take your knowledge of this space to the next
02:30:35.980
level, it's our goal to ensure members get back much more than the price of the subscription.
02:30:40.480
Premium membership includes several benefits. First, comprehensive podcast show notes that
02:30:46.820
detail every topic, paper, person, and thing that we discuss in each episode. And the word on the
02:30:52.680
street is nobody's show notes rival ours. Second, monthly Ask Me Anything or AMA episodes. These
02:31:00.280
episodes are comprised of detailed responses to subscriber questions typically focused on a single
02:31:05.380
topic and are designed to offer a great deal of clarity and detail on topics of special interest
02:31:10.740
to our members. You'll also get access to the show notes for these episodes, of course.
02:31:15.460
Third, delivery of our premium newsletter, which is put together by our dedicated team of research
02:31:20.840
analysts. This newsletter covers a wide range of topics related to longevity and provides much more
02:31:26.780
detail than our free weekly newsletter. Fourth, access to our private podcast feed that provides you
02:31:34.080
with access to every episode, including AMA's sans the spiel you're listening to now and in your
02:31:40.020
regular podcast feed. Fifth, the Qualies, an additional member-only podcast we put together that serves as
02:31:47.320
a highlight reel featuring the best excerpts from previous episodes of The Drive. This is a great way to
02:31:52.960
catch up on previous episodes without having to go back and listen to each one of them. And finally,
02:31:58.040
other benefits that are added along the way. If you want to learn more and access these member-only
02:32:03.240
benefits, you can head over to peteratiamd.com forward slash subscribe. You can also find me
02:32:09.800
on YouTube, Instagram, and Twitter, all with the handle peteratiamd. You can also leave us a review
02:32:15.880
on Apple Podcasts or whatever podcast player you use. This podcast is for general informational purposes
02:32:22.360
only and does not constitute the practice of medicine, nursing, or other professional healthcare
02:32:26.920
services, including the giving of medical advice. No doctor-patient relationship is formed.
02:32:32.240
The use of this information and the materials linked to this podcast is at the user's own risk.
02:32:38.680
The content on this podcast is not intended to be a substitute for professional medical advice,
02:32:43.340
diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice from any
02:32:48.820
medical condition they have, and they should seek the assistance of their healthcare professionals for
02:32:53.640
any such conditions. Finally, I take all conflicts of interest very seriously. For all of my
02:32:59.320
disclosures and the companies I invest in or advise, please visit peteratiamd.com forward slash about
02:33:06.640
where I keep an up-to-date and active list of all disclosures.