Valuetainment - ＂You'll Regain All The Weight＂ - Health Expert's Ozempic WARNING To Charles Barkley & Oprah

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00:00:30.000 The other day I'm watching a, I was watching either a playoff game or something,

00:00:34.600 and then I saw Barkley come up, and Barkley was doing a GLP-1 commercial.

00:00:39.420 I'm like, Charles Barkley, I've seen the Serena Williams one for only $10 or whatever,

00:00:44.360 so it's more of a money ad that she does, and she's lost a lot of weight.

00:00:48.000 But then I saw Barkley, and I saw the numbers reported that Barkley had lost,

00:00:53.080 he went from 360 pounds to weighing 252 pounds to 267.

00:01:03.340 He's lost 85 pounds using this product on Mount Jaro,

00:01:09.960 which is like a form of a GLP-1, okay?

00:01:13.580 And he says, I know GLP-1s are effective.

00:01:15.820 I witnessed it myself.

00:01:17.060 The difficult part was obtaining medication.

00:01:19.760 He wants to get back to his playing days,

00:01:21.400 which, by the way, he looks great.

00:01:22.720 He's 258, he's 267 pounds today.

00:01:25.740 Playing days was 250.

00:01:27.660 And then I had Humberto and Rob pull up some stats on obesity and being overweight.

00:01:32.300 And I saw the video you posted of New York back in 1920 versus today.

00:01:36.300 Rob, I don't know if you have that clip or not.

00:01:38.500 And this is such a great video of comparing what America looked like in 1920.

00:01:44.080 Well, it's overlapping because he's speaking on it.

00:01:46.360 So if you can find another one, Rob will show it.

00:01:48.700 It's just 1920.

00:01:49.520 You type in on X, New York 1920 versus today.

00:01:52.720 And the numbers we pulled up is in 1920, only 3% of Americans were obese.

00:02:00.400 Today, it's 41%.

00:02:02.640 Why do we get so fat in America?

00:02:06.160 It's over 70% obese and overweight, Pat.

00:02:09.500 Over 70% obese and overweight.

00:02:11.540 And that's according to CDC, by the way, that number you're giving.

00:02:13.740 That's according to CDC.

00:02:15.800 And so this is crazy.

00:02:17.060 And it's so interesting because I think that more than anything,

00:02:19.580 the GLP-1 conversation.

00:02:22.600 Manjaro is a dual agonist,

00:02:25.100 so it's GLP-1 and GIP.

00:02:26.740 It's also called terzepatide.

00:02:28.500 These medications work,

00:02:30.720 but the fact that they work so well,

00:02:32.900 I think is a clarion call to this idea

00:02:35.700 that like, how did we get so fat?

00:02:37.160 This question you're asking.

00:02:38.460 They partially ameliorate a problem

00:02:40.600 that did not exist 100 years ago.

00:02:42.440 You look at New York, we were not fat.

00:02:45.600 And so I think that this is a clear indication

00:02:48.040 that our food supply has just become so badly tainted and oprah's talked about this she had a

00:02:53.880 very viral clip on the view i think it was from 2024 or 2025 where she said i have the fat gene

00:03:01.040 which is not true there's no such thing as a fat gene but what there is is something called food

00:03:05.500 noise this idea and i think oprah poor oprah didn't realize this she used to promote weight

00:03:10.520 watchers right so she was promoting low quality food in low calorie packets when we are eating 0.99

00:03:17.060 this tainted food that is full of all these ingredients that no one can pronounce.

00:03:21.580 You, your great-grandmother, my great-grandmother wouldn't recognize these food ingredients.

00:03:25.800 These food ingredients are literally poisoning our brains, the satiety centers in the hypothalamus

00:03:31.080 of our brains, and we cannot stop eating.

00:03:34.100 And so in some ways, these GLP-1s, Monjaro, Ozempic, and Retatrutide, which is a triple

00:03:39.700 agonist, they sort of address this food noise, the poisoning of our brains by the food, but

00:03:45.740 there are things to think about here. There are potential downsides to these medications also.

00:03:50.240 But for me, the biggest thing this conversation around Ozempic, Manjaro, and Reditrutide says is

00:03:55.060 how did we get so poisoned by our food? If we need a medication to actually calm the food noise,

00:04:02.460 to partially reverse the complete destruction of our satiety that these engineered foods have

00:04:10.020 caused, can't we just talk about going back to simple foods? Because in the early 1900s,

00:04:15.740 Most of what we ate were single-ingredient foods.

00:04:19.140 We talked about this on the last podcast.

00:04:21.220 What are single-ingredient foods?

00:04:23.200 Beef, chicken, fish, pork, lettuce, apples, celery.

00:04:29.700 Cheese, milk.

00:04:30.820 These are single-ingredient foods.

00:04:32.120 It is virtually impossible to get fat or stay fat eating those foods.

00:04:39.900 Even if you overeat.

00:04:41.400 It's very difficult to overeat those foods

00:04:43.500 because our body has a programmed satiety mechanism in our brain

00:04:47.480 that is hundreds of thousands of years old.

00:04:50.680 It's very difficult to overeat steak and boiled potatoes.

00:04:54.900 It's very difficult to overeat steak and lettuce.

00:04:57.600 It's very difficult to overeat chicken and avocado.

00:05:00.760 You will get a very clear satiety signal, and you're just not interested in eating.

00:05:05.380 So, Dan, let me ask you this question.

00:05:06.660 I read a book called Ageless Man, and I don't know if you've heard of this book,

00:05:11.520 Ageless Man, where it talks about in the book that men with lower testosterone is worse for

00:05:21.760 their health than higher testosterone. And they did a test on rats, I don't know, mouse,

00:05:27.960 certain testing they did, giving them testosterone and seeing how they would, and they would live 0.97

00:05:32.720 longer, ageless men. So the argument then becomes, you're better off being on TRT than not being on 0.96

00:05:37.800 TRT okay there's a benefit to it some people are not sitting there saying okay Charles Barkley

00:05:43.200 he's been dealing with weight for a while is he healthier continuing to live his lifestyle

00:05:49.600 doesn't change anything he stays at 352 doesn't use GLP-1 or is he better off using GLP-1 drop

00:05:55.780 into 267 he's carrying 85 pounds less fat what's a better decision for a guy like Barkley it's

00:06:02.140 almost certainly using the GLP-1 so in this case it's a good case to use it it's a good case to

00:06:06.740 Use it provided that Charles won't change his diet, right?

00:06:09.800 And we can talk about the long-term consequences of using that GLP-1, potentially.

00:06:14.420 But yeah, there is a use case for these medications, unquestionably.

00:06:18.340 In some ways, like I said, they probably reverse or help address the poisoning of our brains that's been going on by our food system.

00:06:26.640 The first choice that I would have for Charles is, can we just get you a chef to cook you delicious food that's singling?

00:06:33.120 He can afford that.

00:06:33.720 Yeah, to get you single ingredient foods all the time.

00:06:36.740 Because that, I believe, is going to lead to better long-term weight loss.

00:06:41.340 One of the first issues I have with these GLPs is you're probably on them for life.

00:06:45.980 So if Charles stops the GLP-1, the research is pretty clear that he's going to regain the weight within one to two years.

00:06:53.580 Almost all of it and sometimes more.

00:06:56.600 Why is that?

00:06:57.480 Because when you use the GLP-1s, there are changes that happen in the body that don't catch up to the changes that you're making with food.

00:07:05.540 So when you're using a GLP-1, it creates satiety.

00:07:08.620 There are some potentially beneficial metabolic effects of these medications.

00:07:12.440 But when you stop it, you're going to go back to eating the food you were eating before because you haven't made lifestyle changes.

00:07:17.500 You haven't developed discipline.

00:07:18.780 You haven't understood how to make the right food choices.

00:07:21.220 And your eating habits are going to outpace your metabolism because these GLPs will slow down your metabolism because you're eating less food.

00:07:30.280 And so you've lost fat.

00:07:32.420 You've also lost muscle mass.

00:07:33.880 muscle mass is positive for our metabolism. Muscle mass burns calories when we're sitting

00:07:38.500 here having a podcast. That's what you want. And so if you're on a GLP-1, you have to be very

00:07:42.500 careful you don't lose too much muscle mass by continuing to exercise, continuing to eat enough

00:07:46.900 protein. But when you stop it, the eating habits that you never fixed will outpace the metabolism

00:07:53.120 that's been changed by the GLPs. There's a study that came out saying that when you stop a GLP-1,

00:07:57.700 you regain the weight four times faster than if you stopped exercise. Four times faster. So this

00:08:03.980 is the problem. And so it's great for the pharmaceutical companies. I think that they

00:08:08.120 say Manjaro terzepatide is the number one selling drug in the world now. And I think people are

00:08:14.440 suggesting that retitrutide, which is the triple agonist, it's not FDA cleared yet, but probably

00:08:18.940 will obtain FDA clearance in 2027, will be the best selling drug in the world almost immediately.

00:08:25.060 And so here we are with very widely used drugs that people may need to be on for life to maintain the, quote, benefits.

00:08:36.580 That's a little concerning because people run into GI side effects.

00:08:39.760 People can run into other side effects, ocular side effects.

00:08:43.560 And then what do you do if you cannot continue?

00:08:45.780 The discontinuation rate of these drugs is not insignificant because people do run into side effects.

00:08:51.020 So is it a short-term fix?

00:08:53.020 Potentially.

00:08:53.540 Does it have side effects?

00:08:55.060 guess it's they're fairly safe drugs on balance they're not perfect they're fairly safe but you

00:09:00.960 are i want people to understand that when you take these drugs you are essentially committing

00:09:06.220 yourself to a lifelong use of the drug which is always a little bit concerning for us right

00:09:10.580 and there is another way which is like we said humans have eaten single ingredient foods or

00:09:17.860 foods that your great grandmother would recognize the label for hundreds of thousands of years

00:09:21.840 Try getting fat on chicken breast and avocado.

00:09:25.560 It doesn't happen.

00:09:26.140 Regular food.

00:09:26.640 But that's boring, right?

00:09:27.760 That's slow.

00:09:28.640 Come on, Paul.

00:09:30.500 I don't have the time for that.

00:09:31.980 I would much rather take the shortcut.

00:09:33.960 10 million people, according to JPMorgan Chase, are using GLP-1's 2025.

00:09:38.660 They're guesstimating it's going to be $25 million by 2030, four years from now.

00:09:43.540 And then on top of that, the cost is what?

00:09:46.940 $1,200 a month, they say, give or take.

00:09:48.760 If you have insurance, of course, it's a different story.

00:09:51.100 but $1,200. So the average person to do $1,200 a month, and you'll need to be on it for, you know,

00:09:57.400 depending, let's just say it's a year program, that's $15,000. That's a big cost to a lot of

00:10:02.540 different people. So some of these insurance companies are now adding it to it. So then the

00:10:06.820 question becomes, what is it? Is it really, when I talk to people who use it, all it does is it

00:10:12.640 tells you you're not hungry. Is that really all it does? It does a few more things in that. It does.

00:10:16.960 it's a diabetes drug. It's not like it was... It's also a diabetes drug. They're also using

00:10:21.300 it for addictions. It's being studied for addictions, which is a very interesting

00:10:25.200 sort of sidebar. Because the GLP-1 receptors do occur in the pleasure pathways in the brain. So

00:10:32.400 there's a lot of complex names here. VTA, ventral tegmental area, nucleus accumbens.

00:10:37.460 These are the pleasure pathways in our brain that are activated with nicotine, with alcohol,

00:10:41.380 with romance, sex, learning. And so I think that the next use we'll see for these medications is

00:10:48.160 with addictions. But then there's another sort of corollary conversation. And this is perhaps

00:10:54.200 not the most important part of the GLP-1 conversation, but it is relevant for some

00:11:00.400 people that is it possible that if you use these medications, it will affect your ability to make

00:11:06.600 new relationships fall in love and desire and this is at this point it's purely anecdotal but

00:11:11.920 the conversations on x are very compelling what does that mean what does that have to do with

00:11:15.940 relationships well because if you're if you're over stimulating so glp1 agonist if you're

00:11:20.760 over stimulating the glp1 receptors in the pleasure pathways in the brain the vta the

00:11:26.380 nucleus accumbens are you blunting your ability just like they're going to be effective for

00:11:31.380 addictions they sort of decrease the food reward and they're going to decrease the reward of

00:11:36.080 alcohol they decrease the reward of smoking and potentially other addictive drugs are they going

00:11:40.600 to decrease the normal pleasure pathways that are activated when you fall in love with someone

00:11:45.260 when you have desire this is a concern again i don't think this is the primary conversation

00:11:50.280 but this is the corollary conversation of maybe it's not a good thing to be on these for the rest

00:11:55.980 of our lives and we don't know i want to be very clear we don't know the answer to this

00:11:59.780 but if you look at it 2005 right if i'm not mistaken yeah glp1's uh first one that was

00:12:04.980 FDA approved was sold in 2005. So we only have 20 years of data on this. That's for Ozempic,

00:12:11.260 for semaglutide, and Manjaro is very more recent, and retitrutide has never been approved by the

00:12:16.100 FDA. So we don't even have long-term data on retitrutide. Is it on track to get? It is. It

00:12:20.340 is. 2027, yes. So for someone like Charles Barkley, great example, probably on balance,

00:12:25.660 these are positive if he can't make lifestyle changes. But what about the millions of young

00:12:32.400 men who are at 15% body fat and could just eat single ingredient foods, but are going to take

00:12:38.680 retitrutide or terzepatide to get down to 11% to look shredded. Is it going to affect relationships?

00:12:45.180 Is it going to affect how we relate to people? It's a really compelling question because the

00:12:49.180 neurobiological mechanisms in our brain are there. And if you look on X, there are a lot of these

00:12:53.600 threads. People are saying, I was at a conversation. I just saw it last night. You can pull it up on X.

00:12:58.000 I don't know the account. I think it's Tyler Durden's account. It's this guy.

00:13:01.480 This is an eponymous account from Fight Club.

00:13:06.140 And he was just saying, I was at dinner the other day and people were saying that they're falling out of love on Ozempic.

00:13:13.360 And it was like over a million impressions or something.

00:13:16.060 It was really interesting that when you put that out there, people are actually saying, this happened to me.

00:13:21.800 Now, again, there are lots of cases where—

00:13:23.420 Can you pull that up?

00:13:23.820 I'm actually curious to know the comment section on what they said, if you find that.

00:13:27.200 Was that recently?

00:13:27.960 I just saw it last night, so it's got to be pretty recent on his account.

00:13:30.740 We can find it.

00:13:32.260 I would say, yeah, search for Tyler Durden, like falling out of love, GLP-1s or something. 0.99

00:13:37.860 Yeah. 1.00

00:13:39.220 But keep going.

00:13:39.940 Yeah.

00:13:40.140 I'm tracking.

00:13:40.520 So falling out of love.

00:13:42.220 And there's been a lot of theorizing around this just because of these neurobiological preserved pathways in the brain.

00:13:50.160 So who knows here, right?

00:13:51.360 Who knows?

00:13:51.760 But I think that my point with Ozempic, Monjaro, Terzepatide is there is another way, right?

00:13:58.260 And I wish I could have told this to Oprah 15, 20 years ago.

00:14:01.480 There is another way to do this, and it goes back to something that's not sexy,

00:14:06.620 that's a little bit easier, that requires discipline, but that works longer term,

00:14:09.620 which is, hey, simple, single-ingredient foods, this is the way.

00:14:15.600 Yes.

00:14:16.680 Hearing some interesting stories from friends who have friends taking peptides,

00:14:20.340 falling completely out of love overnight with wives and partners.

00:14:23.140 Go a little bit lower.

00:14:24.800 You're not permitted to comment this post if you took failed the COVID IQ test,

00:14:29.060 the rule of 5.5 billion shears go lower let's see if people are saying at this stem keep going lower

00:14:34.740 yeah that's interesting to be to be thinking about that kills enjoyment and and by peptides he's

00:14:39.900 talking about glp1s here because those are the peptides that are affecting the enjoyment in

00:14:44.580 the ventral tegmental area the nucleus accumbens and it's something we don't we don't know for

00:14:49.300 sure but it's it's very concerning could it be that it's because you know every time there's

00:14:53.820 something there's fear porn could it be the fact that you're on glp ones if you're 350 pounds

00:15:00.040 and you don't make a lot of money and you're not that successful odds are your wife is probably 0.90

00:15:05.700 close to 350 pound type of a person i don't know if i'm being a prick here i'm just saying

00:15:10.220 statistically unless if you're charles barkley you're famous you're going to get any girl you

00:15:14.720 want for the most part but odds are you're not dating somebody as attractive as you so then all

00:15:19.860 of a sudden you get on GLP once in Ozembeck and you lose 50, 60, 70 pounds. I'll let you say you

00:15:24.640 were 220. Now you're at 150. You look amazing. People are now looking at you. Maybe it's not

00:15:29.660 that you're falling out of love with your spouse. Maybe you now have options you didn't have before.

00:15:34.580 It's very possible. And there are, there certainly are situations where both people in the relationship

00:15:41.460 get on these medications. Both people become more attractive and probably the relationship gets

00:15:45.580 better but i just think it's a really interesting biological mechanism in the brain with no

00:15:52.360 neurological pathways and you can look it up too these medications do have effects for addiction

00:15:56.520 so there's something going on oh no question pleasure no question about that there's no

00:16:00.300 there's no biological free lunch pat and that's that's just a little note of caution that i want

00:16:05.840 to add to these a little asterisk i want to add to these medications no biological free lunch when

00:16:10.020 people are saying retitrutide is the best thing since sliced bread i'm thinking just wait just

00:16:14.740 wait you know because we're there's there's no biological free line yeah well we'll see we'll

00:16:19.620 see that part on what's going to happen the reality of it is uh in u.s i think the ozempic

00:16:24.980 product by itself plus the diabetes combined together is a 40 to an 80 billion dollar industry

00:16:30.360 right now and they're saying it's going to get to 100 to 200 billion dollars by 2030 2035

00:16:35.760 so when you see a number like that this brings me up to the next question

00:16:40.420 Last year, Big Pharma spent some $7 billion on advertising.

00:16:45.100 And one of the conversations you and I had, as well as I had with Bobby, was with Maha.

00:16:50.960 And when he would get in, there you go, $7 billion in 2025 Big Pharma.

00:16:55.580 That's a lot of money.

00:16:56.440 So that money is going to media, you know, channels, CNN, everybody's, Fox, NBC.

00:17:03.060 They're all getting a part of that money.

00:17:05.160 But one of the things we discussed was there's only two countries in the world that allow this.

00:17:09.640 It's us in New Zealand that, you know, Maha would possibly work on eliminating big pharma from being able to advertise on TV.

00:17:18.280 How much progress have you guys made on that?

00:17:20.200 I don't think there's been much progress on that, unfortunately.

00:17:22.700 Why do you think that is?

00:17:23.680 Well, you talked about it before, because if you eliminate the pharmaceutical ad revenue from television stations, you're going to see all the television stations collapse.

00:17:31.320 We can look up the amount of money spent by, we're looking at it right now,

00:17:34.360 but how much of any television station, any news channel is pharmaceutical ads?

00:17:42.000 It's a lot today.

00:17:43.020 I started off with the first story being Barclay because I saw it on an ad.

00:17:45.880 Yeah.

00:17:46.360 So if I don't see that on ad, I don't know if I know that Barclay lost weight.

00:17:51.920 What does it say, Rob?

00:17:54.080 13.1% of all national linear TV ad spends were from Big Pharma in Q3.

00:17:59.460 14 percent pharma spending grew to 16 percent by 2025 yeah well that's yeah it's a big it's a big

00:18:06.820 deal a lot of ads what's the likelihood that they'll get it done or this is something that's

00:18:12.060 probably not going to get done i don't see it happening okay it's just it's too close to home

00:18:16.400 you know it's too close to home i can't see it the lobby is too strong and again i would love to see

00:18:22.440 it happen a lot of people watch television a lot of people are influenced by these ads i don't see

00:18:28.160 it happening unfortunately okay hey guys i am paul saladino you can find me on minect if you have

00:18:32.600 any questions about diet health recovering from chronic illness or autoimmune disease i'm excited

00:18:37.780 to connect with you guys all there and i'll see you in there if you enjoy this video you want to

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Valuetainment - May 22, 2026

＂You'll Regain All The Weight＂ - Health Expert's Ozempic WARNING To Charles Barkley & Oprah

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